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Valuable Biomolecules from Nine North Atlantic Red macroalgae: Amino Acids, Fatty Acids, Carotenoids, minerals and metals

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Natural Resources 2016年第4期7卷 157-183页

作者： Behnaz Razi Parjikolaei Annette Bruhn karin Loft Eybye martin mørk Larsen michael Bo Rasmussen Knud Villy Christensen Xavier C. Fretté Department of Chemical Engineering Biotechnology and Environmental Technology University of Southern Denmark Odense Denmark Department of Bioscience Aarhus University Silkeborg Denmark Food Technology Department Life Science Division Danish Technological Institute Aarhus Denmark Department of Bioscience Aarhus University Roskilde Denmark

In modern society, novel marine resources are scrutinized pursuing compounds of use in the medical, pharmaceutical, biotech, food or feed industry. Few of the numerous marine macroalgae are currently exploited. In this study, the contents of nutritional compounds from nine common North Atlantic red macroalgae were compared: the lipid content was low and constant among the species, whereas the fatty acid profiles indicated that these species constitute interesting sources of polyunsaturated fatty acids (PUFA). The dominating essential and non-essential amino acids were lysine and leucine, aspartic acid, glutamic acid, and arginine, respectively. The amino acid score of the nine algae varied from 44% to 92%, the most commonly first limiting amino acid being histidine. Lutein, β-carotene, and zeaxanthin were the identified carotenoids. Contents of all macro and trace minerals, with the exception of phosphorus, were higher than those described for conventional food. Low sodium/potassium ratios (0.08 - 2.54) suggested a potential for using the ash fraction for sodium salt replacement. The algae constituted rich sources of carbohydrates (40% to 71% of Dm) which show their potential for a broader commercial exploitation. In some species, the concentrations of arsenic, cadmium, and lead exceeded limit values for application in food or feed. In conclusion, the nine algae represent promising potential sources of health promoting additives for human and animal diets, in whole or in a biorefinery concept.

关键词： Protein Lipid Carotenoids Dry matter Arsenic

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用于混合动力车和电动车的低成本传动模块

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汽车与新动力 2019年第2期2卷 26-30页

作者： C. danzer J.Liebold E.Schreiterer J.müller 范明强不详

目前混合动力的技术开发费用依然较为昂贵,生产成本也较高,因而对于终端用户而言,并无较高吸引力。在该观点的引导下,IAV汽车工程公司开发了一种高效低成本的小型化传动模块,从而制成了一种混合动力车和电动车专用的混合变速器(DHT),该... 详细信息

目前混合动力的技术开发费用依然较为昂贵,生产成本也较高,因而对于终端用户而言,并无较高吸引力。在该观点的引导下,IAV汽车工程公司开发了一种高效低成本的小型化传动模块,从而制成了一种混合动力车和电动车专用的混合变速器(DHT),该变速器也是针对48 V汽车而设计的。该传动模块以一种具有3种行驶速度等级的齿轮组为基础,仅用1个摩擦离合器就能根据当前负荷状态来进行换档。

关键词：混合动力车电动车传动模块

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Actinic prurigo of the lip: Two case reports

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World Journal of Clinical Cases 2014年第8期2卷 385-390页

作者： Ana mO miranda Thiago m Ferrari Juliana T Werneck Arley Silva Junior karin S Cunha Eliane P Dias Department of Pathology Federal Fluminense UniversityNiteroiRio de Janeiro 24220-008Brazil

Actinic prurigo is a photodermatosis that can affect the skin, conjunctiva and lips. It is caused by an abnormal reaction to sunlight and is more common in high-altitude living people, mainly in indigenous descendants. The diagnosis of actinic prurigo can be challenging, mainly when lip lesions are the only manifestation, which is not a common clinical presentation. The aim of this article is to report two cases of actinic prurigo showing only lip lesions. The patients were Afro-American and were unaware of possible Indian ancestry. Clinical exam, photographs, videoroscopy examination and biopsy were performed, and the diagnosis of actinic prurigo was established. Topical corticosteroid and lip balm with ultraviolet protection were prescribed with excellent results. The relevance of this report is to show that although some patients may not demonstrate the classical clinical presentation of actinic prurigo, the associated clinical and histological exams are determinants for the correct diagnosis and successful treatment of this disease.

关键词： Actinic prurigo Follicular cheilitis Photodermatosis High-altitude Lip diseases

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COmT抑制剂:药代动力学和药效学比较

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上海医药 1998年第10期19卷 34-37页

作者： karin m.Jorga 陈生弟 Department of Clinical Pharmacology F. Hoffmann-La Roche Ltd Basel Switzerland 上海第二医科大学附属瑞金医院

儿茶酚—氧位-甲基转移酶(COmT)可代谢带有儿茶酚基团的化合物(如左旋多巴)。抑制COmT可阻止左旋多巴甲基化,减少3-氧-甲基多巴(3-OmD)的形成,因而可改善左旋多巴的药代动力学。通过稳定血浆左旋多巴浓度,COmT抑制剂可改善帕金森症病人... 详细信息

儿茶酚—氧位-甲基转移酶(COmT)可代谢带有儿茶酚基团的化合物(如左旋多巴)。抑制COmT可阻止左旋多巴甲基化,减少3-氧-甲基多巴(3-OmD)的形成,因而可改善左旋多巴的药代动力学。通过稳定血浆左旋多巴浓度,COmT抑制剂可改善帕金森症病人对左旋多巴的疗效。两种有效的选择性、可逆性,可口服给药的COmT抑制剂,tolcapone(托卡朋)和entacapone(安托卡朋)正在临床试验中,在此对来自几项临床药理研究的数据作一总结和比较。tolcapone和entacapone对红细胞COmT活性的抑制作用均呈剂量依赖性。口服单剂200mg后,tolcapone和entacapone的最大抑制效应分别为90％和70％。与entacapone相比,tolcapone抑制作用的持续时间明显长一些。两种化合物均可增加左旋多巴的生物利用度,亦即血浆农度-时间曲线下面积(AUC)。对于tolcapone,最大作用(AUC增加94％)的剂量为200mg,而对于entacapone,其剂量为200mg和400mg时,AUC分别增加42％和65％。使用200mg tolcapone和entacapone后,血浆3-OmD浓度分别下降59％和45％。两种药物均可迅速吸收,在200mg时仍表现出线性药代动力学特性。entacapone的分布容积要大于tolcapone,从体内清除的速度更为迅速;因此,相似剂量的entacapone所产生血浆浓度要明显低于tolcapone。

关键词： COmT抑制剂多巴胺药代动力学药理震颤性麻痹

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Reporter Genes: A Practical Guide (methods in molecular Biology) 1

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丛书名： methods in molecular Biology 411

2007年

作者： Siobhan Loughna and Deborah Henderson Philip A. Seymour and maike Sander maria Limberis Peter Bell and James m. Wilson Wolfgang J. Weninger and Timothy J. mohun George H. Patterson karin Edoff James S. Dods and Andrea H. Brand Charles G. Bailey and

ISBN: (纸本)9781588297396

Reporter genes have played, and continue to play, a vital role in many areas of biological research by providing a ready means for qualitative and quantitative assessment of the activity of genes and location of gene products in different environments. This book describes practical protocols for experimentation with the most useful reporter genes for mammalian systems that are available

关键词： Genes Reporter

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CYP2C19＊2, CYP2C19＊3, CYP2C19＊17 Allele and Genotype Frequencies in Clopidogrel-Treated Patients with Coronary Heart Disease in Russian

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Journal of Pharmacy and Pharmacology 2014年第5期2卷 322-326页

作者： karin Badavievich mirzaev Dmitriy Alekseyevich Sychev Alia Sergeyevna Yugay Andrey Vladimirovich Grachev Ruslan Yevgenyevich Kazakov Department of Clinical Pharmacology 1.M. Sechenov First Moscow State Medical University Moscow 119991 Russian Federation Department of Therapeutics and Clinical Pharmacology Russian Medical Academy of Postgraduate Education Moscow 123995Russian Federation Department of Cardiology "SM-clinic" Medical Center Moscow 134544 Russian Federation Center for Clinical Pharmacology Scientific Center on Expertise of Medical Application Products Moscow 109240 Russian Federation

Individual variation in the response to drug therapy has been mainly attributed to the genetic polymorphism of cytochrome P 450 isoenzymes. mutation in the gene CYP2C19 (cytochrome P450 2C19) has been shown to influence the clinical efficiency of clopidogrel. The aim is to investigate the frequencies of CYP2C19*2 (c. G681A; rs4244285), CYP2C19*3 (c. G636A; rs4986893), CYP2C19*17 (c. C806T; rs12248560) and to compare the allele and genotype frequencies of CYP2C19*2 in patients with CHD (coronary heart disease) to healthy volunteers. We examined 53 patients with CHD received clopidogrel and 146 healthy volunteers. CYP2C19*2, CYP2C19*3, CYP2C19*17 carriages were determined by a polymerase-chain reaction. The observed genotype distribution did not deviate from Hardy-Weinberg equilibrium, it was determined by a Chi-square test with Yates correction. The frequency of CYP2C19*2 allele reported in patients with CHD and in the healthy volunteers was 16.6% and 13.3%, respectively (P = 0.584). The results of the present study may be helpful in developing current and future directions for its management.

关键词：药剂学药理学药学药物分析药典

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Bioinformatics Analysis of NprR-NprX Quorum-Sensing System of <i>Bacillus thuringiensis</i>Isolates from the Papaloapan Region, Oaxaca-mexico

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Advances in Biological Chemistry 2015年第7期5卷 293-304页

作者： Humberto Rafael Bravo-D Alain Cruz-Nolasco Luis Raúl Gutiérrez-Lucas Ana karin Navarro-mtz División de Estudios de Posgrado Universidad del Papaloapan Circuito Central 200 Parque Industrial Tuxtepec Oaxaca México Instituto de Biotecnología Universidad del Papaloapan Circuito Central 200 Parque Industrial Tuxtepec Oaxaca México

Quorum sensing is a chemical communication process that bacteria use to regulate collective behaviors. In Gram-positive bacteria, oligopeptides (called autoinducers) are the signaling molecules to elicit quorum sensing. In Bacillus thuringiensis, NprR is a transcriptional regulator whose activity depends on the NprX signalling peptide. Bacillus thuringiensis is closely related to Bacillus cereus and Bacillus anthracis. The principal difference between them is that Bacillus thuringiensis is the only one that produced Cry protein. The aim of this study is to explore the relation of nprR and 16S rRNA genes in Bacillus thurin-giensis. Phylogenetic trees of nucleotide sequences of nprR and 16S rRNA genes were built. Sequences of fourteen new isolates from Papaloapan region were included in those phylo-genetic trees. In order to identify the isolates, a simple and fast methodology considering the Cry protein formation was used. The 16S rRNA phylogenetic tree allows identify eight isolates as Bacillus thuringiensis and the others as Bacillus spp. The nprR phylogenetic tree does not match with the 16S rRNA phylogenetic tree. This confirms that nprR is not a molecular marker for evolution. most of the new isolates have the same NprR sequence (WTSDIVG). However, the SKPDIVG is the most common NprR sequence in thuringiensis species.

关键词： Quorum-Sensing Bacillus thuringiensis NprR-NprX Phylogenetic Tree

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南京城郊蔬菜基地土壤有效态铅、锌、铜和镉的空间分异及其驱动因子研究

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土壤 2005年第1期37卷 41-47页

作者：张庆利史学正黄标于东升王洪杰 karin Blombaeck Ingrid Oboern 土壤与农业可持续发展国家重点实验室(中国科学院南京土壤研究所) 徐州师范大学国土信息与测绘工程系江苏徐州221116 瑞典农业大学土壤系

利用地统计学和地理信息系统相结合的方法,从小尺度区域角度上研究了南京城郊土壤中铅(Pb)、锌(Zn)、铜(Cu)和镉(Cd)4 种重金属有效态含量的空间分布特征及其主要的影响因子。结果表明:(1) 研究区土壤中有效 Zn 变异程度相对较大,有效 ... 详细信息

利用地统计学和地理信息系统相结合的方法,从小尺度区域角度上研究了南京城郊土壤中铅(Pb)、锌(Zn)、铜(Cu)和镉(Cd)4 种重金属有效态含量的空间分布特征及其主要的影响因子。结果表明:(1) 研究区土壤中有效 Zn 变异程度相对较大,有效 Pb 的变异程度相对较小,而有效 Cu 和 Cd 为中等程度变异。(2) 研究区有效 Pb、Zn 含量空间分布具有中等程度的空间自相关性,而 Cu、Cd 空间分布具有强烈的空间自相关性;有效 Zn、Cd 的空间自相关尺度相对较大,而有效 Cu、Pb 相对较小。(3) 研究区土壤中有效 Pb 的空间分布主要受交通影响,交通量越大的道路附近土壤中有效 Pb 含量越高;有效 Zn 主要受城市生活废水的影响,城市生活污水灌溉和城市地表径流是土壤中有效 Zn 积累的主要原因;有效 Cu 主要与蔬菜种植过程中有机肥(主要是牛粪)施用关系密切,有机肥施用量越大,土壤中有效 Cu 含量越高;有效 Cd 受地形影响较大,地形低洼处土壤中有效 Cd 含量相对较高。

关键词：城郊重金属空间分异地统计学地理信息系统(GIS)

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核因子-κB是癌症治疗的好靶点吗?希望和缺陷

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国际药学研究杂志 2009年第4期36卷 300-303页

作者：姜娜辛文妤陆丽娜 Baud V karin m 烟台大学药学院山东烟台264005

核因子κB(NF-κB)转录因子在许多生理过程中,如固有及获得性免疫应答、细胞增殖、细胞死亡和炎症,都起重要作用。目前已很清楚,NF-κB和控制其活性的信号通路的调节异常与癌症的发生发展以及患者对化疗和放疗产生耐受性有关。本文综述... 详细信息

核因子κB(NF-κB)转录因子在许多生理过程中,如固有及获得性免疫应答、细胞增殖、细胞死亡和炎症,都起重要作用。目前已很清楚,NF-κB和控制其活性的信号通路的调节异常与癌症的发生发展以及患者对化疗和放疗产生耐受性有关。本文综述了NF-κB与癌症的关系、以NF-κB为靶点的癌症治疗潜能和益处以及这种治疗可能引发的并发症和缺陷。

关键词：核因子-κB 核因子-κB诱导激酶凋亡抑制蛋白肿瘤治疗

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Glucocorticoid-induced alterations in titin, nebulin, myosin heavy chain isoform content and viscoelastic properties of rat skeletal muscle

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Advances in Biological Chemistry 2013年第1期3卷 70-75页

作者： maire Aru karin Alev Helena Gapeyeva Arved Vain Raivo Puhke Ando Pehme Priit Kaasik Anne Selart Teet Seene Institute of Exercise Biology and Physiotherapy University of Tartu Tartu Estonia Institute of mathematical Statistics University of Tartu Tartu Estonia Institute of Physics University of Tartu Tartu Estonia Institute of Sport Pedagogy and Coaching University of Tartu Tartu Estonia

Viscoelastic properties of skeletal muscle are associated with a complex network of cytoskeletal proteins where titin and nebulin play a substantial role. The need for evaluation of muscle viscoelastic properties is widely accepted in clinical use to evaluate the effect of treatment or progression of muscle pathology (atrophy). We tested the hypothesis that the viscoelastic properties (elasticity, tone and stiffness) change in atrophied muscles with concomitant changes in cytoskeletal proteins (titin, nebulin) and contractile protein (myosin heavy chain) proportion. Sixteen 24- week-old male rats of the Wistar strain were randomly allocated to two groups: dexamethasone group treated each day for 10 consecutive days with dexamethasone in order to induce atrophy and control group. Skeletal muscle viscoelastic properties (elasticity, tone and stiffness) were determined using a myotonometer. Titin, nebulin and myosin heavy chain content were quantified using SDS-PAGE electrophoresis. We found that glucocorticoid-induced muscle atrophy is accompanied by reduced elasticity and increased tone and stiffness, with concomitant changes in titin, nebulin and myosin heavy chain con- tent. The elasticity decreased by 10.9% (P P methasone group (627.3 N/m vs 758.6 N/m);(P mpared with the control group, the content of titin, nebulin and myosin heavy chain in atrophied muscle was 76.4%, 70.6% and 82.3%, respectively. Our results may lead to a better understanding of the mechanism of muscle atrophy and provide better guidance for rehabilitation practices and help to find rational therapeutic intervention in the future.

关键词： Viscoelastic Properties Skeletal muscle Atrophy myotonometry Cytoskeletal Proteins Glucocorticoids

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