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Nationwide retrospective study of hepatitis B virological response and liver stiffness improvement in 465 patients on nucleos(t)ide analogue

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World Journal of Gastroenterology 2022年第31期28卷 4390-4398页

作者： Alnoor Ramji karen Doucette Curtis Cooper Gerald yosel Minuk Mang Ma Alexander Wong David Wong Edward Tam Brian Conway David Truong Philip Wong lisa Barrett Hin Hin Ko Sarah Haylock-Jacobs Nishi Patel Gilaad G Kaplan Scott Fung Carla S Coffin Department of Medicine University of British ColumbiaVancouver v6t 1z3Canada Department of Medicine University of AlbertaEdmonton t6g 2r7Canada Department of Medicine The Ottawa Hospital Research InstituteUniversity of OttawaOttawa ON K1H 8L6Canada Department of Medicine University of ManitobaWinnipeg r3e 3j7Canada Department of Medicine University of SaskatchewanSaskatoon s7n 5e5Canada Department of Medicine University Health NetworkToronto m5g 2c4Canada Pacific Gastroenterology Associates Vancouver v6z 2k5Canada Vancouver Infectious Disease Centre Vancouver v6z 2c7Canada Department of Medicine McGill UniversityMontreal h3a 0g4Canada Department of Microbiology and Immunology Dalhousie UniversityHalifax b3h 4r2Canada Cumming School of Medicine University of CalgaryCalgary t2n 1n4Canada

BACKGROUND Hepatitis B virus(HBV)nucleos(t)ide analog(NA)therapy reduces liver disease but requires prolonged therapy to achieve hepatitis B surface antigen(HBsAg)*** is limited North American real-world data using non-invasive tools for fibrosis assessment and few have compared 1st generation NA or lamivudine(lAM)to tenofovir disoproxil fumarate(TDF).AIM To assess impact of NA on virological response and fibrosis regression using liver stiffness measurement(lSM)(i.e.,FibroScan®).METHODS Retrospective,observational cohort study from the Canadian HBV *** collected included demographics,NA,HBV DNA,alanine aminotransferase(AlT),and *** were HBV monoinfected patients,treatment naïve,and received 1 NA with minimum 1 year *** In 465(median 49 years,37%female,35%hepatitis B e antigen+at baseline,84%Asian,6%White,and 9%Black).Percentage of 64(n=299)received TDF and 166 were lAM-treated with similar median duration of 3.9 and 3.7 years,*** mean baseline lSM was 11.2 kPa(TDF)vs 8.3 kPa(lAM)(P=0.003).At 5-year follow-up,the mean lSM was 7.0 kPa in TDF vs 6.7 kPa in lAM(P=0.83).There was a significant difference in fibrosis regression between groups(i.e.,mean-4.2 kPa change in TDF and-1.6 kPa in lAM,Plast available data on treatment showed that all had normal AlT,but more TDF patients were virologically suppressed(l)(n=170/190,89%)vs lAM-treated(n=35/58,60%)(Pleared *** In this real-world North American study,approximately 5 years of NA achieves liver fibrosis regression rarely leads to HBsAg loss.

关键词： Nucleos(t)ide analog therapy Functional cure Hepatitis B virus surface antigen loss Fibrosis regression liver stiffness measurement Transient elastography

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Effects of small-volume soccer and vibration training on body composition,aerobic fitness,and muscular PCr kinetics for inactive women aged 20-45

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Journal of Sport and Health Science 2014年第4期3卷 284-292页

作者： luke J.Connolly Suzanne Scott Magni Mohr Giorgos Ermidis Ross Julian Jens Bangsbo Sarah R.Jackman Joanna l.Bowtell Rosemary C.Davies Susan J.Hopkins Richard Seymour karen M.Knapp Peter Krustrup Jonathan Fulford Sport and Health Sciences College of Life and Environmental SciencesSt Luke's CampusUniversity of Exeter:Exeter EXI 2LUUK Faculty of Natural and Health Sciences University of the Faroe IslandsTorshavn 100Faroe Islands Department of Food and Nutrition and Sport ScienceUniversity of GothenburgGothenburg 40530Sweden Department of Physical Education and Sport Science Democritus University of ThraceKomotini 69100Greece Institute of Sports and Preventive Medicine University of SaarlandSaarbrücken 66123Germany Copenhagen Centre for Team Sport and Health Department of NutritionExercise and SportsUniversity of Copenhagen.Copenhagen 2200.Denmark College of Engineering Mathematics and Physical SciencesUniversity of ExeterExeter EX4 4QF.UK NIHR Exeter Clinical Research Facility University of Exeter Medical SchoolExeter EX2 5DW.UK

Purpose： The present study investigated the effects of 16 weeks of small-volume, small-sided soccer training soccer group （SG, n = 13） and oscillating whole-body vibration training vibration group （VG, n = 17） on body composition, aerobic fitness, and muscle PCr kinetics in healthy inactive premenopausal women in comparison with an inactive control group （CO, n = 14）. Methods： Training for SG and VG consisted of twice-weekly 15-min sessions with average heart rates （HRs） of ～ 155 and 90 bpm respectively. Pre- and post-measurements of body composition （DXA）, phosphocreatine （PCr） on- and off-kinetics, and HR measurements during stand- ardised submaximal exercise were performed. Results： After 16 weeks of training in SG, fat percentage was lowered （p = 0.03） by 1.7%±2.4% from 37.5% ± 6.9% to 35.8% ± 6.2% and the PCr decrease in the quadriceps during knee-extension ramp exercise was attenuated （4% ± 8%, p = 0.04）, with no changes in VG or CO （time- group effect： p=0.03 and p = 0.03）. Submaximal exercise HR was also reduced in SG after 16 weeks of training （6%± 5% of HRmax, p = 0.01）. Conclusion： Short duration soccer training for 16 weeks appears to be sufficient to induce favourable changes in body composition and indicators of aerobic fitness and muscle oxidative capacity in untrained premenopausal women.

关键词： Fat percentage Heart rate MRS PCr kinetics Small-sided soccer

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串联微柱在超临界流体色谱中的应用

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色谱 1992年第3期10卷 155-157页

作者：马熙中 H-C.karen Chang l.T.Taylor 北京化工学院应用化学系 Department of Chemistry Virginia Polytechniv Insititute and State UniversityBlacksburgVA 24061USA

得力于气相和液相色谱的进步,一种新的色谱技术,超临界流体色谱(SFC)异军突起,而各种柱技术又推动了这种技术的发展速度。在SFC中开管柱和填充柱都在使用,且各具特色。但除了单位柱长具有较大的压降、柱子使用长度受到限制外,填充柱显... 详细信息

得力于气相和液相色谱的进步,一种新的色谱技术,超临界流体色谱(SFC)异军突起,而各种柱技术又推动了这种技术的发展速度。在SFC中开管柱和填充柱都在使用,且各具特色。但除了单位柱长具有较大的压降、柱子使用长度受到限制外,填充柱显示出更多的优点。微柱,即填充石英毛细管柱,内径小于1mm。它以弹性石英毛细管作为柱管,管内填充色谱填料。

关键词：串联微柱超临界流体色谱

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Spectroscopic Sensing Characteristics of Novel Osmium Carbonyl Complexes to DNA and Other Polyanions

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American Journal of Analytical Chemistry 2021年第7期12卷 277-293页

作者： Gregory Ostner Cody Piotrowski Xinyao Ren yu lei Mehrun Uddin Stacey Wong karen Chen lan Pham Elise Megehee Enju Wang Department of Chemistry St. John’s University Jamaica USA

In this research, the absorbance and luminescence response of two osmium(II) phenathrane (phen) carbonyl complexes to various DNA, heparin and i-carrageenan polyanions were studied. The [Os(phen)2CO(l)]2+ complexes with l either a 4-phenyl pyridine (4-phpy) or phenyl imidazole (phimd) group exhibit moderate luminescent intensity in the visible region, their intensities are highly altered by the addition of DNA and other polyanion samples. These luminescent responses to polyanions were also compared with the [Ru(phen)3]2+ complex. In ethanol solution, the presence of polyanions significantly enhanced the luminescent emission intensity of [Os(phen)2CO(l)]2+ complexes with a blue shift. While the polyanions all showed emission enhancement on the highly lumi-nescent [Ru(phen)3]2+ complex in ethanol solution with a red spectra shift. The [Os(phen)2CO(l)] 2+ with (phimd) ligand has the lowest emission in ethanol solution, its intensity can be enhanced up to 11 times in the presence of DNA polyanions. This enhancement for all the complexes in ethanol is mainly due to their electrostatic interaction with the anion sites and with some degree of ligand intercalation into the polyanion hydrophobic structure which reduced the solvent quenching of the complexes. The blue shift of the (4-phpy) and particularly (phimd) Os(II)CO complexes indicate an insertion of the (4-phpy) or (phimd) group into the polymer chains. The two new Os(II)CO complexes has great potential to be used as luminescence sensors for DNA and polyanion detection in the low micro molar range with high sensitivity.

关键词： Os(II)CO Complex Absorbance luminescence Spectroscopy DNA and Polyanion Sensing

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Method Optimization Study on Isolation of Volatile Compounds by Headspace Solid-Phase Microextraction (HS-SPME) from Custard Apple (<i>Annona squamosa</i>l.) Pulp.

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Journal of Analytical Sciences, Methods and Instrumentation 2020年第3期10卷 59-77页

作者： Mércia de Sousa Galvão karen leticia de Santana Juliete Pedreira Nogueira Maria Terezinha Santos leite Neta Narendra Narain Departament of Food Engineering Federal University of Paraiba Jo&atilde o Pessoa Brazil laboratory of Flavor and Chromatographic Analysis PROCTA Federal University of Sergipe S&atilde o Cristóv&atilde o Brazil

Aroma is an important quality parameter, which can help in delaying degradative processes and hence understanding the volatile compounds that are part of an aroma is extremely important. Thus, the aim of this study was to isolate the volatile compounds present in custard apple (Annona squamosa l.) pulp by solid-phase microextraction (SPME) technique using 3 different fibers (DVB/CAR/PDMS, PDMS and PDMS/DVB). An experimental design was set up to evaluate the best extraction conditions wherein the variables were extraction temperature (minimum 28°C, maximum 62°C), ionic strength (minimum 0, maximum 30.0%) and sample concentration (min 1, max 99.0%). The separation of volatiles was achieved in chromatographic columns of different polarity (polar and non-polar) while identification of volatile compounds was performed by high resolution gas chromatography system coupled with mass spectrometry. The results obtained using 3 different fibers revealed the isolation of 71 compounds with fiber DVB/CAR/PDMS, while only 30 and 21 compounds were isolated using fibers PDMS/DVB and PDMS, respectively. The major classes of compounds identified were terpenes, esters, alcohols and aldehydes. Optimum conditions for obtaining higher number of volatiles for non-polar column were 45°C for extraction temperature, 15% of sodium chloride and 50% of pulp amount which resulted in isolation of a maximum of 78 peaks.

关键词： Flavor SPME Response Surface Methodology Volatiles Gas Chromatography-Mass Spectrometry

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作者： (美)英格丽·格拉-洛佩兹(Ingrid Guerra-lópez)，(美)卡伦·希克斯(karen Hicks)

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西藏牦牛绒原绒细度和伸直长度及其与年龄和性别的关系

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毛纺科技 2024年第5期52卷 98-102页

作者：孙建平阿旺吕汪汪刘云霞贾跃凤斯确多吉汪诗平中国科学院青藏高原研究所青藏高原地球系统与资源环境国家重点实验室北京100101 中国科学院大学北京100049 西藏低碳草牧科技有限公司西藏拉萨850001

为了解藏北高原牦牛绒的基本特征,进一步明晰该区域牦牛绒品质及市场开发前景,采集藏北高原12个县1107头牦牛的牦牛绒样品,采用光学投影显微镜和钢尺分别测量牦牛绒的细度和伸直长度,并分析其与牦牛年龄和性别的关系。结果表明:藏北高... 详细信息

为了解藏北高原牦牛绒的基本特征,进一步明晰该区域牦牛绒品质及市场开发前景,采集藏北高原12个县1107头牦牛的牦牛绒样品,采用光学投影显微镜和钢尺分别测量牦牛绒的细度和伸直长度,并分析其与牦牛年龄和性别的关系。结果表明:藏北高原牦牛绒的平均细度和伸直长度分别为17.88μm和47.2 mm,二者之间无显著相关性;随着牦牛年龄的增长,牦牛绒的细度显著增加,而伸直长度变化不显著;牦牛性别并不影响牦牛绒细度和伸直长度的变化,为藏北高原乃至我国牦牛绒等级评定提供数据支撑。

关键词：藏北高原牦牛绒细度伸直长度年龄性别

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猪巴氏杆菌病

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国外畜牧学（猪与禽） 2014年第S1期34卷 14-26页

作者：高娃林靖凯 karen B. Register Susan l.Brockmeier Marten F. de Jong Carlos Pijoan 山东益生种畜禽股份有限公司

1相关性1880年,路易斯·巴斯德从禽霍乱病例中分离到了多杀性巴氏杆菌(Pasteurella multocida,Pm),从而确认巴氏杆菌属为致病微生物。之后,以他的名字命名了这个菌属。多杀性巴氏杆菌被确认为猪呼吸系统疾病的病原体已经超过125年。然而... 详细信息

1相关性1880年,路易斯·巴斯德从禽霍乱病例中分离到了多杀性巴氏杆菌(Pasteurella multocida,Pm),从而确认巴氏杆菌属为致病微生物。之后,以他的名字命名了这个菌属。多杀性巴氏杆菌被确认为猪呼吸系统疾病的病原体已经超过125年。然而,由于其可引起猪的渐进性萎缩性鼻炎(Atrophic Rhinitis,PAR)和肺炎,因此此细菌在世界各地持续显著影响着猪的健康。

关键词：猪巴氏杆菌病萎缩性鼻炎巴氏杆菌属多杀性巴氏杆菌 multocida Pasteurella 鼻

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汉娜的手提箱

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丛书名：岁月

2004年

作者：（加）凯伦·莱温（karen levine）林达译

该书采用了两名当事人的口述录音－－日本浩劫教育中心的史子和汉娜的哥哥乔治，让他们各自从自己的角度，讲述了半个多世纪前一个死于纳粹集中营的女孩的故事。

ISBN: (纸本)7540431733

关键词：文学美洲文学

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一种新型水分散型IPBC杀菌剂及其性能

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精细与专用化学品 2008年第9期16卷 15-17页

作者：张明刚瞿欣 Winkowski karen 领先特品化学(上海)有限公司上海200233 美国国际特品公司

随着环保意识的不断提高和环保法规的逐步完善,涂料行业对VOC(挥发性有机化合物)和HMPs(有害物质)的控制进一步严格。我国现行的强制性国家标准中,内墙乳胶漆VOC含量要不超过200g/l,如果要获得绿色环保"十环标志",则VOC的含量要低于100... 详细信息

随着环保意识的不断提高和环保法规的逐步完善,涂料行业对VOC(挥发性有机化合物)和HMPs(有害物质)的控制进一步严格。我国现行的强制性国家标准中,内墙乳胶漆VOC含量要不超过200g/l,如果要获得绿色环保"十环标志",则VOC的含量要低于100克g/l。2007年1月1日起,欧盟国家实施新的漆类标准中,要求每升水性漆VOC含量应低于100g,溶剂性漆的VOC含量应低于每升400g。涂料的水性化趋势越来越明显,水性涂料占据了越来越大的市场份额。水性涂料以水为分散介质并富含各种可被微生物作为营养利用的添加剂,为微生物的生长繁殖提供了条件。当细菌、霉菌和酵母菌等微生物污染涂料后大量繁殖会导致涂料产生表面色变、pH值变化、使用性能变化、凝聚以及产生异味等一系列问题,从而使涂料产品失去价值造成巨大损失。随着水性涂料的广泛应用,控制微生物生长和繁殖从而避免涂料被污染,对于保证涂料产品的品质和使用效果是非常重要的。

关键词：水分散型性能变化强制性国家标准杀菌剂 VOC含量微生物污染挥发性有机化合物内墙乳胶漆

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