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The 3～(rd) International Conference on Natural Products :Natural Products -a Must for Human Survival ABSTrACTS

作者： Peter Forgo Dezs Csupor katalin e.kvér Judit Hohmann Department of Organic Chemistry University of Szeged Szeged Hungary Department of Pharmacognosy University of Szeged Szeged Hungary Department of Inorganic and Analytical Chemistry University of Debrecen Debrecen Hungary Department of Pharmacognosy University of Szeged Szeged Hungary

Plants of the genus Aconitum, Consolida, Delphinium produce diterpene and norditerpene alkaloids, which are attracting a growing interest because of their complex structure, interesting chemistry and noteworthy physiological effects. Pharmacological studies of these compounds demonstrated their pronounced antiarrhytmic, antiepileptic and antinociceptive activities, which are due to their interactions with voltage-gated Na+ channel. Different types of norditerpene alkaloids have been reported either as agonists (e.g. aconitine, mesaconitine) or antagonists (e.g. lappaconitine, 6-benzoyl-lappaconitine) of Na+ channel. Furthermore, recent investigations of some norditerpene alkaloids have disclosed their selective antagonistic activity on neuronal nicotinic acetylcholine (nACh) receptor in nanomolar concentration. Such compounds, e.g. methyllycaconitine are valuable neurobiological tools for the study of nAChr and are lead compounds for drug development programs of Alzheimer's *** a part of our continuing search for biologically active compounds from ranunculaceae species native to Hungary, norditerpene alkaloids were isolated from Consolida orientalis, Aconitum vulparia and A. *** enhanced selective one- and two-dimensional NMr methods were used for the structure determination. The assignment of the1H-NMr signals was expected to be relatively straightforwarddue to the moderate size of the investigated compounds. However, as a result of the molecular structure, several signals appear in a relatively narrow chemical shift region. Selective DPFGSe experiments were used to monitor the scalar and dipolar correlations (DPFGSe-COSY, DPFGSe-TOCSY, DPFGSe-NOeSY) of well separated protons. Heteronuclear gradient enhanced. HSQC experiment afforded the chemical shift assignment of the proton-bearing carbons. The assignment of quaternary carbons was based on long-range connectivities as detected by PFG-HSQMBC experiments. The solution state conformation and rel

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exploration of chromene-based BioAIegens

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National Science review 2024年第3期11卷 47-48页

作者： Fritz e.kühn Department of Chemistry&Catalysis research Center School of Natural Sciences Technical University of Munich

Photoemission efficiency is usually higher in solution than in solid *** compounds however, display a reverse behavior. Such a behavior is called aggregation-induced emission(AIe).

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Bio-inspired tetracarbene compounds as a new family of energy saving catalysts

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Journal of energy Chemistry 2023年第4期79卷 559-561页

作者： Bo Zhang Fritz e.kühn CAS key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina' University of Chinese Academy of Science Beijing 100049China Molecular Catalysis Catalysis Research Center and Department of ChemistrySchool of Natural SciencesTechnical University of MunichLichtenbergstr 485748 Garching bei MünchenGermany

efficient use of energy is a pressing *** of chemical processes is currently an important target for energy *** chemical processes are independent of pathways with respect to the final energy output or consumption,the application of catalysts can reduce involved activation energies considerably and therefore save large amounts of energy.

关键词： Catalysis Iron Carbenes Multidentate ligands

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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural regeneration research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 37-62页

作者： r.A.JAFArI-TALOOkOLAeI H.GHANDvAr e.JUMAev S.kHATIr T.CUONG-Le School of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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MicrorNAs as potential diagnostic biomarkers for bipolar disorder

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Neural regeneration research 2025年第6期20卷 1681-1695页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Abnormal expression of microrNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microrNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microrNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be mir-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, mir-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and mir-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microrNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma mir-134 compared to baseline after 4 we.ks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microrNA results. The combined effects of the two drug classes increased the significance of the results for mir-219 and-29c with mir-30e-3p and-526b* acquiring significance. MicrorNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of mir-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of mir-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of mir-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of mir-134 was observed i

关键词： biomarker bipolar disorder blood le.kocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microrNA neural progenitor cells whole blood

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Structural evolution-enabled BiFeO3 modulated by strontium doping with enhanced dielectric,optical and superparamagnetic properties by a modified sol-gel method

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Chinese Physics B 2023年第3期32卷 521-530页

作者： Sharon v S veena Gopalan e Malini k A Department of Physics vimala College Thrissur-9 KeralaIndia

Multiferroic(BFO)nanoparticles doped with strontium with the general formula Bi1-xSrx FeO3(x=0,0.3,0.5,0.7)were synthesized using a modified sol-gel auto-combustion *** structural,electrical,optical,and magnetic properties of the samples are *** structural analysis,carried out using the x-ray powder diffraction technique,shows a structural transition from rhombohedral(r-3c)to cubic(Pm-3m)for the doping amount of strontium(Sr)equal to x=*** analysis of the prepared samples were carried out using scanning electron microscopy(SeM).Frequency-dependent dielectric constant and ac conductivity were *** doped samples,with improved dielectric properties,can be used to fabricate different optoelectronic *** dielectric dispersion and broad relaxation were exhibited by all the ***–Cole plots were employed as an effective tool to study the dispersion parameters,namely,the optical dielectric constant,static dielectric constant,relaxation time,and spreading *** activation energy was calculated from the relaxation pe.ks and Cole–Cole plots,which were found to be compatible with each *** bandgap of the samples was calculated using diffuse reflectance spectral(DrS)*** and strong photoluminescence in the Ir region was observed in the samples,similar to ZnO,which was reported for the first ***-temperature and low-temperature magnetization studies point towards the superparamagnetic nature of the samples,with an improvement in magnetic properties with *** antiferromagnetic behavior of bulk bismuth ferrite transforms to superparamagnetic in nature for both pure and Sr-substituted bismuth ferrite nanoparticles due to the close dimensions of crystallite size with magnetic domains leading to the bre.k-down of the frustrated spin cycloidal moment.

关键词： multiferroics sol-gel process x-ray spectra optical and dielectric properties

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effect of wall temperature modulation on the heat transfer characteristics of droplet-train flow inside a rectangular microchannel

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Chinese Journal of Chemical engineering 2020年第3期28卷 685-697页

作者： vivekanand S.v.B.,raju v.r.k. Department of Mechanical engineering National Institute of TechnologyWarangalTelangana 506004India

The numerical studies of water–oil two-phase slug flow inside a two-dimensional vertical microchannel subjected to modulated wall temperature boundary conditions have been discussed in the present *** researchers have contributed their efforts in exploring the characteristics of Taylor flows inside microchannel under constant wall heat flux or isothermal wall ***,there is no study available in the literature which discusses the impact of modulated thermal wall boundary conditions on the heat transfer behavior of slug flows inside ***,to bridge this gap,an effort has been made to understand the heat transfer characteristics of the flow under sinusoidal wall temperature ***,a single phase flow and heat transfer study was performed in microchannels,and the results of the fully developed velocity profile and heat transfer rate were validated with benchmark analytical *** an optimal selection of the combination of sinusoidal thermal wall boundary conditions has been made for the two-phase slug flow ***,the effects of amplitude(0 bεb 0.03)and frequency(0 bωb 750πrad·s-1)of the sinusoidal wall temperature profile on the heat transfer have been studied using the optimal combination of the wall boundary *** results of the numerical study using modulated temperature conditions on channel walls showed a significant improvement in the heat transfer over liquid-only flow by approximately 50%as well as over two-phase flow without wall temperature *** non-dimensional temperature contours obtained for different cases of temperature modulation clearly explain the root cause of such improvement in the heat ***,the results based on the hydrodynamics of the flow have also been reported in terms of variation of droplet shapes and film *** influence of Capillary number on the film thickness as well as heat transfer rates has also been *** addition,the measured fil

关键词： Heat transfer Microchannel Modulation Surface tension Taylor flow

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Axial variations in anatomical properties and basic density of eucalypt urograndis hybrid(eucalyptus grandis × e. urophylla)clones

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Journal of Forestry research 2015年第3期26卷 739-744页

作者： S. k. Sharma S. r. Shukla S. Shashikala v. Sri Poornima Wood Properties and engineered Wood Division Institute of Wood Science and Technology P.O. MalleswaramBangalore 560 003 India

We studied two clones of eucalypt urograndis hybrid （eucalyptus grandis × e. urophylla）, Gr283 and Gr330, grown in Tumkur district of kamataka （India）, and felled 5-6 years old three trees of each clone. We recorded axial variations in heartwood content, bark properties, wood density and anatomical characteristics of wood in- cluding fibre length, fibre diameter, fibre wall thickness, lumen diameter, vessel frequency, vessel diameter and vessel element length. Clone Gr283 had about 10 % heartwood, significantly lower than for clone Gr330 （37 %）. Basic wood density along the tree height varied significantly within and between the clones. We observed significant variations in fibre length, fibre diameter and wall thickness within and between the two clones. vessel frequency and vessel element length did not vary but vessel diameter differed significantly between the clones. With a greater proportion of sapwood, clone Gr283 can be uti- lized for paper and pulp applications. Clone Gr330 had a higher proportion of heartwood and lower wood density and, hence, is more suitable for light-weight material applications.

关键词： eucalypt urograndis hybrid (eucalyptusgrandis × e. urophylla) Fibre characteristics - vesselcharacteristics - Wood density Bark density

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Biodegradation and ecotoxicological assessment of pectin production wastewater

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Journal of environmental Sciences 2009年第11期21卷 1613-1619页

作者： v.reginatto e.r.Amante.k.Gerhardy S.kunst N.Duran Department of Food Science and Technology Federal University of Santa Catarina - Rodovia Admar Gonzaga Institute of Water Quality-University of Hannover Biological Chemistry Laboratory Chemistry Institute State University of Campinas-UNICAMP

The chemical composition of pectin production wastewater and its toxicity during biological treatment were investigated. Samples of wastewater from different steps of a pectin production wastewater biological treatment plant were investigated including the influent of the treatment （1）, after denitrification tank （2）, after anaerobic treatment （3） and final effuent （4）. The conventional physicochemical characteristics of samples did not indicate wastewater toxicity. However, toxicity assessments carried out on vibrio fischeri and Scenedesmus subspicatus indicated low eC50 values. The fractionation of the samples using an XAD resin showed that the toxicity was associated with the organic matter. Wastewater apparent molecular mass distributions were 14.3, 25.0, 24.4 and 29.6 kDa for samples 1-4, respectively. Finally, characteristics of the sample by pyrolisis-gas chromatography-mass spectrometry （Py-CG-MS） demonstrated its polyphenolic nature and a 23% increase in the levels of such compounds after the first biological treatment step.

关键词： pectin wastewater bioassays ecotoxicity pyrolisis-gas chromatography-mass spectrometry

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