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cortisol levels in skimmed milk during the first 22 weeks of lactation and response to short-term metabolic stress and lameness in dairy cows

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Journal of Animal Science and Biotechnology 2015年第4期6卷 485-491页

作者： katharina Gellrich Tanja Sigl Heinrich H.D.Meyer Steffi Wiedemann Physiology Weihenstephan Technische Universitaet Muenchen Animal Health Institute of Animal Breeding and HusbandryKiel University

Background： cortisol is secreted into blood in reaction to acute stress, but also in phases of diminished feed intake and changed animal behavior. As cows do not always show clear signs of discomfort, reliable diagnostic markers could be used to provide information regarding individual cows＇ distress. The objective of this study was to establish an ether free immunoassay for the detection of cortisol and to determine values during the first 22 weeks of lactation. Furthermore, the response in milk cortisol levels was assessed during times of metabolic stress and pain associated symptoms of lameness. Methods： Milk yield and composition, blood serum glucose, NEFA and BHBA as well as milk cortisol were determined in 24 multiparous Holstein-Friesian cows over the course of the first 22 weeks of lactation. Animals were further checked for signs of clinical diseases on a daily basis. Two feed restrictions over three days （FR; 70 % of precious ad libitum intake） were performed during the 4th wk and the 21st wk, respectively. An ELISA for cortisol measurement in easily accessible bovine skimmed milk was established and applied. Results： On the last day of FR in early lactation, a reduction in milk yield and changes in serum metabolites compared to respective previous values were detected. The FR in mid-lactation resulted in no changes in milk production and serum metabolites. Milk cortisol was highest during first wk of lactation and remained on comparable levels thereafter. Milk yield and composition were not influenced by FR. Lameness resulted in enhanced milk cortisol levels. conclusion： Milk cortisol could be used as an indicator of painful symptoms such as lameness. Higher values of milk cortisol levels during first wk of lactation should be taken into account for interpretation.

关键词： cortisol Dairy cow ELISA Feed restriction Milk

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Living kidney donor assessment:Kidney length vs differential function

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World Journal of Transplantation 2020年第6期10卷 173-182页

作者： Jacob A Akoh katharina J Schumacher Department of Surgery Derriford HospitalUniversity Hospitals Plymouth NHS TrustPlymouth PL68DHDevonUnited Kingdom South West Transplant centre Derriford HospitalUniversity Hospitals Plymouth NHS TrustPlymouth PL68DHDevonUnited Kingdom

BAcKGROUND The key question in living kidney donor assessment is how best to determine the contribution of each kidney to overall renal function and guide selection of which kidney to donate,ensuring safety of procedure and good outcome for both recipient and *** is thought that a length difference>2 cm may indicate significant difference in function and therefore need for measurement of differential *** To determine the effect of using kidney length to decide which kidney to donate in a retrospective cohort of potential *** All 333 potential living kidney donors between January 2009 and August 2018 who completed assessment were retrospectively *** assessment was performed as per United Kingdom *** included age,sex,kidney length(cranio-caudal)obtained by computed tomography/ultrasonography,51-chromium ethylenediamine tetraacetatic acid measured glomerular filtration rate,mercapto acetyl tri glycine split function and vascular *** were 48 exclusions due to inadequate data or incomplete *** analysis was performed using Excel pivot tables and GraphPad *** between kidney length and differential function was determined with Pearson’s correlation *** Of 285 potential donors included in the study,there were 144 males(mean age 49.9±14.75)and 141 females(mean age 51.2±11.23).Overall,the Pearson’s correlation between differences in length and divided function of kidney pairs was 0.1630,P=*** 73 with significant difference(>10%)in divided function,18(24.7%)had no difference in kidney length;54(74%)had a difference ofcm and only one of>2 *** a length difference of>1 cm would only predict significant difference in divided function in 8/34(23.5%)of *** a difference of>2 cm as cut off for performing split function would lead to false reassurance in 72 patients(6 had>20%difference in divided function whereas 66 had 10%-20%difference).cONcLUSION Lengt

关键词： Kidney transplantation Living kidney donor assessment Kidney length Kidney volume Differential function Glomerular filtration rate

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consensus views on competencies and teaching methods for an interprofessional curriculum on complementary and integrative medicine:A Delphi study

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Journal of Integrative Medicine 2021年第3期19卷 282-290页

作者： Angelika Homberg Katja Krug Nadja Klafke katharina Glassen cornelia Mahler Svetla Loukanova Department of General Practice and Health Services Research University Hospital HeidelbergHeidelberg69120 HeidelbergGermany Department of Nursing Science University Hospital Tübingen72076 TubingenGermany

Objective:A collaborative team is necessary to help patients achieve their healthcare goals using complementary *** present,healthcare professionals do not feel sufficiently qualified to provide this *** study sought to identify competencies and teaching methods for interprofessional training on complementary and integrative medicine at medical ***:Sixty-five German-speaking experts with various professional backgrounds were invited to take part in a three-round Delphi *** the first round,predefined competencies were assessed on a seven-point Likert scale,and participants were invited to propose additional competencies that would be evaluated in the subsequent *** competencies were ranked based on the participant assessments and were assigned to four relevance *** the second and third rounds,suitable teaching methods were identified using free-text fields and multiple-choice *** a final workshop,participants synthesized the outcomes of the previous sessions and derived key competencies that would be a benefit to undergraduate interprofessional training in complementary and integrative medicine at medical ***:The three rounds plus final worksop were attended by 50,40,36 and 11 *** competencies that these experts determined to be highly relevant to teaching complementary and integrative medicine emphasized,in particular,the respectful treatment of patients and the importance of taking a medical *** these highly relevant competencies,three key targets were agreed upon in the final workshop:students are able to 1)classify and assess complementary medical terms and methods;2)work collaboratively and integrate patients into the interprofessional team;3)involve patients and their relatives respectfully and empathetically in all healthcare *** achieve these competency goals,the following teaching methods were highlighted:students discuss therapy options based on authentic patient c

关键词： Undergraduate education Interprofessional education complementary medicine Delphi study curriculum competency

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Green tea, epigallocatechin gallate and the prevention of Alzheimer’s disease: clinical evidence

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Food Science and Human Wellness 2022年第4期11卷 765-770页

作者： Klaus W.Lange katharina M.Lange Yukiko Nakamura Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Given its increasing global prevalence,Alzheimer’s disease(AD)has become a major public health challenge *** symptomatic treatments available for AD have shown no significant efficacy,and no disease-modifying interventions are capable of slowing the progression of the *** potential of lifestyle-related factors,including diet,is increasingly recognized as an important consideration in the primary prevention of *** mechanisms potentially underlying neuroprotective effects of bioactive components contained in tea,such as(-)-epigallocatechin-3-gallate,as well as their preventive efficacy against AD,have been elucidated in preclinical ***,in contrast to the abundance of mechanistic findings in animals,clinical results demonstrating efficacy in humans are *** epidemiological studies have provided some evidence indicating that green tea consumption is associated with a reduced risk of age-related cognitive decline and AD,a causal relationship cannot be established on the basis of these *** clinical evidence regarding preventive or therapeutic effects of green tea and its bioactive components is unsatisfactory.A role of green tea in the prevention of AD cannot be recommended until well-designed,randomized,placebo-controlled clinical trials using standardized formulations confirm the purported beneficial effects of green tea.

关键词： Green tea Epigallocatechin gallate Alzheimer’s disease Neurodegeneration Prevention

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A Toolbox for the Analysis of Peptide Signa Biogenesis

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Molecular Plant 2017年第8期10卷 1023-1025页

作者： Nils Stuhrvvohldt katharina Schardon Annick Stintzi Andreas Schaller Institute of Plant Physiology and Biotechnology University of Hohenheim 70593 Stuttgart Germany

Peptides are emerging as a novel class of extracellular signaling molecules for ceil-to-cell communication in plants. As peptide hormones, they contribute to the control of plant growth and development, and to the interaction of plants with their biotic and abiotic environment. Many new signaling peptides have been identified in recent years and considerable progress has been made with respect to the characterization of signal perception and transduction mechanisms culminating in crystal structures for several peptide receptor complexes. However,

关键词： cELL-DEATH PROTEASE ARABIDOPSIS

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Non-linear affine processes with jumps

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Probability, Uncertainty and Quantitative Risk 2023年第2期8卷 235-266页

作者： Francesca Biagini Georg Bollweg katharina Oberpriller Workgroup Financial and Insurance Mathematics Department of MathematicsLudwig-Maximilians-Universität MünchenTheresienstrasse 3980333 MunichGermany University of Freiburg Ernst-Zermelo-Strasse 179104 FreiburgGermany

We present a probabilistic construction of R^(d)-valued non-linear affine processes with *** a setΘof affine parameters,we define a family of sublinear expectations on the Skorokhod space under which the canonical process X is a(sublinear)Markov process with a non-linear *** yields a tractable model for Knightian uncertainty for which the sublinear expectation of a Markovian functional can be calculated via a partial integro-differential equation.

关键词： Sublinear expectation Non-linear affine processes Dynamic programming PIDE

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Prestroke physical activity is associated with admission haematoma volume and the clinical outcome of intracerebral haemorrhage

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Stroke & Vascular Neurology 2023年第6期8卷 511-520,I0081-I0084页

作者： Adam Viktorisson Dongni Buvarp Anna Danielsson Thomas Skoglund katharina S Sunnerhagen Sahlgrenska University Hospital GothenburgSweden Department of clinical Neuroscience University of GothenburgGothenburgSweden Department of Health and Rehabilitation University of GothenburgGothenburgSweden Department of Neurosurgery Sahlgrenska University HospitalGothenburgSweden Department of Rehabilitation Medicine Sahlgrenska University HospitalGothenburgSweden

Background Prestroke physical activity(PA)has been linked to improved outcomes after intracerebral haemorrhage(IcH),but its association with IcH volume is *** aimed to investigate associations of prestroke PA with location-specific haematoma volume and the clinical outcome of *** All patients with primary IcH,admitted to three hospitals between 2014 and 2019,were *** performing light PA≥4 hour/week the year before stroke were considered physically *** volumes were assessed from admission brain *** associations were estimated using multivariate linear and logistic regression *** volume was explored as mediator to the relationship between prestroke PA and mild stroke severity(0-4 points on the National Institutes of Health Stroke Scale),a good 1-week functional status(0-3 points on the modified Rankin Scale)and 90-day *** direct effects(ADE)and average causal mediation effects(AcME)were *** Of 686 primary IcH cases,349 were deep,240 lobar and 97 *** PA predicted smaller haematoma volumes in deep IcH(β=−0.36,SE=0.09,pcH(β=−0.23,SE=0.09,p=0.016).Prestroke PA was also associated with mild stroke severity(OR 2.53,95%cI 1.59 to 4.01),a good 1-week functional status(OR 2.12,95%cI 1.37 to 3.30)and 90-day survival(OR 3.48,95%cI 2.06 to 5.91).Haematoma volume partly mediated the relationships between PA and stroke severity(ADE 0.08,p=0.004;AcME 0.10,pctional status(ADE 0.07,p=0.03;AcME 0.10,pcME 0.05,pconclusions Light PA≥4 hour/week prior to IcH was associated with smaller haematoma volumes in deep and lobar *** active patients with IcH had a higher likelihood of mild stroke,a good 1-week functional status and 90-day survival,in part mediated by smaller haematoma volumes on admission.

关键词： admitted severity clinical

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A Deleted Deletion Site in a New Vector Strain and Exceptional Genomic Stability of Plaque-Purified Modified Vaccinia Ankara(MVA)

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Virologica Sinica 2020年第2期35卷 212-226页

作者： Ingo Jordan Deborah Horn Kristin Thiele Lars Haag katharina Fiddeke Volker Sandig ProBioGen AG.Herbert-Bayer-StraBe 8 13086 BerlinGermany Sartorius Stedim cellca GmbH.Erwin-Rentschler-Str 21 88471 LaupheimGermany Vironova AB Giivlegatan 2211330 StockholmSweden Department of Laboratory Medicine Karolinska Universitetsjukhuset i Huddinge14152 HuddingeSweden

Vectored vaccines based on highly attenuated modified vaccinia Ankara(MVA) are reported to be immunogenic, tolerant to pre-existing immunity, and able to accommodate and stably maintain very large transgenes. MVA is usually produced on primary chicken embryo fibroblasts, but production processes based on continuous cell lines emerge as increasingly robust and cost-effective alternatives. An isolate of a hitherto undescribed genotype was recovered by passage of a nonplaque-purified preparation of MVA in a continuous anatine suspension cell line(***) in chemically defined *** novel isolate(MVA-cR19) replicated to higher infectious titers in the extracellular volume of suspension cultures and induced fewer syncytia in adherent cultures. We now extend previous studies with the investigation of the point mutations in structural genes of MVA-cR19 and describe an additional point mutation in a regulatory gene. We furthermore map and discuss an extensive rearrangement of the left telomer of MVA-cR19 that appears to have occurred by duplication of the right telomer. This event caused deletions and duplications of genes that may modulate immunologic properties of MVAcR19 as a vaccine vector. Our characterizations also highlight the exceptional genetic stability of plaque-purified MVA:although the phenotype of MVA-cR19 appears to be advantageous for replication, we found that all genetic markers that differentiate wildtype and MVA-cR19 are stably maintained in passages of recombinant viruses based on either wildtype or MVA-cR.

关键词： Modified vaccinia Ankara(MVA) MVA-cR19 cR.pIX Suspension cell line Vaccine production Genome stability

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can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics?A systematic review and narrative synthesis

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Bone Research 2022年第4期10卷 661-678页

作者： Anja R.Zelmer Renjy Nelson katharina Richter Gerald J.Atkins centre for Orthopaedic and Trauma Research Faculty of Health and Medical SciencesUniversity of AdelaideAdelaideSA 5000Australia Department of Infectious Diseases Central Adelaide Local Health NetworkAdelaideSA 5000Australia Royal Adelaide Hospital AdelaideSA 5000Australia Richter Lab Department of SurgeryBasil Hetzel Institute for Translational Health ResearchUniversity of AdelaideAdelaideSA 5011Australia

Approximately 40%of treatments of chronic and recurrent osteomyelitis fail in part due to bacterial *** aureus,the predominant pathogen in human osteomyelitis,is known to persist by phenotypic adaptation as small-colony variants(ScVs)and by formation of intracellular reservoirs,including those in major bone cell types,reducing susceptibility to *** infections with *** are difficult to treat;however,there are no evidence-based clinical guidelines addressing these infections in *** conducted a systematic review of the literature to determine the demonstrated efficacy of all antibiotics against intracellular *** relevant to osteomyelitis,including protein biosynthesis inhibitors(lincosamides,streptogramins,macrolides,oxazolidines,tetracyclines,fusidic acid,and aminoglycosides),enzyme inhibitors(fluoroquinolones and ansamycines),and cell wall inhibitors(beta-lactam inhibitors,glycopeptides,fosfomycin,and lipopeptides).The PubMed and Embase databases were screened for articles related to intracellular *** infections that compared the effectiveness of multiple antibiotics or a single antibiotic together with another treatment,which resulted in 34 full-text articles fitting the inclusion *** combined findings of these studies were largely inconclusive,most likely due to the plethora of methodologies ***,the reported findings in the context of the models employed and possible solutions for improved understanding are explored *** rifampicin,oritavancin,linezolid,moxifloxacin and oxacillin were identified as the most effective potential intracellular treatments,the scientific evidence for these is still relatively *** advocate for more standardized research on determining the intracellular effectiveness of antibiotics in *** osteomyelitis to improve treatments and patient outcomes.

关键词： treatment finding synthesis

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Effect of fagade systems on the performance of cooling ceilinss： In situ measurements

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Frontiers of Architectural Research 2015年第1期4卷 68-78页

作者： katharina Eder Thomas Bednar Department for Building Physics and Building Acoustic Vienna University of TechnologyAdolf-Blamauer-Gasse 1-3 1030 Vienna Austria

This article presents an innovative facade system designed to increase the thermal comfort inside an office room and to enhance the cooling capacity of the suspended cooling ceiling. A series of measurements is conducted in an existing office building with different facade systems （i.e., a combination of grazing and shading）. An innovative facade system is devetoped based on this intensive set of measurements. The new system enhances the thermal comfort and cooling capacity of the suspended cooling ceiling. The main usage of the new system is the refurbishment and improvement of existing facade systems.

关键词： Office building Innovative facadesystems cooled ceiling Increase in the cooling capacity of cooledceiling Interaction of buildingenvelope and cooledceiling Effect on comfort

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