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流量检测系统的运行保障

流程工业 2019年第7期 34-35页

作者： katharina Lange Rose技术系统公司

抗干扰超声波流量检测技术已经因拥有一系列优点,而成为流量检测中的标准检验方法了。Flexim公司是这一技术的开拓者,当公司1990年在柏林成立时还只是一个开发和生产流量计的小公司。如今,它已发展成为国际上该领域的技术领导者之一。... 详细信息

抗干扰超声波流量检测技术已经因拥有一系列优点,而成为流量检测中的标准检验方法了。Flexim公司是这一技术的开拓者,当公司1990年在柏林成立时还只是一个开发和生产流量计的小公司。如今,它已发展成为国际上该领域的技术领导者之一。在过去的28年中,Flexim公司已经在欧洲、美洲、亚洲和澳大利亚设立了 19个办事处,在世界各地共有400多名员工。

关键词：流量检测系统运行标准检验方法澳大利亚技术超声波抗干扰开拓者

A versatile Tn7 transposon-based bioluminescence tagging tool for quantitative and spatial detection of bacteria in plants

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Plant Communications 2022年第1期3卷 6-20页

作者： Ayumi Matsumoto Titus Schluter katharina Melkonian Atsushi Takeda Hirofumi Nakagami Akira Mine Research Organization of Science and Technology Ritsumeikan UniversityShiga 525-8577Japan Basic Immune System of Plants Max Planck Institute for Plant Breeding ResearchCologne 50829Germany College of Life Sciences Ritsumeikan UniversityShiga 525-8577Japan JST PRESTO Kawaguchi-shiSaitama 332-0012Japan Laboratory of Plant Pathology Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan

Investigation of plant-bacteria interactions requires quantification of in planta bacterial titers by means of cumbersome and time-consuming colony-counting ***,we devised a broadly applicable tool for bioluminescence-based quantitative and spatial detection of bacteria in *** developed vectors that enable Tn7 transposon-mediated integration of the luxCDABEluciferase operon into a specific genomic location found ubiquitously across bacterial *** vectors allowed for the generation of bioluminescent transformants of various plant pathogenic bacteria from the genera Pseudomonas,Rhizobium(Agrobacterium),and *** luminescence measurements of plant tissues inoculated with bioluminescent Pseudomonas syringae *** DC3000(Pto-lux)reported bacterial titers as accurately as conventional colony-counting assays in Arabidopsis thaliana,Solanum lycopersicum,Nicotiana benthamiana,and Marchantia *** further showed the usefulness of our vectors in converting previously generated Pto derivatives to isogenic bioluminescent ***,quantitative bioluminescence assays using these Pto-lux strains accurately reported the effects of plant immunity and bacterial effectors on bacterial growth,with a dynamic range of four orders of ***,macroscopic bioluminescence imaging illuminated the spatial patterns of Pto-lux growth in/on inoculated plant *** conclusion,our vectors offer untapped opportunities to develop bioluminescence-based assays for a variety of plant-bacteria interactions.

关键词： plant immunity bacterial virulence bioluminescence imaging Pseudomonas syringae Arabidopsis thaliana Marchantia polymorpha

高效的细菌——Linde公司的工艺利用高效细菌辅助工业废水的清洁处理

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流程工业 2006年第12期 53-55页

作者： katharina Becker

化工和石化工厂的工业废水在排放到河流以前需要彻底清洁。Linde公司正利用氧气帮助繁殖废水处理系统中的细菌，更有效地用于科隆附近德国壳牌石油公司的废水清洁处理。采用这一工艺，不但有利于环保，而且还节约了大量资金。

关键词： Linde公司工业废水清洁处理细菌工艺废水处理系统壳牌石油公司石化工厂

Quality of Life and Psychological Distress in Women with Mayer-Rokitansky-Küster-Hauser Syndrome and Individuals with Complete Androgen Insensitivity Syndrome

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Open Journal of Medical Psychology 2014年第3期3卷 212-221页

作者： Kerstin Krupp Maike Fliegner Franziska Brunner Sara Brucker katharina Rall Hertha Richter-Appelt Department of Obstetrics and Gynaecology Tübingen University Hospital Tübingen Germany Institute for Sex Research and Forensic Psychiatry University Medical Center Hamburg-Eppendorf Hamburg Germany

Purpose: This study examines quality of life and psychological distress in individuals with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKHS) and Complete Androgen Insensitivity Syndrome (CAIS), two syndromes belonging to the field of “disorders of sex development”. Methods: Fifty women with MRKHS and eleven individuals with CAIS participated. The German versions of the World Health Organization Quality of Life Questionnaire (short version, WHOQOL-Bref), the Brief Symptom Inventory (BSI), and the Patient Health Questionnaire (PHQ-D) were used as standardized instruments to measure quality of life and psychopathology. Additional questions concerning demographic variables and suicidality were included. Results: In both patient samples examined, general quality of life reported was in the average range (CAIS: mean z-score = ﹣0.43, SD = 1.05;MRKHS: mean z-score = ﹣0.11, SD = 1.06). The standardized instrument assessment revealed increased psychological distress (proportion of clinical cases according to the BSI: CAIS: 54.5%;MRKHS: 55.1%). A correlation between psychological distress and time span from first suspicion to diagnosis was found in women with MRKHS (Spearman’s rho = 0.35, p = 0.018). Conclusions: The results illustrate the importance of individualised and thorough diagnostics when dealing with patients with MRKHS or CAIS. Psychological distress might be an issue for these individuals and therefore should be considered in treatment and counselling.

关键词： Mental Health Quality of Life Disorders of Sex Development (DSD) Mayer-Rokitansky-Küster-Hauser Syndrome (MRKHS) Complete Androgen Insensitivity Syndrome (CAIS)

Body Pushers: Low-Dose CT, Always the Best Choice? A Study of the Diagnostic Performance of CT Scout View

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Open Journal of Radiology 2017年第2期7卷 112-120页

作者： Robin Fabian Gohmann Frauke Heckner Diane Uschner Christiane katharina Kuhl Sebastian Daniel Reinartz Department of Diagnostic and Interventional Radiology University Hospital RWTH Aachen University Aachen Germany University Hospital RWTH Aachen University Aachen Germany Department of Medical Statistics University Hospital RWTH Aachen University Aachen Germany

Purpose: The purpose of this study has been to evaluate the diagnostic information contained in the CT scout view in the detection of body packing. Materials and methods: Retrospect analysis of 43 CT scans between July 2011 and June 2013 in asymptomatic suspects of body packing (29 men, 14 females, mean age 38 ± 9 years). Results: A total of 11 positive cases of body packing were identified. In 10 (91%) of the cases packets were relatively large and spares in number (3 or less);in 7 (64%) a single packet has been identified. 6 (55%) of the packets were located rectally, 4 (36%) vaginally and in 1 (9%) case multiple small packets of approximately 1 cm in size were found to have been ingested orally. Maximum and minimum diameters were 5.9 ± 3 cm and 2.9 ± 1.4 cm, respectively. The mean weight of packets was 7.5 ± 4.2 g (range 2 - 54 g). In 73% (n = 8) heroin had been detected;other drugs such as cocaine (n = 1) and cannabis (n = 1) were encountered once, respectively. One packet was identified retrospectively and its content could therefore not be identified. The average effective dose was 3.8 ± 2.1 mSv for CT, of that 0.12 ± 0.01 mSv was required for the CT scout view. Conclusion: If CT scout view were treated as a diagnostic image, some CT scans may be omitted, thereby maintaining streamlined operations and achieving further dose reduction jointly in the workup of body packing.

关键词： Body Packing CT Scout View CT Dose Reduction X-Ray

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利用现代化终端设备实现物流过程的可视化

现代制造 2020年第23期 64-66页

作者： katharina Ruhland 不详

爱马仕公司正在为自己高度现代化的物流中心寻找一种多功能、面向未来的货场管理解决方案。Advantech公司1500台性能强大的Linux操作系统UTC 318触控一体机和Inconso公司货场管理系统inconsoYMS可以确保长时间工作的性能优势。

关键词： Linux操作系统管理解决方案终端设备物流过程物流中心爱马仕可视化触控一体机

Mood assessment via animated characters: An instrument to access and evaluate emotions in young children

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Open Journal of Psychiatry 2013年第1期3卷 149-157页

作者： katharina Manassis Sandra Mendlowitz Annie Dupuis David Kreindler Charles Lumsden Suneeta Monga Carly Guberman Department of Psychiatry University of Toronto Toronto Canada

Objective: Mood Assessment via Animated Characters (MAAC) is a novel, computer-based instrument to improve assessment and communication about feelings in young children with internalizing distress. Well-validated assessment instruments are lacking for those under age eight years. Method: Children ages 4 - 10 years with primary diagnosis of anxiety disorder (n = 74;33 boys, 41 girls) or no diagnosis (n = 83;40 boys, 43 girls) completed MAAC for 16 feelings. Those 8 - 10 years also completed standardized measures of internalizing symptoms. Results: MAAC’s emotions clustered into positive, negative, fearful, and calm/neutral factors. Clinical children rated themselves less positive (difference score -3.18;p = 0.002) and less calm/neutral (difference score -2.06;p = 0.04), and explored fewer emotions spontaneously (difference score = -2.37;p = 0.02) than nonanxious controls. Older children’s responses correlated with scores on several standardized measures. Conclusions: MAAC appears to be highly engaging, with clinical utility in the assessment of young anxious children. Applications in other populations are considered for future study.

关键词： Anxiety Children Perception of Emotion Computer Animation Assessment

Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs

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Genomics, Proteomics & Bioinformatics 2019年第4期17卷 430-440页

作者： Nicole Ludwig Tobias Fehlmann Fabian Kern Manfred Gogol Walter Maetzler Stephanie Deutscher Simone Gurlit Claudia Schulte Anna-katharina von Thaler Christian Deuschle Florian Metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes Hans-Peter Lenhof Eckart Meese Andreas Keller Department of Human Genetics Saarland University66421 Homburg/SaarGermany Chair for Clinical Bioinformatics Saarland University66123 Saarbru¨ckenGermany Institut fur Gerontologie Universitat Heidelberg69047 HeidelbergGermany Department of Neurology Christian-Albrechts-University of Kiel24118 KielGermany Center for Neurology and Hertie Institute for Clinical Brain Research Department of NeurodegenerationUniversity of Tuebingen72074 TuebingenGermany German Center for Neurodegenerative Diseases(DZNE) 72076 TuebingenGermany Department of Anesthesiology and Intensive Care St.Franziskus Hospital Muenster48145 MuensterGermany Department of Psychiatry and Psychotherapy University Hospital Tuebingen72016 TuebingenGermany Department of Medicine II Saarland University Medical Center66421 Homburg/SaarGermany Center for Bioinformatics Saarland Informatics Campus66123 SaarbruckenGermany

Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic ***,high-throughput approaches are applied to discover biomarker *** have to be validated in larger cohorts and evaluated by adequate statistical learning ***,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and ***,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by *** computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(Mini-Mental State Examination;MMSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted P<0.05)with highest significance for miR-532-5 p(BenjaminiHochberg adjusted P=4.8×10^-30).Machine learning models reached an area under the curve(AUC)value of 87.6%in differentiating AD patients from ***,ten miRNAs were significantly correlated with MMSE,in particular miR-26a/26b-5p(adjusted P=0.0002).Interestingly,the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells,while those up-regulated in AD were enriched in serum,exosomes,cytotoxic t-cells,and *** study represents the next important step in translational research for a miRNA-based AD test.

关键词： miRNAs Neurodegeneration Alzheimer’s disease Biomarker Non-coding RNAs Gene regulation

Proteomics reveals differential adsorption of angiogenic platelet lysate proteins on calcium phosphate bone substitute materials

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Regenerative Biomaterials 2022年第1期9卷 636-649页

作者： Richard da Costa Marques Johanna Simon Cyril d’Arros katharina Landfester Kerstin Jurk Volker Mailänder Dermatology Clinic University Medical Center of the Johannes Gutenberg-University Mainz55131 MainzGermany Max Planck Institute for Polymer Research 55128 MainzGermany INSERM UMR 1229Regenerative Medicine and SkeletonONIRISUniversitéde Nantes44042 NantesFrance Biomatlante—Advanced Medical Solutions Group Plc 44360 Vigneux-de-BretagneFrance Center for Thrombosis and Hemostasis(CTH) University Medical Center of the Johannes Gutenberg-University Mainz55131 MainzGermany

Protein adsorption on biomaterials for bone substitution,such as calcium phosphates(CaP),evokes biological responses and shapes the interactions of biomaterials with the surrounding biological *** adsorb when CaP materials are combined with growth factor-rich hemoderivatives prior to implantation to achieve enhanced angiogenesis and stimulate new bone ***,the identification of the adsorbed proteins and their angiogenic effect on bone homeostasis remain incompletely *** this study,we analyzed the adsorbed complex protein composition on CaP surfaces when using the hemoderivatives plasma,platelet lysate in plasma(PL),and washed platelet lysate proteins(wPL).We detected highly abundant,non-regenerative proteins and anti-angiogenic proteins adsorbed on CaP surfaces after incubation with PL and wPL by liquid chromatography and mass spectrometry(LC–MS)***,we measured a decreased amount of adsorbed pro-angiogenic growth *** formation assays with human umbilical endothelial cells demonstrated that the CaP surfaces only stimulate an angiogenic response when kept in the hemoderivative medium but not after washing with *** results highlight the necessity to correlate biomaterial surfaces with complex adsorbed protein compositions to tailor the biomaterial surface toward an enrichment of pro-angiogenic factors.

关键词： protein adsorption calcium phosphates proteomics angiogenesis platelet lysate