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VISUAL PROGRAmmING FOR BUILDING INFORmATION mODELING:ENERGY AND SHADING ANALYSIS CASE STUDIES

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Journal of Green Building 2015年第4期10卷 28-43页

作者： karen kensek University of Southern California School of ArchitectureWatt Hall#204Los AngelesCA 90089-0291

INTRODUCTION Although visual programming is being broadly implemented in other disciplines,it has only relatively recently become an important supplement to three-dimensional modeling programs in the architecture,engineering,and construction ***,Grasshopper in conjunction with Rhino is a leading example of a visual programming environment that is strongly supported by a user community that is developing additional functionality,but Grasshopper does not yet work directly with building information modeling(BIm)*** is relatively new,but shows considerable promise in becoming a constructive tool to complement BIm,3D modeling,and analysis programs because it includes parametric geom-etries and works with Revit,a leading BIm software *** case studies are described:extensibility of Dynamo through the use of a building energy simu-lation package,controlling a virtual model’s response through light level sensors,and interactively updating shading components for a building facade based on solar *** demonstrate that one can work directly within building information models(BIm)using a visual programming language through updating component *** case studies demonstrate the feasibility of a workflow for sustain-able design simulations that is different than that more commonly used--having a separation between design and analysis models and using a neutral file format exchange such as IFC or gbXmL to transfer *** visual programming languages are still a bit uncommon in the building industry,a short background is provided to place them within the tool set of other customizable tools that designers have been developing.

关键词： visual programming language VPL building information modeling BIm Dynamo Revit Grasshopper computational design

GREEN BUILDING AND BIODIVERSITY: FACILITATING BIRD FRIENDLY DESIGN WITH BUILDING INFORmATION mODELS

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Journal of Green Building 2016年第2期11卷 116-130页

作者： karen kensek Ye Ding Travis Longcore University of Southern California School of ArchitectureWatt Hall#204Los AngelesCA 90089-0291 University of Southern California School of Architecture and Spatial Sciences Institute

Green buildings should respect nature and endeavor to mitigate harmful effects to the environment and *** is often interpreted as creating sustain-able sites,consuming less energy and water,reusing materials,and providing excel-lent indoor environmental *** friendly buildings should also consider literally the impact that they have on birds,millions of them.A major factor in bird collisions with buildings is the choice of building *** choices are usually made by the architect who may not be aware of the issue or may be looking for guidance from certification programs such as *** a proof of concept for an educational tool,we developed a software-assisted approach to characterize whether a proposed building design would earn a point for the LEED Pilot Credit 55:Avoiding Bird *** the visual programming language Dynamo with the common building information modeling software Revit,we automated the assessment of *** approach depends on parameters that incorporate assessments of bird threat for façade materials,analyzes building geom-etry relative to materials,and processes user input on building operation to produce the assessment.

关键词： bird collisions bird avoidance building information modeling BIm Dynamo visual programming language

Regulation ofβ2-adrenoceptors in brain glia:implications for neuroinflammatory and degenerative disorders

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Neural Regeneration Research 2020年第11期15卷 2035-2036页

作者： karen m.Ryan Andrew Harkin Trinity College Institute of Neuroscience Trinity College Dublin Neuropsychopharmacology Research Group School of Pharmacy and Pharmaceutical Sciences&Trinity College Institute of NeuroscienceTrinity College DublinDublinIreland

Noradrenaline:Within the central nervous system(CNS),the primary source of the catecholamine neurotransmitter noradrenaline is the locus coeruleus(LC)in the pontine tegmentum,with LC neurons projecting to almost all regions of the brain and spinal *** its release from LC neurons,noradrenaline has wide ranging *** example,noradrenaline is the endogenous agonist for G-coupledα-andβ-adrenoceptors that are expressed on many cell types,including neurons and glia,in both the peripheral nervous system and *** is via these receptors that noradrenaline exerts its anti-inflammatory and neurotrophic effects in the *** additionally has adrenoceptor-independent neuroprotective actions,and as such plays a role in free radical scavenging and reducing oxidative stress(Feinstein et al.,2016).

关键词： adrenoceptor protective endogenous

Vitamin D improves inflammatory bowel disease outcomes:Basic science and clinical review

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World Journal of Gastroenterology 2014年第17期20卷 4934-4947页

作者： Krista m Reich Richard N Fedorak karen madsen karen I Kroeker Division of Gastroenterology University of AlbertaEdmontonAlberta T6G 2X8Canada

Vitamin D deficiency is commonly diagnosed among patients with inflammatory bowel disease (IBD). Patients with IBD are at risk of low bone density and increased fractures due to low vitamin D levels, long standing disease, and frequent steroid exposures; as a result, it is well established that vitamin D supplementation in this population is important. There is increasing support for the role of vitamin D in strengthening the innate immune system by acting as an immunomodulator and reducing inflammation in experimental and human IBD. The active form of vitamin D, 1,25(OH)D3, acts on T cells to promote T helper (Th)2/regulatory T responses over Th1/Th17 responses; suppresses dendritic cell inflammatory activity; induces antibacterial activity; and regulates cytokine production in favor of an anti-inflammatory response. murine and human IBD studies support a therapeutic role of vitamin D in IBD. Risk factors for vitamin D deficiency in this population include decreased sunlight exposure, disease duration, smoking, and genetics. Vitamin D normalization is associated with reduced risk of relapse, reduced risk of IBD-related surgeries, and improvement in quality of life. Vitamin D is an inexpensive supplement which has been shown to improve IBD outcomes. However, further research is required to determine optimal serum vitamin D levels which will achieve beneficial immune effects, and stronger evidence is needed to support the role of vitamin D in inducing disease response and remission, as well as maintaining this improvement in patients’ disease states.

关键词： Vitamin D Inflammatory bowel disease Immune response Inflammation Cytokines Supplementation

Protein construct optimization:data sharing strategy

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Protein & Cell 2012年第5期3卷 321-322页

作者： karen m.Polizzi Rivka L.Isaacson Center for Synthetic Biology and Innovation Division of Molecular BiosciencesImperial College LondonLondon SW72AZUK Center for Structural Biology Division of Molecular BiosciencesImperial College LondonLondon SW72AZUK

The British medical Journal devoted its first issue of 2012 to the problem of unreported clinical trial data,highlighting the serious impact that incomplete information can have on world health(for an editorial summary see Lehman and Loder,2012).Adopted innovations in clinical intervention,inappro-priately based on only a subset of trial data,can,at best,prove uneconomical and,at worst,lead to large-scale patient *** its consequences may be most severe in medicine this problem applies to many scientific disciplines and we are now seeing a move towards greater transparency in data declaration.

关键词： subset consequences incomplete

Predicting phosphorus sorption isotherm parameters in soil using data of routine laboratory tests

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Pedosphere 2021年第5期31卷 694-704页

作者： Kathleen S.DUNNE Nicholas m.HOLDEN karen DALY Teagasc Johnstown CastleEnvironmental Research CentreCo.Wexford Y35TC97(Ireland) UCD School of Biosystems and Food Engineering University College DublinBelfieldDublin 4 D04VIW8(Ireland)

Knowledge of phosphorus(P)sorption dynamics across different soil types could direct agronomic and environmental management of *** objective of this study was to predict P isotherm parameters for a national soil population using data of routine laboratory *** and Freundlich sorption parameters were calculated from two different ranges(0-25 and 0-50 mg P L^(-1))using an archive of representative agricultural soil types from *** linear regression(mLR)identified labile forms of aluminium(Al)and iron(Fe),organic matter(Om),cation exchange capacity(CEC),and clay as significant *** and Freundlich sorption capacities,Freundlich affinity constant,and Langmuir buffer capacity were predicted reliably,with R^(2) of independent validation>*** isotherm parameters were predicted from P sorbed at a single concentration of 50 mg P L^(-1)(S_(50)).An mLR prediction of P sorption maximum in the 0-50 mg P L-1 range was achieved,to an accurate standard,using S_(50),Om,and mehlich-3 Fe(R^(2) of independent calibration and validation being 0.91 and 0.95,respectively).Using Giles’four shapes of isotherms(C,L,H,and S),L non-strict-and C-shaped isotherm curves accounted for 64% and 27% of the soils,*** clustering identified a separation of isotherm curves influenced by two ranges of mehlich-3 *** with a low range of mehlich-3 Al(2.5-698 mg kg^(-1))had no incidence of rapid sorption(C shape).Single point indices,Al,or available soil data make the regression approach a feasible way of predicting Langmuir parameters that could be included with standard agronomic soil P testing.

关键词： available phosphorus binding fertilizer soil test sorption maximum

Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer risk

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World Journal of Gastroenterology 2009年第19期15卷 2336-2339页

作者： mazyar Shadman Polly A Newcomb John m Hampton karen J Wernli Amy Trentham-Dietz Cancer Prevention Program Fred Hutchinson Cancer Research CenterSeattle 98109United States Department of Epidemiology University of WashingtonSeattle 98195United States Polly A Newcomb University of Wisconsin Paul PCarbone Comprehensive Cancer CenterMadison 53726United States

AIm： To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs （NSAIDs） or statins and colorectal cancer ***： In a population-based case-control study in women, we examined the association between NSAIDs and statin use and the risk of colorectal cancers. We further investigated whether the use of statins modifies the protective effect of NSAIDs. Female cases （n = 669）of colorectal cancer aged 50-74 years were identified from a storewide registry in Wisconsin during 1999-2001. Community control women （n = 1375） were randomly selected from lists of licensed drivers and medicare beneficiaries. medication use and risk factor information were gathered during a structured telephone interview. A multivariable logistic regression model was used to calculate odds ratio （OR） and 95% confidence interval （CI）.RESULTS： Overall, NSAIDs users had a 30% reduction in risk of colorectal cancer （95% CI： 0.56-0.88）. Statin use was not associated with colorectal cancer risk （OR = 1.17, 95% CI： 0.74-1.85）, regardless of structural type （lipophilic or hydrophilic）, duration of use, or recency. There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk （P-interaction = 0.28）.CONCLUSION： Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk, they do not support a risk reduction in statin users, or an interaction effect of combined NSAIDs and statin use.

关键词： Non-steroidal anti-inflammatory drugs Statin Colorectal cancer Cancer prevention Chemoprevention

BIm应用于体育建筑设计研究——国内外案例分析

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建筑技艺 2013年第2期19卷 210-213页

作者：段文婷 karen kensek Douglas Noble 同济大学建筑与城规学院南加州大学

相关软件公司开发了大量适用于当代BIm技术的辅助设计程序,每个软件都有各自的特点,而对于体育建筑设计,需要综合考虑项目自身特点选择设计软件。使用BIm软件不仅仅是一种图纸化的手段,还可以帮助设计师从新的角度去思考建筑设计的方法。

关键词： BIm 体育建筑参数化设计导则

Cx26 heterozygous mutations:role in hyperacusis and vulnerability to noise

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3551-3552页

作者： karen Tawk mehdi Abouzari Department of Otolaryngology-Head and Neck Surgery University of CaliforniaIrvineCAUSA

In a recent study published in Science Advances,Liu et *** that heterozygous deletion of connexin 26(Cx26)in mice is not harmless as they lead to hyperacusis-like hearing *** authors also found that children who carry a single-point heterozygous mutation in the gap junction(GJ)gene Cx26(GJB2)are susceptible to noise,which eventually leads to hearing loss(HL).1 HL affects millions of people worldwide and is considered the most prevalent sensory disorder,encompassing a wide range of heterogeneous characteristics.

关键词： Cx26 noise