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Journal of Integrative Agriculture 2021年第1期20卷 159-167页

作者： Leidy J.VALENCIA-HERNANDEZ karina LÓOPEZ-LÓPEZ Eyder D.GÓMEZ-LÓPEZ Liliana SERNACOCK Cristobal N.AGUILAR Universidad Nacional de Colombia Palmira CampusValle 763533Colombia Food Research Department School of ChemistryAutonomous University of CoahuilaSaltillo CampusCoahuila 25280Mexico

The fungistatic activity of a lactic acid bacterium, which had been isolated from yellow pitahaya cultures, against fungi associated with basal rot(Fusarium oxysporum and Fusarium fujikuroi) was measured in the present study. Its activity was assessed in three fractions: fermented(S1), metabolic products(S2), and biomass(S3), using two fermentation substrates: Man Rogosa Sharpe agar(MRS) and potato dextrose agar(PDA). The bacterium was molecularly identified as Lactobacillus plantarum. S3 reduced F. fujikuroi growth by 100% over 48 h of fermentation, which occurred during the stationary phase of bacterial growth. The three fractions' fungistatic activity against F. fujikuroi depended on the substrate employed. The fermentation kinetic parameters for L. plantarum indicated that its specific growth rate was 0.46 h^–1, with 93.63% substrate consumption, 0.045 kg kg^–1 cell yield, and 0.54 kg kg^–1 product yield. The kinetic parameters calculated will allow for bacteria production scaling. These in-vitro trials reveal L. plantarum's possible application as a biocontrol agent for diseases associated with Fusarium. However, further ex-vivo and in-vivo researches are required to demonstrate its behavior in crops.

关键词： lactic acid bacteria Fusarium fungistatic activity biomass yellow pitahaya

Cell cycle reactivation in mature neurons: a link with brain plasticity, neuronal injury and neurodegenerative diseases?

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Neuroscience Bulletin 2011年第3期27卷 185-196页

作者： karina Hernández-Ortega Ricardo Quiroz-Baez Clorinda Arias 墨西哥国立大学生物医学研究所基因组医学与环境毒理学研究室墨西哥国立卫生研究院老年医学研究所

Although the cell cycle machinery is essentially linked to cellular proliferation, recent findings suggest that neuronal cell death is frequently concurrent with the aberrant expression of cell cycle proteins in post-mitotic neurons. The present work reviews the evidence of cell cycle reentry and expression of cell cycle-associated proteins as a complex response of neurons to insults in the adult brain but also as a mechanism underlying brain plasticity. The basic aspects of cell cycle mechanisms, as well as the evidence showing cell cycle protein expression in the injured brain, are reviewed. The discussion includes recent experimental work attempting to establish a correlation between altered brain plasticity and neuronal death, and an analysis of recent evidence on how neural cell cycle dysregulation is related to neurodegenerative diseases especially the Alzheimer＇s disease. Understanding the mechanisms that control reexpression of proteins required for cell cycle progression which is involved in brain remodeling, may shed new light into the mechanisms involved in neuronal demise under diverse pathological circumstances. This would provide valuable clues about the possible therapeu tic targets, leading to potential treatment of presently challenging neurodegenerative diseases.

关键词： Alzheimer's disease cell cycle neurodegeneration brain plasticity

中国游客对哈萨克斯坦旅游目的地形象感知及旅游市场开发策略研究

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中国游客对哈萨克斯坦旅游目的地形象感知及旅游市场开发策略研究

作者： ZHUASBAYEVA karina 海南大学

学位级别：硕士

随着中国“一带一路”倡议的快速推进,谋求地区层面的产业对接成为一个值得深入探讨也颇为紧迫的策论。中国的“丝绸之路经济带”促进了双方在利益上的互融和机理上的互通。旅游是现代服务业的龙头和先导,但中哈在中哈国际旅游方面的合... 详细信息

随着中国“一带一路”倡议的快速推进,谋求地区层面的产业对接成为一个值得深入探讨也颇为紧迫的策论。中国的“丝绸之路经济带”促进了双方在利益上的互融和机理上的互通。旅游是现代服务业的龙头和先导,但中哈在中哈国际旅游方面的合作开展的较为缓慢,本文从通过中国游客感知对哈萨克斯坦旅游形象的影响的研究,来探讨哈萨克斯坦旅游业针对中国游客的策略。确定中国游客对哈萨克斯坦旅游目的地形象的了解程度及感知,有助于为中哈两国旅游方面在今后的合作建立科学基础,也有助于为哈萨克斯坦和中国政府及相关管理部门发展旅游提供指导意义。本文通过定性定量分析相结合的方法总结分析中国游客对于哈萨克斯坦旅游形象的预期和感知态度,从而为中哈两国的政府及相关管理部门制定旅游规划,来吸引中国游客到哈萨克斯坦出境旅游。本论文主要由六个部分组成:第一部分为绪论,确定研究的目的、意义、内容及方法;第二部分为国内外研究的文献综述以及本论文用到的理论基础;第三部分是对哈萨克斯坦旅游现状的描述以及中哈两国的旅游合作发展;第四部分是对中国游客对于哈萨克斯坦旅游形象感知的具体研究,包含数据分析以及对数据结果的总结;第五部分是根据相关实证研究得到的研究结论以及针对不同人群相关市场的开发策略;第六部分是结语,总结论文的研究不足并对以后的研究提出展望。

关键词：哈萨克斯坦旅游游客感知中国游客开发策略

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中国债券市场交易制度对流动性的影响

中国债券市场交易制度对流动性的影响

作者： karina Wang 上海交通大学

学位级别：硕士

近年来为了加快中国债券市场改革,提高市场流动性,监管部门实施了一系列包括鼓励发展做市商制度、推出匿名点击业务X-Bond在内的措施。但这些措施的实施效果如何,还未见文献进入深入研究。本文通过实证方法来研究这一系列交易制度推出... 详细信息

近年来为了加快中国债券市场改革,提高市场流动性,监管部门实施了一系列包括鼓励发展做市商制度、推出匿名点击业务X-Bond在内的措施。但这些措施的实施效果如何,还未见文献进入深入研究。本文通过实证方法来研究这一系列交易制度推出对中国债券市场的流动性影响。本文首先概述了中国债券市场的现状,并对不同的交易制度及流动性度量方法进行了总结和比较。然后通过使用不同的流动性指标,分别采用多元回归和双重差分方法DID检验做市商报价和匿名点击业务对债券流动性的影响。实证结果发现,目前中国的债券做市商报价并没有对市场流动性产生明显正面影响,而匿名电子交易系统的推出对债券流动性的有一定的提升作用。对于以上结果,本文认为,与国外的分层交易市场结构不同,国内扁平化交易结构难以真正体现做市商提供市场流动性的功能。而匿名电子交易系统在这个以询价为主流的OTC市场,为不被关注企业提供了更多交易和曝光的机会。

关键词：债券市场做市商流动性 X-Bond 中国

Protease activated receptor 2 and epidermal growth factor receptor are involved in the regulation of human sperm motility

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Asian Journal of Andrology 2007年第5期9卷 690-696页

作者： karina Zitta Martin Albrecht Stephan Weidinger Artur Mayerhofer Frank Koehn Department of Dermatology and Allergy Technical University Munich Biedersteiner Strasse 29 Munich 80802 Germany Institute of Anatomy Ludwig-Maximilians-University Biedersteiner Strasse 29 Munich 80802 Germany

Aim： To investigate mechanisms of tryptase-induced reduction of sperm motility and explore whether epidermal growth factor receptor （EGF-R） and protease activated receptor 2 （PAR-2）- associated pathways are involved. Methods： Fresh semen was collected from healthy donors （n = 15）. Semen parameters and quality were assessed in accordance with the World Health Organization （WHO） criteria. Swim-up sperm were fixed and subjected to immunocytochemistry and immunoelectronmicroscopy with specific antibodies directed against PAR-2 and EGF-R. Protein extractions from swim-up spermatozoa were analyzed by Western blotting with antibodies for both receptors. Motility of spermatozoa was evaluated by computer-assisted semen analysis. Results： Immunocytochemistry found PAR-2 and EGF-R in approximately 30% of examined human ejaculated spermatozoa. Both receptors were localized in the plasma membrane. Like tryptase, the PAR-2 synthetic agonist SLIGKV reduced sperm motility, and this effect was inhibited by application of two specific EGF-R pathway blockers （AG1478 and PD168393）. Conclusion： The observed reduction of sperm motility by tryptase through the PAR-2 receptor involves EGF-R pathways.

关键词： spermatozoa motility epidermal growth factor receptor protease activated receptor

Tooth-derived stem cells: Update and perspectives

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World Journal of Stem Cells 2015年第2期7卷 399-407页

作者： Miki Taketomi Saito karina Gonzales Silvério Márcio Zaffalon Casati Enilson Antonio Sallum Francisco Humberto Nociti Jr Department of Prosthodontics and Periodontics Division of PeriodonticsPiracicaba Dental SchoolUniversity of Campinas (UNICAMP)

Tissue engineering is an emerging field of science that focuses on creating suitable conditions for the regeneration of tissues. The basic components for tissue engineering involve an interactive triad of scaffolds, signaling molecules, and cells. In this context,stem cells(SCs) present the characteristics of selfrenewal and differentiation capacity, which make them promising candidates for tissue engineering. Although they present some common markers, such as cluster of differentiation(CD)105, CD146 and STRO-1, SCs derived from various tissues have different patterns in relation to proliferation, clonogenicity, and differentiation abilities in vitro and in vivo. Tooth-derived tissues have been proposed as an accessible source to obtain SCs with limited morbidity, and various tooth-derived SCs(TDSCs) have been isolated and characterized, such as dental pulp SCs, SCs from human exfoliated deciduous teeth, periodontal ligament SCs, dental follicle progenitor cells, SCs from apical papilla, and periodontal ligament of deciduous teeth SCs. However, heterogeneity among these populations has been observed, and the best method to select the most appropriate TDSCs for regeneration approaches has not yet been established. The objective of this review is to outline the current knowledge concerning the various types of TDSCs, and discuss the perspectives for their use in regenerative approaches.

关键词： Cell-based therapy Mesenchymal stem cells Dental stem cells Differentiation Tissue engineering

Influence of H-Type and L-Type Activated Carbon in the Photodegradation of Methylene Blue and Phenol under UV and Visible Light Irradiated TiO<sub>2</sub>

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Modern Research in Catalysis 2012年第1期1卷 1-9页

作者： Juan Matos karina Quintana Andreina García Engineering of Materials and Nanotechnology Centre Venezuelan Institute for Scientific Research (I.V.I.C.) Caracas Venezuela

Photodegradation of methylene blue (MB) and phenol (Ph) on TiO2 in presence of H-type and L-type activated carbons (AC) was studied. Photodegradation of MB and Ph were studied under two different lamps and results were compared against those obtained on a commercial TiO2. Apparent first order rate constant for the degradation of MB was higher in presence of any AC in comparison of TiO2 alone while only in presence of ACco2-800phenol was photodegradated in shorter irradiation time than that required by TiO2. It can be concluded that TiO2 enhances its photoactivity by a factor up to 8.7 in the degradation of MB in presence of AC and this effect is associated to the specific surface properties of AC.

关键词： Photocatalysis TiO2 Activated Carbon Methylene Blue Phenol

Metastatic gastric cancer from breast carcinoma presenting with paraneoplastic rheumatic syndrome:A case report

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World Journal of Clinical Cases 2023年第14期11卷 3282-3287页

作者： Marília Bortoluz Rech Eduarda Renz da-Cruz karina Salgado Raul Angelo Balbinot Silvana Sartori Balbinot Jonathan Soldera School of Medicine Universidade de Caxias do SulCaxias do Sul 95070-560Rio Grande do SulBrazil Department of Pathology ICAP PathologyCaxias do Sul 95020-002Rio Grande do SulBrazil Department of Clinical Gastroenterology Universidade de Caxias do SulCaxias do Sul 95070-560Rio Grande do SulBrazil

BACKGROUND Breast cancer is the most frequently diagnosed cancer *** is the leading cause of death by malignant disease in *** SUMMARY A female patient,73 years of age,sought care due to weakness,mild abdominal pain,arthralgia,and weight *** was taking anastrazole as maintenance therapy for localized breast cancer and had moderate anemia and elevated acutephase *** digestive endoscopy showed isolated erosion in the gastric *** lesion was compatible with signet-ring cell adenocarcinoma in anatomopathological study and was confirmed as metastasis of a breast carcinoma in immunohistochemistry,which was positive for estrogen *** imaging studies determined numerous proximal bone *** patient was treated with prednisone for paraneoplastic syndrome,which improved the anemia and rheumatic disease,and with chemotherapy,which greatly improved the *** has been followed-up for 6 mo,and her anemia,arthralgias,and acute phase markers have *** Systemic treatment strategies seem to be the best choice for gastric metastasis from breast cancer,resulting in disease control and relapse-free *** studies with longer follow-up are needed to better understand the biological,pathological,and clinicopathological characteristics and outcomes of the endoscopic features associated with metastatic gastric cancer from breast carcinoma.

关键词： Breast cancer Gastric metastasis Anemia Paraneoplastic syndrome Case report

Allium sativum Flavor Compounds as an Indicator for Garlic Identity and Quality Determination

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Journal of Food Science and Engineering 2013年第5期3卷 226-234页

作者： Ruta Galoburda karina Bodniece Thierry Talou Department of Food Technology Latvia University of Agriculture Jelgava L V 3001 Latvia Laboratoire de Chimie Agro-industrielle Universite de Toulouse INP-ENSIACET Toulouse 31030 France

The objective of the study was to research the aroma profile of volatile compounds in garlic subspecies originating from Latvia, and compare them with the aroma composition of garlic grown in the region of Midi-Pyrenees （France）. It was established that hard-neck garlic tends to contain more diallyl disulfide （DADS）, the main decomposition product of allicin. Compared to the hard-neck subspecies, the content of allyl mercaptan, one of the major compounds producing the strong odor detectable after ingestion of garlic, was significantly lower in the soft-neck garlic clones. The amount of cyclic compound 3-vinyl-1,2-dithiin differed considerably with higher contents in the soft-neck subspecies. The results also demonstrate the soft-neck garlic as a more suitable subspecies for long-term storage. In general, the results show no significant difference in the content of DADS and the total content of other flavor compounds between hard-neck and soft-neck garlic grown in the region of Midi-Pyrenees and Latvia. However, comparing garlic subspecies originating from France and Latvia by the content of allyl mercaptan, 1,2-dithiolane and 3-vinyl-1,2-dithiin, a considerable proportional difference of these volatiles was determined. Also, a significant difference was established in the content of DADS between the white garlic variety ＂Blanc de Lomagne＂（France, region of Midi-Pyrenees） and white garlic grown in other countries. The results of this study suggest the suitability of solid phase microextraction （SPME） and gas chromatography （GC） methods for quality control of garlic originating from France.

关键词： Allium sativum diallyl disulfide flavor garlic identity

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幕后好莱坞