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MakeHub:Fully Automated Generation of UCSC Genome Browser Assembly Hubs

Genomics, Proteomics & Bioinformatics 2019年第5期17卷 546-549页

作者： katharina jasmin hoff University of Greifswald Institute for Mathematics and Computer Science17489 GreifswaldGermany University of Greifswald Center for Functional Genomics of Microbes17489 GreifswaldGermany

Novel genomes are today often annotated by small consortia or individuals whose background is not from *** audience requires tools that are easy to *** need has been addressed by several genome annotation tools and *** resulting annotation is a crucial step of quality *** UCSC Genome Browser is a powerful and popular genome visualization *** Hubs,which can be hosted on any publicly available web server,allow browsing genomes via UCSC Genome Browser *** steps for creating custom Assembly Hubs are well documented and the required tools are publicly ***,the number of steps for creating a novel Assembly Hub is *** some cases,the format of input files needs to be adapted,which is a difficult task for scientists without programming ***,we describe Make Hub,a novel command line tool that generates Assembly Hubs for the UCSC Genome Browser in a fully automated *** pipeline also allows extending previously created Hubs by additional *** Hub is freely available for downloading at https://***/Gaius-Augustus/Make Hub.

关键词： Genome annotation Annotation visualization RNA-seq Genome browser

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Bioactive glass based scaffolds coated with gelatin for the sustained release of icariin

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Bioactive Materials 2019年第1期4卷 1-7页

作者： Theresa Reiter Tanja Panick katharina Schuhladen Judith A.Roether jasmin Hum Aldo R.Boccaccini Institute of Biomaterials Department Materials Science and EngineeringUniversity of Erlangen-NurembergCauerstr.691058 ErlangenGermany

Gelatin-coated,3D sponge-like scaffolds based on 45S5 bioactive glass were produced using the foam replication *** strength tests of gelatin-coated samples compared to uncoated scaffolds showed significant strengthening and toughening effects of the gelatin coating with compressive strength values in the range of cortical ***,the crosslinked gelatin network(using either caffeic acid or N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride(EDC)/N-hxdroxysuccinimide(NHS)as crosslinking agent)was shown to be a suitable candidate for the sustained release of the bioactive molecule *** bioactivity of the produced scaffolds,characterization by FTIR and SEM indicated the formation of hydroxyapatite(HA)in all samples after immersion in simulated body fluid(SBF)for 14 days,highlighting the favorable combination of mechanical robustness,bioactivity and drug delivery capability of this new type of scaffolds.

关键词： Bioactive glass Icariin Drug release Gelatin Scaffold

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宝马世界

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城市环境设计 2020年第4期126卷 134-149页

作者：沃尔夫·狄·普瑞克斯 Paul Kath Tom Wiscombe Waltraut Hoheneder Mona Marbach Hans Aescht Beatrix Basting Guy Bebiè Chris Beccone Johannes Behrens Marcelo Bernardi Pawel Bodzak Verena Boyer Antja Bulthaup Claudia Buhmann Timo Carl Jan Chaldil Ing Tse Chen Tadeusz Chimiak Andrea Christmann Patrick Erhardt Stephan Exsternbrink Wolfgang Fiel Benedikt Frass Helmut Fr?tscher Volker Gessendorfer Andrea Graser Lukas Haller Markus Henning Armin Hess Jens hoff Tamas Horvath Robert Huebser Astrid Jagersberger Marin Jurycz Gregor Kassl Areta Keller Markus Klausecker Tobias Klein Martin Konrad Quirin Krumbholz Caroline Kufferath Marion Lattenmayer Stefan Laub Wolfgang Leitgeb Andreas Mieling Karin Miesenberger Dennis Milam Elke Müller Henrike Münker Claudia Nehammer Martin Oberascher Alexander Ott Stefan Pfefferle Florian Pfeifer Markus Pillhofer Ekkehard Rehfeld Goswin Rothenthal Wolfgang Ruthensteiner jasmin Sauerbier Florian Schafschetzy Kristina Schinegger Karolin Schmidbaur Patrick Schneider katharina Schneider Hubert Schoba Angus Schoenberger Andrea Sch?ning Anja Sorger Gernot Stangl Mark Steinmetz Sigrid Steinwender Martina Tippelskirch Dionicio Valdez Pascal Vauclair Akvile Rimantaite Andreas Weissenbach Heribert Wolfmayer Irina Zahler 2007 Ari Marcopoulos Gerald Zugmann Hélène Binet Duccio Malagamba Marcus Buck Christian Richters Richard Walch

项目大事记/CHRONOLOGY竞赛（一等奖）/Competition（1st Prize）:2001规划设计起始时间/Start of Planning:11/2001施工起始时间/Start of Construction:08/2003投入使用/Opening:20/10/2007-21/10/2007项目参数/PROJECT DATA用地面积/Site Area:约25 000m2/Approx. 25 000m2建筑毛面积/Gross Floor Area:约73 000m2（除坡道）=100%/Approx.73 000m2（excluding ramps）=100%地上建筑毛面积/Gross Floor Area above ground:约28 500m2=40%/Approx.28 500m2=40%地下建筑毛面积/Gross Floor Area underground:约44 500m2=60%/Approx.44 500m2=60%

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