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Translational bioengineering strategies for peripheral nerve regeneration:opportunities,challenges,and novel concepts

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Neural Regeneration Research 2023年第6期18卷 1229-1234页

作者： karim a.sarhane Chenhu Qiu Thomas G.W.Harris Philip J.Hanwright Hai-Quan Mao Sami H.Tuffaha Department of Plastic and Reconstructive Surgery Peripheral Nerve Research LaboratoryJohns Hopkins University School of MedicineBaltimoreMDUSA Department of Materials Science and Engineering Johns Hopkins University Whiting School of EngineeringBaltimoreMDUSA Institute for NanoBioTechnology Johns Hopkins UniversityBaltimoreMDUSA Translational Tissue Engineering Center Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Biomedical Engineering Johns Hopkins University School of MedicineBaltimoreMDUSA

Peripheral nerve injuries remain a challenging problem in need of better treatment *** best efforts at surgical reconstruction and postoperative rehabilitation,patients are often left with persistent,debilitating motor and sensory *** are currently no therapeutic strategies proven to enhance the regenerative process in humans.A clinical need exists for the development of technologies to promote nerve regeneration and improve functional *** advances in the fields of tissue engineering and nanotechnology have enabled biomaterial scaffolds to modulate the host response to tissue repair through tailored mechanical,chemical,and conductive *** bioengineered approaches have enabled targeted,sustained delivery of protein therapeutics with the capacity to unlock the clinical potential of a myriad of neurotrophic growth factors that have demonstrated promise in enhancing regenerative *** such,further exploration of combinatory strategies leveraging these technological advances may offer a pathway towards clinically translatable solutions to advance the care of patients with peripheral nerve *** review first presents the various emerging bioengineering strategies that can be applied for the management of nerve gap *** cover the rationale and limitations for their use as an alternative to autografts,focusing on the approaches to increase the number of regenerating axons crossing the repair site,and facilitating their growth towards the distal *** also discuss the emerging growth factor-based therapeutic strategies designed to improve functional outcomes in a multimodal fashion,by accelerating axonal growth,improving the distal regenerative environment,and preventing end-organs atrophy.

关键词： bioengineering biomaterials growth hormone insulin-like growth factor 1 nanotechnology neurobiology peripheral nerve regeneration Schwann cells translational research

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Immune mechanisms of ischemia-reperfusion injury in transplantation

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Open Journal of Immunology 2013年第3期3卷 158-164页

作者： Saami Khalifian Justin M. Broyles Sami H. Tuffaha Mohammed Alrakan Zuhaib Ibrahim karim A. sarhane Department of Plastic and Reconstructive Surgery Johns Hopkins University School of Medicine Baltimore USA

All allografts suffer a number of unavoidable ischemic insults. These, starting with brain death and ending with reperfusion, are very troublesome, as ischemia-reperfusion injury (IRI) is demonstrated to be a major cause of allograft damage in various types of transplantations. To counter the threat this poses to allograft function, investigators have worked diligently over the past decades in clinical settings and in the laboratory to understand the pathophysiology and immune mechanism underlying IRI hoping to ultimately devise strategies that lessen its detrimental effects on allografts. Herein, we review the major immune components of the IRI dynamic process. Better understanding of the cellular pathophysiological processes underlying IRI will hopefully result in the design of more targeted therapies to prevent the injury, hasten repair, and minimize chronic progressive allograft damage.

关键词： Ischemia-Reperfusion Reactive Oxygen Species Allograft Damage Solid Organ Transplantation Immune Mechanisms

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