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Prevalence and risk distribution of schistosomiasis among adults in Madagascar:a cross-sectional study

Infectious Diseases of Poverty 2023年第2期12卷 136-136页

作者： Sarah Katharina Gruninger Tahinamandranto Rasamoelina Rivo Andry Rakotoarivelo Anjarasoa Ravo Razafindrakoto Zaraniaina Tahiry Rasolojaona Rodson Morin Rakotozafy Patrick Richard Soloniaina Njary Rakotozandrindrainy Pia Rausche Cheick Oumar Doumbia Anna Jaeger Alexandre Zerbo Heidrun von Thien Philipp Klein Govert van Dam Egbert Tannich Norbert Georg Schwarz Eva lorenz Jürgen May raphael Rakotozandrindrainy Daniela Fusco Department of Infectious Disease Epidemiology Bernhard Nocht Institute for Tropical Medicine Hamburg Germany German Centre for Infection Research (DZIF) Hamburg-Borstel-Lübeck-Riems Germany Centre d’Infectiologie Charles Mérieux (CICM) University of Antananarivo Antananarivo Madagascar Department of Infectious Diseases University of Fianarantsoa Andrainjato Fianarantsoa Madagascar Department of Microbiology and Parasitology University of Antananarivo Antananarivo Madagascar University Clinical Research Centre (UCRC) University of Sciences Technics and Technologies of Bamako (USTTB) Bamako Mali Department of Parasitology Leiden University Medical Centre Leiden The Netherlands National Reference Centre for Tropical Pathogens (NRC) Hamburg Germany Institute of Medical Biostatistics Epidemiology and Informatics University Medical Centre of the Johannes Gutenberg University Mainz Mainz Germany Department of Tropical Medicine I University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany

Background The goal to eliminate the parasitic disease of poverty schistosomiasis as a public health problem is aligned with the 2030 United Nations agenda for sustainable development goals,including universal health coverage(UHC).Current control strategies focus on school-aged children,systematically neglecting *** aimed at providing evidence for the need of shifting the paradigm of schistosomiasis control programs from targeted to generalized approaches as key element for both the elimination of schistosomiasis as a public health problem and the promotion of *** In a cross-sectional study performed between March 2020 and January 2021 at three primary health care centers in Andina,Tsiroanomandidy and Ankazomborona in Madagascar,we determined prevalence and risk factors for schistosomiasis by a semi-quantitative PCR assay from specimens collected from 1482 adult *** and multivariable logistic regression were performed to evaluate odd *** The highest prevalence of ***,*** and co-infection of both species was 59.5%,61.3%and 3.3%,in Andina and Ankazomborona *** prevalence was observed among males(52.4%)and main contributors to the family income(68.1%).Not working as a farmer and higher age were found to be protective factors for *** Our findings provide evidence that adults are a high-risk group for *** data suggests that,for ensuring basic health as a human right,current public health strategies for schistosomiasis prevention and control need to be re-addressed towards more context specific,holistic and integrated approaches.

关键词： Schistosomiasis Schistosoma haematobium Schistosoma mansoni Universal health coverage Madagascar

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美国2007年农业法案对发展中国家的启示(上)

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WTO经济导刊 2008年第4期 12-14页

作者：迪姆·卓斯林（Tim Josling）丹尼尔A．塞莫尔（Daniel A．Sumner）罗伯特l．汤普森（Robert l．Thompson）玛丽·查普里斯（Mary Chambliss）卡拉·兰尼（kara laney）王晓宇（翻译）刘健男（校译）斯坦福大学弗里曼·斯波格里国际研究学会资深会员加利福尼亚大学农业问题中心主任伊利诺依大学香槟分校农业政策教授国际食品援助问题方面的独立咨询人国际食品与农业贸易政策委员会的政策助理商务部世贸司

近年来，经合组织（OECD）国家对农业实行大量补贴，而发展中国家的农民却面临困难，这两者之间的联系已经成为人们关注的焦点。毫无疑问，经合组织国家的农业计划对世界市场的结构产生了巨大的影响，对贸易量、贸易流向及国际农产品价... 详细信息

近年来，经合组织（OECD）国家对农业实行大量补贴，而发展中国家的农民却面临困难，这两者之间的联系已经成为人们关注的焦点。毫无疑问，经合组织国家的农业计划对世界市场的结构产生了巨大的影响，对贸易量、贸易流向及国际农产品价格都产生了影响。世界银行的一份评估认为，它对不同产品的国际价格的影响在10到50％之间不等（见表1）。与此同样重要的一个启示是：许多经合组织国家的农业政策旨在保护他们的农业部门不受外国竞争，甚至在鼓励其他国家开放农产品市场时也是如此。

关键词：发展中国家农业法案经合组织国家农产品价格美国国际价格农产品市场世界市场

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Thyroid Metastasis Revealing Prostatic Adenocarcinoma

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第6期10卷 519-525页

作者： Warou Dolou Ablavi Adani-Ifè Stephen l. A. lawson Essodina Padja Kwamé Doh Department of Oto-Rhino-laryngology University Teaching Hospital of Kara Kara Togo Department of Oncology University Teaching Hospital of Lom&#233 Lom&#233 Togo Department of Urology University Teaching Hospital of Lom&#233 Lom&#233 Togo Department of Pathology University Teaching Hospital of Lom&#233 Lom&#233 Togo

Introduction: Metastasis to the thyroid gland is rarely encountered and usually detected after the diagnosis of the primary tumor. The most common sites of primary are breast, kidney, and lung. Prostate has been rarely reported as primary site. Here is reported a case of thyroid metastasis revealing prostate adenocarcinoma. Case summary: A 59-year-old man was admitted for pulmonary embolism. CT scan showed a hypertrophy of left thyroid lobe, and ultrasonography of the neck revealed cervical nodes. Thyroid function tests were within normal limits. Total thyroidectomy associated to cervical nodes dissection was done. There was no postoperative complication. Histopathological examination of the surgical specimen concluded to a papillary carcinoma. Then, immunohistochemistry examination revealed prostatic metastatic adenocarcinoma to lymph node and thyroid gland. The patient was treated by androgen deprivation therapy. After thirty three months of follow-up, he is still in good condition with stable disease. Conclusion: This case suggests thyroid cancer might be metastasis, and more frequent than known. Surgical specimen of thyroidectomy requires further histological examination such as immunohistochemistry to document primary tumor. Prostate is one of the primary, despite not the most common.

关键词： Thyroid Metastasis Prostatic Adenocarcinoma Immunohistochemistry

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Paraoxonase-1 gene in patients with chronic obstructive pulmonary disease investigation Q192R and l55M polymorphisms

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World Journal of Emergency Medicine 2015年第3期6卷 201-206页

作者： ?ükrü Gürbüz Mustafa Y?ld?z Murat kara Kür?at Kargün Mehtap Gürger Metin Ate??elik ?mer Do?an Alata? Department of Emergency Medicine ?n?nü University Department of Emergency Medicine F?rat University Department of Medical Genetics S?tk? Ko?man University Department of Medical Genetics F?rat University Department of Emergency Medicine S?tk? Ko?man University

BACKGROUND: The effect of increased oxidative stress on the development of chronic obstructive pulmonary disease(COPD) is well known. One of the antioxidative systems against oxidative stress in human body is paraoxonase(PON) enzyme that protects low density lipoproteins(lDl) against oxidation. This study aimed to explore the polymorphisms on PON1, Q192 R, l55 M genes of patients with ***: DNAs extraction was obtained from blood samples of 50 patients diagnosed with COPD and 50 patients as a control group who were presented to emergency clinic. Genotypes were obtained with polymerase chain reaction(PCR) and AIw I and Hsp92 II restriction enzymes were used for Q192 R and l55 M polymorphisms, respectively. Analysis of data was done with the Chi-square test and Fisher's exact ***: A statistically significant difference in Q192 R polymorphism was found between the COPD patients and the control group(P=0.05). There was no statistically significant difference in l55 M polymorphisms between the patient and control groups(P>0.05). Q192 R polymorphism was significantly correlated with the PON1 gene and cigarette smoking; however other risk factors did not show any significant correlation with this polymorphism. Though l55 M polymorphism was significantly correlated with family history and tuberculosis, there was no significant correlation with other risk ***: We believe that more studies are needed to study the correlation of l55 M polymorphism with other factors.

关键词： Chronic obstructive pulmonary disease Paraoxonase Polymorphism Acute attack

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Zebl represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1.1^(+) T cell development

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Cellular & Molecular Immunology 2021年第9期18卷 2140-2152页

作者： Jiang Zhang Melanie Wencker Quentin Marliac Aurore Berton Uzma Hasan raphael Schneider Daphne laubreton Dylan E.Cherrier Anne-laure Mathieu Amaury Rey Wenzheng Jiang Julie Caramel laurent Genestier Antoine Margais Jacqueline Marvel Yad Ghavi-Helm Thierry Walzer CIRI Centre International de Recherche en InfectiologieUniv LyonInsermU1111Universite Claude Bernard Lyon 1CNRSUMR5308ENS de LyonF-69007 LyonFrance Shanghai Key laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghaiChina lnstitut de Genomique Fonctionnelle de lyon CNRS UMR 5242Ecole Normale Superieure de LyonUniversity Claude Bernard Lyon 146 allée d'ltalieF-69364 LyonFrance CRCl Centre de Recherche sur le Cancer de LyonINSERM U1052—CNRS UMR5286Centre Léon BerardUniversity Claude Bernard Lyon 1LyonFrance

T cell development proceeds un der the in fluence of a n etwork of transcription factors(TFs).The precise role of Zeb1,a member of this network,remains ***,we report that Zeb1 expression is induced early during T cell development in CD4^(-)CD8^(-)double-negative(DN)stage 2(DN2).Zeb1 expression was further increased in the CD4^(+)CD8^(+)double-positive(DP)stage before decreasing in more mature T cell *** performed an exhaustive characterization of T cells in Cellophane mice that bear Zeb 7 hypomorphic *** Zebl mutation profoundly affected all thymic subsets,especially DN2 and DP ***1 promoted the survival and proliferation of both cell populations in a cell-intrinsic *** the periphery of Cellophane mice,the number of conventional T cells was near normal,but invariant NKT cells,NK1.1^(+)γδ T cells and ly49^(+)CD8 T cells were virtually *** suggested that Zebl regulates the development of unconventional T cell types from DP progenitors.A transcriptomic analysis of WT and Cellophane DP cells revealed that Zebl regulated the expression of multiple genes involved in the cell cycle and TCR sign aling,which possibly occurred in cooperation with Tcf1 and *** deed,Cellophane DP cells displayed stron ger signaling than WT DP cells upon TCR engagement in terms of the calcium respons巳phosphorylation events,and expression of early ***,Zebl is a key regulator of the cell cycle and TCR signaling during thymic T cell *** propose that thymocyte selection is perturbed in Zeb7-mutated mice in a way that does not allow the survival of unconventional T cell subsets.

关键词： T cell selection TCR signaling Zebl transcription development

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An Ischemic Stroke in a Sub-Saharan African Patient Revealing a Carotid Web: A Case Report and a Systematic literature Review

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World Journal of Neuroscience 2022年第3期12卷 144-152页

作者： léhleng Agba Donissongui Soro Awissoba Awidina-Ama liliane Ngoudjo Hugo Yaïche Olivier Heinzlef Neurology Department Centre Hospitalier Intercommunal de Poissy/Saint-Germain-En-Laye Poissy France Neurology Department CHU-Kara Université de Kara Kara Togo

One third of ischemic strokes have no known cause, and basic understanding of the mechanisms of these “cryptogenic” strokes is lacking. However, observational studies are increasingly bringing to light an etiology that has long remained hidden, the carotid web. The authors report a case of carotid web in a 32-year-old patient, gardener, from sub-Sharan Africa, with no medical history or known cerebrovascular risk factors. Indeed, due to a sudden weakness of his left limbs, the MRI was performed and revealed an ischemic stroke positive on diffusion-weighted within the territory of the right middle cerebral artery. FlAIR sequences were normal, while T2* sequences revealed an M1 thrombus ipsilateral to the brain lesion. After thrombolysis and thrombectomy, the patient’s weakness improved significantly. Digital subtraction angiography of supra-aortic trunks revealed the carotid web, which was incriminated as the etiology of this ischemic stroke in the absence of any abnormality on the other ancillary examinations that were performed. To prevent a recurrence, the patient was given Aspegic 250 mg/day and received physical therapy. The clinical course was improved and at 3 months, there was no new cerebrovascular event and his Rankin score was 1.

关键词： Carotid Web Ischemic Stroke Sub-Saharan Africa

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定义“穿支皮瓣”的标准是什么？

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中国美容整形外科杂志 2013年第5期24卷 I0012-I0012页

作者： raphael Sinna Armand Boloorchi Ajay l. Mahajan Quentin Qassemyar Micheline Robbe 朱利娜(译) 魏峰(译) 高景恒(译) 亚眠北方医院整形再造和美容外科法国亚眠皮卡第儒勒凡尔纳大学英国德文郡&艾克赛特医院英国艾克赛特《中国美容整形外科杂志》编辑部

尽管大家对“穿支皮瓣”这一术语已达成共识，但是关于这些皮瓣的详细描述仍有许多困惑，这让我们很难理解这些手术方法与传统皮瓣方法的不同。通过进一步阐明之前描述的某些方面，我们可以更好地理解穿支皮瓣的意义。笔者建议增加可选... 详细信息

尽管大家对“穿支皮瓣”这一术语已达成共识，但是关于这些皮瓣的详细描述仍有许多困惑，这让我们很难理解这些手术方法与传统皮瓣方法的不同。通过进一步阐明之前描述的某些方面，我们可以更好地理解穿支皮瓣的意义。笔者建议增加可选择的术语丰富命名标准，可选择的术语用来指定穿支皮瓣的其他方面，如血管的起源、血管解剖类型、涉及的肌肉和穿支血管的类型。当描述一个新皮瓣时，这些术语有助于阐明解剖方法和手术方法。最后，更好地理解穿支皮瓣有助于解决该类型手术的争议，也有帮于它的传播以及在重建术中采用。

关键词：穿支皮瓣命名标准手术方法穿支血管传统皮瓣解剖类型解剖方法重建术

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Profile of Forensic State Patients Admitted to ZébéPsychiatric Hospital (Togo)

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Open Journal of Psychiatry 2022年第1期12卷 1-10页

作者： Saliou Salifou Yawo Apélété Agbobli Sonia Kanekatoua Daméga Wenkourama Assad Batcha Charfoundine Affo Kolou Simliwa Dassa Faculté des Sciences de la Santé Université de Lomé Clinique Universitaire de Psychiatrie et de Psychologie Médicale CHU Sylvanus Olympio-Lomé H&#244 pital Psychiatrique de Zébé-Aného Aneho Togo Faculté des Sciences de la Santé Université de Lomé CHU Sylvanus Olympio Lomé Togo Faculté des Sciences de la Santé Université de Lomé Clinique de Psychiatrie et de Psychologie Médicale CHU Campus Lomé Togo Faculté des Sciences de la Santé Université de Kara Service de Psychiatrie CHU Kara Kara Togo Centre Hospitalier des Armées de lomé Lomé Togo Clinique Médico-Psychiatrique de lomé Lomé Togo

Introduction: Zébé Psychiatric Hospital is the only psychiatric hospital able to receive forensic mentally ill patients in Togo. The aim of this study was to describe the socio-demographic, clinical and forensic aspects of forensic mentally ill patients. Method: This was a descriptive cross-sectional study conducted from August 16th to September 16th, 2021 among forensic patients admitted to the Zébé Psychiatric Hospital. Results: During the study period, we recorded 28 forensic mentally ill patients. Fifty-seven point one percent (57.1%) of the forensic patients came from rural areas. The mean age of these patients was 37.3 years, and ranged from 13 to 82 years. Males predominated in 96.4% of cases. Primary education represented 39.3% of cases. Single people predominated in 92.9% of cases. They were unemployed in 64.3% of cases. Forty-six point four percent (46.4%) of these patients were using at least one psychoactive substance. Forensic offenses were dominated by murder in 53.6% of cases. The victim was a family member in 53.6% of cases and male in 60.7% of cases. They had schizophrenia spectrum disorders in 78.6% of the cases. Forty-six point four percent (46.4%) of these patients were not responsible for their offences and 82.1% were abandoned by their families. Conclusion: The information gathered in this study will help to better organize strategies for mental health promotion and prevention of mental illness and crime in the general population.

关键词： Forensic Psychiatry Mental Illness Epidemiology Crime Togo

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Factors Associated with Homicides in Psychiatric Expertise in Togo

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Open Journal of Psychiatry 2023年第4期13卷 280-290页

作者： Saliou Salifou Yawo Apélété Agbobli Daméga Wenkourama Sonia Kanekatoua Gnargonna Bawi Charfoundine Affo Kolou Simliwa Dassa Université de lomé Faculté des Sciences de la Santé Clinique Universitaire de Psychiatrie et de Psychologie Médicale CHU Sylvanus Olympio-Lomé H&#244pital Psychiatrique de Zébé-Aného Togo Université de lomé Faculté des Sciences de la Santé Service de Médecine Légale CHU Sylvanus Olympio Lomé Togo Université de kara Faculté des Sciences de la Santé Service de Psychiatrie CHU Kara Togo Université de lomé Faculté des Sciences de la Santé Clinique de Psychiatrie et de Psychologie Médicale CHU Campus Lomé Togo Clinique Médico-Psychiatrique de lomé Togo

Background: In most societies, homicide or murder is a crime that often leads to imprisonment. Studies around the world have sometimes found cases of mental illness (schizophrenia spectrum disorders) as an explanation for some homicides. The aim of this study was to determine the factors associated with homicide in the Togolese context. Methods: This was a descriptive and analytical cross-sectional study of pre-trial psychiatric expertise reports from January 31st, 2019 to January 30th, 2022. Results: Out of 704 defendants appraised, 206 (29.3%) had committed homicide. Males accounted for 91.7% of Homicide defendants (HD). Their average age was 31.6 ± 12.2 years, with extremes of 16 and 74 years. Factors associated with homicide were female gender, age between 30 and 45 years, married or cohabiting status and occupation as a farmer/fisherman/breeder. Psychoactive substance use (PAS), mental illness and psychiatric history were not associated with homicide. Conclusion: Preventing delinquency and interpersonal conflict, and promoting social cohesion, could significantly reduce homicides in Togo.

关键词： Homicide Associated Factors Forensic Psychiatry Togo

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Determination of Air Pollutant Concentrations in Plant Species in Relation to Pollution Sources

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Open Journal of Air Pollution 2021年第3期10卷 53-62页

作者： lawson Tevi Atator Hodabalo Kamou Anissou Bawa Kodjovi Mawuégnigan léonard Agbodan Akpisso Aniko Polo Sêmihinva Ben Akpavi Koffi Akpagana laboratory of Botany and Plant Ecology University of Lome Lomé Togo Higher Institute of Agricultural Trades University of Kara Kara Togo

Air quality has been a major health issue in urban areas in recent decades. Human activities release a large number of pollutants into the atmosphere which has a direct impact on plant health and leads to ecosystem degradation. The objective of this study is to contribute to a better evaluation of the impact of the air quality of the city of Togo on biological resources. The determination of pollutants was done on samples of plant species with a strong link with the source of pollution. The determination of Sulfur dioxide (SO2) was done by the ripper method. The determination of carbon and estimation of CO2 and CO by the colorimetric method. The determination of nitrogen was done by the Kjeldhal method. The results showed that at the industrial level the amount of CO2 in Alternanthera repens is high with a value of 53.3911 mg/ml. On the other hand, the quantity of CO in Senna occidentalis<

关键词： Air Pollution Anthropogenic Pollution Sources Bio-Sensitive Species City of lomé Togo

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