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Survival and comorbidities in lung cancer patients:Evidence from administrative claims data in Germany

Oncology Research 2022年第4期30卷 173-185页

作者： DIEGO hernandez CHIH-YUAN CHENG karla hernandez-villafuerte MICHAEL SCHLANDER Division of Health Economics German Cancer Research Center(DKFZ)HeidelbergGermany Medical Faculty Mannheim Heidelberg UniversityMannheimGermany

Lung cancer is the most common cancer type worldwide and has the highest and second highest mortality rate for men and women respectively in ***,the role of comorbid illnesses in lung cancer patient prognosis is still *** analyzed administrative claims data from one of the largest statutory health insurance(SHI)funds in Germany,covering close to 9 million people(11%of the national population);observation period was from 2005 to *** cancer patients and their concomitant diseases were identified by ICD-10-GM *** were classified according to the Charlson Comorbidity Index(CCI).Incidence,comorbidity prevalence and survival are estimated considering sex,age at diagnosis,and place of *** Meier curves with 95%confidence intervals were built in relation to common *** identified 70,698 lung cancer incident cases in the *** and survival figures are comparable to official statistics in *** prevalent comorbidities are chronic obstructive pulmonary disease(COPD)(36.7%),followed by peripheral vascular disease(PVD)(18.7%),diabetes without chronic complications(17.4%),congestive heart failure(CHF)(16.5%)and renal disease(14.7%).Relative to overall survival,lung cancer patients with CHF,cerebrovascular disease(CEVD)and renal disease are associated with largest drops in survival probabilities(9%or higher),while those with PVD and diabetes without chronic complications with moderate drops(7%or lower).The study showed a negative association between survival and most common comorbidities among lung cancer patients,based on a large sample for *** research needs to explore the individual effect of comorbidities disentangled from that of other patient characteristics such as cancer stage and histology.

关键词： Lung Cancer Comorbidities Survival Administrative data Statutory health insurance

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Therapies for patients with coexisting heart failure with reduced ejection fraction and non-alcoholic fatty liver disease

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World Journal of Cardiology 2023年第7期15卷 328-341页

作者： Jose Arriola-Montenegro Renato Beas Renato Cerna-Viacava Andres Chaponan-Lavalle karla hernandez Randich Diego Chambergo-Michilot Herson Flores Sanga Pornthira Mutirangura Department of Internal Medicine University of MinnesotaMinneapolisMN 55455United States Department of Medicine Indiana University School of MedicineIndianaIN 46202United States Department of Medicine Henry Ford HospitalDetroitMI 48202United States Escuela de Medicina Universidad Peruana de Ciencias AplicadasLima 15067Peru Universidad Científica del Sur LimaPeru Department of Telemedicine CardiologyHospital Nacional Carlos Alberto Seguin EscobedoArequipa 8610Peru Department of Medicine University of MinnesotaMinneapolisMN 55415United States

Heart failure with reduced ejection fraction(HFrEF)and nonalcoholic fatty liver disease(NAFLD)are two common comorbidities that share similar pathophysiological *** is a growing interest in the potential of targeted therapies to improve outcomes in patients with coexisting HFrEF and *** manuscript reviews current and potential therapies for patients with coexisting HFrEF and *** therapies,including angiotensinconverting enzyme inhibitors/angiotensin receptor blockers,mineralocorticoids receptor antagonist,and sodium-glucose cotransporter-2 inhibitors,have been shown to reduce fibrosis and fat deposits in the ***,there are currently no data showing the beneficial effects of sacubitril/valsartan,ivabradine,hydralazine,isosorbide nitrates,digoxin,or beta blockers on NAFLD in patients with *** study highlights the importance of considering HFrEF and NAFLD when developing treatment plans for patients with these *** research is needed in patients with coexisting HFrEF and NAFLD,with an emphasis on novel therapies and the importance of a multidisciplinary approach for managing these complex comorbidities.

关键词： Non-alcoholic fatty liver disease Heart Failure Heart failure reduced ejection fraction Novel therapies Cardiovascular disease

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Asymmetric Price Transmission and Structural Breaks in the Relationship between Costa Rican Markets of Livestock Cattle, Beef and Milk

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Journal of Agricultural Science and Technology 2010年第5期4卷 37-50页

作者： K. hernandez-villafuerte Department of Agricultural Economics and Rural Development Georg-August-Universittat Gottingen Gottingen 37073 Germany

The vertical price transmission is generally considered as the relationship between two markets of the same production chain. However, we can expand this concept to another relation which has not been deeply investigated: the joint products. They are the products which are produced in a single production process, but not correspond to the same chain. An especial case is the beef and milk markets in Costa Rica. Even if these products usually correspond to disconnect chains, in Costa Rica farms make use of cattle to produce both meat and milk. The cointegration framework is applied in order to indentify the price transmission among these markets. In addition, the asymmetric behavior and structural breaks are taken into account. Price transmission between each market pair was found. First, the cattle prices adjust in the milk-cattle relationship, second, beef meat prices adjust in the cattle-beef meat and in the milk - beef meat relationship. Finally, the equations allowing for structural breaks affect the estimates in the following three ways: after the break the elasticities became higher than 1, there is more evidence of cointegration, and the adjustment coefficients are significant only when a change in the long run is allowed.

关键词：哥斯达黎加牛奶市场价格调整休息时间结构突变牛肉传递非对称

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