检索结果-南通市图书馆

大学英语 2006年第11期 10-11页

作者： karl Ritter Matt Moore 贾庆文（编译）不详山东泰安

2006年10月3日,美国人约翰·c·马瑟和乔治·F·斯莫特荣获了2006年诺贝尔物理学奖,他们的研究工作帮助巩固了宇宙大爆炸理论,加深了人们对星系和恒星起源的理解.

关键词：高校大学英语双语阅读科技文阅读对照读物

Mycophenolic Acid Absorption Profiles in Patients with Kidney or combined Pancreas-Kidney Transplantation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Nephrology 2012年第4期2卷 116-122页

作者： Jan M. Fertmann Helmut P. Arbogast Wolf-D. Illner Walter Land karl-W. Jauch Johannes N. Hoffmann Department of Surgery Klinikum Grosshadern Ludwig-Maximilians University of Munich Munich Germany Department of Surgery Klinikum Grosshadern Ludwig-Maximilians University of Munich Munich Germany Department of Surgery University of Duisburg-Essen Duisburg and Essen Germany

Background: Mycophenolate Mofetil (MMF) is widely used in organ transplant patients to avoid calcineurine inhibittor-associated side effects. Therapeutic monitoring of MMF is up to now perform by using trough level measurements (measurements before drug administration). The present study was designed to characterize potential differences in MMF absorption kinetics between patients with allogenic kidney transplantation [kidney Tx] and simultaneous pancreas kidney transplantation [PK Tx], which might for example occur due to diabetic gastrointestinal atony. Methods: A total of 64 pharmacokinetic profiles were prospectively studied in 44 adult kidney Tx and 20 PK Tx patients. To calculate AUc by the trapezoidal rule, mycophenolic acid (MPA) levels were measured in EDTA-plasma by an EMIT assay at 0, 0.5, 1, 2, 3, 4 6, and 12h after oral MMF administration between postoperative day 14 to 28 instable patients. Results: Substantial differences between kidney Tx and PK Tx patients were evident concerning: donor age, recipient age, number of mismatches, and kidney function (serum creatinine). Despite these dissimilarities pharmacokinetic absorption profiles did not significantly differ between patient groups as measured by AUc, c2, maximum MPA concentration (cmax), and time until maximum absorption (Tmax). Astonishingly, concomitant cyclosporine and tacrolimus medication did not influence adsorption profiles. Only MPA concentrations 6h post administration correlated closely with AUc in both patient groups, whereas trough levels failed to be predictive for AUc. conclusions: In our study population, MMF absorption kinetics did not differ between kidney and PK Tx patients and did not seem influenced by concomitant immunosuppressive medication. Therefore, MPA measurements during the absorption phase could be useful to better estimate AUc in patients with kidney Tx and PK Tx.

关键词： Mycophenolate Mofetil Mycophenolic Acid Pharmacokinetics Kidney Transplantation Pancreas-Kidney Transplantation

Measurement of solar pp neutrino flux using electron recoil data from PandaX-4T commissioning run

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Physics c 2024年第9期48卷 1-7,300页

作者： Xiaoying Lu Abdusalam Abdukerim Zihao Bo Wei chen Xun chen Yunhua chen chen cheng Zhaokan cheng Xiangyi cui Yingjie Fan Deqing Fang Lisheng Geng karl Giboni Xuyuan Guo chencheng Han Ke Han changda He Jinrong He Di Huang Junting Huang Zhou Huang Ruquan Hou Yu Hou Xiangdong Ji Yonglin Ju chenxiang Li Jiafu Li Mingchuan Li Shuaijie Li Tao Li Qing Lin Jianglai Liu congcong Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yajun Mao Yue Meng Xuyang Ning Binyu Pang Ningchun Qi Zhicheng Qian Xiangxiang Ren Nasir Shaheed Xiaofeng Shang Xiyuan Shao Guofang Shen Manbin Shen Lin Si Wenliang Sun Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Xu Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Yuan Wu Mengjiao Xiao Xiang Xiao Kaizhi Xiong Binbin Yan Xiyu Yan Yong Yang chunxu Yu Ying Yuan Zhe Yuan Youhui Yun Xinning Zeng Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Wei Zhang Yang Zhang Yingxin Zhang Yuanyuan Zhang Li Zhao Jifang Zhou Ning Zhou Xiaopeng Zhou Yubo Zhou Zhizhen Zhou Research center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China New cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Jinping Deep Underground Frontier Science and Dark Matter Key Laboratory of Sichuan Province Liangshan 615000China Yalong River Hydropower Development company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Beihang UniversityBeijing 102206China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China Peng Huanwu collaborative center for Research and Education Beihang UniversityBeijing 100191China Southern center for Nuclear-Science Theory(ScNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Peking UniversityBeijing 100871Ch

The proton-proton(pp)fusion chain dominates the neutrino production in the *** uncertainty of the predicted pp neutrino flux is at the sub-percent level,whereas that of the best measurement is O(10%).In this study,for the first time,we measure solar pp neutrinos in the electron recoil energy range from 24 to 144 keV using the PandaX-4T commissioning data with 0.63 tonne×year *** pp neutrino flux is determined as(8.0±3.9(stat)±10.0(syst))×1010 s^(-1)cm^(-2),which is consistent with the Standard Solar Model and existing measurements,corresponding to an upper flux limit of 23.3×10^(10)s^(-1)cm^(-2)at 90%c.L..

关键词： solar pp neutrino flux PandaX-4T electron recoil spectrum

An Evaluation of Manure Management Strategies, Phosphorus Surface Runoff Potential and Water Usage at an Arkansas Discovery Dairy Farm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Protection 2023年第9期14卷 742-760页

作者： James M. Burke Mike B. Daniels Pearl Webb Andrew N. Sharpley Timothy Glover Lawrence Berry karl W. Van Devender Stan Rose Department of crop Soil and Environmental Sciences University of Arkansas Fayetteville AR USA University of Arkansas Division of Agriculture Little Rock AR USA United States Department of Agriculture-Natural Resources conservation Service Fort Smith AR USA

Manure management is an essential component of dairy production. Nutrient-laden, field-applied dairy manure often serves as a fertilizer source, but can also pose environmental threats if not properly managed. The Haak dairy farm, located in Decatur, Arkansas, was granted a permit by the Arkansas Department of Environmental Quality (ADEQ) to employ a unique method in treating and storing cattle manure generated during the milking process. This method includes minimizing water use in wash water, dry scraping solids to combine with sawdust for composting and pumping effluent underground into a sloped concrete basin that serves as secondary solid separator before transporting the manure effluent into an interception trench and an adjacent grassed field to facilitate manure nutrient uptake and retention. The Arkansas Discovery Farm program (ADF) is conducting research to evaluate the environmental performance of the dairy’s milk center wash water treatment system (McWW) by statistical analysis, characterization of phosphorus (P) migration in soil downslope from the inception trench, temperature measurements, and nutrient analysis of a stored dry stack manure/sawdust mixture. Goals included determining possible composting effectiveness along with comparisons to untreated dairy manure and quantifying the use of on-farm water. Results from this research demonstrated that: 1) The McWW was effective at retaining manure-derived nutrients and reducing field nutrient migration as the McWW interception trench had significantly higher total nitrogen (TN) (804.2 to 4.1), total phosphorus (TP) (135.6 to 1.5), and water extractable phosphorus (WEP) (55.0 to 1.0) concentrations in milligrams per liter (mg⋅L-1) than the downhill freshwater pond respectively;2) temperature readings of the manure dry stack indicated heightened levels of microbial and thermal activity, but did not reach a standard composting temperature of 54°c;3) manure dry stack nutrient content was typicall

关键词： Manure Management Soil Test Phosphorus Surface Runoff Water Usage Manure composting Environmental Hazards Arkansas Milk center Wastewater Treatment System Statistical Analysis

Residual urinary output in high body mass index individuals on chronic hemodialysis:A disregarded life vest?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Nephrology 2014年第4期3卷 317-323页

作者： Hernán Trimarchi María S Ra?a Alejandra karl José Andrews Mariana Dicugno Vanesa Pomeranz Pablo Young Mariano Forrester Mirta Alonso Fernando Lombi Alexis Muryan Nephrology Hospital Británico de Buenos Aires Biochemistry Hospital Británico de Buenos Aires Internal Medicine Services Hospital Británico de Buenos Aires

AIM： To assess residual diuresis and diverse variables according to body mass index （BMI）.METHODS： cross-sectional study （n = 57）, with 3 groups. Group A： BMI 〈 25, n = 22; Group B： BMI 25-30, n = 15; Group c： BMI 〉 30, n = 20. Diuresis, hematocrit, albumin, c-reactive protein, Malnutrition infammatory score, Pro-BNP, Troponin T, leptin and in-sulin levels are expressed as median and ranges （r）. RESULTS： Albumin （g/dL）： GA vs Gc, 3.70 （r2.20-4.90） vs 3.85 （r3.40-4.90）, P = 0.02. Diuresis （mL/d）： GA 690 （r0-1780）; GB 660 （r60-1800）; Gc 840 （r40-2840）. Diuresis GA vs Gc, P = 0.01. Leptin （ng/mL）： GA vs Gc, 3.81 （r0.78-69.60） vs Gc, 32.80 （r0.78-124.50）, P 〈 0.001. Insulin （μU/mL）： GA vs GB, 7 （r2-44） vs 11.50 （r4-38）, P = 0.02; GA vs Gc, 7 （r2-44） vs 19.5 （r5-155）, P = 0.0001. Troponin T and Pro-BNP levels were not different. Significant correlations： Gc, Insulin-UF： ρ= 0.53; P = 0.03; TroponinT-diuresis： ρ = -0.48, P 〈 0.05; Pro-BNP-diuresis： ρ = -0.39, P 〈 0.01; Troponin T-ProBNP： ρ = 0.77, P 〈 0.0001; albumin-Troponin T： ρ = -0.66, P 〈 0.0001; albumin-ProBNP： ρ = -0.44, P 〈 ***： High BMI associated positively with higher diuresis and albuminemia, and negatively with TropT and Pro-BNP. High BMI-associated better survival may be explained by better urinary output, lowering cardiovascular stress.

关键词： Hemodialysis Residual diuresis Body mass index Troponin T Pro-BNP Insulin

Vaccination with the Live Attenuated FrancisellanovicidaMutant FTN0109Protects against Pulmonary Tularemia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Vaccines 2015年第1期5卷 25-36页

作者： Aimee L. cunningham M. Neal Guentzel Jieh-Juen Yu Nikita Trivedi karl E. Klose James P. chambers Bernard P. Arulanandam South Texas center for Emerging Infectious Disease and center for Excellence in Infection Genomics University of Texas at San Antonio San Antonio TX USA Department of Microbiology and Immunology University of Texas Health Science Center at San Antonio San Antonio TX USA

Francisella tularensis is considered a potential bioterrorism agent due to its low infectious dose, high mortality rate, and ability to be spread via the aerosol route. We characterized the F. tularensis subspecies novicida mutant strain FTN0109 as a potential vaccine candidate against tularemia. This strain, which lacks an outer membrane lipoprotein, is attenuated in vitro and in vivo, as it exhibits reduced replication within murine J774 macrophages and has a pulmonary LD50 in BALB/c and c57BL/6 mice of >105 cFU (compared to WT parental strain U112, LD50 FTN0109 also conferred complete protection in BALB/c mice against subsequent pulmonary challenge with 10 LD50 (60,000 cFU) of the murine virulent Francisella strain LVS. We also have demonstrated partial protection (50%) against the highly human virulent subspecies tularensis strain ScHU S4 (25 LD50, 12,500 cFU) following intratracheal vaccination in the Fischer 344 rat, a second rodent model for tularemia. Overall, our results suggest that FTN0109 serves as a potential putative vaccine candidate against pulmonary tularemia.

关键词： Tularemia F. tularensis Vaccines Live Attenuated

Dietary intake of advanced glycation endproducts(AGEs)and cancer risk across more than 20 anatomical sites:A multinational cohort study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

cancer communications 2022年第10期42卷 1041-1045页

作者： Reynalda córdova Ana-Lucia Mayén Viktoria Knaze Elom Kouassivi Aglago casper Schalkwijk karl-Heinz Wagner Kim Overvad Anne Tjønneland cecilie Kyrø Verena Andrea Katzke charlotte Le cornet Matthias Bernd Schulze Anna Birukov Domenico Palli Sara Grioni Fabrizio Pasanisi Alberto catalano Torkjel Manning Sandanger Inger Torhild Gram Guri Skeie Marta crous-Bou Esther Molina-Montes Pilar Amiano Sandra Milena colorado-Yohar Eva Ardanaz Isabel Drake Jonas Manjer Ingegerd Johansson Anders Esberg Aurora Perez-cornago Elisabete Weiderpass Mazda Jenab Heinz Freisling Nutrition and Metabolism Branch International Agency for Research on Cancer(IARC-WHO)Lyon 69008France Department of Nutritional Sciences University of ViennaVienna 1090Austria Department of Internal Medicine Maastricht University Medical CentreMaastricht 6229the Netherlands Department of Public Health Aarhus UniversityAarhus 8000Denmark Danish cancer Society Research center Copenhagen 2100Denmark Division of cancer Epidemiology German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Molecular Epidemiology German Institute of Human Nutrition Potsdam-RehbrueckeNuthetal 14558Germany Institute of Nutritional Science University of PotsdamNuthetal 14558Germany cancer Risk Factors and Lifestyle Epidemiology Unit Institute for Cancer ResearchPrevention and Clinical Network(ISPRO)Florence 2-50139Italy Epidemiology and Prevention Unit Fondazione IRccS Istituto Nazionale dei Tumori di Milano Milan 20133Italy Department of clinical Medicine and Surgery University of Naples Federico IINaples 80138Italy Department of clinical and Biological Sciences University of TurinTurin 1012Italy Department of community Medicine UiT-the Arctic University of NorwayTromsø9037Norway Unit of Nutrition and cancer Cancer Epidemiology Research ProgramCatalan Institute of Oncology(ICO)-Bellvitge Biomedical Research Institute(IDIBELL)L’Hospitalet de LlobregatBarcelona 08908Spain Department of Epidemiology Harvard T.H.Chan School of Public HealthBoston 02115USA Department of Nutrition and Food Science Faculty of PharmacyUniversity of GranadaGranada 18071Spain Ministry of Health of the Basque Government Sub Directorate for Public Health and Addictions of GipuzkoaSan Sebastian 20013Spain Biodonostia Health Research Institute Epidemiology of Chronic and Communicable Diseases GroupSan Sebastián 2014Spain Spanish consortium for Research on Epidemiology and Public Health(cIBERESP) Instituto de Salud Carlos IIIMadrid 28029Spain Department of Epidemiology Murcia Regional Health CouncilIMIB-ArrixacaM

Dear Editor,In the European region,which shares 22.8%of the global cancer burden for 10%of the global population,there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020[1].The reasons for the high cancer incidence rates are complex;however,diet and dietary components are among the main contributors to cancer risk[2].In modern-day living,a growing proportion of people include in their diets ultra-processed *** of food processing and home-prepared foods are so-called dietary advanced glycation endproducts(AGEs),which are reactive metabolites emerging during the breakdown of reducing *** production is preponderant in dry high-heat processes(e.g.,baking,roasting);hence foods such as cakes,crisps,crackers,cereal products,meat and meat-derived products represent a major source of dietary AGEs[3].

关键词： dietary intake hence

GREENHOUSE GAS AND AMMONIA EMISSION MITIGATION PRIORITIES FOR UK POLIcY TARGETS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Agricultural Science and Engineering 2023年第2期10卷 268-280页

作者： Sarah BUcKINGHAM cairistiona F.E.TOPP Pete SMITH Vera EORY David R.cHADWIcK christina K.BAXTER Joanna M.cLOY Shaun cONNOLLY Emily c.cOOLEDGE Nicholas J.cOWAN Julia DREWER colm DUFFY Naomi JFOX Asma JEBARI Becky JENKINS Dominika J.KROL Karina A.MARSDEN Graham A.McAULIFFE Steven J.MORRISON Vincent O'FLAHERTY Rachael RAMSEY karl G.RIcHARDS Rainer ROEHE Jo SMITH Kate SMITH Taro TAKAHASHI Rachel E.THORMAN John WILLIAMS Jeremy WILTSHIRE Robert M.REES Scotland’s Rural college EdinburghEH93JGUK Institute of Biological&Environmental Sciences AberdeenAB243UUUK School of Natural Sciences Bangor UniversityBangorGwyneddLL572DGUK Agricultural Development and Advisory Service(ADAS) BoxworthCambridgeCB234NNUK School of Biological and chemical Sciences University of GalwayH91 TK33Ireland centre for Ecology and Hydrology Bush EstateMidlothianEH260QBUK The James Hutton Institute DundeeDD25DAUK Rothamsted Research North WykeOkehamptonDevonEX202SBUK Ricardo Energy&Environment HarwellOxonOX110QRUK Environment Soils and Land Use DepartmentTeagascCounty WexfordY35 TC97Ireland Agri-food and Biosciences Institute HillsboroughCounty DownBT266DRUK Bristol Veterinary School University of BristolSomersetBS405DUUK

Agriculture is essential for providing food and maintaining food security while concurrently delivering multiple other ecosystem services. However,agricultural systems are generally a net source of greenhouse gases and ammonia. They, therefore, need to substantively contribute to climate change mitigation and net zero ambitions. It is widely acknowledged that there is a need to further reduce and mitigate emissions across sectors, including agriculture to address the climate emergency and emissions gap. This discussion paper outlines a collation of opinions from a range of experts within agricultural research and advisory roles following a greenhouse gas and ammonia emission mitigation workshop held in the UK in March 2022. The meeting identified the top mitigation priorities within the UK's agricultural sector to achieve reductions in greenhouse gases and ammonia that are compatible with policy targets. In addition, experts provided an overview of what they believe are the key knowledge gaps, future opportunities and cobenefits to mitigation practices as well as indicating the potential barriers to uptake for mitigation scenarios discussed.

关键词： agriculture ammonia greenhouse gas mitigation net zero

c-reactive protein and radiographic findings of lower respiratory tract infection in infants

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Radiology 2017年第4期9卷 206-211页

作者： Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee crush Siobhan B O’Neill Oisin Flanagan karl James conor Bogue Owen J O’connor Michael M Maher Department of Radiology Cork University HospitalWiltonT12 DC4A CorkIreland

AIM To evaluate the association between c-reactive protein(cRP) and radiological evidence of lower respiratory tract infection(LRTI) in *** All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and cRP blood measurement over an 18-mo period were included in the ***,gender,source of referral,cRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were *** Three hundred and eleven patients met the *** chest radiographs were more common in patients with elevated cRP levels(P c signs of LRTI were identified in 73.7% of chest radiographs when a patient had a cRP level between 50-99 mg/*** levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or *** cRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs.

关键词： chest radiograph c-reactive protein chest infection Respiratory infection Pediatric

^(32)P胶体致人胰腺癌Pc-3移植瘤细胞凋亡及其相关基因表达的研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华核医学杂志 2003年第5期23卷 294-296页

作者：王宇刘璐端木浩童冠圣刘龙东南大学核医学技术研究所南京210009 南京市第二医院外科铁道部北京铁路总医院

目的　观察低剂量32 P胶体瘤体内注射诱导裸鼠人胰腺癌Pc 3移植瘤细胞凋亡的生物学效应、相关基因的表达及其可能的作用机理。方法　建立BALB c裸鼠人胰腺癌Pc 3移植瘤动物模型 ,分别向 3 0只荷瘤鼠瘤块中心注射不同剂量 (0 3 7、0 74... 详细信息

目的　观察低剂量32 P胶体瘤体内注射诱导裸鼠人胰腺癌Pc 3移植瘤细胞凋亡的生物学效应、相关基因的表达及其可能的作用机理。方法　建立BALB c裸鼠人胰腺癌Pc 3移植瘤动物模型 ,分别向 3 0只荷瘤鼠瘤块中心注射不同剂量 (0 3 7、0 74、1 48、2 96和 5 92MBq)的3 2 P胶体溶液 ,对照组注射等体积冷胶体。于注射后 2 4h取出瘤块 ;通过流式细胞仪、透射电镜及免疫组织化学检测等方法 ,研究肿瘤组织的细胞凋亡率、细胞坏死率、细胞超微结构改变及Apo2 7、caspase 3、bcl 2、bax相关基因的表达。结果　 0 74、1 48和 2 96MBq组瘤体内注射后电镜下可见典型的细胞凋亡表现 ,5 92MBq组细胞则以大量坏死为主。辐射诱导凋亡过程中 ,bcl 2 bax比值下调 ,Apo2 7、caspase 3蛋白表达均明显增加。结论　32 P胶体瘤体注射可诱导荷瘤裸鼠人胰腺癌Pc 3肿瘤细胞凋亡 ;Apo2 7、caspase 3、bcl

关键词： ^32P胶体人胰腺癌 Pc-3移植瘤细胞凋亡基因表达生物学效应瘤体内注射