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Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls

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World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： Cornelia Wiechers Julian Sowula karen Kreutzer Christoph E.Schwarz Christina Weismann Michael Krimmel Christian F.Poets Bernd Koos department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft Lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany department of Orthodontics Tuebingen University HospitalTuebingenGermany department of Oral and Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background Various conservative and surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between May 2018 and Nov *** with RS received 3d-photographs during clinically indicated *** controls were recruited from dec 2018 to Sep 2019 and received 3d-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(L),and the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANB’.Results A total of 2073d images,obtained in 19 infants with RS and 32 controls,were *** and ANB’decreased over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANB’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANB’-1.7°(95%CI−2.4 to−1.0)].Also,the ANB’model showed a significant effect of the interaction term diagnosis x *** Based on longitudinal 3d images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant Mandibular catch-up growth Pre-epiglottic Baton Plate Robin sequence Three-dimensional photography

Are there sex-based disparities in cataract surgery?

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 137-143页

作者： Matthew d.Geiger Anne M.Lynch Alan G.Palestine Nathan C.Grove karen L.Christopher Richard S.davidson Michael J.Taravella Naresh Mandava Jennifer L.Patnaik department of Ophthalmology University of Colorado School of MedicineAuroraCO 80045USA

AIM:To investigate sex-based differences in the occurrence of intra-operative and post-operative complications and associated visual outcomes following cataract ***:This was a retrospective study of patients who had phacoemulsification cataract surgery at the University of Colorado School of *** collected included the patient’s health history,ocular comorbidities,operative and post-operative complications,and the post-operative best corrected visual acuity(BCVA).The data were analyzed using univariate and multivariable logistic regression with generalized estimating equations to account for the correlation of some patients having two eyes included in the ***:A total of 11977 eyes from 7253 patients were included in the *** comorbidities differed by sex,with males having significantly higher percentages of traumatic cataracts(males 0.7%vs females 0.1%),prior ocular surgery(6.7%vs 5.5%),and mature cataracts(2.8%vs 1.9%).Conversely,females had significantly higher rates of pseudoexfoliation(2.0%vs 3.2%).In unadjusted analysis,males had higher rates of posterior capsular rupture(0.8%vs 0.4%)and vitreous loss(1.0%vs 0.6%),but this difference was not significant after adjustment for *** had a significantly increased risk of post-operative retinal detachment,but in multivariable analysis this was no longer *** were significantly less likely to undergo post-operative neodymium-doped yttrium aluminum garnet(Nd:YAG)laser capsulotomy for posterior capsule opacification(OR=0.8,95%CI=0.7-0.9,P=0.0005).The BCVA was slightly worse for males pre-operatively;but post-operatively,both sexes exhibited similar visual acuity of Snellen equivalent 20/***:The study finds that in a cohort of patients presenting for cataract surgery,sex differences exist in pre-operative comorbidities and surgical characteristics that contribute to higher rates of some complications for ***,observed surgical complicatio

关键词： cataract surgery sex-based disparity phacoemulsification outcomes

Surgical or medical treatment of obesity-associated type 2 diabetesan increasing clinical conundrum

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World Journal of diabetes 2024年第10期15卷 2036-2040页

作者： Ryan J Jalleh karen L Jones Md Shahidul Islam Lu Cai Michael Horowitz Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Endocrine and Metabolic Unit Royal Adelaide HospitalAdelaide 5000South AustraliaAustralia department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Pediatric Research Institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States

In this editorial,we comment on the article by He et al,specifically in relation to the efficacy of bariatric surgery vs glucagon-like peptide-1 receptor agonist(GLP-1RA)therapy in the management of type 2 diabetes(T2d)associated with *** surgery has now also been shown to be safe and effective in pre-teens and teenagers with obesity and T2d,but information on newer GLP-1RAs in these groups is predictably *** older individuals(age>65 years),both bariatric surgery and GLP-1RA therapy improve cardiovascular ***-tric surgery is not infrequently associated with post-operative postprandial hypoglycemia,which is not the case with GLP-1RAs and,paradoxically,there is evidence that GLP-1RAs may reduce both the frequency and severity of postprandial *** trials of the long-term efficacy of bariatric surgery and GLP-1RAs are indicated.

关键词： Glucagon-like peptide-1 Glucagon-like peptide-1 receptor agonist Obesity diabetes Weight loss Bariatric surgery Metabolic surgery Hypoglycemia

Confirmation of a Sub-Saturn-size Transiting Exoplanet Orbiting a G dwarf:TOI-1194 b and a Very Low Mass Companion Star: TOI-1251 B from TESS

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Research in Astronomy and Astrophysics 2024年第3期24卷 129-143页

作者： Jia-Qi Wang Xiao-Jun Jiang Jie Zheng Hanna Kellermann Arno Riffeser Liang Wang karen A.Collins Allyson Bieryla Lars A.Buchhave Steve B.Howell Elise Furlan Eric Girardin Joao Gregorio Eric Jensen Felipe Murgas Mesut Yilmaz Sam Quinn Xing Gao Ruo-Yu Zhou Frank Grupp Hui-Juan Wang CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy Of SciencesBeijing 10010China University of Chinese Academy of Sciences Beijing 100049China University Observatory Munich Scheinertrsse 1.D-81679 MunichGemany Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1D-85748 GarchingGermany National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China Center for Astrophysics Harvard&Smithsonian60 Garden Street.CambridgeMA 02138USA National Space Institute Technical University of DenmarkElektrovejDK-2800 KgsLyngbyDenmark NASA Ames Research Center Moffett FieldCA 94035USA NASA Exoplanet Science Institute Caltech/IPACMail Code 100-221200 E.California Blvd.PasadenaCA91125USA Grand Pra Observatory Switzerland department of Physics Washington UniversitySt.LouisMO 63130.USA department of Physics and Astronomy Swarthmore CollegeSwarthmorePA 19081USA Instituto de Astrofísica de Canarias(IAC) E-38205 La Laguna.TenerifeSpain departamento de Astrofísica Universidad de La LagunaSpain dept.of Astronomy and Space Sciences Ankara UniversityTandogan 06100AnkaraTurkey Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Urumqi No.1 Senior High School Urumqi 830002China Lijiang Gemini Observatory Lijiang 674199China

We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(J),and a very low mass companion star with a mass of about 96.5±1.5 MJ,TOI-1251 *** candidates provided by the Transiting Exoplanet Survey Satellite(TESS)are suitable for further follow-up observations by ground-based telescopes with small and medium *** analysis is performed based on data from several telescopes worldwide,including telescopes in the Sino-German multiband photometric campaign,which aimed at confirming TESS Objects of Interest(TOIs)using ground-based small-aperture and medium-aperture telescopes,especially for long-period ***-1194 b is confirmed based on the consistent periodic transit depths from the multiband photometric *** measure an orbital period of 2.310644±0.000001 days,the radius is 0.767+0.045-0.041RJ and the amplitude of the RV curve is 69.4_(-7.3)^(+7.9)m s^(-1).TOI-1251 B is confirmed based on the multiband photometric and high-resolution spectroscopic data,whose orbital period is 5.963054+0.000002-0.000001days,radius is 0.947+0.035-0.033 R_(J) and amplitude of the RV curve is 9849_(-40)^(+42)ms^(-1).

关键词： planets and satellites fundamental parameters-planets and satellites gaseous planets-stars fundamental parameters-stars low-mass-methods data analysis-techniques photometric-techniques spectroscopic

Results of selective decontamination with oral neomycin and metronidazole for major colorectal surgery in Australia:A cohort study

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 72-78页

作者： James Wei Tatt Toh devansh Shah Henry Wang Charlotte Kwik Joseph do Woong Choi Chelsie Leonie Beinke Paul Morris Eleni Baird-Gunning Geoffrey Peter Collins Fiona Gavegan karen Shedden Toufic El-Khoury Nimalan Pathma-Nathan Kerry Hitos department of Colorectal Surgery Westmead HospitalWestmeadNew South WalesAustralia The University of Sydney Westmead HospitalWestmeadNew South WalesAustralia Western Sydney University New South WalesAustralia University of Notre dame New South WalesAustralia Westmead Research Centre for Evaluation of Surgical Outcomes Westmead HospitalSydneyAustralia

Objective The role of selective decontamination with oral antibiotics(OABs)and mechanical bowel preparation(MBP)prior to elective colorectal surgery is still widely *** objective of this study was to compare the outcomes of selective decontamination with neomycin,metronidazole and MBP compared to those of decontamination with MBP alone or with no *** Selective decontamination with neomycin and metronidazole combined with bowel preparation was introduced prior to elective colorectal surgery as part of an enhanced recovery after surgery program at Westmead Hospital,a major Australian tertiary referral hospital,between June 2017 and January *** between short-term outcomes of OAB+MBP and MBP/no preparation were made using prospectively collected data on length of stay(LOS),readmission,mortality within 30 days,anastomotic leakage(AL),surgical site infection(SSI),urinary tract infection,deep venous thrombosis and/or pulmonary embolism,pneumonia,and ***-up was limited to hospital stays and subsequent presentations within the health district within thirty days of *** Mann-Whitney U test was used to analyse continuous data,and the chi-square test was used for categorical *** and multivariate regression modelling was performed to identify risk factors associated with an increased likelihood of SSI and *** Patients with oral neomycin and metronidazole combined with bowel preparation had reduced superficial SSI(2.7%vs.7.6%,p=0.043)and overall complications(32.7%vs.44.6%,p=0.020),particularly Clavien-dindo 1 complications(7.3%vs.16.5%,p=0.009).However,the differences in AL(2.7%vs.4.5%,p=0.369)and organ/space SSI(1.3%vs.3.7%,p=0.327)were not statistically *** median LOS(6 d vs.6 d,p=0.370)was not different between the *** Selective decontamination with neomycin and metronidazole reduces the risk of SSIs and overall *** was a trend to toward a lower AL,but this differ

关键词： Neomycin Metronidazole Colorectal surgery Anastomotic leakage Surgical site infection

2023年美国麻醉医师学会神经肌肉阻滞监测与拮抗实践指南:美国麻醉医师学会工作组关于神经肌肉阻滞的报告

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中华麻醉学杂志 2024年第5期44卷 518-542页

作者： Stephan R.Thilen Wade A.Weigel Michael M.Todd Richard P.dutton Cynthia A.Lien Stuart A.Grant Joseph W.Szokol Lars I.Eriksson Myron Yaster Mark d.Grant Madhulika Agarkar Anne M.Marbella Jaime F.Blanck karen B.domino 西雅图华盛顿州明尼阿波里斯明尼苏达州达拉斯得克萨斯州密尔沃基威斯康星州教堂山北卡罗来纳州洛杉矶加利福尼亚州斯德哥尔摩瑞典丹佛科罗拉多州绍姆堡伊利诺斯州巴尔的摩马里兰州

本实践指南基于证据提供了全身麻醉期间及术后神经肌肉功能监测与阻滞拮抗的管理推荐。主要关注神经肌肉功能监测的类型与部位及阻滞拮抗的过程,以减少肌肉松弛药残留阻滞。

关键词：神经肌肉阻滞肌肉松弛药神经肌肉功能监测舒更葡糖钠新斯的明

Potential for natural and enhanced attenuation of sulphanilamide in a contaminated chalk aquifer

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Journal of Environmental Sciences 2017年第12期29卷 39-48页

作者： karen A.Bennett Simon d.Kelly Xiangyu Tang Brian J.Reid School of Environmental Sciences University of East AngliaNorwich Research ParkNorwich NR4 7TJUK Food and Environmental Protection Laboratory International Atomic Energy Agency1400 ViennaAustria Key Laboratory of Mountain Surface Processes and Ecological Regulation Institute of Mountain Hazards and EnvironmentChinese Academyof SciencesChengdu 610041China

Understanding antibiotic biodegradation is important to the appreciation of their fate and removal from the environment. In this research an Isotope Ratio Mass Spectrometry（IRMS）method was developed to evaluate the extent of biodegradation of the antibiotic,sulphanilamide, in contaminated groundwater. Results indicted an enrichment in δ^（13）C of8.44‰ from-26.56（at the contaminant source） to-18.12‰（300 m downfield of the source）.These results confirm reductions in sulphanilamide concentrations（from 650 to 10 mg/L）across the contaminant plume to be attributable to biodegradation（56%） vs. other natural attenuation processes, such as dilution or dispersion（42%）. To understand the controls on sulphanilamide degradation ex-situ microcosms assessed the influence of sulphanilamide concentration, redox conditions and an alternative carbon source. Results indicated, high levels of anaerobic capacity（~50% mineralisation） to degrade sulphanilamide under high（263 mg/L）, moderate（10 mg/L） and low（0.02 mg/L） substrate concentrations. The addition of electron acceptors; nitrate and sulphate, did not significantly enhance the capacity of the groundwater to anaerobically biodegrade sulphanilamide. Interestingly, where alternative carbon sources were present, the addition of nitrate and sulphate inhibited sulphanilamide biodegradation. These results suggest, under in-situ conditions, when a preferential carbon source was available for biodegradation, sulphanilamide could be acting as a nitrogen and/or sulphur source. These findings are important as they highlight sulphanilamide being used as a carbon and a putative nitrogen and sulphur source, under prevailing iron reducing conditions.

关键词： Antibiotics Sulphonamide Groundwater contamination Biodegradation Stable isotope fractionation IRMS

Controlling human platelet activation with calcium-binding nanoparticles

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Nano Research 2020年第10期13卷 2697-2705页

作者： david Cabrera karen Walker Sandhya Moise Neil d.Telling Alan G.S.Harper School of Pharmacy and Bioengineering Keele UniversityGuy Hilton Research CenireThormburrow DriveHartshill Stoke-on Trent ST47QBUK ?Central Electron Microscope Unit School of Life SciencesKeele UniversityNewcastle-under LIymeStaffordshireST55BGUK department of Chemical Engineering University of BathBath BA27AYUK School of Medicine Keele UniversityNewcastle-under-LymeStaffordshireST55BGUK

Human platelets aggregate at sites of blood vessel damage in response to a rise in their cytosolic calcium *** these cytosolic calcium rises would provide a method to inhibit platelet activation and prevent the unwanted blood clots that causes heart attack and *** we have predicted that calcium accumulation within the lumen of an infolded portion of the platelet plasma membrane called the open canalicular system(OCS)is essential for maintaining this cytosolic calcium *** to its nanometer dimensions of the OCS,it has been difficult to measure or interfere with the predicted luminal calcium *** we utilise iron oxide magnetic nanoparticles coated with the known calcium chelator,citrate,to create calcium-binding *** were used to assess whether an OCS calcium store plays a role in controlling the dynamics of human platelet activation and *** demonstrate that citrate-coated nanoparticles are rapidly and selectively uptaken into the OCS of activated human platelets,where they act to buffer the accumulation of calcium *** with these calcium-binding nanoparticles reduced thrombin-evoked cytosolic calcium rises,and slowed platelet aggregation and clot retraction in human *** contrast,nanoparticles that cannot bind calcium have no *** study demonstrates that the OCS acts as a key source of calcium for maintaining cytosolic calcium rises and accelerating platelet aggregation,and that calcium-binding nanoparticles targeted to the OCS could provide an anti-platelet therapy to treat patients at risk of suffering heart attacks or strokes.

关键词： nanochelators human platelets open canalicular system calcium signaling nanoparticles

Taphonomy of Early Triassic fish fossils of the Vega-Phroso Siltstone Member of the Sulphur Mountain Formation near Wapiti Lake,British Columbia,Canada

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Journal of Palaeogeography 2013年第4期2卷 321-343页

作者： karen Anderson Adam d. Woods department of Geological Sciences California State University

Abstract The taphonomy of fishes living in lacustrine environments has been extensively studied in both the laboratory and the fossil record;the taphonomy of marine fishes,however,is poorly *** marine fishes with heavy ganoid and cosmoid scales,which provided protection from rapid taphonomic loss,offer a means to examine marine fish taphonomy in the fossil *** genera of Early Triassic fishes(the ray-finned actinopterygians Albertonia,Bobasatrania,Boreosomus,and the lobe-finned coelacanth(sarcopterygian),Whiteia)from the Wapiti Lake,British Columbia locality of the Lower Triassic Sulphur Mountain Formation were examined in order to gain a better understanding of the taphonomy of fish in marine environments,determine ambient environmental conditions in the region during the Early Triassic,and ascertain the habitat and mode of life of the *** indicate that environmental conditions that contributed to the preservation of the fossil fishes of the current study included deposition in deep,quiet waters,which reduced the odds of disarticulation,colder waters under higher pressure,which slowed decay and limited postmortem floatation,and waters that were anoxic,which discouraged predators and *** addition,the thickness of the primitive ganoid and cosmoid scales of the fossil fishes also increased their preservation ***,physiological and environmental indicators suggest that Whiteia,Albertonia,and possibly Bobasatrania lived in deep,cold waters near the oxygen minimum zone,while Boreosomus lived higher in the water *** the anatomical and physiological characteristics of modern fishes will likely continue to inhibit marine taphonomy studies,examination of ancient fish,particularly those with ganoid or cosmoid scales,may provide future avenues of research to gain a better understanding of marine fish taphonomy and provide a powerful tool to examine ancient fish behavior and their environment.

关键词： taphonomy fish fossils fossil fishes Early Triassic