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Anthocyanins from purple corn affect gut microbiota and metabolome in IBD patients under Infliximab infusion: the SiCURA pilot study

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Food Science and Human Wellness 2023年

作者： Muni Swamy Ganjayi Karunakaran Reddy Sankaran Balaji Meriga Ruchika Bhatia Shikha Sharma kanthi kiran kondepudi Department of Biochemistry Sri Venkateswara University Food and Nutrition Biotechnology Division National Agri-Food Biotechnology Institute

Nowadays， IBD-patient therapies are mainly based on corticosteroid， thiopurine， and immunomodulator treatments. Patients with active disease， that do not respond to corticosteroid and/or thiopurine treatment， can switch to the usage of the chimeric monoclonal antibody infliximab (IFX). However， to date， no treatment appeared to be conclusive in lowering the incidence of IBD relapses. With the aim to increase the effectiveness of IFX treatment， we combined it with an adjuvant purple corn supplementation enriched in anthocyanins. IBD-patients were enrolled before they underwent to the IFX-infusion， and they were allocated in two different study arms. Patients in the intervention-arm followed a dietary supplementation with purple corn water-soluble extract， whereas control patients had a daily consumption of red fruit tea. 16S rDNA gene-sequencing and high-resolution mass-spectrometry metabo-lipidomics analyses were conducted on stool and sera samples， respectively. As a result， the experimental intervention mainly affected the serum metabolome of IBD-patients by decreasing the concentration of specific lipids. Focusing on IBD patient annotated taxa， a significant decrease in Lactobacillus and Bifidobacterium relative abundances was found. As far as it concerns the ulcerative colitis patient subset， the experimental intervention led to a decrease in Alistipes and Erysipelotrichaceae UCG-003 genus abundances and a concomitant Parabacteroides increase. On the contrary， after treatment， Crohn’s disease patients did not exhibit metataxonomics differences at the genus level. At the end of the treatment that led to a reshaped microbiota community， the gathered data paves the way for the usage of a specifically designed probiotic supplementation as a valuable strategy for IBD-patients under IFX infusion.

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Astragalin and rutin restore gut microbiota dysbiosis， alleviate obesity and insulin resistance in high-fat diet-fed C57BL/6J mice

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Food Science and Human Wellness 2023年

In the present study we investigated the impact of the Combination of Astragalin and Rutin (CAR) on restoring gut-microbial dysbiosis and obesity and obesity related disorders. Randomized male C57BL/6J mice were experimentally divided into five groups and fed either a normal diet or a high-fat diet (HFD) for 16 weeks. Compared to vehicle treated group (HFD group)， CAR could substantially improve selected gut microbiota abundance (Akkermansia， Lactobacillus， Bifidobacteria， muciniphila， Roseburia)， reversed the Firmicutes/Bacteroidetes proportions， and inhibited the growth of Escherichia coli， Salmonella， and Klebsiella in obese mice. In addition， CAR-treated mice showed significantly (P < 0.05) increased total short-chain fatty acid production， reduced body weight gain， organs’ weights， serum lipid profile (except HDL) and insulin resistance. The mRNA expressions of CCAAT/enhancer binding protein-α (C/EBP-α)， sterol regulatory element-binding protein-1c (SREBP-1c)， peroxisome proliferator-activated receptor-γ (PPAR‐γ)， acetyl-CoA carboxylase (ACC)， adipocyte protein 2 (aP2)， and fatty acid synthase (FAS) were downregulated (P < 0.05) and the protein expression of PPAR-γ was downregulated while AMPK was phosphorylated in CAR-treated HFD-fed mice compared to the HFD control group. Interestingly， CAR-treated HFD-fed mice showed significantly improved tissue architecture in the liver and fatty tissues. In conclusion， the findings suggest that CAR/Moringa oleifera may be beneficial in the treatment of insulin resistance and obesity disorders.

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Antioxidative,antimicrobial and anti-inflammatory activities and release of ultra-filtered antioxidative and antimicrobial peptides during fermentation of sheep milk:In-vitro,in-silico and molecular interaction studies

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Food Bioscience 2022年第3期47卷 583-594页

作者： Jodhani Keyur Ashokbhai Bethsheba Basaiawmoit Sujit Das Amar Sakure Ruchika Maurya Mahendra Bishnoi kanthi kiran kondepudi Srichandan Padhi Amit Kumar Rai Zhenbin Liu Subrota Hatia Deptt.of Dairy Microbiology Anand Agricultural UniversityAnand388110GujaratIndia Deptt.of Rural Development and Agricultural Production North-Eastern Hill UniversityTura CampusTura794002MeghalayaIndia Deptt.of Agriculture Biotechnology Anand Agricultural UniversityAnand388110GujaratIndia Regional Center for Biotechnology FaridabadHaryana121001India Healthy Gut Research Group Food & Nutritional Biotechnology DivisionNational Agri-Food Biotechnology InstituteKnowledge CitySector 81SAS NagarPunjab140306India Institute of Bioresources and Sustainable Development Regional CentreTadong737102SikkimIndia School of Food and Biological Engineering Shaanxi University of Science and Technology18Xi'an710021China

The antioxidative,antimicrobial,and anti-inflammatory properties of fermented sheep milk with *** (KGL4),as well as the generation of antioxidative and antimicrobial peptides,are evaluated in the *** and antibacterial activities in sheep milk fermented with KGL4 increased with incubation hours,along with varied antioxidative properties (ABTS assay:35.12%,hydroxyl free radical scavenging assay:29.12%,superoxide free radical scavenging activity:36.38%).Antimicrobial activity of fermented sheep milk against *** (19 mm),*** (15.67 mm),*** (14 mm),and *** (13 mm) was also ***,after 48 h,the KGL4 showed maximum proteolysis (10.40 mg/ml) at 2.5% rate of addition sheep *** antioxidative and antimicrobial activities of fermented sheep milk fractions (3 kDa and 10 kDa permeates and retentates) were also *** highest ABTS activity (26.90%) was found in 10 kDa permeate,whereas the 3 kDa retentate had higher hydroxyl free radical scavenging activity (69.20%) and 3 kDa permeate showed maximum superoxide free radical scavenging activity (32.85%).The 10 kDa retentate had shown maximum antimicrobial activity against *** (13.67 mm) and *** (17.00 mm).Proteins spotted on 2D gel electrophoresis of KGL4 were varied from 10 to 70 ***-LC/MS was used to identify 5 novel peptide sequences from 2-D gel *** in the BIOPEP database confirmed the antioxidative and antimicrobial effects of the novel fermented sheep milk *** sheep milk with KGL4 (SMKGL4) significantly reduced excessive TNF-α,IL-6,& IL-1β production in LPS-activated RAW 264.7 cells.

关键词： Fermentation Sheep milk Lactobacillus fermentum Antioxidative Antimicrobial Anti-inflammatory Peptides

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