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Successful use of adalimumab for treating fistulizing Crohn's disease with pyoderma gangrenosum:Two birds with one stone

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World Journal of Gastroenterology 2009年第18期15卷 2293-2295页

作者： Eva Zold Arpad Nagy katalin devenyi Margit Zeher Zsolt Barta Division of Clinical Immunology 3rd Department of MedicineMedical and Health Science CenterUniversity of DebrecenDebrecen 4004Hungary Euromedic Diagnostics Szeged Kft Debrecen 4004Hungary

Crohn＇s disease （CD） is a chronic relapsing and remitting autoinflammatory disorder of the gastrointestinal tract that has many intestinal and extraintestinal complications. The purpose of treatment is long-term remission, reduction of complications, and improvement of patients＇ quality of life. In many cases, this can be quite challenging and it is necessary to have a well thought out management strategy. We present the case of a 38-year-old woman with fistulizing CD that manifested as diffuse abdominal pain and bloody diarrhea accompanied by arthralgia. In addition, there were ulcerative lesions surrounded by cutaneous inflammation and erythema on her extremities, indicative of pyoderma gangrenosum. The patient was treated with high doses of parenteral methylprednisolone without any improvement and was started on adalimumab. A positive response to adalimumab therapy was observed： after 2 mo of therapy, the ulcerative skin lesion healed completely and the enterogastric fistula was closed affcer 5 mo adalimumab treatment. Adalimumab might be a suitable initial as well as maintenance therapy in patients with complicated CD.

关键词： Adalimumab Crohn's disease Pyoderma gangrenosum

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