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Infant’s Sigh Breathing Matters—The Role of the Hering-Breuer Deflation Reflex in Bronchial Decongestion

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Open Journal of Therapy and Rehabilitation 2024年第3期12卷 197-212页

作者： karine Truflandier Kevin Albert Jean-Jacques Moraine Department of Cardio-Pulmonary Physiotherapy Hpital de La Tour Meyrin Switzerland Paediatric Intensive Care Unit Centre Hospitalier Universitaire Sainte-Justine Montral Canada Laboratoire des Sciences de la Motricit Universit Libre de Bruxelles Brussel Belgium

Background: The prolonged slow expiratory (PSE) technique can induce sigh breaths related to the Hering-Breuer reflex in *** is a specific chest physiotherapy technique often used in children to help with the clearance of secretions, reduce pulmonary obstruction and decrease ventilatory effort. Purpose: The main objective of this review was to synthesize and clarify the existing knowledge of the physiological mechanism behind the Hering-Breuer reflex and its utility in the PSE technique. The secondary objective was to provide an overview of PSE which is probably the main mechanical feature for mucus clearance in infants and to identify gaps and any further research required. Method: A comprehensive literature search was performed using PubMed/MEDLINE and Ovid EMBASE, from 1968 to January 2024, using search terms relating to “Interaction of Hering-Breuer reflex and chest physiotherapy therapy, sigh breath in infants and prolonged slow expiration technique” to create an overview of the advances and gaps in current knowledge of PSE. Result: The data obtained following treatment with PSE maneuvers in infants with histories of recurrent wheezing shows that the presence of sighs could be the main active principle of treatment. Conclusion: Changes in volume induced by PSE technique and, effects from crying may stimulate the Hering-Breuer deflation reflex and sighs in turn improving alveolar ventilation as well as lung volume in infants.

关键词： Hering-Breuer (HB) Reflex Sigh Breath Infants Prolonged Slow Expiration Technique Large Volume Chest Physiotherapy

The Therapeutic Effects of Baicalein on the Hepatopulmonary Syndrome in the Rat Model of Chronic Common Bile Duct Ligation

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 496-504页

作者： Ziyang Zeng Yuhao Lei Chunyong Yang Xianfeng Wu Liang Zhang Zhiyong Yang Lin Chen Xiaobo Wang karine Belguise Yujie Li Bin Yi Department of Anesthesiology Southwest HospitalThird Military Medical UniversityChongqingChina Department of Anesthesiology Chongqing Traditional Chinese Medicine HospitalChongqingChina MCD Center de Biologie IntégrativeUniversitéde ToulouseCNRSUPSToulouseFrance

Background and Aims:Hepatopulmonary syndrome(HPS)is characterized by arterial oxygenation defects due to pulmonary vascular dilation in liver *** date,liver transplantation remains the only effective treatment for *** study aimed to explore the preventative role of baicalein in HPS ***:Sixty male rats were randomly assigned to three groups:sham,common bile duct ligation(CBDL),and baicalein,receiving intraperitoneal injections of baicalein(40 mg·kg􀃭1·d􀃭1,diluted in saline)for 21 *** rate,liver and kidney function,and bile acid metabolism levels were *** and lung angiogenesis and hepatic glycogen staining were assessed,and the expression of relevant proteins was evaluated by ***:Baicalein improved survival rates and hypoxemia in rats post-CBDL,reducing angiogenic protein levels and enhancing glucose *** to the untreated group,baicalein suppressed the expression of vascular endothelial growth factor,placental growth factors,matrix metalloprotease 9 and C-X-C motif chemokine 2,and it increased the expression of glycemic regulatory proteins,including dipeptidyl peptidase-4,sirtuin 1,peroxisome proliferatoractivated receptor gamma co-activator 1􀄮,and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase ***:Baicalein significantly improves hepatic function and hypoxia in HPS rats by attenuating pathological angiogenesis in the liver and lungs,showing promise as a treatment for HPS.

关键词： Baicalein Hepatopulmonary syndrome Common bile duct ligation Angiogenesis Glucose metabolism Liver fibrosis Glycolysis

基于CiteSpace分析的国内外乡村碳排放研究进展与展望

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现代城市研究 2024年第8期39卷 103-111页

作者：戴林琳罗杰 karine Dupre 北京大学城市与环境学院格里菲斯大学建筑工程学院

文章采用CiteSpace软件对国内外乡村碳排放研究进展进行可视化分析,旨在为明晰规划减排目标与技术路径提供支撑。结果表明:国内外相关研究均高度集中于环境科学与农学,研究热点都包括农业碳排放及影响因素,研究思路上都逐渐注重多尺度... 详细信息

文章采用CiteSpace软件对国内外乡村碳排放研究进展进行可视化分析,旨在为明晰规划减排目标与技术路径提供支撑。结果表明:国内外相关研究均高度集中于环境科学与农学,研究热点都包括农业碳排放及影响因素,研究思路上都逐渐注重多尺度机制探究和综合要素分析,研究进展聚焦在乡村碳排放核算和预测、影响因素和减排路径。未来应建立多学科融合的研究框架,拓展研究尺度和基础技术途径,强化乡村主体研究。

关键词：乡村温室气体排放碳中和可视化分析国土空间规划

Gifted Students’Special Educational Programs in France:An Analysis of Students’Needs as Perceived by Headmasters-A Secondary Publication

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Journal of Contemporary Educational Research 2024年第4期8卷 316-327页

作者： karine Buard Minna Puustinen Amélie Courtinat-Camps Research Group on Disability AccessibilityEducational and School Practices(GRHAPES)INSHEAFrance Developmental and Educational Psychology “Psychology of Socialisation-Development and Work”Laboratory(LPS-DT)Toulouse Jean Jaurès UniversityFrance

Some French public middle schools offer gifted students the opportunity to pursue their education in general classes,while benefiting from specific facilities within the framework of a dedicated educational *** this study,we sought to identify and analyze the needs of these students as perceived by the headmaster of each middle school *** results highlight two main student needs,common to all these programs(uneasiness and difficulties in peer relationships)as well as needs specifically mentioned by some headmasters(non-adaptive behavior).

关键词： Learning difficulties Students in difficulty Education policies

Exploring the effects of dietary inulin in rainbow trout fed a high‑starch,100%plant‑based diet

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Journal of Animal Science and Biotechnology 2024年第2期15卷 713-732页

作者： Raphaël Defaix Jep Lokesh Laura Frohn Mickael Le Bechec Thierry Pigot Vincent Veron Anne Surget Sandra Biasutti Frederic Terrier Sandrine Skiba-Cassy Jerome Roy Stephane Panserat karine Ricaud Universite de Pau Et Des Pays de L’Adour E2S UPPAINRAENUMEASaint‑Pee‑Sur‑NivelleFrance Universite de Pau Et Des Pays de L’Adour E2S UPPACNRSIMT Mines AlesIPREMPauFrance Universite de Pau Et Des Pays de L’Adour E2S UPPAIUT des Pays de l’AdourDepartement Genie BiologiqueMont de MarsanFrance.

Background High dietary carbohydrates can spare protein in rainbow trout(Oncorhynchus mykiss)but may affect growth and ***,a prebiotic,could have nutritional and metabolic effects,along with anti-inflammatory properties in teleosts,improving growth and *** tested this hypothesis in rainbow trout by feeding them a 100%plant-based diet,which is a viable alternative to fishmeal and fish oil in aquaculture *** a two-factor design,we examined the impact of inulin(2%)as well as the variation in the carbohydrates(CHO)/plant protein ratio on rainbow *** assessed the influence of these factors on zootechnical parameters,plasma metabolites,gut microbiota,production of short-chain fatty acids and lactic acid,as well as the expression of free-fatty acid receptor genes in the mid-intestine,intermediary liver metabolism,and immune markers in a 12-week feeding *** The use of 2%inulin did not significantly change the fish intestinal microbiota,but interestingly,the high CHO/protein ratio group showed a change in intestinal microbiota and in particular the beta diversity,with 21 bacterial genera affected,including Ralstonia,Bacillus,and 11 lactic-acid producing *** were higher levels of butyric,and valeric acid in groups fed with high CHO/protein diet but not with *** high CHO/protein group showed a decrease in the expression of pro-inflammatory cytokines(il1b,il8,and tnfa)in liver and a lower expression of the genes coding for tight-junction proteins in mid-intestine(tjp1a and tjp3).However,the 2%inulin did not modify the expression of plasma immune ***,inulin induced a negative effect on rainbow trout growth performance irrespective of the dietary *** With a 100%plant-based diet,inclusion of high levels of carbohydrates could be a promising way for fish nutrition in aquaculture through a protein sparing effect whereas the supplementation of 2%inulin does not appear to improve the use of CHO wh

关键词： Aquaculture Fish nutrition Gut microbiota Immune markers Intermediary metabolism Inulin Prebiotic Rainbow trout Short-chain fatty acids

E-commerce development in rural and remote areas of BRICS countries

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Journal of Integrative Agriculture 2021年第4期20卷 979-997页

作者： karine HAJI Institute for International Economics and Finance Russian Foreign Trade AcademyMoscow 119285Russia

E-commerce plays an essential role in modern trade *** is expected that e-commerce volume amounted to 29 trillion USD in the world in 2017,and would grow with the spread of the Internet and information and communication technologies(ICTs).Brazil,Russia,India,China and South Africa(BRICS),together with many others,consider e-commerce a means to facilitate rapid,inclusive and sustainable economic growth,improving the living standards and alleviating *** article examines areas for potential cooperation by BRICS countries in e-commerce development across rural and remote areas to fight *** analyses the current state of e-commerce development in rural and remote areas in each of the BRICS countries,including cases of public and private initiatives to support *** article also defines the opportunities which e-commerce brings to people living in rural and remote ***,it evaluates the existing challenges and *** article concludes that despite the rapid e-commerce development in BRICS countries,and significant opportunities created,there are still issues of disproportionate e-commerce in varied regions and the lack of BRICS cooperation in this *** on a comparative and normative in-depth,systematic analysis,the article develops a set of recommendations for deepening BRICS countries'cooperation in the following areas:infrastructure in rural and remote regions;education;consumer protection;online dispute resolution;coordinated policy in the international scene,including representation of BRICS countries in international indexes,such as the Organization of Economic Co-operation and Development(OECD)Digital Services Trade Restrictiveness Index(STRI).

关键词： e-commerce BRICS poverty alleviation international cooperation remote and rural areas ICT infrastructure educational cooperation online dispute resolution consumer protection online Digital STRI

Vespa velutina nest distribution at a local scale： An 8-year survey of the invasive honeybee predator

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Insect Science 2017年第4期24卷 663-674页

作者： karine Monceau Denis Thiery INRA UMR 1065 Sante et Agroecologie du Vignoble Bordeaux Sciences Agro ISVV F-33883 Villenave d'Omon Cedex France

Vespa velutina is an invasive species that was observed for the first time in France and Europe in 2004, which rapidly threatened domestic honeybees with active predation. For the first time in this study, we analyzed the distribution of V. velutina nests at a local scale to understand the pattern of nesting, and in 8 years of monitoring, a total of 528 nests were surveyed. With the exception of 2 years, the nests of V. velutina were randomly distributed within the monitored area, which suggested that intraspecific competition for nesting sites and/or food was unlikely. When the data for all years were combined, an aggregated distribution of nests at the seafront in the vicinity of the oyster farm and sportfishing activities was observed. This distribution suggested that seafood, attractive to vespids, might provide a valuable alternative food source that favored colony development. We also tested the effect of spring queen trapping of V. velutina on the distribution of nests in 2014, which was the year with the greatest number of colonies within the area; the position of the traps did not influence the distribution of the nests. For the first time, this study showed that （i） intraspecific competition was unlikely to be a mechanism for population regulation, （ii） some areas were more likely favored for hornet nests, and （iii） spring queen wasp trapping was inefficient as a method to limit the distribution of the V. velutina population.

关键词： intraspecific competition nesting habits spring queen trapping yellow-legged hornet

Complement genetics,deficiencies,and disease associations

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Protein & Cell 2012年第7期3卷 487-496页

作者： karine R.Mayilyan Institute of Molecular Biology Armenian National Academy SciencesYerevan 0014Armenia

The complement system is a key component of innate *** than 45 genes encoding the proteins of complement components or their isotypes and subu-nits,receptors,and regulators have been *** genes are distributed throughout different chro-mosomes,with 19 genes comprising three significant complement gene clusters in the human ***-netic deficiency of any early component of the classical pathway(C1q,C1r/s,C2,C4,and C3)is associated with autoimmune diseases due to the failure of clearance of immune complexes(IC)and apoptotic materials,and the impairment of normal humoral ***-cies of mannan-binding lectin(MBL)and the early components of the alternative(factor D,properdin)and terminal pathways(from C3 onward components:C5,C6,C7,C8,C9)increase susceptibility to infections and their *** the association of MBL defi-ciency with a number of autoimmune and infectious disorders has been well established,the effects of the deficiency of other lectin pathway components(ficolins,MASPs)have been less extensively investigated due to our incomplete knowledge of the genetic background of such deficiencies and the functional activity of those *** complement regulators and receptors,the consequences of their genetic deficiency vary de-pending on their specific involvement in the regulatory or signalling steps within the complement cascade and *** article reviews current knowledge and concepts about the genetic load of complement com-ponent deficiencies and their association with *** integrative presentation of genetic data with the latest updates provides a background to further inves-tigations of the disease association investigations of the complement system from the perspective of sys-tems biology and systems genetics.

关键词： complement system deficiency disease association HLA-III RCA

A Generic Model to Estimate Wheat LAI over Growing Season Regardless of the Soil-Type Background

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Plant Phenomics 2023年第2期5卷 333-352页

作者： Qiaomin Chen Bangyou Zheng karine Chenu Scott C.Chapman School of Agriculture and Food Sciences The University of QueenslandSt LuciaQLDAustralia Agriculture and Food CSIROQueensland Bioscience PrecinctSt LuciaQLDAustralia The University of Queensland Queensland Alliance for Agriculture and Food InnovationToowoombaQLDAustralia

It is valuable to develop a generic model that can accurately estimate the leaf area index(LAI)of wheat from unmanned aerial vehicle-based multispectral data for diverse soil backgrounds without any ground *** achieve this objective,2 strategies were investigated to improve our existing random forest regression(RFR)model,which was trained with simulations from a radiative transfer model(PROSAIL).The 2 strategies consisted of(a)broadening the reflectance domain of soil background to generate training data and(b)finding an appropriate set of indicators(band reflectance and/or vegetation indices)as inputs of the RFR *** RFR models were tested in diverse soils representing varying soil types in *** analysis indicated that adopting both strategies resulted in a generic model that can provide accurate estimation for wheat LAI and is resistant to changes in soil *** validation on 2 years of field trials,this model achieved high prediction accuracy for LAI over the entire crop cycle(LAI up to 7 m^(2)m^(−2))(root mean square error(RMSE):0.23 to 0.89 m^(2)m^(−2)),including for sparse canopy(LAI less than 0.3 m^(2)m^(−2))grown on different soil types(RMSE:0.02 to 0.25 m^(2)m^(−2)).The model reliably captured the seasonal pattern of LAI dynamics for different treatments in terms of genotypes,plant densities,and water–nitrogen managements(correlation coefficient:0.82 to 0.98).With appropriate adaptations,this framework can be adjusted to any type of sensors to estimate various traits for various species(including but not limited to LAI of wheat)in associated disciplines,e.g.,crop breeding,precision agriculture,etc.

关键词： soil Wheat breeding