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SARS-COV-2 infection(coronavirus disease 2019)for the gastrointestinal consultant

World Journal of Gastroenterology 2020年第14期26卷 1546-1553页

作者： Kaveh Hajifathalian Srihari Mahadev Robert E Schwartz Shawn Shah kartik sampath Felice Schnoll-Sussman Robert S Brown Jr David Carr-Locke David E Cohen Reem Z Sharaiha Division of Gastroenterology and Hepatology Weill Cornell MedicineNew York-Presbyterian HospitalNew YorkNY 10021United States

The current pandemic due to the severe acute respiratory syndrome coronavirus 2 has caused an extreme burden for health care systems globally,and the number of cases is expected to continue to increase,at least in the immediate *** virus is estimated to have infected more than 1.5 million *** available reports suggest that gastrointestinal(GI)involvement in coronavirus disease 2019(COVID-19)is common and in some cases the GI symptoms may precede the respiratory *** addition to direct effects of severe acute respiratory syndrome coronavirus 2,the infected patients remain at risk for the complications commonly managed by gastroenterology and hepatology *** most commonly reported GI manifestation of COVID-19 is diarrhea,which is reported in a third to up to more than half of the *** to moderate elevation of the liver enzymes are also common,although no case of acute liver failure has been reported so *** of the medications used for treatment of COVID-19 can also be associated with GI symptoms or liver injury and can be included in the differential diagnosis in these *** the diagnosis of the infection is currently based on RNA analysis in respiratory samples,the available literature on fecal shedding of this virus suggests that fecal RNA testing might prove to be a useful diagnostic *** is reasonable to delay all non-urgent endoscopic procedures during the peak of the pandemic and use additional protective equipment such as N95 respirators during endoscopy while most patients can be considered high risk for having been exposed to the virus.

关键词： SARS-CoV-2 COVID-19 Gastroenterology Hepatology Liver

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High-Dose Intra-Dermal Hepatitis B Vaccine in a Liver Transplant Patient Who Failed Prior Intramuscular Vaccination: A Brief Case Report

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World Journal of Vaccines 2013年第1期3卷 16-18页

作者： Sonu Dhillon kartik sampath Christopher M. Moore Anil Dosanjh David H. Van Thiel Division of Gastroenterology and Hepatology Saint Francis Medical Center Peoria USA Divison of Digestive Diseases Rush University Medical Center Chicago USA University of California Davis USA

Hepatitis B virus (HBV) chronic infection represents a significant cause of morbidity and mortality worldwide. While traditional intramuscular (IM) HBV vaccination is an excellent method for robust and sustained seroconversion in healthy individuals, its efficacy in chronic liver disease is sub-optimal and scant data exists in the post-liver transplant state. Importantly, HBV complications are even more severe in these same immunocompromised populations. Intra-dermal (ID) vaccination has shown initial promise as a successful alternative to achieving HBV seroconversion in patients refractory to standard vaccination protocols. Herein is a case report of a 61 year-old female who underwent liver transplantation for chronic HBV infection and achieved HBsAg seroconversion with a robust HSsAb titer with ID vaccination after having failed both standard and double dose IM vaccination.

关键词： Hepatitis B Virus Intra-Dermal Vaccination Orthotopic Liver Transplant

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Drug eluting biliary stents to decrease stent failure rates:Areview of the literature

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World Journal of Gastrointestinal Endoscopy 2016年第2期8卷 77-85页

作者： Joseph Shatzel Jisoo Kim kartik sampath Sharjeel Syed Jennifer Saad Zilla H Hussain Kabir Mody J Marc Pipas Stuart Gordon Timothy Gardner Richard I Rothstein Section of Hematology-Oncology Dartmouth Hitchcock Medical CenterLebanonNH 03756United States Geisel School of Medicine at Dartmouth HanoverNH 03755United States Section of Gastroenterology Dartmouth Hitchcock Medical CenterLebanonNH 03756United States Section of Internal Medicine Dartmouth Hitchcock Medical CenterLebanonNH 03756United States Mayo Clinic Cancer Center Section of Hematology/OncologyMayo Clinic FloridaJacksonvilleFL 32224United States

Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy.

关键词： Bile ducts Cholangiocarcinoma Endoscopy Pancreas

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