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水稻恶苗病及其防治策略之洞察（英文）

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第9期 755-779页

作者： Chinnannan karthik 舒庆尧浙江大学海南研究院西弗吉尼亚州立大学格斯·道格拉斯研究所与生物学系浙江大学现代种业研究所/水稻生物育种全国重点实验室

恶苗病是由种传或土传藤仓镰孢菌（Fusarium fujikuroi）引起的一种水稻的新兴病害，正日益威胁着世界不同产区水稻的可持续生产。恶苗病发病率因地区和品种而异，造成的产量损失可达3%～95%。认识恶苗病病原菌的特性、致病性、病害流... 详细信息

恶苗病是由种传或土传藤仓镰孢菌（Fusarium fujikuroi）引起的一种水稻的新兴病害，正日益威胁着世界不同产区水稻的可持续生产。恶苗病发病率因地区和品种而异，造成的产量损失可达3%～95%。认识恶苗病病原菌的特性、致病性、病害流行学、病害症状、寄主–病原菌互作以及病害发生周期中次生代谢物的作用，将有助于制定高效、可持续的病害防治策略，但迄今仍缺乏对水稻恶苗病全面和详细的描述。为此，本篇综述对1898至2023年间恶苗病各关键领域的研究进行总结和深入探讨，并对今后研究提出展望。

关键词：水稻恶苗病藤仓镰孢菌寄主–病原菌互作致病性赤霉素信号传导病害治理

Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia

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The Journal of Biomedical Research 2014年第5期28卷 406-415页

作者： Talambedu Usha Sushil Kumar Middha Arvind Kumar Goyal Mahesh karthik DA Manoj Syed Faizan Peyush Goyal HP Prashanth Veena Pande Department of Biochemistry and Biotechnology Maharani Lakshmi Ammanni College For Women Bamboo Technology Bodoland University Department of Biotechnology Sapthagiri College of Engineering Department of Biotechnology M S Ramaiah Institute of Technology Department of Biotechnology Bhimtal CampusKumaun University Ministry of Science Govt.of IndiaNew DelhiIndia

Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTPase family,is a promising target to treat various kinds of *** in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock *** studies revealed that four compounds,isorhamnetin-7-rhamnoside,quercetin-3-glucoside-7-rhamnoside（present in ***）,zeaxanthin,and translutein（present in ***） significantly bind with binding energies-17.1534,-14.7936,-10.2105 and-17.2217 Kcal/mol,respectively,even though they slightly deviate from Lipinski＇s ***,distribution,metabolism,excretion and toxicity（ADME/tox） analyses of these compounds and their stereoisomers showed that they were less toxic and *** them,isorhamntein-7-rhamnoside showed ***,these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers.

关键词： Hippophae H-Ras cancer docking Discovery Studio 3.5 H.rhamnoides H.salicifolia

Local sum uncertainty relations for angular momentum operators of bipartite permutation symmetric systems

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Chinese Physics B 2022年第6期31卷 163-169页

作者： I Reena H S karthik J Prabhu Tej Sudha A R Usha Devi A K Rajagopal Department of Physics JnanabharathiBangalore UniversityBangalore-560056India 2 International Centre for Theory of Quantum Technologies University of GdanskGdansk80-308Poland Department of Physics Ramaiah University of Applied SciencesBangalore-560054India Department of Physics Kuvempu UniversityShankaraghattaShimoga-577451India Inspire Institute Inc. AlexandriaVirginia22303USA

We show that violation of the variance based local sum uncertainty relation(LSUR)for angular momentum operators of a bipartite system,proposed by Hofmann and Takeuchi[***.A 68032103(2003)],reflects entanglement in the equal bipartitions of an N-qubit symmetric state with even *** establish the one-to-one connection with the violation of LSUR with negativity of covariance matrix[***.A 364203(2007)]of the two-qubit reduced system of a permutation symmetric N-qubit state.

关键词： sum uncertainty relations permutation symmetry rotational invariance

Brocaeloid D,a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049

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Synthetic and Systems Biotechnology 2019年第4期4卷 173-179页

作者： Jingyu Zhang Zhenzhen Wang Zhijun Song Loganathan karthik Chengjian Hou Guoliang Zhu Lan Jiang Jianying Han Rong Ma Li Li Lixin Zhang Xueting Liu Tom Hsiang State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China Department of Medicinal Chemistry Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China School of Environmental Sciences University of Guelph50 Stone Road EastGuelphOntarioN1G 2W1Canada University of Chinese Academy of Sciences Beijing100049China

Microbes serve as the most important resource for drug *** our screening for bioactive compounds from our natural products library,a pathogenic fungus,Microdochium majus strain 99049,from wheat was selected for further investigation.A new alkaloid named brocaeloid D(1),together with six previously characterized compounds(2–7)were *** 1 belongs to 4-oxoquinoline with C-2 reversed prenylation and a succinimide *** the structures of these newly isolated compounds were determined by different means in spectroscopic *** absolute configurations of 1 was further deduced from comparison of its CD spectrum with that of known compound *** bioactivities of these identified compounds were evaluated against several pathogenic microorganisms and cancer cell *** 1–5 showed activity against HUH-7 human hepatoma cells with IC50 values of 80μg/*** 6 showed mild activity against HeLa cells(IC50=51.9μg/mL),weak anti-MTB activity(MIC=80μg/mL),and moderate anti-MRSA activity(MIC=25μg/mL),and compound 7 showed weak anti-MRSA activity(MIC=100μg/mL).

关键词： Wheat pathogenic fungus Anticancer Antibacterial Natural product

Can regadenoson pharmacologic SPECT be performed effectively in patients with left bundle branch block or paced rhythm patients? A retrospective comparison to adenosine SPECT

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World Journal of Cardiovascular Diseases 2013年第2期3卷 222-227页

作者： Gurunanthan Palani Aarthee S. karthikeyan Jacobsen Gordon karthik Ananthasubramaniam Department of Internal Medicine McLaren/Michigan State University Flint USA Heart and Vascular Institute Henry Ford Hospital Detroit USA

Purpose: Regadenoson (REG) is currently becoming the stress agent of choice in patients undergoing pharmacologic single photon emission computed tomography (SPECT). However, in patients with left bundle branch block (LBBB) and ventricular paced rhythm (VPR), hesitation exists amongst clinicians to use REG-SPECT due to the concern that the increased heart rate could cause false positive SPECT results. We sought to evaluate the comparability of A-SPECT and REG-SPECT in patients with LBBB and VPR. Methods: Retrospective study of 30 patients who served as their own controls. All 30 patients who underwent REG-SPECT (Grp 1) were compared to their prior A-SPECT (Grp 2) done within two years prior to REG-SPECT. Heart rate (HR) and blood pressure (BP) parameters, ECG, stress perfusion and gated variables, SPECT ischemia, and side-effects were evaluated. Statistical significance was set at P < 0.05. Results: Grp 1 and Grp 2 were comparable in hemodynamic parameters with increase in HR and decrease in systolic and diastolic BP with administration of adenosine and REG stress agents. However, there were no significant differences found in hemodynamic parameters and II degree AV block between the groups. All normal A-SPECT were found to be normal with REG-SPECT. No differences could be found between the two groups among SPECT parameters. Muscle pain was significantly higher in REG (10.0% vs. 0.0%, P = 0.083) and so was the use of aminophylline (16.7% vs. 0.0%, P = 0.025) to relieve the side-effect. Conclusion: REG-SPECT can be administered in patients with LBBB and VPR patients based on favorable and comparable hemodynamic responses and arrhythmia occurrences to A-SPECT. REG-SPECT can also be used for adequate interpretation of presence or absence of SPECT ischemia particularly in the LAD territory without any concern for false positive perfusion defects.

关键词： Regadenoson Single Photon Emission Computed Tomography Left Bundle Branch Block Ventricular Paced Rhythm Adenosine False Positive SPECT

Human Sperm Freezing: Mini Update

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Advances in Reproductive Sciences 2018年第3期6卷 59-69页

作者： Shah Dupesh P. Rasappan S. Shila karthik Gunasekaran VRR Institute of Biomedical Sciences (Affiliated to the University of Madras) Chennai India The Metromale Clinic & Fertility Center A Unit of Gunasekaran Hospitals Ltd Chennai India

Sperm freezing is widely used in ART clinics around the globe. Very little has actually changed with respect to cryopreservation protocols and methodology of freezing over the last 50 years. The aim of this paper is to briefly review the basic principles that underlie freezing and ice crystal formation and also provide a brief overview of newer sperm freezing techniques like sperm vitrification and freeze drying of sperm.

关键词： Sperm Freezing Principles of Freezing Freezing Injury Ice Nucleation Cryoprotectants Sperm Vitrification and Freeze Drying Sperm

Management practices and technologies for efficient biological sample collection from domestic animals with special reference to Indian field conditions

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Animal Diseases 2023年第4期3卷 242-255页

作者： Gokula Kannan Ragavan Purushothaman Selvaraj Dharman Murugesan Tirumurugaan Krishnaswamy Gopalan Soundararajan Chinnaiyan Dhinakar Raj Gopal Aravindh Babu Ramasamy Parthiban karthik Kumaragurubaran Azhahianambi Palavesam Translational Research Platform for Veterinary Biologicals Centre for Animal Health StudiesTamil Nadu Veterinary and Animal Sciences UniversityChennaiTamil Nadu 600051India Centre for Animal Health Studies Tamil Nadu Veterinary and Animal Sciences UniversityChennaiTamil Nadu 600051India Department of Animal Biotechnology Madras Veterinary CollegeVeperyChennaiTamil Nadu 600007India Department of Veterinary Microbiology Veterinary College and Research InstituteUdumalpetTamil Nadu 642126India

Management strategies and the use of advanced technologies are equally important for determining the sample number and sampling frame for successful field sampling for animal disease prevalence *** quality of the biological samples collected in the field has a direct bearing on the integrity of the data generated,prevalence estimates and subsequent policy decisions on disease ***,compromising the quality of biological samples collected in the field could potentially undermine the priority setting principles in disease control *** samples collected from domestic animals in the field are precious materials and require meticulous planning for sample collection,sample storage in the field,transportation,and storage in the *** managed field sampling has a significant detrimental impact on the sample quality and quantity and directly affects the accuracy of disease prevalence data.A bad choice of sampling tools,containers,storage and transport all have a negative impact on the integrity of the sample and consequently have an impact on the *** the last two years,as part of our one health animal sampling work in ndia,we have observed challenges and opportunities in the field sampling of animals for disease prevalence *** paper aims to provide information on management practices and technologies for efficient biological sample collection from the field and ensure that good quality samples are available fortesting.

关键词： One health Domestic animals Sample quality Technology Management

Renal manifestations of hepatitis E among immunocompetent and solid organ transplant recipients

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World Journal of Hepatology 2022年第3期14卷 516-524页

作者： karthik Kovvuru Nicholas Carbajal Abhinandan Reddy Pakanati Charat Thongprayoon Panupong Hansrivijit Boonphiphop Boonpheng Pattharawin Pattharanitima Voravech Nissaisorakarn Wisit Cheungpasitporn Swetha R Kanduri Department of Medicine Ochsner Clinic FoundationNew OrleansLA 70121United States Department of Medicine The Kidney Clinic LLCSnellvilleGA 30078United States Department of Nephrology and Hypertension Mayo ClinicRochesterMN 55905United States Department of Internal Medicine UPMC PinnacleHarrisburgPA 17104United States Department of Nephrology David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095United States Department of Internal Medicine Faculty of MedicineThammasat UniversityPathum Thani 12121Thailand Department of Internal Medicine MetroWest Medical CenterTufts University School of MedicineBostonMA 01760United States Department of Medicine Mayo ClinicRochesterMN 55905United States

Hepatitis E virus(HEV)infections are generally *** cases of hepatitis E induced fulminant liver failure requiring liver transplantation are reported in the *** though HEV infection is generally encountered among developing countries,a recent uptrend is reported in developed *** of unprocessed meat and zoonosis are considered to be the likely transmission modalities in developed *** involvement of HEV generally holds a benign and self-limited *** rare cases of cryoglobulinemia are reported in immunocompetent patients,glomerular manifestations of HEV infection are frequently encountered in immunocompromised and solid organ transplant *** spectrum of renal manifestations of HEV infection include prerenal failure,glomerular disorders,tubular and interstitial *** biopsy is the gold standard diagnostic test that confirms the pattern of *** predominantly includes conservative *** of immunosuppressive medications and ribavirin(for 3-6 mo)is considered among patients with solid organ *** we review the clinical course,pathogenesis,renal manifestations,and management of HEV among immunocompetent and solid organ transplant recipients.

关键词： Hepatitis E Acute kidney injury Glomerular disorders Kidney biopsy Solid organ transplant Kidney transplant

Structural Models of the Human Chemokine Receptor CCR5

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Structural Models of the Human Chemokine Receptor CCR5