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青年博览 2023年第10期 8-9页

作者： karen 不详

打开试卷,发现第一个题型是选择题,我的紧张情绪得以缓解一一就算不会做,最起码还有概率蒙对。然而短的题干令我不敢掉以轻心,长的题干则需要忍住想要跳过大段文字而直接看最后一句话的冲动认真分析,生怕错过任何细节;AbCD四个选项带着... 详细信息

打开试卷,发现第一个题型是选择题,我的紧张情绪得以缓解一一就算不会做,最起码还有概率蒙对。然而短的题干令我不敢掉以轻心,长的题干则需要忍住想要跳过大段文字而直接看最后一句话的冲动认真分析,生怕错过任何细节;AbCD四个选项带着或熟悉或陌生的面孔在下方整齐排开,从思考、计算、勾画、对比,到“这道题我以前好像做过”,再到“三长一短选最短,三短一长选最长,长短不一就选b,参差不齐就选D”,最后到“实在不会就选C”,我已使出浑身解数应对。

关键词：选择题紧张情绪认真分析

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高血压患者常规行眼底镜检查的价值:系统性综述

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英国医学杂志中文版 2005年第6期8卷 341-344页

作者： bert-Jan H van den born Caroline A A Hulsman Joost b L Hoekstra Reinier O Schlingemann Gert A van Montfrans 高展 Department of Internal Medicine Academic Medical Centre PO 226601100 DD AmsterdamNetherlands Department of Ophthalmology Academic Medical CentreAmsterdam

目的评价高血压患者常规眼底检查的价值。设计系统性综述。入选患者 ≥19岁的高血压视网膜病变患者。数据来源从1990起的Medline、Embase和Cochrane图书馆的数据库。综述方法纳入的研究包括：评估了高血压视网膜病变性失明与心血管... 详细信息

目的评价高血压患者常规眼底检查的价值。设计系统性综述。入选患者 ≥19岁的高血压视网膜病变患者。数据来源从1990起的Medline、Embase和Cochrane图书馆的数据库。综述方法纳入的研究包括：评估了高血压视网膜病变性失明与心血管危险因素之间联系的研究。研究必须由2名或2名以上观察者得出一致评价结果，用K统计分析表示。对于高血压患者，研究高血压视网膜病变与高血压脏器损害之间的联系。对于非选择的血压正常者和无糖尿病高血压患者，评价高血压视网膜病变与心血管危险因素之间的联系。结果由于观察者之间的巨大差异限制了对视网膜微血管变化的评价。高血压视网膜病变与血压水平之间的阳性及阴性预测值均较低（分别为47％～72％和32％-67％）。除了视网膜病变与脑卒中之间有联系外，视网膜微血管变化与心血管危险因素之问无明显联系。但在血压正常的视网膜病变患者中同样发现脑卒中增加。这些研究没有对高血压脏器损害的其他预测因子进行调整。结论研究表明，高血压患者常规进行眼底检查有额外价值的观点尚缺乏证据。

关键词：高血压患者系统性综述眼底镜检查价值 Cochrane图书馆心血管危险因素视网膜病变 Medline 微血管变化眼底检查

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Synergistic Antitumor Activity of Vitamins C and K3 on Human bladder Cancer Cell Lines

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Journal of Cancer Therapy 2013年第6期4卷 7-19页

作者： karen McGuire James M. Jamison Jacques Gilloteaux Jack L. Summers Department of Anatomical Sciences St Georges’ University International School of Medicine K B Taylor Scholar’s Programme Newcastle upon Tyne UK. The Apatone Development Center St. Thomas Hospital Summa Health System Akron USA

Exponentially growing cultures of human bladder tumor cells (RT4 and T24) were treated with Vitamin C (VC) alone, Vitamin K3 (VK3) alone, or with a VC:VK3 combination continuously for 5 days or treated with vitamins for 1 h, washed with PbS and then incubated in culture medium for 5 days. Co-administration of the vitamins enhanced the antitumor activity 12- to 24-fold for the RT-4 cells and 6- to 41-fold for the T24 cells. Flow cytometry of RT4 cells exposed to the vitamins revealed a growth arrested population and a population undergoing cell death. Growth arrested cells were blocked near the G0/G1-S-phase interface, while cell death was due to autoschizis. Catalase treatment abrogated both cell cycle arrest and cell death which implicated hydrogen peroxide (H2O2) in these processes. The H2O2 production resulted in a moderate increase in lipid peroxidation and depletion of cell thiol levels. Analysis of cellular ATP levels revealed a transient increase in ATP production for VC and the VC:VK3 combination, but decreased ATP levels following VK3 treatment. Lipid peroxidation, thiol depletion and ATP modulation occurred at a 17-fold lower concentration in the vitamin combination than with either vitamin alone. These results suggested that the increased cytotoxicity of the vitamin combination was due to redox cycling and increased oxidative stress.

关键词： bladder Carcinoma Vitamin C Vitamin K3

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Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease

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World Journal of Hepatology 2014年第4期6卷 188-198页

作者： Sara Heebll karen Louise Thomsen Steen b Pedersen Hendrik Vilstrup Jacob George Henning Grnbk Department of Hepatology and Gastroenterology Aarhus University Hospital Department of Endocrinology Aarhus University Hospital Storr Liver Unit Westmead Millennium InstituteWestmead Hospital and University of Sydney

The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are *** treatment options are therefore intensively sought *** interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory ***,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant *** review the in vivo evidence from animal studies and clinical *** abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid *** studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation ***,AMPK/SIRT1-independent actions are also *** trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver *** clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Steatosis Resveratrol AMPactivated protein kinase Silent information regulation-2 homolog 1 Anti-oxidants Anti-inflammatory agents Animal studies Clinical trial

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karen Cvornyek专访

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世界建筑导报 2019年第5期34卷 52-57页

作者： karen Cvornyek b+H

自2002年以合伙人的身份加入b+H以来,karen见证了亚洲经济的高速增长时期,并带领b+H在亚洲的发展。过去十几年间,b+H稳步增长,相继在上海、胡志明市、新加坡以及香港开设办公室,目前b+H在亚洲拥有将近300名员工,服务于亚洲乃至全世界范... 详细信息

自2002年以合伙人的身份加入b+H以来,karen见证了亚洲经济的高速增长时期,并带领b+H在亚洲的发展。过去十几年间,b+H稳步增长,相继在上海、胡志明市、新加坡以及香港开设办公室,目前b+H在亚洲拥有将近300名员工,服务于亚洲乃至全世界范围内一些高知名度的客户。

关键词：亚洲经济胡志明市办公室新加坡知名度

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高血压患者常规眼底镜检查的价值:系统回顾

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世界核心医学期刊文摘（心脏病学分册） 2005年第12期1卷 18-19页

作者： Van Den born b.-J. H. Hulsman C. A. A. Hoekstra J. b. L. 韩瑞娟 Department of Internal Medicine Academic Medical Centre PO 22660 1100 DD Amsterdam Netherlands

Objective: To evaluate the additional value of funduscopy in the routine management of patients with hypertension. Design: Systematic review. Participants: Adults aged 19 or more with hypertensive retinopathy. Data sources: Medline, Embase, and the Cochrane Library from 1990. Review methods: Studies were included that assessed hypertensive retinopathy with blinding for blood pressure and cardiovascular risk factors. Studies on observer agreement had to be assessed by two or more observers and expressed as a κstatistic. Studies on the association between hypertensive retinopathy and hypertensive organ damage were carried out in patients with hypertension. The association between hypertensive retinopathy and cardiovascular risk was carried out in unselected normotensive and hypertensive people without diabetes mellitus. Results: The assessment of microvascular changes in the retina is limited by large variation between observers. The positive and negative predictive values for the association between hypertensive retinopathy and blood pressure were low(47%to 72%and 32%to 67%, respectively). Associations between retinal microvascular changes and cardiovascular risk were inconsistent, except for retinopathy and stroke. The increased risk of stroke, however, was also present in normotensive people with retinopathy. These studies did not adjust for other indicators of hypertensive organ damage. Conclusion: Evidence is lacking that routine funduscopy is of additional value in the management of hypertensive patients.

关键词：眼底镜检查正常血压视网膜病变视网膜微血管心血管风险血管危险因素阴性预测值 Cochrane 选择评价统计值

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Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus

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World Journal of Gastroenterology 2020年第20期26卷 2570-2583页

作者： karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim bright Lorelle T Smith Imogen A ball Joanne M bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey Discipline of Surgery College of Medicine and Public HealthFlinders University of South AustraliaAdelaideSA 5042Australia Flinders Health and Medical Research Institute Cancer Program College of Medicine and Public HealthFlinders UniversityAdelaideSA 5042Australia Discipline of Surgery The University of AdelaideAdelaideSA 5005Australia Adelaide Medical School The University of AdelaideAdelaideSA 5005Australia Faculty of Health Sciences The University of AdelaideAdelaideSA 5005Australia

bACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many ***,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA *** small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been *** To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker *** Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano *** was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q *** overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV *** diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also *** The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,Pbetween the plasma and serum s EV preparations,but was consistently higher in the plasma s EV *** blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct