检索结果-南通市图书馆

Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease

World Journal of Gastroenterology 2008年第6期14卷 845-852页

作者： Gert De Hertogh Jeroen Aerssens karen p geboes Karel geboes Karel geboes Department of Pathology University Hospitals KULeuven Minderbroedersstraat 12 Leuven 3000 Belgium Tibotec bvba Generaal De Wittelaan L 11B 3 Mechelen 2800 Belgium Department of Gastroenterology University Hospitals KULeuven Herestraat 49 Leuven 3000 Belgium

Many advances have been made in the understanding of Crohn’s disease (CD) pathogenesis during the last decade. CD is currently seen as a predominantly T-lym-phocyte-driven disease characterized by the presence of a complex cocktail of interacting cytokines, chemokines and other mediators produced by a variety of cell types. prevailing theories of CD pathogenesis suggest that patients’ T-lymphocytes are inappropriately activated in the setting of an immune imbalance, which is itself caused by an unfortunate confluence of genetic and en- vironmental factors. The T-cell response then leads to the chronic inflammation characteristic for the disease. Various environmental factors may play a role in the development of CD, but microbes are most consistently implied. This theory is based on epidemiological, clinico- pathological, genetic and experimental evidence. Despite the abundance of arguments for the implication of bac-teria in the aetiopathogenesis of CD, the precise role of bacteria in this disease still remains elusive. Three not necessarily mutually exclusive theories have been pro- posed: (1) an unidentified persistent pathogen; (2) an abnormally permeable mucosal barrier leading to exces-sive bacterial translocation; and (3) a breakdown in the balance between putative "protective" versus "harmful" intestinal bacteria ("dysbiosis"). At present, one cannot exclude with certainty any of these three proposed hy-potheses; they may all apply to CD to a certain extent.

关键词： Crohn's disease Etiology Microbiology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Social cliques in male northern muriquis Brachyteles hypoxanthus

引用

Current Zoology 2012年第2期58卷 342-352页

作者： Marcos TOKUDA Jean p. BOUBLI patricia IZAR karen B. STRIER Department of Experimental psychology University of S~io Paulo Av. Prof. Mello Moraes 1721 CEP 05508-030 Sao Paulo Brazil Wildlife Conservation Society Rio de Janeiro Brazil Department of Anthropology University of Wisconsin-Madison USA

Analyses of spatial relationships and social interactions provide insights into the social structure of animal societies and the ways in which social preferences among and between dyads affect higher order social relationships. In this paper we de- scribe the patterns of spatial associations and social interactions among adult male northern muriquis in order to evaluate the dy- namics of their social networks above the dyadic levels. Systematic observations were made on the 17 adult males present in a multi-male/multi-female group from April 2004 through February 2005, and in July 2005. Analyses of their spatial relationships identified two distinct male cliques; some adult males （called ＂N＂ males） were more connected to the females and immatures than other adult males （＂MU＂ males）, which were more connected to one another. Affiliative interactions were significantly higher among dyads belonging to the same clique than to different cliques. Although frequencies of dyadic agonistic interactions were similarly low among individuals within and between cliques, MU males appeared to be subordinate to N males. Nonetheless, there were no significant differences in the copulation rates estimated for MU males and N males. Mutual benefits of cooperation between MU and N cliques in intergroup encounters might explain their ongoing associations in the same mixed-sex group

关键词： Brachyteles hypoxanthus Male northern muriquis Social relationship Social clique Social network analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Safety and efficacy outcomes of the Xen45 Gel Stent use for refractory glaucoma:a surgery series from surgeon trainees at a tertiary teaching hospital

引用

Eye and Vision 2020年第1期7卷 47-57页

作者： karen Hong John Lind Arsham Sheybani Department of Ophthalmology and Visual Sciences Washington University School of MedicineSt.LouisMOUSA Barnes-Jewish Center for Outpatient Health 4901 Forest Park AvenueSt LouisMO 63110USA

Background:To study the effect of an ab interno gelatin stent(XEN45 Gel Stent,Allergan Inc.,Irvine,California,USA)on intraocular pressure(IOp)as placed by glaucoma fellowship trainees in eyes with refractory ***:A prospective noncomparative study at a tertiary training center on 28 unique eyes undergoing ab interno gelatin stent implantation by glaucoma fellowship *** was collected at baseline and postoperatively at day 1,week 1,and months 1,3,5,and *** outcome was mean IOp *** outcomes included change in number of glaucoma medication classes and visual *** outcomes included needling *** success was defined by achieving≥20%reduction in IOp with the same or fewer classes of antiglaucoma medications from baseline without the need for secondary surgical intervention and/or stent ***:At baseline,28.6%(8/28)of the subjects had prior failed incisional glaucoma surgery in a study population that was 54%African-American,with 78%with severe glaucoma(average mean deviation of−14.58 dB).Thirteen subjects terminated their clinic visits before their 12-month postoperative visit,leaving 15 subjects for end point *** IOp went from 21.6 mmHg(range 12.0–31.0,SD 6.6)at baseline to 12.5 mmHg(range 7.0–19.0,SD 3.6),a 42.1%reduction(ppp at 12 *** Kaplan-Meier cumulative probability of success for all 28 subjects at 12 months was 70.4%(95%CI:44.7–85.8%).Regardless of the length of follow-up,21.4%(6/28)met failure criteria:3 subjects failed because they required secondary surgical intervention,and the other 3 did not have adequate IOp *** bleb needling rate was 28.6%(8/28)and repeat was 17.9%(5/28).Conclusions:Compared to the re

关键词： XEN Investigational devices Glaucoma Gelatin stent Ab interno surgery Minimally invasive glaucoma surgery Subconjunctival drainage Gelatin microstent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-invasive electrical stimulation as a potential treatment for retinal degenerative diseases

引用

Neural Regeneration Research 2021年第8期16卷 1558-1559页

作者： karen Chang Sam Enayati Kin-Sang Cho Tor p.Utheim Dong Feng Chen Schepens Eye Research Institute of Massachusetts Eye and Ear Department of OphthalmologyHarvard Medical SchoolBostonMAUSA Department of Medical Biochemistry Oslo University HospitalOsloNorway Department of Ophthalmology Drammen HospitalNorway

More than 38.5 million people are estimated to be affected by blindness worldwide in 2020(Flaxman et al., 2017). Among the diseases that cause visual impairment, refractive errors are typically corrected with glasses and cataract with surgery. The leading causes of irreversible blindness nowadays are usually degenerative diseases related to the retina and its extending optic nerves.

关键词： glasses treatment typically

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Taking up the reins of power:metabolic functions of p53

引用

Journal of Molecular Cell Biology 2019年第7期11卷 610-614页

作者： Timothy Humpton karen H.Vousden The CRUK Beatson Institute Glasgow G61 1BDUK The Francis Crick Institute London NW1 1ATUK

The clear importance of p53 as a tumour suppressor protein has propelled decades of in tense research focused on understanding the functions of p53 and attempting to harness this knowledge for patient benefit.p53 plays a pivotal role in the ability of cells to sense and respond to stress-functions that contribute not only to limitation of cancer development,but also to modulating numerous other aspects of health and *** the can on ical activities of p53 relate to the elimination of damaged cells through cell death or senescenee,more recent work has highlighted a role for p53 as a guardian of cell survival and facilitator of adaptation during metabolic *** emerging metabolic features of p53 activity are proving to be crucial for many of its essential functions.

关键词： importance protein functions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Occurrence and fate of endogenous steroid hormones,alkylphenol ethoxylates, bisphenol A and phthalates in municipal sewage treatment systems

引用

Journal of Environmental Sciences 2017年第11期29卷 49-58页

作者： Qian Wu James C.W.Lam karen Y.Kwok Mirabelle M.p.Tsui paul K.S.Lam State Key Laboratory in Marine pollution (SKLMp) Department of Biology and Chemistry Research Centre for the Oceans and Human Health Shenzhen Key Laboratory for Sustainable Use of Marine Biodiversity City University of Hong Kong Department of Science and Environmental Studies The Education University of Hong of Kong

Steroid hormones, alkylphenol ethoxylates（ApEOs） and phthalic acid esters（pAEs） are emerging endocrine disrupting chemicals（EDCs） that can interfere with the endocrine function in organisms at low concentrations. The occurrence, distribution behavior, removal rate and the fate of 31 target EDCs in sewage treatment plants, which consist of various treatment facilities and receiving water in Hong Kong, were investigated. Estrone,nonylphenol-di-ethoxylate and diethyl phthalate were found to be dominant in each group of influent samples with concentrations ranging from 11–33, 747–3945 and 445–4635 ng/L,respectively. Conversely, progesterone, nonylphenol-mono-ethoxylate and bis（2-ethylhexyl）phthalate were the most abundant in dewatered sludge, with concentrations ranging from 0.9–237, 75–19,743 and 4310–37,016 ng/g（dry weight）. The removal rates of primary sedimentation and disinfection approaches were lower than 30% for most of the chemicals,while those of activated sludge and reverse osmosis were greater than 80% for more than two-thirds of the compounds, noticeably decreasing the estrogenic risk of sewage discharged into the environment. Steroid hormones were removed via biological degradation, while some ApEOs and pAEs adsorbed to the sludge. Victoria Harbor poses a low to medium estrogenic risk mainly contributed by estrone and estradiol and deserves attention.

关键词： Endocrine disruptor Steroid hormone Alkylphenol ethoxylate phthalic acid ester Risk assessment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High pressure responsive luminescence of flexible Eu^(3+) doped pVDF fibrous mats

引用

Journal of Materials Science & Technology 2021年第7期66卷 103-111页

作者： Carlos Hernandez San tosh K.Gupta Jose p.Zuniga Jorge Vidal Rene Galvan Hector Guzman Lilian Chavez karen Lozano Yuanbing Mao Department Department of Chemistry University of Texas Rio Grande Valley1201 West University DriveEdinburgTX 78539USA Radiochemistry Division Bhabha Atomic Research CentreTrombayMumbai400085USA Department of Electrical Engineering University of Texas Rio Grande ValleyEdinburgTX 78539USA Department of Chemistry Illinois Institute of Technology3105 South Dearborn StreetChicagoIL 60616USA

Exploring lanthanide doped materials and their high-pressure optical properties is important from the perspective of designing pressure sensors, piezoelectric materials, scintillators, and optoelectronic devices, just to mention a few. Understanding the high-pressure optical properties of polymeric fibrous mats provides significant advantages in terms of flexibility, tunability, facile processability, and malleability. In this work, we have developed flexible polyvinylidene difluoride(pVDF) fibrous mats doped with an Eu^(3+) source of Eu(NO_(3))_(3)·5H_(2)O(EN-pF) or Eu_(2)(SO_(4))_(3)(ES-pF) by a Forcespinning■ method. Microstructural analysis of these two systems indicates that Eu(NO_(3))_(3)·5H_(2)O and Eu_(2)(SO_(4))_(3) are homogeneously distributed and dispersed into the pVDF matrix. Fiber formation promotes a β-phase pVDF. Eu^(3+) doping increases the β-phase. Its fraction is larger for the ES-pF mats. To understand their high-pressure optical properties, their photoluminescence spectra have been taken at various pressures up to 58 Gpa in a diamond anvil cell. High-pressure luminescence illustrates a clear change in asymmetry ratio, peak intensity, peak breadth, color coordinate, and color temperature of Eu^(3+) ions from both EN-pF and ES-pF with a different extent of changes. Specifically, Eu^(3+) ions in the ES-pF mats switch from asymmetric to symmetric environment as pressure increases. Those in the EN-pF mats present symmetric environment for all tested pressures. Both of the Eu^(3+) doped pVDF systems present irreversible changes. Therefore,the EN-pF fibrous mats present an opportunity to make pressure induced red-orange-yellow tunable phosphors for multifunctional applications.

关键词： polyvinylidene difluoride Europium Fiber High pressure Luminescence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Monarchs in decline： a collateral landscape-level effect of modern agriculture

引用

Insect Science 2018年第4期25卷 528-541页

作者： Carl Stenoien Kelly R. Nail Jacinta M. Zalucki Hazel parry karen S. Oberhauser Myron p. Zalucki Department of Ecology Evolution and Behavior University of Minnesota St. Paul Minnesota Australia Conservation Biology Graduate program University of Minnesota St. Paul Minnesota USA School of Environmental Studies Griffith University Brisbane Queensland Australia CSIRO Ecosystems Sciences Precinct Brisbane Queensland Australia Department of Fisheries Wildlife and Conservation Biology University of Minnesota St. Paul Minnesota USA School of Biological Sciences the University of Queensland Brisbane Queensland Australia

We review the postulated threatening processes that may have affected the de- cline in the eastern population of the monarch butterfly, Danausplexippus L. （Lepidoptera： Nymphalidae）, in North America. Although there are likely multiple contributing factors, such as climate and resource-related effects on breeding, migrating, and overwintering populations, the key landscape-level change appears to be associated with the widespread use of genetically modified herbicide resistant crops that have rapidly come to dominate the extensive core summer breeding range. We dismiss misinterpretations of the apparent lack of population change in summer adult count data as logically flawed. Glyphosate-tolerant soybean and maize have enabled the extensive use of this herbicide, generating widespread losses of milkweed （Asclepias spp.）, the only host plants for monarch larvae. Modeling studies that simulate lifetime realized fecundity at a landscape scale, direct counts of milkweeds, and extensive citizen science data across the breeding range suggest that a herbicide-induced, landscape-level reduction in milkweed has precipitated the decline in monarchs. A recovery will likely require a monumental effort for the re-establishment of milkweed resources at a commensurate landscape scale.

关键词： Asclepias citizen science conservation Danausplexippus migration transgenic GM crops

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Meat juice contributes to the stability of ethanol adaptation in Salmonella enterica serovar Enteritidis

引用

Food Quality and Safety 2021年第3期5卷 291-296页

作者： Shoukui He karen Fong Siyun Wang Xianming Shi MOST-USDA Joint Research Center for Food Safety School of Agriculture and BiologyState Key Lab of Microbial MetabolismShanghai Jiao Tong UniversityShanghaiChina Food Nutrition and HealthFaculty of Land and Food SystemsThe University of British ColumbiaVancouverBCCanada

Stability assessme nt of observed tolerance phe no types is integral in un dersta nding stress adaptati on in food-borne ***,the current work was carried out to determine whether ethanol adaptation induced by exposure to 5 percent ethanol for 60 min is a stable phenomenon in Salmonella enterica serovar *** capacity of Salmonella Enteritidis(***)to maintain the acquired ethanol adaptation in the absenee of sublethal ethanol stress was investigated at 37℃,25℃ or 4℃ in Luria-Bertani broth and two types of meat *** was found that ethanol adaptation was completely reversed within 40 min at 37℃ or within 60 min at 25℃,but was stable at 4℃ for at least 48 h in the broth *** adaptation was retained in chicken juice during 60-min incubation at 25℃ or 48h incubation at 4℃.Moreover,exposure to pork juice stored at either 25℃ or 4℃ sigrdficantly(ppted ***,these fin dings suggest that ethanol adaptation stability in *** teritidis under cold conditi ons and in meat juices should be take n into acco unt whe n con ducting a comprehensive risk analysis during food processing.

关键词： Salmonella Enteritidis ethanol adaptation stability temperature meat juice.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Technological,environmental and biological factors:referent variance values for infrared imaging of the bovine

引用

Journal of Animal Science and Biotechnology 2015年第4期6卷 469-484页

作者： Yuri R.Montanholi Melissa Lim Alaina Macdonald Brock A.Smith Christy Goldhawk karen Schwartzkopf-Genswein Stephen p.Miller Department of Animal and poultry Science University of Guelph Department of plant and Animal Sciences Dalhousie University Monsanto HeadingleyMB R3T 6E3Canada Agriculture and Agri-Food Canada Faculty of Veterinary Medicine University of Calgary Invermay Agricultural Centre AgResearch Limited

Background： Despite its variety of potential applications, the wide implementation of infrared technology in cattle production faces technical, environmental and biological challenges similar to other indicators of metabolic state. Nine trials, divided into three classes （technological, environmental and biological factors） were conducted to illustrate the influence of these factors on body surface temperature assessed through infrared imaging. Results： Evaluation of technological factors indicated the following： measurements of body temperatures were strongly repeatable when taken within ]0 s; appropriateness of differing infrared camera technologies was influenced by distance to the target; and results were consistent when analysis of thermographs was compared between judges. Evaluation of environmental factors illustrated that wind and debris caused decreases in body surface temperatures without affecting metabolic rate; additionally, body surface temperature increased due to sunlight but returned to baseline values within minutes of shade exposure. Examination/investigation/exploration of animal factors demonstrated that exercise caused an increase in body surface temperature and metabolic rate. Administration of sedative and anti-sedative caused changes on body surface temperature and metabolic rate, and during late pregnancy a foetal thermal imprint was visible through abdominal infrared imaging. Conclusion： The above factors should be considered in order to standardize operational procedures for taking thermographs, thereby optimizing the use of such technology in cattle operations.

关键词： Body heat loss Convective heat loss Infrared imaging Oxygen consumption pharmacodynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：