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Anaplastic Large Cell Lymphoma, ALK-Negative Presenting in the Rectum: A Case Report and Review of the Literature

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Open Journal of Pathology 2013年第1期3卷 37-40页

作者： Komal Galani Suryakanth R. Gurudu Longwen Chen katalin Kelemen Department of Gastroenterology Mayo Clinic Phoenix USA Department of Laboratory Medicine and Pathology Mayo Clinic Phoenix USA Super Religare Laboratories Nagpur India

ALK-negative anaplastic large cell lymphoma (ALCL, ALK-) is a CD30+ T-cell neoplasm composed of large lymphoid cells with abundant cytoplasm and pleomorphic nuclei that lacks expression of ALK protein. We describe a case of ALCL, ALK-with primary involvement of the rectum in a 37 year old man, where the original diagnosis was established based on a colonoscopic biopsy. T-cell lymphomas are rare in the colorectal area and besides ALCL, their differential diagnosis includes enteropathic T-cell lymphoma, peripheral T-cell lymphoma, not otherwise specified, NK/T cell lymphoma, or NK-cell enteropathy. In addition, syncytial variant of classical Hodgkin lymphoma or a pleomorphic CD30-positive diffuse large B-cell lymphoma should also be ruled out. We discuss pitfalls of the differential diagnosis and review the literature of anaplastic large cell lymphoma in the gastrointestinal tract. Correct diagnosis of ALCL in the colon is important to avoid a colorectal surgery for an assumed adenocarcinoma, and to open the possibility for lymphoma-directed chemotherapy.

关键词： Anaplastic Large Cell Lymphoma CD30+ Lymphoma Gastrointestinal Lymphoma

One in four patients with gastrointestinal bleeding develops shock or hemodynamic instability:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第28期29卷 4466-4480页

作者： Mahmoud Obeidat Brigitta Teutsch Anett Rancz Edina Tari katalin Márta Dániel Sándor Veres Nóra Hosszúfalusi Emese Mihály Péter Hegyi Bálint Erőss Centre for Translational Medicine Semmelweis UniversityBudapest 1085Hungary Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7623Hungary Department of Internal Medicine and Hematology Semmelweis UniversityFaculty of MedicineBudapest 1085Hungary Institute of Pancreatic Diseases Semmelweis UniversityBudapest 1083Hungary Department of Biophysics and Radiation Biology Semmelweis UniversityBudapest 1085Hungary

BACKGROUND Hemodynamic instability and shock are associated with untoward outcomes in gastrointestinal ***,there are no studies in the existing literature on the proportion of patients who developed these outcomes after gastrointestinal *** To determine the pooled event rates in the available literature and specify them based on the bleeding *** The protocol was registered on PROSPERO in advance(CRD42021283258).A systematic search was performed in three databases(PubMed,EMBASE,and CENTRAL)on 14^(th) October *** proportions with 95%CI were calculated with a random-effects model.A subgroup analysis was carried out based on the time of assessment(on admission or during hospital stay).Heterogeneity was assessed by Higgins and Thompson’s I^(2) *** Joanna Briggs Institute Prevalence Critical Appraisal Tool was used for the risk of bias *** Reference Citation Analysis(https://***/)tool was applied to obtain the latest highlight *** We identified 11589 records,of which 220 studies were eligible for data *** overall proportion of shock and hemodynamic instability in general gastrointestinal bleeding patients was 0.25(95%CI:0.17-0.36,I^(2)=100%).In non-variceal bleeding,the proportion was 0.22(95%CI:0.14-0.31,I^(2)=100%),whereas it was 0.25(95%CI:0.19-0.32,I^(2)=100%)in variceal *** proportion of patients with colonic diverticular bleeding who developed shock or hemodynamic instability was 0.12(95%CI:0.06-0.22,I^(2)=90%).The risk of bias was low,and heterogeneity was high in all *** One in five,one in four,and one in eight patients develops shock or hemodynamic instability on admission or during hospitalization in the case of non-variceal,variceal,and colonic diverticular bleeding,respectively.

关键词： Gastrointestinal bleeding Hemodynamic instability Shock Meta-analysis Statistics Review

Influence of Photo-Transformation on Chemical Behaviour and Biological Effects of Pesticides

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Influence of Photo-Transformation on Chemical Behaviour and ...

Arterial stiffness, vascular calcification and bone metabolism in chronic kidney disease

第三十五届国际光谱会议

作者： A.kiss D.Virág Egerfood Regional Knowledge Centre Eszterhazy Karoly University H-3300 EgerEszterhazy sqr.1.Hungary Egerfood Regional Knowledge Centre Eszterhazy Karoly University H-3300 EgerEszterhazy sqr.1.Hungary

＜正＞Transformation of pesticides in the environment is a highly complex process affected by different *** biological and physical-chemical factors play a role in the degradation,whose ratio depends on the actual environmental conditions. Our study aims at revealing specific details of photolytic degradation of pesticides as important soil contaminants,and to map biological effects of possibly toxic degradation products.

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World Journal of Nephrology 2012年第1期1卷 25-34页

作者： János Nemcsik István kiss András Tislér Department of Family Medicine Semmelweis University 1125 Budapest Hungary Division of Angiology and Nephrology Department of Medicine St. Imre Teaching Hospital 1115 BudapestHungary 1st Department of Medicine Semmelweis University 1125 Budapest Hungary

Patients with chronic kidney disease （CKD） have an extremely poor cardiovascular outcome. Arterial stiff-ness, a strong independent predictor of survival in CKD, is connected to arterial media calcification. A huge number of different factors contribute to the increased arterial calcification and stiffening in CKD, a process which is in parallel with impaired bone metabolism. This coincidence was demonstrated to be part of the direct inhibition of calcifcation in the vessels, which is a counterbalancing effect but also leads to low bone turnover. Due to the growing evidence, the defnition of “CKD mineral bone disorder” was created recently, un-derlining the strong connection of the two phenomena. In this review, we aim to demonstrate the mechanisms leading to increased arterial stiffness and the up-to date data of the bone-vascular axis in CKD. We over-view a list of the different factors, including inhibitors of bone metabolism like osteoprotegerin, fetuin-A, pyro-phosphates, matrix Gla protein, osteopontin, fbroblast growth factor 23 and bone morphogenic protein, which seem to play role in the progression of vascular calcif-cation and we evaluate their connection to impaired ar-terial stiffness in the mirror of recent scientifc results.

关键词： Arterial stiffness Vascular calcification Bone metabolism Chronic kidney disease

Prophylactic transcatheter arterial embolization reduces rebleeding in non-variceal upper gastrointestinal bleeding: A meta-analysis

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World Journal of Gastroenterology 2021年第40期27卷 6985-6999页

作者： Eszter Boros Zoltán Sipos Péter Hegyi Brigitta Teutsch Levente Frim Szilárd Váncsa Szabolcs kiss FanniDembrovszky Eduard Oštarijaš Andrew Shawyer Bálint Erőss Institute for Translational Medicine University of PecsMedical SchoolPécs 7624Hungary First Department of Internal Medicine St.George University Teaching Hospital of County FejérSzékesfehérvár 8000Hungary Szentágothai Research Center University of PecsPécs 7624Hungary Doctoral School of Clinical Medicine University of SzegedSzeged 6720Hungary Department of Interventional Radiology University Hospitals Dorset NHS Foundation TrustBournemouth BH77DWUnited Kingdom

BACKGROUND Despite the improvement in the endoscopic hemostasis of non-variceal upper gastrointestinal bleeding(NVUGIB),rebleeding remains a major *** To assess the role of prophylactic transcatheter arterial embolization(PTAE)added to successful hemostatic treatment among NVUGIB *** We searched three databases from inception through October 19th,*** controlled trials(RCTs)and observational cohort studies were *** compared patients with NVUGIB receiving PTAE to those who did not get *** outcomes were rebleeding,mortality,reintervention,need for surgery and transfusion,length of hospital(LOH),and intensive care unit(ICU)*** the quantitative synthesis,odds ratios(ORs)and weighted mean differences(WMDs)were calculated with the random-effects model and interpreted with 95%confidence intervals(CIs).RESULTS We included a total of 3 RCTs and 9 observational studies with a total of 1329 patients,with 486 in the intervention *** was associated with lower odds of rebleeding(OR=0.48,95%CI:0.29–0.78).There was no difference in the 30-d mortality rates(OR=0.82,95%CI:0.39–1.72)between the PTAE and control *** who underwent PTAE treatment had a lower chance for reintervention(OR=0.48,95%CI:0.31–0.76)or rescue surgery(OR=0.35,95%CI:0.14–0.92).The LOH and ICU stay was shorter in the PTAE group,but the difference was non-significant[WMD=-3.77,95%CI:(-8.00)–0.45;WMD=-1.33,95%CI:(-2.84)–0.18,respectively].CONCLUSION PTAE is associated with lower odds of rebleeding and any reintervention in ***,further RCTs are needed to have a higher level of evidence.

关键词： Prophylactic transcatheter arterial embolization Non-variceal upper gastrointestinal bleeding Rebleeding Reintervention Meta-analysis Review

Complex open elbow fracture Gustilo-Anderson type IIIB treated with the primary elbow arthroplasty: A case report

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Chinese Journal of Traumatology 2021年第2期24卷 120-124页

作者： Zoltan Cibula Maros Hrubina Jeno kiss Marian Melisik Libor Necas Jessenius Faculty of Medicine in Martin Comenius University in BratislavaKollarova 2Martin03659Slovak Republic University Department of Orthopaedic Surgery University Hospital MartinKollarova 2Martin03659Slovak Republic Department of Orthopaedic and Traumatologic Surgery Szent Janos Hospital BudapestDios Arok 1-3Budapest1125Hungary

Total elbow arthroplasty as a treatment option for open elbow fracture is relatively rare *** reported a 39 years old polytrauma patient with complex open elbow fracture(Gustilo-Anderson type IIIB).The patient presented with large soft tissues defect on dorsal part of the left elbow,ulnar palsy due to the irreparable loss of the ulnar nerve,distal triceps loss due to the complete loss of the olecranon,loss of both humeral condyles with collateral ligaments and complex elbow *** few similar cases have been *** surgery included repetitive radical debridement,irrigation,vacuum assisted closure system therapy,external fixation,coverage of the soft tissue defect with fascia ecutaneous flap from the *** months after the injury,total elbow arthroplasty with autologous bone graft(from the proximal radius)inserted in the ulnar component,was *** 3 years postoperatively,the patient is able to perform an active flexion from 0to 110with full *** passive extension is *** ulnar neuropathy is *** has no signs of infection or loosening of the prosthesis.

关键词： Elbow arthroplasty Complications Complex open elbow fracture

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发酵液内妥布拉霉素的选择性定量测定

国外医药（抗生素分册） 1990年第2期11卷 103-104页

作者： Gy.B.kiss 廖福荣

黑暗链霉菌可产生一种属于氨基环醇类抗生素的尼拉霉素(nebramycin)复合物。该复合物是由3种主要组分;阿普拉霉素。6″-O-氨甲酰基卡那霉素B与6″-0-氨甲酰基妥布拉霉素,以及一些次要组分所组成。阿普拉霉素可用作兽药,而6″-O-氨甲酰... 详细信息

黑暗链霉菌可产生一种属于氨基环醇类抗生素的尼拉霉素(nebramycin)复合物。该复合物是由3种主要组分;阿普拉霉素。6″-O-氨甲酰基卡那霉素B与6″-0-氨甲酰基妥布拉霉素,以及一些次要组分所组成。阿普拉霉素可用作兽药,而6″-O-氨甲酰基卡那霉素B与6″-O-氨甲酰基妥布拉霉素经碱性水解,分别生成适于临床应用的卡那霉素B和妥布拉霉素。由于妥布拉霉素在治疗葡萄球菌及假单胞菌感染方面已证明是一种有效药物,故其工业生产具有重要意义。用于抗生素微生物测定的检定菌对所试验的所有组分均敏感。

关键词：发酵液妥布拉霉素测定

Role of (myo)fibroblasts in the development of vascular and connective tissue structure of the C38 colorectal cancer in mice

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Cancer Communications 2018年第1期38卷 488-498页

作者： Edina Bugyik Vanessza Szabó katalin Dezső András Rókusz Armanda Szücs Péter Nagy József Tóvári Viktória László Balázs Döme Sándor Paku First Department of Pathology and Experimental Cancer Research Sem-melweis UniversityBudapestÜllőiút 261085Hungary Department of Experimental Pharmacology National Institute of OncologyBudapest 1122Hungary Department of Thoracic Surgery Semmelweis University-National Institute of OncologyBudapest 1122Hungary. Department of Thoracic Surgery Medical University of ViennaWaehringer Guertel 18-201090 ViennaAustria Department of Biomedical Imaging and Image-guided Therapy Medical University of Vienna1090 ViennaAustria National Koranyi Institute of Pulmonology Budapest 1122Hungary. Tumor Progression Research Group Hungarian Academy of Sciences-Semmelweis UniversityBudapest 1085Hungary

Background:It remains unclear if the vascular and connective tissue structures of primary and metastatic tumors are intrinsically determined or whether these characteristics are defined by the host *** we examined the microanatomical steps of vasculature and connective tissue development of C38 colon carcinoma in different ***:Tumors produced in mice at five different locations(the cecal wall,skin,liver,lung,and brain)were ana-lyzed using fluorescent immunohistochemistry,electron microscopy and quantitative real-time polymerase chain ***:We found that in the cecal wall,skin,liver,and lung,resident fibroblasts differentiate into collagenous matrix-producing myofibroblasts at the tumor *** activated fibroblasts together with the produced matrix were incorporated by the *** connective tissue development culminated in the appearance of intratumoral tissue columns(centrally located single microvessels embedded in connective tissue and smooth muscle actin-expressing myofibroblasts surrounded by basement membrane).Conversely,in the brain(which lacks fibroblasts),C38 metasta-ses only induced the development of vascularized desmoplastic tissue columns when the growing tumor reached the fibroblast-containing ***:Our data suggest that the desmoplastic host tissue response is induced by tumor-derived fibrogenic molecules acting on host tissue *** concluded that not only the host tissue characteristics but also the tumor-derived fibrogenic signals determine the vascular and connective tissue structure of tumors.

关键词： Metastasis Vasculature Myofibroblasts Incorporation

Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis

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World Journal of Gastroenterology 2018年第21期24卷 2311-2319页

作者： László Szapáry Benedek Tinusz Nelli Farkas katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Institute of Bioanalysis Medical SchoolUniversity of PécsPécs 7624Hungary Department of Gastroenterology First Department of MedicineMedical SchoolUniversity of PécsPécs 7624Hungary Department of Public Health Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of Pharmacognosy Faculty of PharmacyUniversity of SzegedSzeged 6720Hungary

AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal *** A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment *** Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid *** Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research.

关键词： Intralesional steroid Meta-analysis Benign refractory esophageal stricture Dilation