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Hepatitis C virus clearance and less liver damage in patients with high cholesterol, low-density lipoprotein cholesterol and APOE ε4 allele

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World Journal of Gastroenterology 2019年第38期25卷 5826-5837页

作者： karina gonzalez-aldaco Sonia Roman Rafael Torres-Valadez Claudia Ojeda-Granados Luis A Torres-Reyes Arturo Panduro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" and Health Sciences Center University of Guadalajara

BACKGROUND Cholesterol is related to improvements in the rate of sustained virological response and a robust immune response against the hepatitis C virus(HCV).APOE gene polymorphisms regulate cholesterol levels modifying the course of the HCV *** relationship between cholesterol,APOE alleles,and the outcome of HCV infection has not been evaluated in the admixed population of *** To investigate the role of APOE-ε2,-ε3,and-ε4 alleles and the metabolic profile in the outcome of HCV *** A total of 299 treatment-na?ve HCV patients were included in this retrospective *** were stratified in chronic hepatitis C(CHC)(n=206)and spontaneous clearance(SC)(n=93).A clinical record was *** tests were assessed by dry chemistry *** genotypes were determined using a Real-Time polymerase chain reaction *** Total cholesterol,low-density lipoprotein cholesterol(LDL-c),triglycerides,and hypercholesterolemia were higher in SC than CHC patients as well as the frequency of the APOEε4 allele(12.4%vs 7.3%).SC patients were overweight(54.8%).Theε4 allele was associated with SC(OR=0.55,95%CI:0.31-0.98,P=0.042)and mild fibrosis(F1-F2)in CHC patients(OR 0.091,95%CI 0.01-0.75,P=0.020).LDL-c≥101.5 mg/dL(OR=0.20,95%CI:0.10-0.41,P<0.001)and BMI≥26.6 kg/m2(OR=0.37,95%CI:0.18-0.76,P<0.001)were associated with SC status;while ALT≥50.5 IU/L was negatively associated(OR=5.67,95%CI:2.69-11.97,P<0.001).CONCLUSION In SC patients,the APOEε4 allele and LDL-c conferred a protective effect in the course of the HCV infection in the context of excess body weight.

关键词： Liver damage Body mass index Spontaneous hepatitis C virus clearance Low-density lipoprotein Cholesterol

Differential distribution of gene polymorphisms associated with hypercholesterolemia,hypertriglyceridemia,and hypoalphalipoproteinemia among Native American and Mestizo Mexicans

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World Journal of Hepatology 2022年第7期14卷 1408-1420页

作者： Rafael Torres-Valadez Sonia Roman Claudia Ojeda-Granados karina gonzalez-aldaco Arturo Panduro Department of Genomic Medicine in Hepatology Civil Hospital of Guadalajara Fray Antonio Alcalde/Health Sciences CenterUniversity of GuadalajaraGuadalajaraJalisco 44280Mexico Unidad Especializada en Investigación Desarrollo e Innovación en Medicina Genómica Centro Nayarita de Innovación y Transferencia de TecnologíaUniversidad Autónoma de NayaritUnidad Académica de Salud IntegralTepicNayarit 63173Mexico

BACKGROUND Dyslipidemias are metabolic abnormalities associated with chronic diseases caused by genetic and environmental *** Mexican population displays regional differences according to ethnicity with an impact on the type of *** To define the main dyslipidemias,the frequency of lipid-related risk alleles,and their association with hyperlipidemic states among different ethnic groups in West *** In a retrospective study,1324 adults were selected to compare dyslipidemias and lipid-related gene ***,clinical,and laboratory data were collected.A subgroup of 196 normal weight subjects without impaired glucose was selected for the association *** was determined by allelic discrimination *** Hypercholesterolemia was the most prevalent dyslipidemia(42.3%).The frequency of the risk alleles associated with hypoalphalipoproteinemia(ABCA1)and hypercholesterolemia(APOE,LDLR)was higher in the Native Americans(P=0.047).In contrast,the Mestizos with European ancestry showed a higher frequency of the risk alleles for hypertriglyceridemia(APOE2,MTTP)(P=0.045).In normal weight Mestizo subjects,the APOB TT and LDLR GG genotypes were associated risk factors for hypercholesterolemia(OR=5.33,95%CI:1.537-18.502,P=0.008 and OR=3.90,95%CI:1.042-14.583,P=0.043,respectively),and displayed an increase in low-density lipoprotein cholesterol levels(APOB:β=40.39,95%CI:14.415-66.366,P=0.004;LDLR:β=20.77,95%CI:5.763-35.784,P=0.007).CONCLUSION Gene polymorphisms and dyslipidemias showed a differential *** primary health care strategies are required to mitigate their prevalence considering the genetic and environmental features which could have important implications for personalized medicine within the new era of precision medicine.

关键词： Dyslipidemia Ethnicity Genes Obesity Lipids Liver disease Diet

CD36 genetic variation, fat intake and liver fibrosis in chronic hepatitis C virus infection

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World Journal of Hepatology 2016年第25期8卷 1067-1074页

作者： Omar Ramos-Lopez Sonia Roman Erika Martinez-Lopez Nora A Fierro karina gonzalez-aldaco Alexis Jose-Abrego Arturo Panduro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" Health Sciences University Center University of Guadalajara

AIM To analyze the association of the CD36 polymorphism(rs1761667) with dietary intake and liver fibrosis(LF) in chronic hepatitis C(CHC) patients. METHODS In this study, 73 patients with CHC were recruited. The CD36 genotype(G > A) was determined by a TaqM an real-time PCR system. Dietary assessment was carried out using a three-day food record to register the daily intake of macronutrients. Serum lipids and liver enzymes were measured by a dry chemistry assay. LF evaluated by transient elastography(Fibroscan~)and APRI score was classified as mild LF(F1-F2) and advanced LF(F3-F4).RESULTS Overall, the CD36 genotypic frequencies were AA(30.1%), AG(54.8%), and GG(15.1%), whereas the allelic A and G frequencies were 57.5% and 42.5%, respectively. CHC patients who were carriers of the CD36 AA genotype had a higher intake of calories attributable to total fat and saturated fatty acids than those with the non-AA genotypes. Additionally, aspartate aminotransferase(AST) serum values were higher in AA genotype carriers compared to non-AA carriers(91.7 IU/L vs 69.8 IU/L, P = 0.02). Moreover, the AA genotype was associated with an increase of 30.23 IU/L of AST(β = 30.23, 95%CI: 9.0-51.46, P = 0.006). Likewise, the AA genotype was associated with advanced LF compared to the AG(OR = 3.60, 95%CI: 1.16-11.15, P = 0.02) or AG + GG genotypes(OR = 3.52, 95%CI: 1.18-10.45, P = 0.02).CONCLUSION This study suggests that the CD36(rs1761667) AA genotype is associated with higher fat intake and more instances of advanced LF in CHC patients.

关键词： Hepatitis C virus infection CD36 receptor Lipids Liver fibrosis Mexico

Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1528-1549页

作者： Rosane Mazzarella karina Canon‑Beltran Yulia N.Cajas Meriem Hamdi Encina M.gonzalez Juliano C.da Silveira Claudia L.V.Leal D.Rizos Department of Animal Reproduction INIA-CSICMadridSpain Department of Biochemistry and Molecular Biology Veterinary FacultyComplutense University of Madrid(UCM)MadridSpain Department Agrarian Production Technical University of MadridUPMMadridSpain Departamento de Ciencias Biologicas Universidad Tecnica Particular de LojaUTPLLojaEcuador Department of Anatomy and Embryology FV-UCMMadridSpain Department of Veterinary Medicine FZEA-USPPirassunungaBrazil

Background Extracellular vesicles(EVs) present in oviductal(OF) and uterine fluid(UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing lipid contents and modulating lipid metabolism-related genes(LMGs), while also influencing cell proliferation, suggesting their involvement on the regulation of different biological pathways. The regulation of signaling pathways related to cell differentiation, proliferation, and metabo-lism is crucial for early embryo development and can determine the success or failure of the pregnancy. Bioactive molecules within EVs in maternal reproductive fluids, such as micro RNAs(miRNAs), may contribute to this regulatory process as they modulate gene expression through post-transcriptional *** This study evaluated miRNA cargo in OF-EVs from the early luteal phase and UF-EVs from the mid-luteal phase, coinciding with embryo transit within oviduct and uterus in vivo, and its possible influence on LMGs and sign-aling pathways crucial for early embryo development. A total of 333 miRNAs were detected, with 11 exclusive to OF, 59 to UF, and 263 were common between both groups. From the 20 differentially expressed miRNAs, 19 up-regulated in UF-EVs(bta-miR-134, bta-miR-151-3p, bta-miR-155, bta-miR-188, bta-miR-181b, bta-miR-181d, bta-miR-224, bta-miR-23b-3p, bta-miR-24-3p, bta-miR-27a-3p, bta-miR-29a, bta-miR-324, bta-miR-326, bta-miR-345-3p, bta-miR-410, bta-miR-652, bta-miR-677, bta-miR-873 and bta-miR-708) and one(bta-miR-148b) in OF-EVs. These miRNAs were predicted to modulate several pathways such as Wnt, Hippo, MAPK, and lipid metabolism and degradation. Differ-ences in miRNAs found in OF-EVs from the early luteal phase and UF-EVs from mid-luteal phase may reflect differ-ent environments to meet the changing needs of the embryo. Additionally, miRNAs may be involved, particularly in the uterus, in the regulation of embryo lipid metabolism, immune system, and *** Our study su

关键词： Embryo-maternal interaction Epigenetic Exosomes Mammalian Preimplantation Reproductive fluids

Effect of phacoemulsification on intraocular pressure in patients with primary open angle glaucoma and pseudoexfoliation glaucoma

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1374-1378页

作者： Jesus Jimenez-Roman Gabriel Lazcano-Gomez karina Martínez-Baez Mauricio Turati Rosario Gulías-Canizo Luis F.Hernández-Zimbrón Lenin Ochoa-De la Paz Rubén Zamora Roberto gonzalez-Salinas Glaucoma Department Asociation to Prevent Blindness inMexicoMexico City 04030Mexico Research Department Asociation to Prevent Blindness inMexicoMexico City 04030Mexico Cell Biology Department Advanced Research CenterI.P.N.(CINVESTAV)in Mexico CityMexico City 07360Mexico

AIM：To compare the effect of phacoemulsification on intraocular pressure（IOP）in patients with primary open angle glaucoma（POAG）and pseudoexfoliation glaucoma（PXG）.METHODS：A retrospective comparative case series conducted at the Glaucoma Department at the Association to Prevent Blindness in *** study enrolled consecutive patients having phacoemulsification with intraocular lens（IOL）implantation and a diagnosis of POAG or *** about IOP values and number of glaucoma medications used was collected at baseline,1,3,6 and12mo ***：The study enrolled 88 patients（88 eyes）.After phacoemulsification,there was a statistically significant reduction in IOP values and glaucoma medications use compared to baseline in both POAG and PXG patients（P〈0.001）.In the POAG group,a 20%decrease in IOP values was evidenced,and a 56.5%reduction in the number of medications used at the one-year *** PXG group showed a 20.39%,and a 34.46%decrease in IOP and number of medications used,respectively.A significant difference in the meanΔIOP（postoperative changes in IOP）was evidenced between groups（P=0.005）.The reduction of the postsurgical IOP mean values in both groups,the POAG group showed a greater reduction in IOP values compared to the PXG ***：In both types of glaucoma,phacoemulsification cataract surgery can result in a significant IOP reduction（20%）over a 12mo follow-up *** number of medications used is also significantly reduced up to 12mo after surgery,especially in the PXG group.

关键词： cataract surgery pseudoexfoliation glaucoma secondary glaucoma primary open angle glaucoma intraocularpressure

BRAF-testing medical education needs in Latin America

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Cancer Pathogenesis and Therapy 2023年第4期1卷 295-298页

作者： João Mauricio Castaldelli-Maia Gislaine Koch Gimenes Giuliana Perrotte Stefani gonzalez Ainur Okassova karina Malvido Julio Torales Clima Clinic São PauloSP 01422-000Brazil Medical School FMABC University Center BrazilSanto AndréSP 09060-870Brazil School of Medical Sciences National University of AsunciónSan Lorenzo 1120Paraguay Clinics Hospital Medical SchoolUniversity of São Paulo(USP)São PauloSP 05403-010Brazil Medical Education and Clinical Research Center(CEMIC) Buenos Aires C1425ASGArgentina Regional Institute for Health Research National University of CaaguazúCoronel Oviedo3300Paraguay School of Medical Sciences Universidad SudamericanaPedro Juan Caballero130110Paraguay

Managing Editor:Peng Lyu While the specter of cancer looms large globally,Latin America and the Caribbean are experiencing an escalation,with colorectal cancer(CRC)and malignant melanoma(MM)representing particularly pressing *** rise in CRC,which ranks among the top five cancers in nearly 80%of the countries in this region,is emblematic of the economic development and westernization occurring in Latin America and the Caribbean.

关键词： Latin cancer BRAF