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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Association between Helicobacter pylori infection,mismatch repair,HER2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn Sanchez Matteo Fassan katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri Eloy Ruiz Juvenal Sanchez Fernando Barreda Daniel Valdivia Yaqueline Bazan Milagros Abad-Licham Claudio Mengoa Hugo Fuentes Paola Montenegro Ebert Poquioma Raul Alatrista Claudio J Flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGROUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMR),HER2-status and *** infection and their association with TIL levels in *** Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)*** density of CD3,CD8 and CD163 immune cells,and dMMR and HER2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCR(qPCR)in a subset of *** dMMR was found in 34.4%,HER2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(P<0.001),intestinal-histology(P<0.001)and no-recurrence(P=0.003).dMMR was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCR.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMR and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HER2 Mismatch repair

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华尔街“赌徒” 比尔·黄被判有罪

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商业周刊（中文版） 2024年第11期 22-23页

作者： Sridhar Natarajan Ava Benny-Morrison katherine Burton 王非(译) 不详

这位在一周内赔掉360亿美元的著名金融家现在或面临牢狱之灾。比尔·黄(Bill Hwang)说,那来自他的一个梦。在梦里,基督的鲜血冲刷着纽约,洗涤着这座大都市的罪恶。比尔·黄被这个意象深深打动,于是委托一位著名艺术家把他的梦境呈现出来。

关键词：牢狱之灾华尔街大都市金融家赌徒

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Two-dimensional d-πconjugated metal-organic framework based on hexahydroxytrinaphthylene

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Nano Research 2021年第2期14卷 369-375页

作者： Zheng Meng katherine A.Mirica Department of Chemistry Burke Laboratory41 College Streety Dartmouth CollegeHanoverNH 03755USA

The development of new two-dimensional(2D)d-πconjugated metal-organic frameworks(MOFs)holds great promise for the construction of a new generation of porous and semiconductive *** paper describes the synthesis,structural characterization,and electronic properties of a new d-πconjugated 2D MOF based on the use of a new ligand 2,3,8,9,14,*** reticular self-assembly of this largeπ-conjugated organic building block with Cu(II)ions in a mixed solvent system of 1,3-dimethyl-2-imidazolidinone(DMI)and H2 O with the addition of ammonia water or ethylenediamine leads to a highly crystalline MOF Cu3(HHTN)2,which possesses pore aperture of 2.5 ***3(HHTN)2 MOF shows moderate electrical conductivity of 9.01×10^(-8)S·cm^(-1)at 385 K and temperature-dependent band gap ranging from 0.75 to 1.65 *** chemical oxidation by l2,the conductivity of Cu3(HHTN)2 can be increased by 360 *** access to HHTN based MOF adds an important member to previously reported MOF systems with hexagonal lattice,paving the way towards systematic studies of structure-property relationships of semiconductive MOFs.

关键词： two-dimensional metal-organic framework(MOF) trinaphthylene conductive MOF

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Plasmon point spread functions： How do we model plasmon-mediated emission processes？

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Frontiers of physics 2014年第1期9卷 3-16页

作者： katherine A. Willets Department of Chemistry University of Texas at AustinWelch Hall 1.202 105 E 2~TH ST. STOP A5300 Austin TX 78712 USA

A major challenge with studying plasmon-mediated emission events is the small size of plasmonic nanoparticles relative to the wavelength of light. Objects smaller than roughly half the wavelength of light will appear as diffraction-limited spots in far-field optical images, presenting a significant experimental challenge for studying plasmonic processes on the nanoscale. Super-resolution imaging has recently been applied to plasmonic nanosystems and allows plasmon-mediated emission to be resolved on the order of ~5 nm. In super-resolution imaging, a diffraction-limited spot is fit to some model function in order to calculate the position of the emission centroid, which represents the loca- tion of the emitter. However, the accuracy of the centroid position strongly depends on how well the fitting function describes the data. This Perspective discusses the commonly used two-dimensional Gaussian fitting function applied to super-resolution imaging of plasmon-mediated emission, then introduces an alternative model based on dipole point spread flmctions. The two fitting models are compared and contrasted for super-resolution imaging of nanoparticle scattering/luminescence, surface-enhanced Raman scattering, and surface-enhanced fluorescence.

关键词： plasmon point spread function dipole super-resolution surface-enhanced Ramanscattering (SERS)

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Applications of carbon nanomaterials in perovskite solar cells for solar energy conversion

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Nano Materials Science 2021年第3期3卷 276-290页

作者： katherine Moore Wei Wei Department of Mechanical Engineering Wichita State University1845 Fairmount StWichitaKS67260USA

The energy issues and environmental concern have led to intense research activities in renewable energy conversion,such as photovoltaic(PV)to convert solar energy into *** solar cells(PSCs)based on metal halides are rapidly emerging as the most promising and competing PV technology due to its high record power conversion efficiencies and potentially low production *** carbon materials,which are abundantly available and low-cost,are introduced into the *** article provides a mini review of applications of carbon materials for perovskite solar ***,a brief introduction of the development of perovskite solar cell is ***,applications of carbon nanomaterials in perovskite solar cells are presented and ***,an outlook and perspective on the future research directions of carbon nanomaterial for perovskite solar cells is provided.

关键词： Carbon nanomaterials Perovskite solar cells Solar energy

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The state of mountain research in Canada

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Journal of Mountain Science 2022年第10期19卷 3013-3025页

作者： Graham MCDOWELL katherine HANLY Department of Geography University of CalgaryCalgaryABT2NiN4Canada Department of Geography University of ZurichCH-8006 ZurichSwitzerland

Nearly a quarter of Canada’s landmass is covered by mountainous terrain,making mountains an important aspect of the physical and human geography of the *** areas in Canada have motivated a great deal of research activity,yet the state of mountain research in the country has never been systematically characterized,precluding a detailed understanding of what is being studied,when,where,how,and by *** response,we conducted a systematic scoping review to rigorously identify,collate,and critically examine existing peer-reviewed articles related to mountains in Canada.2,888 articles were included in our review,which reveals strong biases towards work in the natural sciences and in the mountain west,with little work to date in the social and health sciences or in other mountainous regions of the *** results demonstrate that Canada is among the most productive contributors to mountain research globally,but that topical and geographical biases in existing research effort leave important gaps that must be addressed to successfully navigate challenges and opportunities facing mountain areas in *** provide a roadmap to guide future mountain-focused research activities in the country.

关键词： Canada Mountains Systematic scoping review Research

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巴勒收藏博物馆英国格拉斯哥

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世界建筑导报 2024年第4期39卷 75-79页

作者： Chris Ravenscroft Heather Macey katherine Watts Tom Roberts Paddy Pugh Hannah Lawson 约翰•麦卡兰建筑事务所

巴勒珍藏馆是欧洲最好的博物馆之一,也是为数不多的A类苏格兰战后建筑之一。珍藏馆拥有约9000件精美和装饰性的艺术作品,极其丰富的藏品来自的年代横跨6 000年。1983年,巴勒珍藏馆被置于由三位年轻剑桥建筑师学者巴里·加松、布力特·... 详细信息

巴勒珍藏馆是欧洲最好的博物馆之一,也是为数不多的A类苏格兰战后建筑之一。珍藏馆拥有约9000件精美和装饰性的艺术作品,极其丰富的藏品来自的年代横跨6 000年。1983年,巴勒珍藏馆被置于由三位年轻剑桥建筑师学者巴里·加松、布力特·安德烈森和约翰·梅乌涅尔设计的、广受好评的博物馆建筑中。这座20世纪开创性的建筑由红色邓弗里斯郡砂岩、抛光混凝土、不锈钢、木材和玻璃建成,位于距格拉斯哥市中心4英里的波洛克郊野公园的环境中。2016年,代表格拉斯哥市议会提供文化、体育和学习活动的慈善机构格拉斯哥慈善组织指定约翰·麦卡兰建筑事务所为建筑师和景观设计师,负责博物馆的五年翻新和提升项目。

关键词：建筑事务所博物馆建筑郊野公园格拉斯哥安德烈波洛克慈善机构市议会

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The contribution of botanic gardens to ex situ conservation through seed banking

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Plant Diversity 2017年第6期39卷 373-378页

作者： katherine O'Donnell Suzanne Sharrock Botanic Gardens Conservation International Descanso House

Target 8 of the Global Strategy for Plant Conservation calls for 'at least 75 per cent of threatened plant species in ex situ collections, preferably in the country of origin, and at least 20 per cent available for recovery and restoration programmes by 2020'.Botanic gardens make a significant contribution to ex situ conservation of wild species with more than a third of plant species represented in botanic gardens collections. These collections are a combination of living collection and seed banked material. Seed banking can provide an efficient form of conservation for wild plant genetic *** from Botanic Gardens Conservation International's(BGCI) databases(GardenSearch,PlantSearch, ThreatSearch and GlobalTreeSearch) has been analysed as well as survey data to report on global, regional and national seed banking *** from BGCI's databases indicates that there are at least 350 seed banking botanic gardens in 74 countries. In total 56,987 taxa have been banked including more than 9000 taxa that are threatened with extinction. 6881 tree species are stored in ex situ seed bank collections. More than half(3562) of these tree species are single country endemics and represent species from more than 166 *** study suggests that institutions are increasingly conserving plant species via seed *** the majority of species in collections that have a conservation assessment are not threatened with extinction. This disjunction between species that are threatened and those conserved in seed banks needs to be addressed. Data from BGCI's databases can be used to enable prioritisation of threatened plant species for collection and conservation in seed banks. Further recommendations for botanic gardens involved in seed conservation are presented.

关键词： Seed banking GSPC ex situ conservation Conservation assessments Botanic gardens

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Recurrent varicocele

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Asian Journal of Andrology 2016年第2期18卷 229-233,J0004,J0005页

作者： katherine Rotker Mark Sigman Department of Surgery division of Urology Brown University 2 Dudley Street Suite #174 Providence RI 02905 USA.

Varicocele recurrence is one of the most common complications associated with varicocele repair. A systematic review was performed to evaluate varicocele recurrence rates, anatomic causes of recurrence, and methods of management of recurrent varicoceles. The PubMed database was evaluated using keywords ＂recurrent＂ and ＂varicocele＂ as well as MESH criteria ＂recurrent＂ and ＂varicocele.＂ Articles were not included that were not in English, represented single case reports, focused solely on subclinical varicocele, or focused solely on a pediatric population （age 〈18）. Rates of recurrence vary with the technique of varicocele repair from 0% to 35%. Anatomy of recurrence can be defined by venography. Management of varicocele recurrence can be surgical or via embolization.

关键词： infertility recurrence varicocele

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