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C1q recognizes antigen-bound IgG in a curvature-dependent manner

Nano Research 2020年第6期13卷 1651-1658页

作者： Christina M.Zeuthen Ali Shahrokhtash karin fromell Kristina Nilsson Ekdahl Hossein Mohammad-Beigi Duncan S.Sutherland Interdisciplinary Nanoscience Center Aarhus UniversityGustav Wieds vej 148000Aarhus CDenmark Department of Immunology Genetics and PathologyUppsala UniversityDag Hammarskjölds väg 2075185UppsalaSweden Linnaeus Center of Biomaterials Chemistry Linnaeus University39182KalmarSweden Sino-Danish Center for Education and Research Niels Jensens Vej 2Building 11908000Aarhus CDenmark The Centre for Cellular Signal Patterns(CellPAT) Gustav Wieds vej 148000Aarhus CDenmark

Nano Research volume 13,pages1651–1658(2020)Cite this article 109 Accesses Metrics details Abstract C1q is an important recognition protein in the complement system,which is a major protein cascade in the innate immune *** recognition of a target by C1q,the target is marked for opsonization and destruction.C1q recognizes many pathogenic patterns directly,but an important target is the Fc domain of antibodies binding to their *** this paper,the curvature-dependence of the interaction between IgG and C1q is studied by surface plasmon resonance and quartz crystal *** is organized in similar surface coverage densities on flat polystyrene surfaces and polystyrene nanoparticles of different sizes,and the amount of C1q binding to the IgG is *** in solution were found to aggregate upon incubation with IgG,and therefore a new technique utilizing nanoparticles binding to antifouling polymer brush functionalized surfaces was used to prepare surfaces with nanoparticles for measurements with surface plasmon *** antigen-bound IgG at the curved surface of nanoparticles showed 5.6 times lower binding of C1q compared to at matched flat *** was no significant difference between the binding at 100 and 200 nm polystyrene *** findings are important for designing drug delivery systems to evade the complement system.

关键词： C1q complement system antibodies curvature nanoparticles

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