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The Ca^(2+)-sensing receptor and the pocketome:comparing nature's complexity with human intervention in receptor modulation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3153-3154页

作者： Edda S.F.Matthees Carsten hoffmann Institut fur Molekulare Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany Friedrich-Schiller-Universitat Jena Hans-KnollStraBe2D-07745 JenaGermany

In a recent paper published in Nature,the relatively understudied Ca^(2+)-sensing,receptor(CasR)within the Gprotein-coupled receptor(GPCR)family C,gained attention due to pioneering research led by Georgios Skiniotis ... 详细信息

关键词： Stanford gained Skin

Navigating the Challenges of Emerging Contaminants to Protect Human and Ecological Health

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Engineering 2024年第6期37卷 1-2页

作者： Jiuhui Qu Michael R.hoffmann Gang Yu School of Environment Tsinghua UniversityBeijing 100084China Linde-Robinson Laboratories California Institute of TechnologyPasadenaCA 91125USA Advanced Interdisciplinary Institute of Environmental and Ecology Beijing Normal UniversityZhuhai 519000China

Emerging contaminants are defined as chemicals that are not currently(or have only recently been)regulated and about which there are concerns regarding their impact on human or ecological *** contaminants are widely detected in air,water,soil,sediment,and biotic *** is against this backdrop of urgency that we have curated this special issue titled“Emerging Contaminants Control:Science and Technology,”with the goal of uniting the latest scientific insights and pioneering strategies to address this global *** special issue embarks on a comprehensive examination of the emerging contaminants dilemma,covering aspects such as risk assessment,remediation technologies,environmental surveying,and the broader implications for *** a collection of articles,we probe deep into the core of this issue,showcasing studies that range from appraising environmental risks to forging new methods for treatment and scrutinizing the occurrence of contaminants across different environmental settings.

关键词： Ecological surveying environmental

The 5C Model of Linguistic Creativity:Construction Grammar as a Cognitive Theory of Verbal Creativity

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Journal of Foreign Languages and Cultures 2024年第1期8卷 139-154页

作者： Thomas hoffmann Catholic University Eichstatt-Ingolstadt

Creativity is a design feature of human *** paper presents a cognitive model of verbal creativity that draws on insights from the psychological research into creativity-particularly Glaveanu's 5A model that distinguishes five crucial perspectives on a creative act(actors,audience,artefacts,actions and affordances).The paper will outline a linguistic version of this model that adopts Construction Grammar as its theoretical *** resulting"5C model of constructional creativity"argues that the central elements of linguistic creativity are constructors,co-constructors,constructs,constructional blending and the constructional network.

关键词： creativity construction grammar cognitive linguistics blending 5C model of constructional creativity cognition constructional networks

Egg-associated secretions from the brown planthopper(Nilaparvata lugens)activate rice immune responses

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Insect Science 2024年第4期31卷 1135-1149页

作者： Jing Li Shuai Li Jing Li Xinyang Tan Zhichang Zhao Lei Jiang Ary A.hoffmann Jichao Fang Rui Ji Institute of Plant Protection Jiangsu Academy of Agricultural SciencesJiangsu Key Laboratory for Food and Safety-State Key Laboratory Cultivation Base of Ministry of Science and TechnologyNanjingChina College of Plant Protection Nanjing Agricultural UniversityNanjingChina School of Plant Protection Anhui Agricultural UniversityHefeiChina School of BioSciences Bio21 InstituteUniversity of MelbourneParkvilleVICAustralia Jiangsu Collaborative Innovation Center of Regional Modern Agriculture&Environmental Protection Huaiyin Normal UniversityHuaianJiangsu ProvinceChina

The brown planthopper(BPH,Nilaparvata lugens)is a notorious sap-sucking insect pest that damages rice(Oryza sativa)plants throughout *** BPH feeding,saliva enters rice plant tissues,whereas during oviposition egg-associated secretions(EAS)are deposited in damaged plant *** changes in rice to planthopper salivary effectors have been widely ***,the effects of EAS from planthopper on rice immunity remains largely *** this study,we found that both infestation of rice by gravid BPH female adults and treatment with the EAS elicited a strong and rapid accumulation of jasmonic acid(JA),JA-isoleucine,and hydrogen peroxide in *** enhanced plant defenses not only in rice but also in tobacco,and these impaired the performance of BPH on rice,as well as the performance of aphids and whiteflies on ***-throughput proteome sequencing of EAS led to 110 proteins being identified and 53 proteins with 2 or more unique peptides being *** proteins from BPH EAS were also found in the salivary proteome from herbivores,suggesting potential evolutionary conservation of effector functions across feeding and oviposition;however,others were only identified in EAS,and these are likely specifically related to *** findings point to novel proteins affecting interactions between planthoppers and rice during oviposition,providing an additional source of information for effector studies.

关键词： egg-associated secretion Nilaparvata lugens oviposition plant immunity proteome

应对新污染物挑战，保护人类和生态健康（英文）

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Engineering 2024年第6期 1-2页

作者：曲久辉 Michael R.hoffmann 余刚 School of Environment Tsinghua University Linde-Robinson Laboratories California Institute of Technology Advanced Interdisciplinary Institute of Environmental and Ecology Beijing Normal University

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涂料助剂:用量小,作用大

中国涂料 2024年第2期39卷 75-76页

作者： Bettina hoffmann 不详

自2020年以来,涂料市场经历了一段动荡、艰难的时期,至今仍未完全稳定下来,不过,助剂的好日子也即将又一次到来。即使增长潜力既不可靠,规模也不大,但再也不会存在挥之不去的不确定性迹象。近年来,助剂制造商面临着各种挑战。与所有原... 详细信息

自2020年以来,涂料市场经历了一段动荡、艰难的时期,至今仍未完全稳定下来,不过,助剂的好日子也即将又一次到来。即使增长潜力既不可靠,规模也不大,但再也不会存在挥之不去的不确定性迹象。近年来,助剂制造商面临着各种挑战。与所有原材料供应商一样,大多数的全球性问题引起了很多连锁反应:新冠肺炎疫情、通货膨胀和价格波动引起的材料短缺、供应链延误、需求波动。然而,全球涂料助剂市场的发展令人备受鼓舞:市场研究机构Frost&Sullivan认为,2022年的销售额约为98亿欧元。这相当于估计250万~300万t的销售量(见图1)。

关键词：涂料助剂市场研究机构涂料市场原材料供应商全球性问题连锁反应需求波动增长潜力

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磁性非对称双链长表面活性剂囊泡凝胶

物理化学学报 2017年第8期33卷 1655-1664页

作者：赵文荣郝京诚 heinz hoffmann 山东大学胶体与界面化学教育部重点实验室济南250100 Physikalische Chemie I Bayreuth University

合成了一系列含磁性反离子的非对称双疏水链长的阳离子表面活性剂,其中三氯一溴铁合十六烷基戊基二甲基铵(C_(16)C_5DMA^+[FeCl_3Br]-~)与偶氮羧酸钠盐(AzoNa_4)在酸性条件水溶液中形成磁性囊泡凝胶。运用cryo-透射电镜(TEM)、冷冻蚀刻T... 详细信息

合成了一系列含磁性反离子的非对称双疏水链长的阳离子表面活性剂,其中三氯一溴铁合十六烷基戊基二甲基铵(C_(16)C_5DMA^+[FeCl_3Br]-~)与偶氮羧酸钠盐(AzoNa_4)在酸性条件水溶液中形成磁性囊泡凝胶。运用cryo-透射电镜(TEM)、冷冻蚀刻TEM(FF-TEM)、流变仪、傅里叶变换红外光谱(FT-IR)和超导量子干涉(SQUID)等表征技术对囊泡凝胶进行了结构和性质研究,结果发现:凝胶含有曲率多变的融合性的双层囊泡,这些双分子层结构模构了自然界中各种物象的结构轮廓,展现了不可预测的多变曲率和良好柔性。聚集体双分子层膜内由长短不对称烷基链采取交错相扣的双分子层排列模式,这种构建模式结构稳定,短烷基链可游离出囊泡双分子层并伸向外部水相介质。两个相邻囊泡间的短链在疏水相互作用下形成非共价的囊泡"补丁",疏水的囊泡"补丁"克服相邻囊泡之间的斥力而融合。磁性反离子[FeCl_3Br]^-不仅赋予囊泡磁性,且在囊泡的形成过程中调控烷基链的组装。这种多形态融合性囊泡为揭示膜曲率的调节机制和构建人工细胞提供实验数据和理论参考。

关键词：非对称双链长表面活性剂粘连囊泡磁性凝胶双分子层多曲率

The Merits of Passive Compliant Joints in Legged Locomotion： Fast Learning, Superior Energy Efficiency and Versatile Sensing in a Quadruped Robot

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Journal of Bionic Engineering 2017年第1期14卷 1-14页

作者： Matej hoffmann Jakub Simanek iCub Facility Istituto Italiano di Tecnologia Genova 16123 Italy Artificial Intelligence Laboratory Department of lnformatics University of Zurich Zurich 8050 Switzerland Department of Measurement Faculty of Electrical Engineering Czech Technical University in Prague Prague 166 27 Czech Republic

A quadruped robot with four actuated hip joints and four passive highly compliant knee joints is used to demonstrate the potential of underactuation from two standpoints： learning locomotion and perception. First, we show that：（i） forward locomotion on flat ground can be learned rapidly （minutes of optimization time）; （ii） a simulation study reveals that a passive knee configuration leads to faster, more stable, and more efficient locomotion than a variant of the robot with active knees; （iii） the robot is capable of learning turning gaits as well. The merits of underactuation （reduced controller complexity, weight, and energy consumption） are thus preserved without compromising the versatility of behavior. Direct optimization on the reduced space of active joints leads to effective learning of model-free controllers. Second, we find passive compliant joints with po- tentiometers to effectively complement inertial sensors in a velocity estimation task and to outperform inertial and pressure sensors in a terrain detection task. Encoders on passive compliant joints thus constitute a cheap and compact but powerful sensing device that gauges joint position and force/torque, and -- if mounted more distally than the last actuated joints in a legged robot -- it delivers valuable information about the interaction of the robot with the ground.

关键词： legged robots underactuated robots compliant joints learning locomotion force and tactile sensing haptic terrain classification

Patient-derived skin fibroblasts as a model to study frontotemporal lobar degeneration

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Neural Regeneration Research 2022年第12期17卷 2669-2671页

作者： Dorit hoffmann Annakaisa Haapasalo A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland

Frontotemporal lobar degeneration(FTLD)is one of the most common causes of early-onset dementia in patients under the age of 65 *** is a clinically,genetically,and neuropathologically heterogeneous group of neurodegenerative syndromes,causing atrophy in the temporal and frontal lobes of the *** is accompanied by progressive cognitive dysfunction,behavioral changes,difficulties in understanding or producing speech,and often also neuropsychiatric symptoms(Haapasalo and Remes,2015).Moreover,the clinical,genetic,and neuropathological features of FTLD may overlap with those of amyotrophic lateral sclerosis(ALS).Motor dysfunction is commonly present in FTLD patients and a portion of ALS patients experience frontal and temporal lobe dysfunction(Smith et al.,2019).

关键词： degeneration patients