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The AlMaQUEST Survey ⅩⅤ:The dependence of the molecular-to-atomic gas ratios on resolved optical diagnostics

Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 174-196页

作者： Niankun Yu Zheng Zheng Chao-Wei Tsai Pei Zuo Sara l.Ellison David V.Stark Di li Jingwen Wu karen l.masters Ting Xiao Yinghui Zheng Zongnan li Kai Zhang Hongying Chen Shu liu Sihan Jiao Fanyi Meng National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Key laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Department of Physics&Astronomy University of VictoriaVictoriaV8P 1A1Canada Departments of Physics and Astronomy Haverford CollegeHaverford19041USA Space Telescope Science Institute San Martin Dr.Baltimore 21218USA Zhejiang laboratory Hangzhou 311121China New Cornerstone Science laboratory Shenzhen 518054China School of Physics Zhejiang UniversityHangzhou 310058China

The atomic-to-molecular gas conversion is a critical step in the baryon cycle of galaxies,which sets the initial conditions for subsequent star formation and influences the multi-phase interstellar *** compiled a sample of 94 nearby galaxies with observations of multi-phase gas contents by utilizing public H_(Ⅰ),CO,and optical IFU data from the Ma NGA survey together with new FAST H_(Ⅰ)*** agreement with previous results,our sample shows that the global molecular-to-atomic gas ratio(R_(mol)≡log M_(H2)/M_(H_(Ⅰ)))is correlated with the global stellar mass surface densityμ_*with a Kendall'sτcoefficient of 0.25 and pless tightly but still correlated with stellar mass and NUV-r color,and not related to the specific star formation rate(sSFR).The cold gas distribution and kinematics inferred from the H_(Ⅰ)and CO global profile asymmetry and shape do not significantly rely on R_(mol).Thanks to the availability of kpc-scale observations of MaNGA,we decompose galaxies into H_(Ⅱ),composite,and AGN-dominated regions by using the BPT *** increasing R_(mol),the fraction of H_(Ⅱ)regions within 1.5 effective radius decreases slightly;the density distribution in the spatially resolved BPT diagram also changes significantly,suggesting changes in metallicity and ionization *** with high R_(mol)tend to have high oxygen abundance,both at one effective radius with a Kendall'sτcoefficient of 0.37(pl *** all parameters investigated here,the oxygen abundance at one effective radius has the strongest relation with global R_(mol).The dependence of gas conversion on gas distribution and galaxy ionization states is *** contrast,the observed positive relation between oxygen abundance(μ_(*))and R_(mol)indicates that the gas conversion is efficient in regions of high metallicity(density).

关键词： Galaxies baryon cycle radio lines H_(Ⅰ)21 cm atomic-to-molecular gas conversion

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Are there sex-based disparities in cataract surgery?

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 137-143页

作者： Matthew D.Geiger Anne M.lynch Alan G.Palestine Nathan C.Grove karen l.Christopher Richard S.Davidson Michael J.Taravella Naresh Mandava Jennifer l.Patnaik Department of Ophthalmology University of Colorado School of MedicineAuroraCO 80045USA

AIM:To investigate sex-based differences in the occurrence of intra-operative and post-operative complications and associated visual outcomes following cataract ***:This was a retrospective study of patients who had phacoemulsification cataract surgery at the University of Colorado School of *** collected included the patient’s health history,ocular comorbidities,operative and post-operative complications,and the post-operative best corrected visual acuity(BCVA).The data were analyzed using univariate and multivariable logistic regression with generalized estimating equations to account for the correlation of some patients having two eyes included in the ***:A total of 11977 eyes from 7253 patients were included in the *** comorbidities differed by sex,with males having significantly higher percentages of traumatic cataracts(males 0.7%vs females 0.1%),prior ocular surgery(6.7%vs 5.5%),and mature cataracts(2.8%vs 1.9%).Conversely,females had significantly higher rates of pseudoexfoliation(2.0%vs 3.2%).In unadjusted analysis,males had higher rates of posterior capsular rupture(0.8%vs 0.4%)and vitreous loss(1.0%vs 0.6%),but this difference was not significant after adjustment for *** had a significantly increased risk of post-operative retinal detachment,but in multivariable analysis this was no longer *** were significantly less likely to undergo post-operative neodymium-doped yttrium aluminum garnet(Nd:YAG)laser capsulotomy for posterior capsule opacification(OR=0.8,95%CI=0.7-0.9,P=0.0005).The BCVA was slightly worse for males pre-operatively;but post-operatively,both sexes exhibited similar visual acuity of Snellen equivalent 20/***:The study finds that in a cohort of patients presenting for cataract surgery,sex differences exist in pre-operative comorbidities and surgical characteristics that contribute to higher rates of some complications for ***,observed surgical complicatio

关键词： cataract surgery sex-based disparity phacoemulsification outcomes

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Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls

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World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： Cornelia Wiechers Julian Sowula karen Kreutzer Christoph E.Schwarz Christina Weismann Michael Krimmel Christian F.Poets Bernd Koos Department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany Department of Orthodontics Tuebingen University HospitalTuebingenGermany Department of Oral and Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background Various conservative and surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between May 2018 and Nov *** with RS received 3D-photographs during clinically indicated *** controls were recruited from Dec 2018 to Sep 2019 and received 3D-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(l),and the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANB’.Results A total of 2073D images,obtained in 19 infants with RS and 32 controls,were *** and ANB’decreased over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANB’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANB’-1.7°(95%CI−2.4 to−1.0)].Also,the ANB’model showed a significant effect of the interaction term diagnosis x *** Based on longitudinal 3D images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant Mandibular catch-up growth Pre-epiglottic Baton Plate Robin sequence Three-dimensional photography

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A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(Froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

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Insect Science 2024年第4期31卷 1285-1295页

作者： Melissa l.Starkie Elizabeth V.Fowler Alexander M.Piper Xiaocheng Zhu Pauline Wyatt David Gopurenko Matt N.Krosch Francesca Strutt karen F.Armstrong Hamish Patrick Mark K.Schutze Mark J.Blacket Department of Agriculture and Fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia Forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;however,some characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then developed a tetra-primer amplification refractory mutation system(ARMS)PCR assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer universal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surveillance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

关键词： ARMS-PCR colony molecular diagnostics pangolin tetra-primer

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Surgical or medical treatment of obesity-associated type 2 diabetesan increasing clinical conundrum

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World Journal of Diabetes 2024年第10期15卷 2036-2040页

作者： Ryan J Jalleh karen l Jones Md Shahidul Islam lu Cai Michael Horowitz Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Endocrine and Metabolic Unit Royal Adelaide HospitalAdelaide 5000South AustraliaAustralia Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Pediatric Research Institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States

In this editorial,we comment on the article by He et al,specifically in relation to the efficacy of bariatric surgery vs glucagon-like peptide-1 receptor agonist(GlP-1RA)therapy in the management of type 2 diabetes(T2D)associated with *** surgery has now also been shown to be safe and effective in pre-teens and teenagers with obesity and T2D,but information on newer GlP-1RAs in these groups is predictably *** older individuals(age>65 years),both bariatric surgery and GlP-1RA therapy improve cardiovascular ***-tric surgery is not infrequently associated with post-operative postprandial hypoglycemia,which is not the case with GlP-1RAs and,paradoxically,there is evidence that GlP-1RAs may reduce both the frequency and severity of postprandial *** trials of the long-term efficacy of bariatric surgery and GlP-1RAs are indicated.

关键词： Glucagon-like peptide-1 Glucagon-like peptide-1 receptor agonist Obesity Diabetes Weight loss Bariatric surgery Metabolic surgery Hypoglycemia

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Protein construct optimization:data sharing strategy

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Protein & Cell 2012年第5期3卷 321-322页

作者： karen M.Polizzi Rivka l.Isaacson Center for Synthetic Biology and Innovation Division of Molecular BiosciencesImperial College LondonLondon SW72AZUK Center for Structural Biology Division of Molecular BiosciencesImperial College LondonLondon SW72AZUK

The British Medical Journal devoted its first issue of 2012 to the problem of unreported clinical trial data,highlighting the serious impact that incomplete information can have on world health(for an editorial summary see lehman and loder,2012).Adopted innovations in clinical intervention,inappro-priately based on only a subset of trial data,can,at best,prove uneconomical and,at worst,lead to large-scale patient *** its consequences may be most severe in medicine this problem applies to many scientific disciplines and we are now seeing a move towards greater transparency in data declaration.

关键词： subset consequences incomplete

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Taxonomy of Pseudolagarobasidium(Polyporales,Basidiomycota)

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Fungal Diversity 2012年第4期55卷 155-169页

作者： karen K.Nakasone Daniel l.lindner Center for Forest Mycology Research Northern Research StationU.S.Forest ServiceOne Gifford Pinchot DriveMadisonWI 53726-2398USA

Pseudolagarobasidium(Polyporales,Basidiomycota)is a small,monophyletic genus of crustose,wood-inhabiting fungi with spines and a saprobic,endophytic,or parasitic *** species are accepted in the genus including two new species,*** from Belize and *** from *** analysis of the internal transcribed spacer of the ribosomal RNA gene places *** in a monophyletic clade with *** and an undescribed foliar *** combinations proposed include *** for Irpex modestus Berk.,*** for Hydnum pronum Berk.&Broome which is an earlier name for ***,and *** for Radulodon venustus Hjortstam&*** colliculosum Berk.&Broome from Sri lanka is conspecific with *** species,Sistotrema ochroleucum and Radulum concentricum are not accepted in *** is compared with Radulodon and similar genera.A key to the species of Pseudolagarobasidium is provided.

关键词： Pirex concentricum Pseudolagarobasidium acaciicola P.leguminicola Hydnum ayresii Microbinding hyphae

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Sharing Results with Clinical Trial Participants： Insights from an Online Survey of Chinese Consumers

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Chinese Medical Journal 2016年第8期129卷 1007-1008页

作者： Janelle R Keys Julie A Monk karen l Woolley ProScribe-Envision Pharma Group Sydney NSW 2113 Australia Faculty of Science Health Education and Engineering University of the Sunshine Coast Maroochydore DC Queensland Australia Faculty of Health and Behavioural Sciences University of Queensland Brisbane Queensland Australia

To the Editor：Clinical trial participants have a right to know the results from the trials that they enable. European and North American research,however,shows that trial results are rarely shared with participants. Given the increase in industry-sponsored trials in China,we conducted the first investigation into Chinese consumer views about sharing the clinical trial results with participants.

关键词： Sharing Results Clinical Trial Participants Chinese Consumers

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Metadata requirements analysis for the emerging Sensor Web

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International Journal of Digital Earth 2009年第S01期2卷 3-17页

作者： liping Di karen l.Moe Genong(Eugene)Yu Center for Spatial Information Science and Systems(CSISS) George Mason University6301 Ivy LnSuite 620GreenbeltMD 20770USA Earth System Technology Office NASA/GSFC MS Code 407GreenbeltMD 20771USA

The Sensor Web has emerged from Earth Science research with the development of Web technology,to achieve process automation,sensor interoperation,and service *** promises require the discovery of the right sensor at the right time and the right location with the right ***,for sensor,platform,and data,are crucial for achieving such ***,analysis and practical use of these metadata reveals that the metadata and their associations are not applicable or suitable for the Sensor *** shortfalls are(1)the nonstandard metadata expression language;(2)the missing link between sensor and domain knowledge;(3)the insufficiency in the information for geographic locating and sensor tasking;and(4)the enhanced requirements on the quality,security,and ownership of both sensors and their sensed *** paper reviews the current standards that have metadata components for the sensor and its platform,especially those from ISO TC211,Open Geospatial Consortium Inc.,and The National Aeronautics and Space Administration Global Change Master Directory.A recommendation on metadata that meets the requirement of crossmission sensor discovery in a pervasive Web environment is derived from *** recommendation addresses issues on language formalization,sensor geolocation,semantics,quality,and *** of the emerging semantic Web technology for enabling robust discovery of sensor are discussed.

关键词： Sensor Web geospatial standards metadata interoperation semantic web

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Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant *** infection with osseointegration in murine models of implant-associated osteomyelitis

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Bone Research 2023年第4期11卷 751-763页

作者： Youliang Ren Jason Weeks Thomas Xue Joshua Rainbolt karen l.de Mesy Bentley Ye Shu Yuting liu Elysia masters Philip Cherian Charles E.McKenna Jeffrey Neighbors Frank H.Ebetino Edward M.Schwarz Shuting Sun Chao Xie Center for Musculoskeletal Research University of Rochester Medical CenterRochesterNY 14642USA Department of Orthopaedics University of Rochester Medical CenterRochesterNY 14642USA Department of Pathology and Center for Advanced Research Technologies University of Rochester Medical CenterRochesterNY 14642USA BioVinc LLCPasadenaCA 91107USA Department of Chemistry University of Southern CaliforniaLos AngelesCA 90089USA Department of Pharmacology Pennsylvania State UniversityHersheyPA 17033USA Department of Chemistry University of RochesterRoche

Eradication of MRSA osteomyelitis requires elimination of distinct *** overcome this,we developed bisphosphonateconjugated sitafloxacin(BCS,BV600072)and hydroxybisphosphonate-conjugate sitafloxacin(HBCS,BV63072),which achieve“target-and-release”drug delivery proximal to the bone infection and have prophylactic efficacy against MRSA static biofilm in vitro and in *** we evaluated their therapeutic efficacy in a murine 1-stage exchange femoral plate model with bioluminescent MRSA(USA300lAC::lux).Osteomyelitis was confirmed by CFU on the explants and longitudinal bioluminescent imaging(BlI)after debridement and implant exchange surgery on day 7,and mice were randomized into seven groups:1)Baseline(harvested at day7,no treatment);2)HPBP(bisphosphonate control for BCS)+vancomycin;3)HPHBP(hydroxybisphosphonate control for HBCS)+vancomycin;4)vancomycin;5)sitafloxacin;6)BCS+vancomycin;and 7)HBCS+*** confirmed infection persisted in all groups except for mice treated with BCS or HBCS+*** revealed catastrophic femur fractures in all groups except mice treated with BCS or HBCS+vancomycin,which also displayed decreases in peri-implant bone loss,osteoclast numbers,and *** confirm this,we assessed the efficacy of vancomycin,sitafloxacin,and HBCS monotherapy in a transtibial implant *** results showed complete lack of vancomycin efficacy while all mice treated with HBCS had evidence of infection control,and some had evidence of osseous integrated septic implants,suggestive of biofilm *** together these studies demonstrate that HBCS adjuvant with standard of care debridement and vancomycin therapy has the potential to eradicate MRSA osteomyelitis.

关键词： implant infection overcome

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