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Magmatism and metamorphism at ca. 1.45 Ga in the northern Gawler Craton: The Australian record of rifting within Nuna(Columbia)

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Geoscience Frontiers 2019年第1期10卷 175-194页

作者： Laura J.Morrissey Karin M.Barovich Martin Hand katherine e.howard Justin L.Payne School of Natural and Built environments University of South Australia Department of earth Sciences School of Physical Sciences University of Adelaide

U-Pb monazite and zircon geochronology and calculated metamorphic phase diagrams from drill holes in the northern Gawler Craton, southern Australia, reveal the presence of ca. 1.45 Ga magmatism and metamorphism. Magmatism and granulite facies metamorphism of this age has not previously been recognised in the Gawler Craton. The magmatic rocks have steep LRee-enriched patterns and high Ga/Al values, suggesting they are A-type granites. Calculated metamorphic forward models suggest that this event was associated with high apparent thermal gradients and reached pressures of 3.2 -5.4 kbar and temperatures of 775-815℃. The high apparent thermal gradients may reflect pluton-enhanced metamorphism, consistent with the presence of A-type granites. The recognition of ca. 1.45 Ga tectonism in the northern Gawler Craton is added to a compilation of ca. 1.50 -1.40 Ga magmatism, shear zone reactivation, rift basin development and isotope resetting throughout the South and North Australian Cratons that shows that this event was widespread in eastern Proterozoic Australia. This event is stylistically similar to ca. 1.45 Ga A-type magmatism and high thermal gradient metamorphism in Laurentia in this interval and provides further support for a connection between Australia and Laurentia during the Mesoproterozoic. The tectonic setting of the 1.50-1.40 Ga event is unclear but may record rifting within the Nuna(or Columbia) supercontinent, or a period of intracontinental extension within a long-lived convergent setting.

关键词： Gawler Craton Laurentia Metamorphism U-Pb geochronology Paleogeographic reconstruction

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Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders

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Translational Neurodegeneration 2014年第1期3卷 180-203,179页

作者： Kristi M Anderson katherine e Olson katherine A estes Ken Flanagan howard e Gendelman R Lee Mosley Department of Pharmacology and experimental Neuroscience Center for Neurodegenerative DisordersThe University of Nebraska Medical CenterOmahaNE 68198USA Prothena Biosciences Inc.650 Gateway BoulevardSouth San FranciscoCA 94080USA

Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s *** the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective *** temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent ***,immune responses that affect neurodegeneration may occur within or outside the *** of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal *** destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T ***,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the *** responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific *** final result is altered glial and neuronal behaviors that influence the disease ***,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression.

关键词： Neurodegeneration Neuroprotection Migration MPTP MCAM Regulatory T cell effector T cell,Neuroinflammation

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An open-label multiyear study of sargramostim-treated Parkinson’s disease patients examining drug safety,tolerability,and immune biomarkers from limited case numbers

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Translational Neurodegeneration 2023年第1期12卷 529-545页

作者： katherine e.Olson Mai M.Abdelmoaty Krista L.Namminga Yaman Lu Helen Obaro Pamela Santamaria R.Lee Mosley howard e.Gendelman Department of Pharmacology and experimental Neuroscience Center for Neurodegenerative DisordersUniversity of Nebraska Medical CenterOmahaNE 68198USA Great Plains Center for Clinical and Translational Research Nebraska MedicineOmahaNEUSA Neurology Consultants of Nebraska PC and Nebraska MedicineOmahaNEUSA

Background The clinical utility and safety of sargramostim has previously been reported in cancer,acute radiation syndrome,autoimmune disease,inflammatory conditions,and Alzheimer’s *** safety,tolerability,and mecha-nisms of action in Parkinson’s disease(PD)during extended use has not been *** As a primary goal,safety and tolerability was assessed in five PD patients treated with sargramostim(Leukine®,granulocyte-macrophage colony-stimulating factor)for 33 *** goals included numbers of CD4+T cells and monocytes and motor ***,metabolic,immune,and neurological evaluations were assessed during a 5-day on,2-day off therapeutic regimen given at 3μg/*** 2 years,drug use was discon-tinued for 3 *** was then followed by an additional 6 months of *** Sargramostim-associated adverse events included injection-site reactions,elevated total white cell counts,and bone *** drug,blood analyses and metabolic panels revealed no untoward side effects linked to long-term *** Parkinson’s Disease Rating Scale scores remained stable throughout the study while regulatory T cell number and function were *** the initial 6 months of treatment,transcriptomic and proteomic mono-cyte tests demonstrated autophagy and sirtuin *** finding paralleled anti-inflammatory and antioxidant activities within both the adaptive and innate immune profile *** Taken together,the data affirmed long-term safety as well as immune and anti-inflammatory responses reflecting clinical stability in PD under the sargramostim *** in larger patient populations is planned in a future phase II evaluation.

关键词： Parkinson’s disease Granulocyte-macrophage colony-stimulating factor Unified Parkinson’s Disease Rating Scale Regulatory T cells Neuroprotection Sargramostim therapy

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Surgery for oligometastasis of pancreatic cancer

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Chinese Journal of Cancer Research 2015年第4期27卷 358-367页

作者： Fengchun Lu katherine e.Poruk Matthew J.Weiss Department of General Surgery Union Hospital Fujian Medical University Department of Surgery The Sol Goldman Pancreatic Cancer Research Center The Johns Hopkins University School of Medicine

The incidence of pancreatic adenocarcinoma（PDAC） has steadily increased over the past several decades. The majority of PDAC patients will present with distant metastases, limiting surgical management in this population. Hepatectomy and pulmonary metastasectomy（PM） has been well established for colorectal cancer patients with isolated, resectable hepatic or pulmonary metastatic disease. Recent advancements in effective systemic therapy for PDAC have led to the selection of certain patients where metastectomy may be potentially indicated. However, the indication for resection of oligometastases in PDAC is not well defined. This review will discuss the current literature on the surgical management of metastatic disease for PDAC with a specific focus on surgical resection for isolated hepatic and pulmonary metastases.

关键词： Pancreatic cancer(PC) oligometastasis hepatic metastasis pulmonary metastasis surgical management

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Journey Through the Groan Zone with Academics and Practitioners: Bridging Conflict and Difference to Strengthen Disaster Risk Reduction and Recovery Work

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International Journal of Disaster Risk Science 2018年第3期9卷 421-428页

作者： katherine e.Browne Caela O'Connell Laura Meitzner Yoder Department of Anthropology Colorado State University Department of Anthropology – Disasters Displacement and Human Rights Program University of Tennessee Program in Human Needs and Global Resources Wheaton College

Academic-practitioner divides in disaster management and research can be persistent and pernicious,bearing consequences for disaster survivors and future affected populations. The gap between disaster professionals and academic researchers is often treated as an unavoidable structural problem or a neutral accident of professional silos and circumstance. We suggest that these gaps are not neutral, and that they can and must be overcome. With hundreds of millions of people affected by disaster each year and recovery costs skyrocketing, there is urgency in connecting researcher and practitioner knowledges to avoid expensive mistakes and most importantly, to decrease human suffering. Yet the difficulties that US academic anthropologists and practitioners experienced in their efforts to collaborate became evident in a cross-sector National Science Foundation(NSF)-funded workshop on the relevance of culture in disaster work. We suggest and illustrate how more systematic cross-field communication can be operationalized through engaging in an ongoing and relational process of bridging. Such a process can offer long-term benefits to the people and institutions involved,dramatically enhance the science of disaster management,and help reduce the social and material costs of disaster impacts.

关键词： Academic and practitioner divide Applied research Cross-sector communication Culture and disaster Disaster anthropology Disaster management

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Different paths to sexual size dimorphism in two praying mantids, Pseudomantis albofimbriata and Hierodula majuscula

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Insect Science 2014年第2期21卷 227-233页

作者： Louise e. Allen katherine L. Barry Gregory I. Holwell Department of Biological Sciences Macquarie University North Ryde NSW 2109 Australia School of Biological Sciences The University of Auckland Auckland New Zealand

Sexual size dimorphism （SSD） is widespread among diverse animal taxa and has attracted the attention of evolutionary biologists for over a century. SSD is likely to be adaptive and the result of divergent selection on different size optima for males and females, given their different roles in reproduction. The developmental trajectory leading to SSD may help us to understand how selection acts on male and female size. Here, we describe the growth and development of two Australian praying mantids, Pseudomantis albofimbriata and Hierodula majuscula including the number of moults, time to adulthood, size at each moult, and the degree of SSD. While both species exhibit the common pattern of female-biased SSD, the number of moults required for individuals to reach adulthood differed between males and females and between species. Despite their larger adult size, P. albofimbriata females require fewer moults and less time than males to reach adulthood, but are significantly larger than males from the second instar onwards. In contrast, H. majuscula males reached adulthood in fewer moults, and less time than females, however males and females did not differ in size until females went through their final moult into adulthood. H. majuscula also required more time and more moults to reach adulthood than 17. albofimbriata. We discuss these different developmental pathways in light of the existing knowledge of reproductive biology for each species. We also suggest that these differences may relate to the different phenologies that occur in strongly seasonal temperate environments compared with those in the tropics. This study provides evidence that SSD can result from two different patterns of growth and development in closely related species.

关键词： developmental trajectories Mantodea sexual size dimorphism

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Two-dimensional d-πconjugated metal-organic framework based on hexahydroxytrinaphthylene

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Nano Research 2021年第2期14卷 369-375页

作者： Zheng Meng katherine A.Mirica Department of Chemistry Burke Laboratory41 College Streety Dartmouth CollegeHanoverNH 03755USA

The development of new two-dimensional(2D)d-πconjugated metal-organic frameworks(MOFs)holds great promise for the construction of a new generation of porous and semiconductive *** paper describes the synthesis,structural characterization,and electronic properties of a new d-πconjugated 2D MOF based on the use of a new ligand 2,3,8,9,14,*** reticular self-assembly of this largeπ-conjugated organic building block with Cu(II)ions in a mixed solvent system of 1,3-dimethyl-2-imidazolidinone(DMI)and H2 O with the addition of ammonia water or ethylenediamine leads to a highly crystalline MOF Cu3(HHTN)2,which possesses pore aperture of 2.5 ***3(HHTN)2 MOF shows moderate electrical conductivity of 9.01×10^(-8)S·cm^(-1)at 385 K and temperature-dependent band gap ranging from 0.75 to 1.65 *** chemical oxidation by l2,the conductivity of Cu3(HHTN)2 can be increased by 360 *** access to HHTN based MOF adds an important member to previously reported MOF systems with hexagonal lattice,paving the way towards systematic studies of structure-property relationships of semiconductive MOFs.

关键词： two-dimensional metal-organic framework(MOF) trinaphthylene conductive MOF

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Plasmon point spread functions： How do we model plasmon-mediated emission processes？

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Frontiers of physics 2014年第1期9卷 3-16页

作者： katherine A. Willets Department of Chemistry University of Texas at AustinWelch Hall 1.202 105 E 2~TH ST. STOP A5300 Austin TX 78712 USA

A major challenge with studying plasmon-mediated emission events is the small size of plasmonic nanoparticles relative to the wavelength of light. Objects smaller than roughly half the wavelength of light will appear as diffraction-limited spots in far-field optical images, presenting a significant experimental challenge for studying plasmonic processes on the nanoscale. Super-resolution imaging has recently been applied to plasmonic nanosystems and allows plasmon-mediated emission to be resolved on the order of ~5 nm. In super-resolution imaging, a diffraction-limited spot is fit to some model function in order to calculate the position of the emission centroid, which represents the loca- tion of the emitter. However, the accuracy of the centroid position strongly depends on how well the fitting function describes the data. This Perspective discusses the commonly used two-dimensional Gaussian fitting function applied to super-resolution imaging of plasmon-mediated emission, then introduces an alternative model based on dipole point spread flmctions. The two fitting models are compared and contrasted for super-resolution imaging of nanoparticle scattering/luminescence, surface-enhanced Raman scattering, and surface-enhanced fluorescence.

关键词： plasmon point spread function dipole super-resolution surface-enhanced Ramanscattering (SeRS)

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The effect of the CHAMP intervention on fundamental motor skills and outdoor physical activity in preschoolers

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Journal of Sport and Health Science 2019年第2期8卷 98-105页

作者： Kara K.Palmer katherine M.Chinn Leah e.Robinson Child Movement Activity and Developmental Heanlth Laboratory University of Michigan Center for Human Growth and Development University of Michigan

Purpose: Physical activity(PA) and fundamental motor skills are important components of current and future trajectories of health in young children. This study examined the effects of a 5-week motor skill intervention on preschoolers' motor skill competence and their PA behaviors while participating in the motor skill intervention or outdoor free play(recess).Methods: A total of 102 preschoolers served as participants and were part of a motor skill intervention group(n = 64) or a control/outdoor free play group(n = 38). Children's motor skills were assessed before and after the intervention using the Test of Gross Motor Development-3 rd edition. PA during the motor skill intervention and outdoor free play was assessed using accelerometers both immediately before the start(baseline, Week 0 or Week 1) and end(late, Week 5 or Week 6) of the ***: All children significantly improved their motor skills from baseline to late assessment(p en in the motor skill intervention demonstrated greater rates of change(p ed higher on all motor skills at the late assessment compared with the control group(p ere was no effect of group(control vs. intervention), but there was a significant effect of sex on children's PA during outdoor free play at baseline(p ere was no effect of group on PA during days with the movement program(intervention vs. outdoor free play) at either time point, but boys were more active than girls at the late assessment(p en in the intervention engaged in more PA while participating in the intervention toward the end of the intervention than at the ***: The 5-week motor skill intervention was effective at improving preschoolers' motor skills and rates of change in motor skills were higher for children who completed the intervention compared with children in the control group. Preschoolers in the intervention did demonstrate PA changes while par

关键词： Gross motor skills Intervention Motor development: Pediatrics Physical activity

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Neuroimaging of inflammation in alcohol use disorder: a review

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Science China(Information Sciences) 2020年第7期63卷 19-37页

作者： Dana e.FeLDMAN katherine L.MCPHeRSON Catherine L.BIeSeCKeR Corinde e.WIeRS Peter MANZA Nora D.VOLKOW Gene-Jack WANG National Institute on Alcohol Abuse and Alcoholism National Institute on Drug Abuse

Alcohol use disorder(AUD) is a global health concern associated with several *** health problems related to AUD, such as cognitive deficits, have been linked to *** use has been associated with changes in neuroimmune activity, although current literature has yielded mixed results. For example, markers of gliosis, including translocator protein 18-kDa(TSPO), proinflammatory cytokines, glutamate(Glu), and myo-inositol(mI), are disrupted in the alcohol-dependent brain. Further, neuroinflammatory-related phenomena including membrane turnover, blood brain barrier(BBB) permeability, and adenosine release have also shown alterations in AUD. However, current literature remains inconclusive about the directionality of these changes. Both in vivo and in vitro studies have provided insight on the relationship between alcohol use and neuroinflammatory processes, suggesting considerable treatment potential for alcohol use disorder and its inflammatory comorbidities. Here, we review current neuroimaging literature assessing the impacts of alcohol use on neuroimmune activity in the brain.

关键词： acetate adenosine alcohol use disorder blood brain barrier choline gliosis glutamate myoinositol neuroimaging neuroinflammation

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