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Fat injection to correct contour deformities of the reconstructed breast:a single surgeon experience

Plastic and Aesthetic research 2015年第1期2卷 115-119页

作者： Youssef Tahiri Jonathan Kanevsky Joshua Vorstenbosch James Lee karl Schwarz Department of Surgery Division of Plastic and Reconstructive SurgeryRiley Hospital for ChildrenIndiana UniversityIndianapolisIN 46202USA Department of Surgery Division of Plastic and Reconstructive SurgeryMcGill University Health CentreMontrealQC H3G 1B3Canada Department of Surgery Section of Plastic SurgeryUniversity of ManitobaWinnipegMB R3T 2N2Canada Schwarz Plastic Surgery MontrealQC H3G 1B9Canada

Aim:Autologous fat grafting has gained acceptance as a technique to improve aesthetic outcomes in breast *** purpose of this study was to share our clinical experience using autologous fat injection to correct contour deformities during breast ***:A single surgeon,prospectively maintained database of patients who underwent autologous fat injection during breast reconstruction from January 2008 to November 2013 at McGill University Health Center was *** characteristics,breast history,type of breast reconstruction,volume of fat injected,and complications were ***:One hundred and twenty-four patients benefited from autologous fat injection from January 2008 to November 2013,for a total of 187 treated *** patients were on average 49.3 years old(±8.9 years).Fat was harvested from the medial thighs(20.5%),flanks(39.1%),medial thighs and flanks(2.9%),trochanters(13.3%),medial knees(2.7%),and abdomen(21.9%).An average of 49.25 mL of fat was injected into each reconstructed breast.A total of 187 breasts in 124 patients were lipo-infiltrated during the second stage of breast *** breasts(in 12 separate patients)were injected several years after having undergone lumpectomy and *** the 187 treated breasts,118 were reconstructed with expanders to implants,45 with deep inferior epigastric perforator flaps,9 with latissimus dorsi flaps with implants,4 with transverse rectus abdominis myocutaneous flaps,and 13 had previously undergone lumpectomy and *** complications were noted in the entire series,for a rate of 3.2%.All were in previously radiated *** follow-up time was 12 months(range:2-36 months).Conclusion:Fat injection continues to grow in popularity as an adjunct to breast *** experience demonstrates a low complication rate as compared to most surgical interventions of the breast and further supports its safety in breast ***

关键词： Breast contour deformities fat injection

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一个遭受人为富营养化的亚热带大湖的快速生态变化

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人类环境杂志 1996年第3期25卷 150-155页

作者： karl Havens Nicholas Aumen r.Thomas James 张康生美国南佛罗里达水管区(SFWMD) SFWMD任奥基乔比湖系统研究组 SFWMD

本文描述人类活动是如何影响一个亚热带大湖——美国佛罗里达奥基乔比湖(0keechobee)的生态状况的。自20世纪初以来,该湖经历了水文变化和地貌变化,是近已出现加速富营养化现象。总磷浓度增加了1倍;氮磷比(氮:磷)下降了50%;湖泊沉积物... 详细信息

本文描述人类活动是如何影响一个亚热带大湖——美国佛罗里达奥基乔比湖(0keechobee)的生态状况的。自20世纪初以来,该湖经历了水文变化和地貌变化,是近已出现加速富营养化现象。总磷浓度增加了1倍;氮磷比(氮:磷)下降了50%;湖泊沉积物也累积了大量磷。生物群落已经历了看来是因富营养化所致的变化:贫毛类环虫在大型底牺生物中占据优势;蓝菌藻已取代硅藻成为优势浮游植物;氮限制的出现次数增加;固氮已成为所输入的主要途径。有证据表明:该湖已达到一种新的生态稳定状态,通过沉积物的营养输入来缓冲变化。湖水的深度变浅和风积物悬浮有助于这种局势的形成。

关键词：美国亚热带湖泊生态变化

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Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype

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Journal of Molecular Cell Biology 2020年第7期12卷 499-514页

作者： Eduard Sarró Mónica Durán Ana rico Diana Bou-Teen Vanesa Fernández-Majada Anthony J.Croatt karl A.Nath Maria Teresa Salcedo Justin H.Gundelach Daniel Batlle richard J.Bram Anna Meseguer renal Physiopathology Group CIBBIM-NanomedicineVall d’Hebron Research Institute08035 BarcelonaSpain Cardiovascular Diseases Group Vall d’Hebron Research Institute08035 BarcelonaSpain Biomimetic Systems for Cell Engineering Laboratory Institute for Bioengineering of Catalonia(IBEC)The Barcelona Institute of Science and Technology(BIST)08028 BarcelonaSpain Division of Nephrology and Hypertension and Department of Medicine Mayo ClinicRochesterMN 55905USA Department of Pathology Hospital Universitari Vall d’Hebron08035 BarcelonaSpain Department of Pediatric and Adolescent Medicine College of MedicineMayo ClinicRochesterMN 55905USA Department of Biochemistry and Molecular Biology College of MedicineMayo ClinicRochesterMN 55905USA Division of Nephrology and Hypertension Northwestern University Feinberg School of MedicineChicagoIL 60611USA Department of Immunology College of MedicineMayo ClinicRochesterMN 55905USA Departament de Bioquímica i Biologia Molecular Unitat de Bioquímica de MedicinaUniversitat Autònoma de Barcelona08193 BellaterraSpain red de Investigación renal(rEDINrEN) Instituto de Salud Carlos III-FEDER28040 MadridSpain

restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial–mesenchymal transition(pEMT),proliferation,and further redifferentiation into specialized tubule epithelial cells(TECs).Because the immunosuppressant cyclosporine-A produces pEMT in TECs and inhibits the peptidyl-prolyl isomerase(PPIase)activity of cyclophilin(Cyp)proteins,we hypothesized that cyclophilins could regulate TEC *** we demonstrate that in cultured TECs,CypA silencing triggers loss of epithelial features and enhances transforming growth factorβ(TGFβ)-induced EMT in association with upregulation of epithelial repressors Slug and *** pro-epithelial action of CypA relies on its PPIase *** contrast,CypB emerges as an epithelial repressor,because CypB silencing promotes epithelial differentiation,prevents TGFβ-induced EMT,and induces tubular structures in 3D *** addition,in the kidneys of CypB knockout mice subjected to unilateral ureteral obstruction,inflammatory and pro-fibrotic events were *** silencing/knockout leads to Slug,but not Snail,*** support of Slug expression depends on its endoplasmic reticulum location,where it interacts with calreticulin,a calcium-buffering chaperone related to Slug *** CypB silencing reduces ionomycin-induced calcium release and Slug upregulation,we suggest that Slug expression may rely on CypB modulation of calreticulin-dependent calcium *** conclusion,this work uncovers new roles for CypA and CypB in modulating TEC plasticity and identifies CypB as a druggable target potentially relevant in promoting kidney repair.

关键词： cyclophilins epithelial phenotype Slug TGFβ UUO fibrosis

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比对分析与故障检测技术及其在航天工程中应用

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空军工程大学学报（自然科学版） 2007年第4期8卷 1-4页

作者：胡绍林 Meinke karl 陈如山 Huajiang Ouyang 南京理工大学南京210017 royal Institute of Technology The University of Liverpool L69 7ZXUnited Kingdom

比对分析是工程信号分析与故障诊断的重要手段之一。论文提出并构建了3组可以分别适用于不同情况的数值比对算法,并建立了基于比对残差的渐变型故障分离和突发性故障诊断的实用方法。通过实例说明了比对分析方法在航天外测故障诊断等领... 详细信息

比对分析是工程信号分析与故障诊断的重要手段之一。论文提出并构建了3组可以分别适用于不同情况的数值比对算法,并建立了基于比对残差的渐变型故障分离和突发性故障诊断的实用方法。通过实例说明了比对分析方法在航天外测故障诊断等领域的重要应用。

关键词：比对分析故障检测故障诊断趋势项分离

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Interacting with α7 nAChr is a new mechanism for AChE to enhance the inflammatory response in macrophages

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Acta Pharmaceutica Sinica B 2020年第10期10卷 1926-1942,2020页

作者： Etta Y.L.Liu Yingjie Xia Xiangpeng Kong Maggie S.S.Guo Anna X.D.Yu Brody Z.Y.Zheng Shinghung Mak Miranda L.Xu karl W.K.Tsim Key Laboratory of Food Quality and Safety of Guangdong Province College of Food ScienceSouth China Agricultural UniversityGuangzhou 510642China Shenzhen Key Laboratory of Edible and Medicinal Bioresources the Hong Kong University of Science and TechnologyShenzhen 518057China Division of Life Science Center for Chinese Medicinethe Hong Kong University of Science and TechnologyHong kongChina

Acetylcholine(ACh)regulates inflammation viaα7 nicotinic acetylcholine receptor(α7 nAChr).Acetylcholinesterase(AChE),an enzyme hydrolyzing ACh,is expressed in immune cells suggesting non-classical function in inflammatory ***,the expression of PriMA-linked G4 AChE was identified on the surface of *** lipopolysaccharide-induced inflammatory processes,AChE was upregulated by the binding of NF-κB onto the ACHE ***,the overexpression of G4 AChE inhibited ACh-suppressed cytokine release and cell migration,which was in contrast to that of applied AChE ***,a DNA construct without enzymatic activity,was adopted to identify the protein role of AChE in immune *** of G4 AChEmt induced cell migration and inhibited ACh-suppressed cell *** co-localization ofα7 nAChr and AChE was found in macrophases,suggesting the potential interaction ofα7 nAChr and ***,immunoprecipitation showed a close association ofα7 nAChr and AChE protein in cell ***,the novel function of AChE in macrophage by interacting withα7 nAChr was *** with hydrolysis of ACh,AChE plays a direct role in the regulation of inflammatory *** such,AChE could serve as a novel target to treat age-related diseases by antiinflammatory responses.

关键词： Macrophage AChE Cholinergic anti-inflammatory pathway α7 nAChr

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Adhesion as the Base of Cleaning in Food and Pharma Industry

Adhesion as the Base of Cleaning in Food and Pharma Industry

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第三届世界粘接及相关现象大会暨北京粘接学会第十五届学术年会

作者： Ulrich Bobe karl Sommer Uwe Beck Georg reiners Lehrstuhl fr Maschinen-und Apparatekunde TU-Munich85350 Freising-Weihenstephan

The aim of the research was to study the effects of different surface parameters on the adhesion that is relevant for food and pharma industry regarding the detachment of single *** enables a qualitative characterisation of the cleanability of technical *** analysed parameters were the surface material(roughness ra,surface energy, imperfections) and also the particles(diameter,material) and the cleaning fluid(pH-value,temperature,surfactants). The studied imperfections have been welding seams and *** experiments show the influences of the different parameters on the particle detachment(cleaning) and give a link to the importance of the structure of the surface roughnesses. In oncoming experiments the cleanability studies will be done with cross linked contaminations as *** and the effects of different roughness structures will be studied.

关键词： cleaning adhesion surfaces contamination roughness surface energy

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Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue

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Microsystems & Nanoengineering 2021年第1期7卷 133-140页

作者： Josh Javor Jourdan K.Ewoldt Paige E.Cloonan Anant Chopra rebeccah J.Luu Guillaume Freychet Mikhail Zhernenkov karl Ludwig Jonathan G.Seidman Christine E.Seidman Christopher S.Chen David J.Bishop Department of Mechanical Engineering Boston UniversityBostonMA 02215USA Department of Biomedical Engineering Boston UniversityBostonMA 02215USA SMI Beamline 12-ID Brookhaven National LaboratoryUptonNY 11973USA Department of Physics Boston UniversityBostonMA 02215USA Division of Materials Science Boston UniversityBostonMassachusetts 02215USA Department of Genetics Harvard Medical SchoolBostonMA 02215USA Department of Electrical Engineering Boston UniversityBostonMA 02215USA

The structural and functional maturation of human induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)is essential for pharmaceutical testing,disease modeling,and ultimately therapeutic *** 3D-tissue platforms have improved the functional maturation of hiPSC-CMs,but probing cardiac contractile properties in a 3D environment remains challenging,especially at depth and in live *** small-angle X-ray scattering(SAXS)imaging,we show that hiPSC-CMs matured and examined in a 3D environment exhibit a periodic spatial arrangement of the myofilament lattice,which has not been previously detected in *** contractile force is found to correlate with both the scattering intensity(r^(2)=0.44)and lattice spacing(r^(2)=0.46).The scattering intensity also correlates with lattice spacing(r^(2)=0.81),suggestive of lower noise in our structural measurement than in the functional ***,we observed decreased myofilament ordering in tissues with a myofilament mutation known to lead to hypertrophic cardiomyopathy(HCM).Our results highlight the progress of human cardiac tissue engineering and enable unprecedented study of structural maturation in hiPSC-CMs.

关键词： cardiac cardiomyocytes spacing

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Psychometric Properties of a Chinese Version of Self-compassion Scale in Chinese University Students

Psychometric Properties of a Chinese Version of Self-compass...

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第二十一届全国心理学学术会议

作者： Mengya Zhao Anke karl Yuanlin Li Peng Wang Psychology University of Exeter Psychology Shandong Normal University

Self-compassion means being kind to oneself when facing difficulties(Neff, 2003). Although there are several versions of self-compassion scale translated by different Chinese researchers, many lack psychometric integrity, which hinders the research of self-compassion in Chinese culture. This study aims to test psychometric properties of a Chinese version of self-compassion scale(SCS-C) as well as the short form in Chinese undergraduates via four studies. Study 1 is an online questionnaire study recruiting 465 Chinese University students(141 males;324 females. M age = 20.26;SD age = 2.18) to test the factor structure using Exploratory Factor Analysis, the convergent validity using correlation analysis and internal reliability via reliability test. results showed that: firstly, SCS-C did not show a clear factor structure as previous research(Neff, 2003);secondly, SCS-C has good convergent validity. Specifically, the SCS-C was significantly negatively associated with Personal Standard Subscale, r(465) =-.212, p r(465) =.558, p rait-Meta Scale, Attention, r(465) =.327, p rity, r(465) =.464, p repair, r(465) =.686, p rdly, the total scale’s reliability is great, however, the subscales suffered from low level of internal reliability, especially for self-judgement. Study 2 is a paper-and-pen questionnaire recruiting participants from a north China university to explore the factor structure, discriminant validity and test-retest reliability. 392undergraduate students(71 males;317 females. M age = 18.97;SD age =.975) were recruited at Time 1 and 187 students(38 males;149 females. M age = 18.88;SD age =.982) were given a second administration of the SCS-C after 2 weeks(Time 2). The results showed that: firstly, SCS-C did not follow any factor structures proposed by Neff(2016);Secondly, SCS-C is different from other self-attitude scales, and specifically, SCS-

关键词： self-compassion scale Chinese version factor structure validity reliability

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方法问题即宪法问题?

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南大法学 2024年第3期 167-188页

作者： [德]伯恩·魏德士汪西兴(译) 不详北京大学法学院

二战后,法学方法论在德意志联邦共和国的法学教育中处于相当边缘的地位,关于法学方法史的讨论更为寥落,甚至成为禁忌。当代法律人掌握了很多方法论工具,却对这些方法在历史上的“法律政治”后果毫无所悉。德国极权时期(如纳粹)的沉痛教... 详细信息

二战后,法学方法论在德意志联邦共和国的法学教育中处于相当边缘的地位,关于法学方法史的讨论更为寥落,甚至成为禁忌。当代法律人掌握了很多方法论工具,却对这些方法在历史上的“法律政治”后果毫无所悉。德国极权时期(如纳粹)的沉痛教训不应简单归咎于法律实证主义,当时盛行的客观解释方法也应负很大的责任。法律的客观目的只是浪漫的虚构,法律文本的客观意义并不存在,故客观解释相当盲目,释法者可以借此将自己的主观意志或者“时代精神”注入法律。德国极权时期的法律人将当时主导性的意识形态注入法律,对法体系重新解释、整体改造,使法律沦为政治的婢女。需要强调的是,方法问题关乎宪法:法官受法律的拘束是民主法治国的内在要求。以解释之名行造法之实,法官自由选择方法来追求所欲的结果,法律在被法官适用之前根本不存在的“自由法”观念,等等,方法上的恣意违反了宪法所要求的民主、平等、权力分立与法治国原则,使得司法过程不具有可证伪性和可检验性。司法造法是必要的,法官法的法源地位应得到承认。但法官不能以客观解释的名义恣意造法,而应坚持方法论的诚实,为造法行为承担更高的论证义务:只有证实漏洞存在,或者在对立法目的进行历史考察,并证明当下的情事与价值确已变迁时,才可进行造法。造法的内容也要受到宪法的控制。

关键词：法学方法论客观解释民主法治国司法造法卡尔·拉伦茨

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Effect of coaxial laser cladding parameters on bead formation

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International Journal of Minerals,Metallurgy and Materials 2017年第5期24卷 550-556页

作者： A.I.Noskov A.Kh.Gilmutdinov r.M.Yanbaev Kazan National research Technical University 10 Karl Marx Str. Kazan 420111 Republic of Tatarstan Russian Federation

We investigated the shape and morphology of nickel-based powder particles (Sulzer Metco) and coatings produced by laser gas-powder deposition onto steel substrates. Laser deposition was performed using an LC-10 IPG-Photonics laser complex equipped with a 10-kW fiber laser. The shape and microstructure of the samples were studied using optical and electronic microscopy and X-ray diffraction analysis. The results showed that the deposition speed and laser power significantly influenced the shape and size of the beads. The depth of diffusion of nickel into the steel substrate after deposition was less than 20 μm; the microstructure of the resulting coating was fcc Fe3Ni. As a result, detailed information about the form and shape of the filler powder, modes of its deposition, and the resulting coating structure was obtained; this information is important for the production of high-quality products by additive technologies.

关键词： laser cladding additive manufacturing microstructure morphology bead formation

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