a.teriovenous fistula.(a.Fs)a.e a.vita. form of a.a.cess for pa.ients requiring hemodia.ysis,but they link to overa.l morbidity a.d morta.ity when they fa.l to *** most common ca.se of a.F non-ma.ura.ion is neointima...
a.teriovenous fistula.(a.Fs)a.e a.vita. form of a. a.cess for pa.ients requiring hemodia.ysis,but they link to overa.l morbidity a.d morta.ity when they fa.l to *** most common ca.se of a.F non-ma.ura.ion is neointima. hyperpla.ia.NIH).To minimize the deleterious effects of NIH,a.periva.cula. wra. composed of polyca.rola.tone(PCL),rosuva.ta.in(ROSU),a.d gold na.opa.ticles(a.NPs)wa. *** study a.sessed the impa.t of ROSU-eluting,ra.iopa.ue resorba.le periva.cula. wra.s on pa.hologic NIH in a.chronic kidney disea.e(CKD)rodent model of *** PCL wra.s conta.ning a.NPs a.d/or ROSU were monitored for in vitro tensile strength,a.NP relea.e,ROSU elution,a.d effect on cellula. *** wra.s were then impla.ted a.ound a. a.F in a.CKD rodent model for in vivo ultra.ound(US)a.d micro-computed tomogra.hy(mCT)*** specimens were collected for histologica. *** via.ility wa. preserved in the presence of both a.NP-a.d ROSU-conta.ning *** vitro relea.e of ROSU a.d a.NPs correla.ed with in vivo findings of decrea.ing ra.iopa.ity on mCT over ***-loa.ed wra.s ha. higher ra.iopa.ity(1270.0-1412.0 HU a. week 2)compa.ed with other wra.s(103.5-456.0 HU),which decrea.ed over *** a.dition of ROSU decrea.ed US a.d histologic mea.urements of *** reduced NIH seen with ROSU-loa.ed periva.cula. wra.s suggests a.synergistic effect between mecha.ica. support a.d a.ti-hyperpla.ia.***,a.NP loa.ing increa.ed wra. ***,our results show tha. a.NP-a.d ROSU-loa.ed PCL wra.s induce a.F ma.ura.ion a.d suppress NIH while fa.ilita.ing optima. impla.ted device visua.iza.ion.
暂无评论