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National Science Review 2022年第9期9卷 10-18页

作者： J.Miguel Carceller karen S.Arias Maria J.Climent Sara Iborra Avelino Corma Instituto de Tecnologia Química (UPV-CSIC) Universitat Politècnica de València

Amino transaminases(ATAs) have been supported on a 2D ITQ-2 zeolite through electrostatic interactions, resulting in a highly stable active biocatalyst to obtain a variety of valuable chiral amines starting from prochiral ketones derived from biomass. We have extended the biocatalyst applications by designing a chemo-enzymatic process that allows, as the first step, prochiral ketones to be obtained from biomass-derived compounds through an aldol condensation–reduction step using a bifunctional metal/base catalyst. The prochiral ketone is subsequently converted into the chiral amine using the immobilized ATA. We show that it is feasible to couple both steps in a semi-continuous process to produce industrially relevant chiral amines with yields of >95% and ～100% enantiomer excess.

关键词： amino transaminase ITQ-2 zeolite chemo-enzymatic process biomass semi-continuous process Pd/MgO

Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

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Frontiers of Medicine 2014年第2期8卷 254-258页

作者： Muhammad Furqan Yamei Chen Akintunde Akinleye Judy Sarungbam Alan Gass karen Seiter Delong Liu Division of Hematology and Oneology Department of Medicine Westchester Medical Center 100 Woods Rd Valhalla NY 10595 USA Department of Hematology Xiamen Zhongshan Hospital Xiamen University Xiamen 361004 China Department of Pathology Westehester Medical Center 100 Woods Rd Valhalla NY 10595 USA Division of Cardiology Department of Medicine Westchester Medical Center 100 Woods Rd Valhalla NY 10595 USA

Mantle cell lymphoma is an aggressive subtype of b cell non-Hodgkin lymphoma. It can progress to leukemic phase but frank leukemic picture at initial presentation is not common. Leukemic phase indicates advance stage of the disease and generally associated with extensive extra-nodal involvement. Pericardial invasion has been reported, however we could not find a report of myocardial infiltration by this disease since the appraisal of the term ＂mantle cell lymphoma＂ in 1992. Here we report a case of cardiac involvement by mantle cell leukemia leading to cardiogenic shock which complicates the treatment decisions.

关键词： mantle cell lymphoma bendamustine cardiogenic shock

Mercury bioaccumulation in aquatic biota along a salinity gradient in the Saint John River estuary

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Journal of Environmental Sciences 2018年第6期30卷 41-54页

作者： bethany L.Reinhart karen A.Kidd R.Allen Curry Nelson J.O’Driscoll Scott A.Pavey Department of biology and Canadian Rivers Institute University of New Brunswick Saint John Saint John New Brunswick E2L4L5 Canada Department of biology Forestry and Environmental Management and Canadian Rivers Institute University of New Brunswick Fredericton New Brunswick E3B4A3 Canada Department of Earth and Environmental Sciences Acadia University Wolfville Nova Scotia B4P2R6 Canada Department of biology and School of Geography & Earth Sciences McMaster University Hamilton Ontario LSS 4K1 Canada

Although estuaries are critical habitats for many aquatic species, the spatial trends of toxic methylmercury（MeHg） in biota from fresh to marine waters are poorly understood. Our objective was to determine if MeHg concentrations in biota changed along a salinity gradient in an estuary. Fourspine Stickleback（Apeltes quadracus）, invertebrates（snails,amphipods, and chironomids）, sediments, and water were collected from ten sites along the Saint John River estuary, New brunswick, Canada in 2015 and 2016, with salinities ranging from 0.06 to 6.96. Total mercury（proxy for MeHg） was measured in whole fish and MeHg was measured in a subset of fish, pooled invertebrates, sediments, and water. Stable sulfur（δ34S）, carbon（δ13 C）, and nitrogen（δ15N） isotope values were measured to assess energy sources（S, C） and relative trophic level（N）. There were increases in biotic δ13C and δ34S from fresh to more saline sites and these measures were correlated with *** aqueous MeHg was higher at the freshwater than more saline sites, only chironomid MeHg increased significantly with salinity. In the Saint John River estuary, there was little evidence that MeHg and its associated risks increased along a salinity gradient.

关键词： Stickleback Amphipod Methylmercury biomagnification Stable isotopes Food web

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Diagnosing heart failure in centenarians

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Journal of Geriatric Cardiology 2019年第1期16卷 1-11页

作者： Signe Hoi Rasmussen karen Andersen-Ranberg Jordi Sanchez Dahl Mads Nybo bernard Jeune Kaare Christensen Sabine Gill Danish Aging Research Center Department of Public HealthUniversity of Southern DenmarkOdenseDenmark Department of Geriatrics Odense University HospitalOdenseDenmark Department of Cardiology Odense University HospitalOdenseDenmark Department of Clinical biochemistry and Pharmacology Odense University'HospitalOdenseDenmark Max-Planck Odense Center on the biodemography of Aging University of Southern DenmarkOdenseDenmark

background As a consequence of the demographic development with increasing proportion of older people,the prevalence of heart failure(HF)is expected to rise with considerable economic and societal ***,knowledge on cardiac structure and function among population-based samples of the exceptional old is *** Population-based study of all persons(no exclusion criteria)living in the western part of Denmark and turning 100 years in the year ***-home face-to-face interviews were conducted,and echocardiography and blood sampling for plasma brain Natriuretic Peptide(bNP)were offered to those who were able to give *** Out of 303 eligible,238(79%)participated,of which 125(53%)accepted *** ventricular(LV)dysfunction was present in 68(54%)of the participants of whom less than half had HF *** hypertension was present in 31(42%)with no correlation to LV *** well-known association between increased level of bNP and the prevalence of LV dysfunction could not be *** This in-home echocardiographic study shows that more than half of the participants had LV dysfunction,although mostly *** was no association between heart failure symptoms and LV ***,bNP seems to have lost its biomarker potential to rule out heart failure in *** to the latter,and the questionable symptom validity among centenarians,the current criteria to diagnose HF might be less valid in a centenarian population than in younger olds.

关键词： brain Natriuretic Peptide Centenarian Heart failure In-home echocardiography Left ventricular dysfunction

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A systematic review of metabolism of methionine sources in animals:One parameter does not convey a comprehensive story

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Animal Nutrition 2023年第2期13卷 31-49页

作者： Philippe becquet Mercedes Vazquez-Anon Yves Mercier karen Wedekind Tahir Mahmood Dolores I.batonon-Alavo Frances Yan International Methionine Analogue Association Regus Brussels City CentreStephanie SquareAvenue Louise65B-1050 BrusselsBelgium Novus International Inc. 20 Research Park DriveSaint CharlesMissouri 63304USA Adisseo France SAS Antony Parc II10 Place Du General de GaulleAntony 92160France

The goal of this review article,based on a systematic literature search,is to critically assess the state of knowledge and experimental methodologies used to delineate the conversion and metabolism of the 2 methionine(Met)sources DL-methionine(DL-Met)and DL-2-hydroxy-4-(methylthio)butanoic acid(HMTba).The difference in the chemical structures of HMTba and DL-Met indicates that these molecules are absorbed and metabolized differently in *** review explores the methodologies used to describe the 2-step enzymatic conversion of the 3 enantiomers(D-HMTba,L-HMTba and D-Met)to L-Met,as well as the site of conversion at the organ and tissue *** work was published documenting the conversion of HMTba and D-Met into L-Met and,consequently,the incorporation into protein using a variety of in vitro techniques,such as tissue homogenates,cell lines,primary cell lines,and everted gut sacs of individual *** studies illustrated the role of the liver,kidney,and intestine in the con-version of Met precursors into L-Met.A combination of in vivo studies using stable isotopes and infusions provided evidence of the wide conversion of HMTba to L-Met by all tissues and how some tissues are net users of HMTba,whereas others are net secreters of L-Met derived from *** of D-Met to L-Met in organs other than the liver and kidney is poorly *** methodology cited in the literature to determine conversion efficiency ranged from measurements of urinary,fecal,and respiratory excretion to plasma concentration and tissue incorporation of isotopes after intraperitoneal and oral *** observed between these methodologies reflect differences in the metabolism of Met sources rather than differences in conversion *** factors affecting conversion efficiency are explored in this paper and are mostly associated with extreme dietary conditions,such as noncommercial crystalline diets that are very deficient in total sulfur amino a

关键词： DL-Methionine Hydroxy-analog of methionine 2-Hydroxy-4-(methylthio)butanoic acid Conversion Metabolism Methodology

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