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Natural Regeneration on Planted Clearcuts—The Easy Way to mixed Forest?

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Open Journal of Forestry 2016年第4期6卷 281-294页

作者： Emma Holmström Per magnus Ekö karin Hjelm matts Karlsson Urban Nilsson Southern Swedish Forest Research Centre Swedish University of Agricultural Science Alnarp Sweden Skogforsk Sval&oumlv Sweden

Establishing mixed stands by stimulating natural in combination with planting could potentially ensure adequate stocking and meet shifting demands for forest products. Two long-term experiments were separately established in former Norway spruce (Picea abies L. Karst) stands in southern Sweden to be able to evaluate mixed forest establishment and management. The treatment plots were treated with different intensity of soil scarification (disc trenching, soil inversion and control) to test effects of soil disturbance on regeneration success. Five years later, both experiments were used for a first evaluation, where seedlings of all naturally regenerated tree species were counted together with estimates of the cover and height of other vegetation. This was made in sample plots in symmetric grids. Testing the effects of scarification and distance to seed source on natural regeneration of silver birch (Betula pendula Roth.) and downy birch (B. pubescens Ehrh.) showed that both scarification type and degree of soil disturbance significantly affected seedling counts but only if seed sources were close. In conclusion, conventional management practices for regenerating coniferous forest may be suitable for establishing mixed forest stands with combinations of planted and naturally regenerated seedlings.

关键词： Betula Birch Soil Scarification Seed Dispersal

The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function

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分子细胞生物学报:英文版 2015年第5期7卷 402-414页

作者： Gesa I.Albert Christoph Schell karin m.Kirschner Sebastian Schafer Ronald Naumann Alexandra muller Oliver Kretz Benno Kuropka mathias Girbig Norbert Hubner Eberhard Krause Holger Scholz Tobias B.Huber Klaus-Peter Knobeloch Christian Freund Institute for Chemistry and Biochemistry Freie Universitat Berlin14195 BerlinGermany Leibniz-Institut fuer molekulare Pharmakologie 13125 BerlinGermany Renal Division University Hospital Freiburg79106 FreiburgGermany Speman Graduate School for medicine and Biology University of Freiburg79106 FreiburgGermany Faculty of Biology University Freiburg79106 FreiburgGermany Institute fuer Vegetative Physiologie Charité-Universitatsmedizin Berlin10117 BerlinGermany Experimental Genetics and Cardiovascular Diseases MDC13125 BerlinGermany Transgenic Core Facility Max-Planck-Institute of Molecular Cell Biology and GeneticsDresdenGermany Institute of Neuropathology University of Freiburg79106 FreiburgGermany Institute of Cell Biology&Anatomy University of Freiburg79106 FreiburgGermany BIOSS Centre for Biological Signaling Studies Albert-Ludwigs-University79106 FreiburgGermany

Scaffolding proteins play pivotal roles in the assembly of macromolecular machines such as the *** adaptor protein CD2BP2,originally identified as a binding partner of the adhesion molecule CD2,is a pre-spliceosomal assembly factor that utilizes its glycine-tyrosine-phenylalanine(GYF)domain to co-localize with spliceosomal *** far,its function in vertebrates is *** conditional gene targeting in mice,we show that CD2BP2 is crucial for embryogenesis,leading to growth retardation,defects in vascularization,and premature death at embryonic day 10.5 when *** of the protein in bone marrow-derived macrophages indicates that CD2BP2 is involved in the alternative splicing of mRNA transcripts from diverse *** the molecular level,we identified the phosphatase PP1 to be recruited to the spliceosome via the N-terminus of *** the strong expression of CD2BP2 in podocytes of the kidney,we use selective depletion of CD2BP2,in combination with next-generation sequencing,to monitor changes in exon usage of genes critical for podocyte functions,including VEGF and actin ***2BP2-depleted podocytes display foot process effacement,and cause proteinuria and ultimately lethal kidney failure in ***,our study defines CD2BP2 as a non-redundant splicing factor essential for embryonic development and podocyte integrity.

关键词： GYF domain CD2BP2 alternative splicing PP1 podocytes VEGF

石墨烯/聚合物纳米复合材料去除水中废油污染物的研究进展

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新型炭材料 2021年第2期36卷 235-252页

作者：冯昭璇徐亚男岳维勋 karin H.Adolfsson 吴明铂中国石油大学(华东)化学工程学院重质油国家重点实验室山东青岛266580 中国石油大学(华东)新能源学院重质油国家重点实验室山东青岛266580 Department of Fibre and Polymer Technology KTH Royal Institute of TechnologyStockholm 10044

频繁的海上溢油事故和工业含油污水的肆意排放严重破坏海洋生态平衡。因此,开发先进的除油材料迫在眉睫。石墨烯(G)及其衍生物氧化石墨烯(GO)因其具有高比表面积、低密度、高孔隙率、表面功能可调等优异的理化性质,在油水分离领域成为... 详细信息

频繁的海上溢油事故和工业含油污水的肆意排放严重破坏海洋生态平衡。因此,开发先进的除油材料迫在眉睫。石墨烯(G)及其衍生物氧化石墨烯(GO)因其具有高比表面积、低密度、高孔隙率、表面功能可调等优异的理化性质,在油水分离领域成为研究热点。为充分发挥其优势,近年来,将G或GO与聚合物复合制备成功能化G/聚合物或GO/聚合物纳米复合材料,因其具有良好的除油能力、优异的机械性能、价格低廉、形貌及表面化学组分可调等优势而越来越受到人们的青睐。目前已开发出气凝胶、泡沫、海绵、膜等具有三维结构的G/聚合物或GO/聚合物复合吸油剂和过滤膜。本文系统性地总结了从表面润湿理论到G/聚合物或GO/聚合物复合吸油材料和滤膜材料的最新研究进展。此外,重点归纳了近年来有关油品回收及吸油材料再生的方法策略。最后,提出该研究领域目前面临的挑战和未来研究方向,旨在为该领域的深入探索开辟新的视角。

关键词：石墨烯或氧化石墨烯/聚合物复合材料除油吸附剂滤膜表面润湿性

Can gene editing reduce postharvest waste and loss of fruit, vegetables, and ornamentals?

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Horticulture Research 2021年第1期8卷 51-71页

作者： Emma N.Shipman Jingwei Yu Jiaqi Zhou karin Albornoz Diane m.Beckles Department of Plant Sciences University of CaliforniaDavisCA 95616USA Plant Biology Graduate Group University of CaliforniaDavisCA 95616USA Graduate Group of Horticulture&Agronomy University of CaliforniaDavisCA 95616USA Departamento de Produccion Vegetal Universidad de ConcepcionRegion del BioBioConcepcionChile

Postharvest waste and loss of horticultural crops exacerbates the agricultural problems facing humankind and will continue to do so in the next *** and vegetables provide us with a vast spectrum of healthful nutrients,and along with ornamentals,enrich our lives with a wide array of pleasant sensory *** commodities are,however,highly *** 33%of the produce that is harvested is never consumed since these products naturally have a short shelf-life,which leads to postharvest loss and *** loss,however,could be reduced by breeding new crops that retain desirable traits and accrue less damage over the course of long supply *** gene-editing tools promise the rapid and inexpensive production of new varieties of crops with enhanced traits more easily than was previously *** aim in this review is to critically evaluate gene editing as a tool to modify the biological pathways that determine fruit,vegetable,and ornamental quality,especially after *** provide brief and accessible overviews of both the CRISPR-Cas9 method and the produce supply ***,we survey the literature of the last 30 years,to catalog genes that control or regulate quality or senescence traits that are"ripe"for gene ***,we discuss barriers to implementing gene editing for postharvest,from the limitations of experimental methods to international *** conclude that in spite of the hurdles that remain,gene editing of produce and ornamentals will likely have a measurable impact on reducing postharvest loss and waste in the next 5-10 years.

关键词： crops editing harvest

Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma

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Cancer Biology & medicine 2021年第3期18卷 721-733页

作者： Fengjuan Jiang Hui Liu Fengping Peng Zhaoyun Liu Kai Ding Jia Song Lijuan Li Jin Chen Qing Shao Siyang Yan Kim De Veirman karin Vanderkerken Rong Fu Department of Hematology Tianjin Medical University General HospitalTianjin 300052China Department of Hematology and Immunology-myeloma Center Brussels Vrije Universiteit BrusselBrussels 1090Belgium

Objective:myeloma bone disease(mBD)is the most common complication of multiple myeloma(mm).Our previous study showed that the serum levels of C3/C4 in mm patients were significantly positively correlated with the severity of bone ***,the mechanism of C3 a/C4 a in osteoclasts mm patients remains ***:The formation and function of osteoclasts were analyzed after adding C3 a/C4 a in ***-seq analysis was used to screen the potential pathways affecting osteoclasts,and the results were verified by Western blot,q RT-PCR,and pathway ***:The osteoclast area per view induced by 1μg/m L(mean±SD:50.828±12.984%)and 10μg/m L(53.663±12.685%)of C3 a was significantly increased compared to the control group(0μg/m L)(34.635±8.916%)(Pm RNA expressions of genes,OSCAR/TRAP/RANKL/cathepsin K,induced by 1μg/m L(median:5.041,3.726,1.638,and 4.752,respectively)and 10μg/m L(median:5.140,3.702,2.250,and 5.172,respectively)of C3 a was significantly increased compared to the control group(median:3.137,2.004,0.573,and 2.257,respectively)(1μg/m L P=0.001,P=0.003,Pm L:Pm L(mean±SD:51.464±11.983%)and 10μg/m L(50.219±12.067%)of C3 a was also significantly increased(33.845±8.331%)(Pmpared to the *** was no difference between the C4 a and control ***-seq analysis showed that C3 a promoted the proliferation of osteoclasts using the phosphoinositide 3-kinase(PI3 K)signaling *** relative expressions of PIK3 CA/phosphoinositide dependent kinase-1(PDK1)/serum and glucocorticoid inducible protein kinases(SGK3)genes and PI3 K/PDK1/p-SGK3 protein in the C3 a group were significantly higher than in the control *** activation role of C3 a in osteoclasts of mm patients was reduced by the SGK inhibi

关键词： multiple myeloma complement C3a osteoclasts PI3K/PDK1/SGK3 pathways SGK inhibitor

Screening Preeclamptic Cord Plasma for Proteins Associated with Decreased Breast Cancer Susceptibility

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Genomics, Proteomics & Bioinformatics 2013年第6期11卷 335-344页

作者： Hoi Pang Low Ashutosh Tiwari Jagadeesh Janjanam Li Qiu Chien-I Chang William C.Strohsnitter Errol R.Norwitz Sun W.Tam James E.Evans karin m.Green Joao A.Paulo mats Lambe Chung-Cheng Hsieh Department of Cancer Biology University of Massachusetts Medical School Department of Chemistry Michigan Technological University Department of Obstetrics and Gynecology Tufts Medical Center Proteomics and mass Spectrometry Facility Department of Biochemistry and Molecular PharmacologyUniversity of Massachusetts Medical School Department of Chemistry and Biochemistry Clark University Roskamp Institute Inc. Department of Cell Biology Harvard Medical School Department of medical Epidemiology and Biostatistics Karolinska Institute

Preeclampsia, a complication of pregnancy characterized by hypertension and proteinuria, has been found to reduce the subsequent risk for breast cancer in female offspring. As this pro- tective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic profiles of umbilical cord blood plasma between preeclamptic and normotensive pregnancies were compared. Umbilical cord plasma samples, depleted of 14 abundant proteins, were subjected to proteomic analysis using the quantitative method of nanoACQUITY ultra performance liquid chromatography-mass spectrometry with elevated energy mode of acquisitionE （NanoUPLC-mSE）. Sixty-nine differentially expressed proteins were identified, of which 15 and 6 proteins were only detected in preeclamptic and normotensive pregnancies, ***, expression of 8 proteins （gelsolin, complement C5, keratin type I cytoskeletal 10, pigment epithelium-derived factor, complement factor B, complement component C7, hemoglobin subunit gamma-2 and alpha-fetoprotein） were up-regulated in preeclampsia with a fold change of 1〉 2.0 when compared to normotensive pregnancies. The identification of alpha-fetoprotein in pre- eclamptic umbilical cord blood plasma supported the validity of this screen as alpha-fetoprotein has anti-estrogenic properties and has previously been linked to preeclampsia as well as a reduced breast cancer risk. The findings of this pilot study may provide new insights into the mechanistic link between preeclampsia and potentially reduced breast cancer susceptibility in adult life.

关键词： Biomarkers Intrauterine environment mass spectrometry Pregnancy Prenatal Preeclampsia

Valuable Biomolecules from Nine North Atlantic Red macroalgae: Amino Acids, Fatty Acids, Carotenoids, minerals and metals

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Natural Resources 2016年第4期7卷 157-183页

作者： Behnaz Razi Parjikolaei Annette Bruhn karin Loft Eybye martin mørk Larsen michael Bo Rasmussen Knud Villy Christensen Xavier C. Fretté Department of Chemical Engineering Biotechnology and Environmental Technology University of Southern Denmark Odense Denmark Department of Bioscience Aarhus University Silkeborg Denmark Food Technology Department Life Science Division Danish Technological Institute Aarhus Denmark Department of Bioscience Aarhus University Roskilde Denmark

In modern society, novel marine resources are scrutinized pursuing compounds of use in the medical, pharmaceutical, biotech, food or feed industry. Few of the numerous marine macroalgae are currently exploited. In this study, the contents of nutritional compounds from nine common North Atlantic red macroalgae were compared: the lipid content was low and constant among the species, whereas the fatty acid profiles indicated that these species constitute interesting sources of polyunsaturated fatty acids (PUFA). The dominating essential and non-essential amino acids were lysine and leucine, aspartic acid, glutamic acid, and arginine, respectively. The amino acid score of the nine algae varied from 44% to 92%, the most commonly first limiting amino acid being histidine. Lutein, β-carotene, and zeaxanthin were the identified carotenoids. Contents of all macro and trace minerals, with the exception of phosphorus, were higher than those described for conventional food. Low sodium/potassium ratios (0.08 - 2.54) suggested a potential for using the ash fraction for sodium salt replacement. The algae constituted rich sources of carbohydrates (40% to 71% of Dm) which show their potential for a broader commercial exploitation. In some species, the concentrations of arsenic, cadmium, and lead exceeded limit values for application in food or feed. In conclusion, the nine algae represent promising potential sources of health promoting additives for human and animal diets, in whole or in a biorefinery concept.

关键词： Protein Lipid Carotenoids Dry matter Arsenic

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用于混合动力车和电动车的低成本传动模块

汽车与新动力 2019年第2期2卷 26-30页

作者： C. danzer J.Liebold E.Schreiterer J.müller 范明强不详

目前混合动力的技术开发费用依然较为昂贵,生产成本也较高,因而对于终端用户而言,并无较高吸引力。在该观点的引导下,IAV汽车工程公司开发了一种高效低成本的小型化传动模块,从而制成了一种混合动力车和电动车专用的混合变速器(DHT),该... 详细信息

目前混合动力的技术开发费用依然较为昂贵,生产成本也较高,因而对于终端用户而言,并无较高吸引力。在该观点的引导下,IAV汽车工程公司开发了一种高效低成本的小型化传动模块,从而制成了一种混合动力车和电动车专用的混合变速器(DHT),该变速器也是针对48 V汽车而设计的。该传动模块以一种具有3种行驶速度等级的齿轮组为基础,仅用1个摩擦离合器就能根据当前负荷状态来进行换档。

关键词：混合动力车电动车传动模块

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COmT抑制剂:药代动力学和药效学比较

上海医药 1998年第10期19卷 34-37页

作者： karin m.Jorga 陈生弟 Department of Clinical Pharmacology F. Hoffmann-La Roche Ltd Basel Switzerland 上海第二医科大学附属瑞金医院

儿茶酚—氧位-甲基转移酶(COmT)可代谢带有儿茶酚基团的化合物(如左旋多巴)。抑制COmT可阻止左旋多巴甲基化,减少3-氧-甲基多巴(3-OmD)的形成,因而可改善左旋多巴的药代动力学。通过稳定血浆左旋多巴浓度,COmT抑制剂可改善帕金森症病人... 详细信息

儿茶酚—氧位-甲基转移酶(COmT)可代谢带有儿茶酚基团的化合物(如左旋多巴)。抑制COmT可阻止左旋多巴甲基化,减少3-氧-甲基多巴(3-OmD)的形成,因而可改善左旋多巴的药代动力学。通过稳定血浆左旋多巴浓度,COmT抑制剂可改善帕金森症病人对左旋多巴的疗效。两种有效的选择性、可逆性,可口服给药的COmT抑制剂,tolcapone(托卡朋)和entacapone(安托卡朋)正在临床试验中,在此对来自几项临床药理研究的数据作一总结和比较。tolcapone和entacapone对红细胞COmT活性的抑制作用均呈剂量依赖性。口服单剂200mg后,tolcapone和entacapone的最大抑制效应分别为90％和70％。与entacapone相比,tolcapone抑制作用的持续时间明显长一些。两种化合物均可增加左旋多巴的生物利用度,亦即血浆农度-时间曲线下面积(AUC)。对于tolcapone,最大作用(AUC增加94％)的剂量为200mg,而对于entacapone,其剂量为200mg和400mg时,AUC分别增加42％和65％。使用200mg tolcapone和entacapone后,血浆3-OmD浓度分别下降59％和45％。两种药物均可迅速吸收,在200mg时仍表现出线性药代动力学特性。entacapone的分布容积要大于tolcapone,从体内清除的速度更为迅速;因此,相似剂量的entacapone所产生血浆浓度要明显低于tolcapone。

关键词： COmT抑制剂多巴胺药代动力学药理震颤性麻痹