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Weight gain after 35 years of age is associated with increased breast cancer risk: findings from a large prospective cohort study

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Cancer Biology & Medicine 2024年第8期21卷 651-655页

作者： katherine de.la torre.woo-kyoung shin Hwi-Won Lee Dan Huang Sukhong Min Aesun shin Wonshik Han Daehee Kang department of Preventive Medicine Seoul National University College of MedicineSeoul 03080Republic of Korea department of Biomedical Sciences Seoul National University Graduate SchoolSeoul 03080Republic of Korea Division of Food and Pharmaceutical Technology Mokwon UniversityDaejeon 35349Republic of Korea Integrated Major in Innovative Medical Science Seoul National University Graduate SchoolSeoul 03080Republic of Korea Cancer Research Institute Seoul National UniversitySeoul 03080Republic of Korea department of Surgery Seoul National University College of MedicineSeoul 03080Republic of Korea Biomedical Research Institute Seoul National University HospitalSeoul 03080Republicof Korea

Adiposity affects lifetime estrogen exposure,which is a key factor in breast ***,adiposity effects,often assessed as the body mass index(BMI),on pre-and post-menopausal breast cancer risk are *** weight gain may reflect body fat mass accumulation during adulthood better than the BMI,potentially representing age-related metabolic changes.

关键词： breast cancer assessed

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Frequent low dose alcohol intake increases gastric cancer risk: the Health Examinees-Gem (HEXA-G) study

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Cancer Biology & Medicine 2022年第8期19卷 1224-1234页

作者： Hwi-Won Lee Dan Huang woo-kyoung shin katherine de.la torre Minkyo Song Aesun shin Jong-Koo Lee Daehee Kang department of Biomedical Sciences Seoul National University Graduate SchoolSeoul 03080Korea department of Preventive Medicine Seoul National University College of MedicineSeoul 03080Korea Integrated Major in Innovative Medical Science Seoul National University Graduate SchoolSeoul 03080Korea department of Family Medicine Seoul National University HospitalSeoul 03080Korea

Objective:Epidemiological studies indicate that alcohol increases gastric cancer(GC)risk,yet most studies have focused on heavy alcohol intake,leaving other factors understudied.A comprehensive investigation of the effects of the frequency and amount of alcohol intake may help elucidate the GC risk associated with drinking ***:The Health Examinees-Gem(HEXA-G)study,a community-based large-scale prospective cohort study,enrolled Korean adults 40–69 years of age between the years 2004 and *** GC cases were identified through linkage to Korea Central Cancer Registry data until december 31,***-reported questionnaires were used to survey alcohol consumption-related factors(duration,frequency,amount,and type of alcoholic beverages).The frequency and amount of alcohol consumption were combined to explore GC risk according to 4 drinking patterns:“infrequent-light”,“frequent-light”,“infrequent-heavy”,and“frequent-heavy”.We used Cox proportional hazard models to estimate the adjusted hazard ratios(HRs)and 95%confidence intervals(CIs),and investigate the relationship between alcohol intake and GC ***:A total of 128,218 participants were included in the *** an average follow-up period of 8.6 years,462 men and 385 women were diagnosed with *** men,current drinkers showed a 31%greater risk of GC than non-drinkers(HR 1.31,95%CI 1.03–1.66),whereas no significant association was observed in *** men,GC risk was associated with a higher frequency(P trend 0.02)and dose of ethanol intake in grams(P trend 0.03).In men,the“frequent-light”(≥5 times/week andlationship between alcohol and GC in detai

关键词： Gastric cancer alcohol consumption drinking behavior prospective cohort Health Examinees-Gem(HEXA-G)study

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