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Trace element geochemistry and stable isotopic(δ^(13)C andδ^(15)N)records of the Paleocene coals,Salt Range,Punjab,Pakistan

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International Journal of Mining Science and Technology 2022年第3期32卷 551-561页

作者： Noshin Masood Tehseen Zafar karen a.hudson-edwards Hafiz U.Rehman Abida Farooqi Environmental Geochemistry Laboratory Department of Environmental SciencesFaculty of Biological SciencesQuaid-i-Azam UniversityPO 45320Pakistan Institute of Geochemistry Chinese Academy of SciencesGuiyang 550081China Institute of Geology University of the PunjabLahore 54590Pakistan Environment&Sustainability Institute and Camborne School of Mines University of ExeterTR109EZUK Graduate School of Sciences and Engineering Kagoshima UniversityKagoshima 890-0065Japan

The Paleocene coals of the Salt Range in the Punjab Province of Pakistan have great economic potential;however,their trace element and stable isotopic characteristics have not been studied in detail except for a few sporadic *** this study,a total of 59 coal samples of which 14 are obtained from open cast mines have been investigated for elemental composition andδ^(13)C-δ^(15)N isotopic *** contents of trace elements such as Co,Cr,Cu,Pb,Sr,Th,U,V,and Zn are 7.4,41.7,11.2,12.5,90.2,4.0,1.9,128,and 31.1 mg/kg,*** values,when compared with the World Coal Clarke values,were relatively higher in low-rank coals in comparison with Clarke values for brown ***,As(20.4 mg/kg),Co(6.6 mg/kg),Cr(22.4 mg/kg),Cu(^(13).3 mg/kg),Pb(19.2 mg/kg),Sr(^(15)4.7 mg/kg),Th(2.5 mg/kg),V(47.8 mg/kg),and Zn(75.1 mg/kg)were significantly higher in the sub-bituminous to bituminous coals of the Salt *** analysis,based on X-ray diffraction and energy dispersive X-ray spectroscopy,revealed that the studied samples contain illite,kaolinite calcite,gypsum,pyrite,and *** affinity with organic and inorganic phases of coals calculated by an indirect statistical approach indicated a positive association of ash content with Ag,Al,Co,Cr,Cs,Cu,Mn,P,Rb,Pb,Th,U,and V,suggesting the presence of inorganic components in studied ***,As,Fe,Sr,and Zn exhibit negative correlations that imply their association with the organic ***δ^(13)C andδ^(15)N isotopic range and average−24.94‰to−25.86‰(−25.41‰)and−2.77‰to 3.22‰(0.96‰),respectively,reflecting 3C type modern terrestrial vegetation were common in the palaeomires of studied coal *** addition,the trivial variations of 0.92‰and 0.45‰among^(13)C and^(15)N values can be attributed to water level fluctuations and plant assemblies.

关键词： Coal Salt Range Pakistan Geochemistry Trace elements δ^(13)C andδ^(15)N isotopes

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Study of a damage constitutive model for water-bearing coal measures sedimentary rock with nonlinear deformation during compaction stage

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Geohazard Mechanics 2023年第3期1卷 244-254页

作者： Weinan Wang Qiangling Yao Aiwen Wang karen a.hudson-edwards Chuangkai Zheng Lun Yan Lianpeng Dai Yihong Liu Institute of Disaster Rock Mechanics Liaoning UniversityShenyang110036PR China State Key Laboratory of Coal Resources and Safe Mining China University of Mining&TechnologyXuzhou221116PR China Camborne School of Mines and Environment and Sustainability Institute University of ExeterPenrynTR109FEUK

The problem of repeated immersion-induced fatigue damage in engineering coal measures sedimentary rock,including coal-rock pillars,reservoir bank slopes,and water-rich tunnels at the boundary of coal mine underground reservoirs,has profound implications for their stability,safety,and operation,and can even lead to geological *** address this issue,this paper aims to construct a constitutive model that accurately captures the comprehensive process of deformation and failure in water-bearing coal measures sedimentary *** explores the deformation characteristics of these formations and provides a theoretical foundation for numerical simulations of geological disasters induced by water-rock *** study integrates the deformation mechanisms of void and matrix deformation in coal seam sedimentary rocks,while considering the influence of immersion ***,it formulates a segmented constitutive model to depict the entire process of deformation and failure in cyclically immersed water-bearing coal measures sedimentary rock under uniaxial *** proposed model's accuracy and rationality are validated through comparisons with experimental research findings and existing theoretical curves from similar *** results demonstrate the model's effectiveness in describing the deformation behavior of non-dense water-bearing coal measures sedimentary rock under uniaxial compression or low confining pressure before reaching peak stress,although further refinements may be necessary to precisely capture post-peak deformation *** parameters,including the deformation caused by voids(γ0)between voids,increase exponentially with immersion times,while the elastic modulus(Ev)of voids and the parameter(F0)related to the average strength of microelements decrease expo*** homogeneity degree(m)exhibits no discernible *** research outcomes provide valuable insights for the stability control of engineering coal

关键词： Cyclic immersion Water-rock interaction Void compaction Deformation characteristic Constitutive model

Thermoregulation,incubator humidity,and skincare practices in appropriate for gestational age ultra-low birth weight infants:need for more evidence

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World Journal of Pediatrics 2024年第7期20卷 643-652页

作者： Umesh Mishra Deanne August karen Walker Pranav R.Jani Mark Tracy Faculty of Medicine and Health University of SydneySydneyAustralia Department of Neonatology Westmead HospitalWestmeadNSWAustralia Grantley Stable Neonatal Unit Royal Brisbane and Women’s HospitalBrisbaneAustralia School of Nursing Midwifery and Social WorkUniversity of QueenslandBrisbaneAustralia Department of Newborn Care Royal Prince Alfred HospitalCamperdownAustralia

Background Although not universal,active care is being offered to infants weighing<500 g at birth,referred to as ultra-low birth weight(ULBW)infants appropriate for gestational *** infants have the greatest risk of dying or developing major *** infants face challenges related to fluid and heat loss as well as skin injury in the initial days of life from extreme anatomical and physiological immaturity of the *** there is an emerging literature on the outcomes of ULBW infants,there is a paucity of evidence to inform practice guidelines for delivering optimal care to this cohort of *** sources A comprehensive review of the literature was performed using the PubMed and Embase *** keywords included“thermoregulation or body temperature regulation”,“incubator humidity”,“skin care”,“infant,extremely low birth weight”and“ultra-low birth weight infants”.Results Evidences for thermoregulation,incubator humidity,and skincare practices are available for preterm infants weighing<1500 g at birth but not specifically for ULBW *** on thermoregulation,incubator humidity,or skincare practices had a small sample size and did not include a sub-group analysis for ULBW *** practice recommendations in ULBW infants are adopted from research in very and/or extremely low birth weight *** This narrative review focuses on challenges in thermoregulation,incubator humidity,and skincare practices in ULBW infants,highlights current research gaps and suggests potential developments for informing practices for improving health outcomes in ULBW infants.

关键词： Incubator humidity Neonatal intensive care unit Skincare Thermoregulation Ultra-low birth weight

Chemical degradation of platinum oncolytics in urine and speciation of the inorganic contaminants cisplatin and carboplatin relevant in waste water

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Emerging Contaminants 2024年第1期10卷 47-53页

作者： Karel Folens Janis Baeten karen Couvreur Gijs Du Laing Laboratory of Analytical Chemistry and Applied Ecochemistry(ECOCHEM) Department of Green Chemistry and TechnologyGhent UniversityFrieda Saeystraat 19052ZwijnaardeBelgium Center for Microbial Ecology and Technology(CMET) Department of BiotechnologyGhent UniversityCoupure Links 6539000GentBelgium Medical Oncology AZ GlorieuxGlorieuxlaan 559600RonseBelgium

Understanding the prevalent form of platinum(Pt)based antineoplastic agents,used in chemotherapy,is of importance to develop a remediation strategy that restricts aquatic *** speciation of Pt-based compounds was measured in actual patients’urine using hydrophobic interaction liquid chromatography(HILIC)equipped with an ICP-MS *** showed poor metabolization and intact excretion 11 h after administration,whereas cisplatin underwent a rapid aquation in the first 7 *** compare,the in vitro degradation rate of cisplatin,carboplatin and oxaliplatin was determined in synthetic human urine,mimicking true environmental *** fraction of intact molecules was measured at regular intervals following incubation at 37°C,resulting in degradation rate *** chemical stability was highest for carboplatin(k=0.0143±0.0012 min−1),versus faster degradation of oxaliplatin and cisplatin by exponential decay with k1 of 0.0026±0.0001 min−1 and k_(2)=5.59±0.46×10^(−6) min−1,*** kinetic parameters can serve as input to further expand modelling databases and improve the predictive power of speciation software to estimate eco-toxicity *** the strong residual cytotoxicity of the platinum antineoplastic molecules following renal clearance and human excretion,the contaminants are of high environmental concern and offer potential for metal recovery using advanced treatment *** such water treatment processes,especially carboplatin,above all cancerostatic platinum compounds,should be addressed since it is more persistent in the aquatic environment.

关键词： Pharmaceuticals Inorganic contaminants Speciation analysis Ecotoxicity

Boston type I keratoprosthesis

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Annals of Eye Science 2024年第2期9卷 12-23页

作者： karen Hu Imane Tarib Maria Soledad Cortina Department of Ophthalmology and Visual Sciences University of Illinois at ChicagoChicagoILUSA

Successful corneal solid tissue transplantation,beginning with penetrating keratoplasty(PKP),and evolving to include contemporary lamellar and endothelial keratoplasty,has been a tremendous advancement in the struggle to combat corneal ***,there remain patients with high-risk features predictive of transplant failure,for whom donor keratoplasty is not a viable *** corneas have therefore been developed in order to meet the needs of these *** Boston type I keratoprosthesis(BKPro)is the most widely used prosthetic cornea in the treatment of corneal *** the years since the BKPro’s introduction,refinement of surgical technique and clinical management as well as improvements in prosthetic design have contributed to promising patient outcomes,particularly in the short *** such,patients with keratoprosthesis implants continue to grow in number,and the indications for the BKPro have commensurately ***,risks of permanently blinding complications after implantation persist over all stages of *** the foreseeable future,the success of keratoprosthesis(KPro)implantation will continue to depend on refined patient selection,preoperative optimization,and incisive postoperative *** we explore indications,surgical technique and postoperative outcomes as well as several core tenants in the management of BKPro patients:limiting glaucomatous progression,controlling inflammation,and optimizing the ocular *** exquisite sensitivity of the BKPro-implanted eye to perturbations in any one of these areas showcases the intimate relationship between the prosthetic device and its surrounding environment.

关键词： Keratoprosthesis corneal transplant Boston type I keratoprosthesis(BKPro) keratoprosthesis(KPro)

Reproductive patterns in Araucaria araucana forests in the Andean range, Chile

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Ecological Processes 2024年第1期13卷 252-261页

作者： Sergio Donoso karen Pe?a-Rojas Claudia Espinoza Carolain Badaracco Rómulo Santelices-Moya Antonio Cabrera-Ariza Mediterranean Forests Laboratory Faculty of Forestry and Nature Conservation Centro Secano Faculty of Agricultural and Forestry Sciences Universidad Católica del Maule Maule Advanced Studies Research Center Vice-Rector's Office for Research and Postgraduate Studies Catholic University of Maule

Background Araucaria araucana is a mast species that presents a high variability in annual cone production. Researchers have recorded synchronization events in cone production in different populations, which allows the seed production to be concentrated, reducing the percentage of seeds consumed by different animal *** We sampled three populations located in the Andes Mountains, Araucanía Region, Chile. In 2004 we began the collection of data on cone production, for which we installed permanent plots（1200 m2each） at each location. We identified and labeled each female tree in each plot to monitor its cone production. In 2012 we selected a total of 30 trees near the plots to evaluate the number of seeds per cone. In each February from 2012 to 2014 we selected two mature cones and covered them with a porous mesh for subsequent collection and storage in March. At the beginning of June, we counted and weighed the seeds, determining the average weight, the number of seeds per cone, the germination capacity（GC）, and the germination speed（GS）.Results Cone production was synchronous across the three locations. We observed significant differences among the locations and years evaluated. The cones had fewer seeds in 2013（high production） compared to those in 2012（low production）, but their weights were similar. In 2014 the cones produced smaller seeds in fewer quantities. The difference between the years 2013 and 2014 resulted from the high-energy expenditure in 2013. Regarding GC and GS, there were significant differences among the three locations（GC: F = 45.41, p < 0.01; GS: F = 96.08, p < 0.01）, where the highest values were observed in *** Both GC and GS are related to seed weight but not to the number of cones produced in a given year. These annual fluctuations in seed production are determining factors in the population dynamics of forest species. Our results allow a better understanding of the reproductive phenology of A. araucana and could hel

关键词： Seed weight Germination potential Masting species Sustainable use Dioecious species

Alzheimer’s visual variant: a report of a diagnosis easily missed on ophthalmic examination

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1571-1575页

作者： Jorge Cárdenas-Belaunzarán Lorena Wheelock-Gutierrez karen A.Cerrillo-Avila Department of Neuro-Ophthalmology Association to Prevent Blindness in MexicoI.A.P.Mexico City 04030Mexico Independent Researcher Mexico City 04040Mexico

Dear Editor,We present a case of posterior cortical atrophy(PCA),which is a syndromic entity caused by different neurodegenerative diseases,mainly Alzheimer’s disease,but it has been described in several other *** frequency is reported to be as high as 5%of all cases;however,it remains widely under-recognized among ophthalmologists and optometrists due to scarce reports in visual health-related journals[1].

关键词： diagnosis Alzheimer diseases

Multiple myeloma survival in New South Wales, Australia, by treatment era to 2020

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Cancer Biology & Medicine 2024年第8期21卷 703-711页

作者： Eleonora Feletto Qingwei Luo Anna Kelly Marianne Weber David Goldsbury Katherine Barron karen Canfell Xue Qin Yu The Daffodil Centre The University of SydneyA Joint Venture with Cancer Council NSWSydney NSW 2006Australia

Objective: Australia has relatively high multiple myeloma(MM) incidence and mortality rates. Advancements in MM treatment over recent decades have driven improvements in MM survival in high-income countries;however, reporting in Australia is limited. We investigated temporal trends in population-wide MM survival across 3 periods of treatment advancements in New South Wales(NSW), ***: Individuals with an MM diagnosis in the NSW Cancer Registry between 1985 and 2015 with vital follow-up to 2020, were categorized into 3 previously defined treatment eras according to their diagnosis date(1985±1995, chemotherapy only;1996±2007, autologous stem cell transplantation;and 2008±2015, novel agents including proteasome inhibitors and immunomodulatory drugs). Both relative survival and cause-specific survival according to Fine and Gray's competing risks cumulative incidence function were calculated by treatment era and age at ***: Overall, 11,591 individuals were included in the study, with a median age of 70 years at diagnosis. Five-year relative survival improved over the 36-year(1985±2020) study period(31.0% in 1985±1995;41.9% in 1996±2007;and 56.1% in 2008±2015). For individuals diagnosed before 70 years of age, the 5-year relative survival nearly doubled, from 36.5% in 1985±1995 to 68.5% in 2008±2015. Improvements for those > 70 years of age were less pronounced between 1985±1995 and 1996±2007;however, significant improvements were observed for those diagnosed in 2008±2015. Similar overall and age-specific patterns were observed for causespecific survival. After adjustment for gender and age at diagnosis, treatment era was strongly associated with both relative and cause-specific survival(P < 0.0001).Conclusions: Survival of individuals with MM is improving in Australia with treatment advances. However, older age groups continue to experience poor survival outcomes with only modest improvements over time. Given the increasing prevalence of MM in

关键词： Multiple myeloma cancer epidemiology survival analysis competing risk analysis Australia

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Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls

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World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： Cornelia Wiechers Julian Sowula karen Kreutzer Christoph E.Schwarz Christina Weismann Michael Krimmel Christian F.Poets Bernd Koos Department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft Lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany Department of Orthodontics Tuebingen University HospitalTuebingenGermany Department of Oral and Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background Various conservative and surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between May 2018 and Nov *** with RS received 3D-photographs during clinically indicated *** controls were recruited from Dec 2018 to Sep 2019 and received 3D-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(L),and the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANB’.Results A total of 2073D images,obtained in 19 infants with RS and 32 controls,were *** and ANB’decreased over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANB’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANB’-1.7°(95%CI−2.4 to−1.0)].Also,the ANB’model showed a significant effect of the interaction term diagnosis x *** Based on longitudinal 3D images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant Mandibular catch-up growth Pre-epiglottic Baton Plate Robin sequence Three-dimensional photography