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Foveal regeneration after resolution of cystoid macular edema without and with internal limiting membrane detachment:presumed role of glial cells for foveal structure stabilization

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 818-833页

作者： Andreas Bringmann Martin karol Jan Darius Unterlauft Thomas Barth Renate Wiedemann Leon Kohen Matus Rehak Peter Wiedemann Department of Ophthalmology and Eye Hospital University of LeipzigLeipzig 04103Germany Helios Klinikum Aue Aue 08280Germany

AIM: To document with spectral-domain optical coherence tomography the morphological regeneration of the fovea after resolution of cystoid macular edema(CME) without and with internal limiting membrane(ILM) detachment and to discuss the presumed role of the glial scaffold for foveal structure stabilization. METHODS: A retrospective case series of 38 eyes of 35 patients is described. Of these, 17 eyes of 16 patients displayed foveal regeneration after resolution of CME, and 6 eyes of 6 patients displayed CME with ILM detachment. Eleven eyes of 9 patients displayed other kinds of foveal and retinal disorders associated with ILM detachment. RESULTS: The pattern of edematous cyst distribution, with or without a large cyst in the foveola and preferred location of cysts in the inner nuclear layer or Henle fiber layer(HFL), may vary between different eyes with CME or in one eye during different CME episodes. Large cysts in the foveola may be associated with a tractional elevation of the inner foveal layers and the formation of a foveoschisis in the HFL. Edematous cysts are usually not formed in the ganglion cell layer. Eyes with CME and ILM detachment display a schisis between the detached ILM and nerve fiber layer(NFL) which is traversed by Müller cell trunks. ILM detachment was also found in single eyes with myopic traction maculopathy, macular pucker, full-thickness macular holes, outer lamellar holes, and glaucomatous parapapillary retinoschisis, and in 3 eyes with Müller cell sheen dystrophy(MCSD). As observed in eyes with MCSD, cellophane maculopathy, and macular pucker, respectively, fundus light reflections can be caused by different highly reflective membranes or layers: the thickened and tightened ILM which may or may not be detached from the NFL, the NFL, or idiopathic epiretinal membranes. In eyes with short single or multiple CME episodes, the central fovea regenerated either completely, which included the disappearance of irregularities of the photoreceptor l

关键词： fovea cystoid macular edema internal limiting membrane detachment Müller cell sheen dystrophy Müller glia astrocytes

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高流速辉光放电质谱法检测镍基高温合金中痕量元素及其深度分布

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冶金分析 2011年第11期31卷 18-23页

作者： Kenghsien Su Xinwei Wang karol Putyera 埃文思分析集团纽约13211

为了制造效率更高,输出功率更大,同时散热更少的飞机引擎,需要燃料的燃烧温度也越来越高,因此航空发动机的生产商和涡轮发动机的制造者对材料和部件提出了新的要求。在较高的温度时,为了维持材料的机械性能和提高合金部件的控制能力,需... 详细信息

为了制造效率更高,输出功率更大,同时散热更少的飞机引擎,需要燃料的燃烧温度也越来越高,因此航空发动机的生产商和涡轮发动机的制造者对材料和部件提出了新的要求。在较高的温度时,为了维持材料的机械性能和提高合金部件的控制能力,需要继续改进原有的高温合金或者开发新一代高温合金,同时制造者也在建立更加严格的规格界限和质量控制规程。本文主要描述具有高流速离子源的辉光放电质谱仪,这种仪器的分析速度快,灵敏度高,非常适合于高温合金的分析。仪器除了可以做搜索分析和基材的杂质元素含量的检测之外,其直接进样的方法可以更好地检测出各种元素在产品高温受热之后的分布情况,以及痕量元素在保护层和界面的纵向分布。

关键词：辉光放电质谱法高温合金搜索分析基材的杂质直接进样痕量和超痕量元素

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The Explanation of the Michelson-Morley Experiment Results by Means Universal Frame of Reference

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Journal of Modern Physics 2017年第11期8卷 1868-1883页

作者： karol Szostek Roman Szostek Dept of Thermodynamics and Fluid Mechanics Rzeszow University of Technology Rzeszow Poland Department of Quantitative Methods Rzeszow University of Technology Rzeszow Poland

It is commonly thought that the Michelson-Morley experiment from 1887 and Kennedy-Thorndike experiment from 1932 demonstrated that the universal frame of reference (ether) does not exist and that the velocity of light in vacuum is absolutely constant. The analysis of this experiment led to the creation of the Special Theory of Relativity (STR). The article explains why Michelson-Morley and Kennedy-Thorndike experiments could not detect the universal frame of reference. In this article, a different transformation of time and position than the Lorentz transformation is derived on the basis of the geometric analysis of the Michelson-Morley and Kennedy-Thorndike experiments. The transformation is derived based on the assumption that the universal frame of reference (UFR) exists. UFR is a frame of reference in which the velocity of light is constant in every direction. In inertial frames of reference moving in the UFR, the velocity of light may be different. The article has derived the formula for relative speed and patterns for the maximum and minimum speed of light that can be measured in the inertial system. Finally, the anisotropy of the microwave background radiation has been explained by using the presented theory. According to the body kinematics model presented in this article, anisotropy of cosmic microwave background is the Doppler effect for observer moving in the UFR.

关键词： Kinematics of Bodies Universal Frame of Reference Coordinate and Time Transformation One-Way Speed of Light Anisotropy of Cosmic Microwave Background

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THE SLOW TRAIN TO XINJIANG A ride through Chinazs rapidly changing Western frontier

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城市漫步（上海版、英文） 2015年第1期 30-33页

作者： WILL PHILIPPS karol INE KAN 不详

"Keyi le!"exclaims the man I'm sharing a train compart-ment with,as I lay down on my cabin bed.I've just proved to him that all 193 centimeters of me can comfortably lie straight on the sleeper berth(there had been some doubt when we first boarded).The man's name is Junfeng,and he's a mechanic from Turpan,an ancient city close to Urumqi,capital of the Uyghur Autonomous Region,and our next *** ethnically Han family moved from Shandong two generations ago,and he continues to live in Xinjiang with his wife and *** has no plans to move back east.

关键词： frontier doubt straight

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Ultra-long-working-distance spectroscopy of single nanostructures with aspherical solid immersion microlenses

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Light(Science & Applications) 2020年第1期9卷 1561-1571页

作者： Aleksander Bogucki Lukasz Zinkiewicz Magdalena Grzeszczyk Wojciech Pacuski karol Nogajewski Tomasz Kazimierczuk Aleksander Rodek Jan Suffczynski Kenji Watanabe Takashi Taniguchi Piotr Wasylczyk Marek Potemski Piotr Kossacki Faculty of Physics University of Warsawul.Pasteura 502-093 WarsawPoland National Institute for Materials Science TsukubaIbaraki 305-0044Japan Laboratoire National des Champs Magnetiques Intenses CNRS-UJF-UPS-INSAavenue des Martyrs 2538042 GrenobleFrance

In light science and applications,equally important roles are played by efficient light emitters/detectors and by the optical elements responsible for light extraction and *** latter should be simple,cost effective,broadband,versatile and compatible with other components of widely desired micro-optical ***,they should also operate without high-numerical-aperture ***,we demonstrate that all these requirements can be met with elliptical microlenses 3D printed on top of light ***,the microlenses we propose readily form the collected light into an ultra-low divergence beam(half-angle divergence below 1°)perfectly suited for ultra-longworking-distance optical measurements(600mm with a 1-inch collection lens),which are not accessible to date with other spectroscopic *** microlenses can be fabricated on a wide variety of samples,including semiconductor quantum dots and fragile van der Waals heterostructures made of novel two-dimensional materials,such as monolayer and few-layer transition metal dichalcogenides.

关键词： versatile latter optics

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Dysregulation of IL-34 ligation to SDC-1 mitigates collagen-induced arthritis

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Cellular & Molecular Immunology 2022年第9期19卷 1070-1072页

作者： Anja Meyer Ryan Sienes Brian Zanotti Katrien van Raemdonck karol Palasiewicz Daniel P.Mass Michael V.Volin Shiva Shahrara Jesse Brown VA Medical Center ChicagoILUSA Department of Medicine Division of RheumatologyThe University of Illinois at ChicagoChicagoILUSA Department of Microbiology and Immunology Midwestern UniversityDowners GroveILUSA Department of Orthopedic Surgery The University of Illinois at ChicagoChicagoILUSA

IL-34 is a novel biomarker for rheumatoid arthritis(RA),as its serum levels are linked to C-reactive protein,erythrocyte sedimentation rate,rheumatoid factor(RF),IL-6 and radiographic progression[1,2].IL-34 reprograms naïve circulating M0 cells into glycolytic(CD14^(+)CD86^(+)GLUT1^(high))M34 macrophages(MΦs)by binding to its pathogenic receptor,SDC-1,which controls the activation of its coreceptor/M-CSFR[3].Glycolytic M34 MΦs are primed to differentiate into osteoclasts through SDC-1 ligation[3].

关键词： CD86 GLUT1 sedimentation

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利用高分辨辉光放电质谱技术对难熔金属材料进行痕量元素定量和深度剖面分析

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冶金分析 2010年第2期31卷 1-7页

作者： PUTYERA karol BOYEA Nick CUQ Nicole MICHELLON Cyril 埃文斯分析小组-纽约Shiva技术公司欧洲Shiva技术公司

直接采样的高分辨辉光放电质谱(GDMS)是当今高纯固体常规分析中可用的高灵敏度分析方法之一。这种多元素分析技术通常用于主量化学成分的定量分析、监测元素质量分数随微米级深度(深度分布)的变化,或用于对多种固体和镀层上肉眼可见体... 详细信息

直接采样的高分辨辉光放电质谱(GDMS)是当今高纯固体常规分析中可用的高灵敏度分析方法之一。这种多元素分析技术通常用于主量化学成分的定量分析、监测元素质量分数随微米级深度(深度分布)的变化,或用于对多种固体和镀层上肉眼可见体积的高灵敏度的分布研究,包括纯金属、高温合金、陶瓷或其中陶瓷金属。由于GDMS的检测几乎涵盖了所有方法,因此在监测痕量级的多元素含量方面是最具成本优势的。另外,它使对在包含绝缘层和(或)镀层及两者化合物的平面上的高灵敏度的含量深度分布分析成为可能。本文着重介绍直流辉光质谱技术用于监测痕量至超含量元素分析技术目前的进展以及直接采样分析实践中应当采用的策略。

关键词：高温材料难熔金属痕量杂质元素浓度分布辉光放电质谱法

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沥青体系的分子动力学研究进展及展望

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材料导报 2020年第19期34卷 19083-19093页

作者：何亮李冠男郑雨丰 Alessio Alexiadis Jan Valentin karol J Kowalski 重庆交通大学交通土建材料国家地方联合实验室重庆400074 哈尔滨工业大学交通科学与工程学院哈尔滨150090 伯明翰大学化学工程学院伯明翰B152TT 捷克理工大学土木工程学院布拉格16629 华沙理工大学土木工程学院华沙00-637

随着我国道路工程的飞速发展,沥青混凝土在路面工程中有越来越广泛的应用。近年来,沥青材料的研究已不仅局限于宏观性能试验,还拓展到介观与微观层面对沥青材料进行多尺度研究。分子动力学方法属于微观研究方法的一种,它是通过积分算法... 详细信息

随着我国道路工程的飞速发展,沥青混凝土在路面工程中有越来越广泛的应用。近年来,沥青材料的研究已不仅局限于宏观性能试验,还拓展到介观与微观层面对沥青材料进行多尺度研究。分子动力学方法属于微观研究方法的一种,它是通过积分算法模拟研究对象在不同条件下的分子运动轨迹与体系能量变化,并分析模拟数据得出结论。该方法已被广泛应用于分子尺度下路面沥青材料设计与微观机理研究,其优势在于从分子运动的角度解释沥青体系的各种现象与性质。因此,许多学者采用宏观试验和分子动力学模拟相结合的多尺度方法研究沥青体系,这将推动沥青材料的进一步发展。本文对沥青体系的分子动力学进行了全面的分析,构建了沥青体系分子动力学模型的一般平衡步骤,提出采用密度、玻璃态转变温度、黏度、溶解度参数等对沥青体系分子动力学模型的有效性进行验证。综合分析了分子动力学方法对沥青纳米聚集、自修复、改性、老化、界面黏附等行为机理的研究进展,提出采用耗散粒子动力学与粗粒化分子动力学对现阶段沥青体系分子动力学的研究尺度进行扩展。研究结果表明,沥青类材料的分子动力学方法还处于早期探索阶段,但其发展潜力极大,利用分子动力学方法研究沥青体系各组分分子的动力学行为,可揭示常规试验无法观察到的分子含时运动规律,预测沥青材料的宏观性能并针对沥青的分子结构提出其路用性能改善措施,从分子尺度上推动沥青路面多尺度试验仿真方法的发展与完善,为沥青材料基因组的开发研究奠定基础。

关键词：分子动力学道路沥青耗散粒子动力学粗粒化分子动力学

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3D resistive RAM cell design for high-density storage class memory—a review

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Science China(Information Sciences) 2016年第6期59卷 35-55页

作者： Boris HUDEC Chung-Wei HSU I-Ting WANG Wei-Li LAI Che-Chia CHANG Taifang WANG karol FRHLICH Chia-Hua HO Chen-Hsi LIN Tuo-Hung HOU Department of Electronics Engineering and Institute of Electronics National Chiao-Tung University Institute of Electrical Engineering Slovak Academy of Sciences Winbond Electronics Corporation

In this article, we comprehensively review recent progress in the Re RAM cell technology for 3D integration focusing on a material/device level. First we briefly mention pioneering work on high-density crossbar Re RAM arrays which paved the way to 3D integration. We discuss the two main proposed 3D integration schemes—3D horizontally stacked Re RAM vs 3D Vertical Re RAM and their respective advantages and disadvantages. We follow with the detailed memory cell design on important work in both areas, utilizing either filamentary or interface-limited switching mechanisms. We also discuss our own contributions on Hf O2-based filamentary 3D Vertical Re RAM as well as Ta Ox/Ti O2 bilayer-based self-rectifying 3D Vertical Re RAM. Finally,we summarize the present status and provide an outlook for the nearterm future.

关键词： RRAM ReRAM resistive switching crossbar cross-point storage class memory 3D integration atomic layer deposition selector

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Is more evidence needed for thrombectomy in basilar artery occlusion? The BASICS and BEST meta- analytical approaches

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Stroke & Vascular Neurology 2021年第4期6卷 671-672,I0094-I0096页

作者： Davi J Fontoura Solla Felipe Coelho Argolo karol P Budohoski Angelos G Kolias JoséGuilherme M P Caldas Jamary Oliveira-Filho Division of Neurosurgery Department of NeurologyUniversity of Sao PauloSao PauloBrazil NIHR Global Health Research Group on Neurotrauma Cambridge UniversityCambridgeUK Machine Learning for Mental Health Lab King's College LondonLondonUK Division of Neurosurgery Department of Clinical NeurosciencesAddenbrooke's HospitalCambridge UniversityCambridgeUK Radiology University of Sao PauloSao PauloBrazil Postgraduate Program in Health Sciences Federal University of BahiaSalvadorBahiaBrazil

INTRODUCTION The benefit of mechanical thrombectomy for stroke associated with anterior circulation large vessel occlusion(LVO)is well established and among the most effective treatments in medicine.1 Stroke associated with basilar artery occlusion(BAO)was not included in the seminal thrombectomy randomised clin-ical trials(RCTs).BAO accounts for 1%of the ischaemic strokes and 5%-10%of the LVO,but 70%-80%of BAO victims evolve to death or full dependence.23 The terminal nature of the brainstem and thalamic circulations may predispose to such dismal *** two RCT designed to assess the efficacy of early(<6-8 hours since symptoms onset)thrombectomy for BAO treatment,the BEST and BASICS trials.24 Given the prior evidence for thrombectomy benefit for anterior circu-lation stroke is well settled;BAO stroke shares a similar physiopathology with very poor prog-nosis.

关键词： throm occlusion basilar

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