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Correlations between serum kidney injury molecule-1,cystatin C and immunosuppressants:A cross-sectional study of renal transplant patients in Bahrain

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Journal of Biomedical Research 2024年第3期38卷 269-277页

作者： kannan sridharan Shamik Shah Mona Al Hammad Fatima Ali Mohammed Sindhan Veeramuthu Mona Abdulla Taher Mustafa Mohamed Hammad Lamees Jawad Eman Farid Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Department of Nephrology Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Internal Medicine College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Salmaniya Medical Complex ManamaKingdom of Bahrain Department of Laboratory Medicine Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Microbiology Immunologyand Infectious DiseasesCollege of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain

Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for *** creatinine is the standard for monitoring kidney function;however,cystatin C(Cys C)and kidney injury molecule-1(KIM-1)have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney ***,we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil,tacrolimus,sirolimus,everolimus,or cyclosporine to evaluate kidney *** used both the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)2021 equation,which is based on creatinine and combined creatinine with Cys C,and the CKD-EPI 2012 equation,which is based on Cys C alone,to estimate glomerular filtration rate(GFR).Then,we assessed the association between serum KIM-1 and GFR<90 mL per minute per 1.73 *** observed significantly higher serum Cys C levels in patients with the elevated serum creatinine,compared with those with normal serum *** estimated GFRs based on creatinine were significantly higher than those based on the other equations,while a significant positive correlation was observed among all *** KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations.A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR<90 mL per minute per 1.73 *** observed a significant correlation between serum creatinine and Cys C in our renal transplant ***,serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.

关键词： KIM-1 cystatin C mycophenolate mofetil tacrolimus everolimus sirolimus cyclosporine

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Modelling an Efficient Clinical Decision Support System for Heart Disease Prediction Using Learning and Optimization Approaches

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Computer Modeling in Engineering & Sciences 2022年第5期131卷 677-694页

作者： sridharan kannan Department of Computer Science and Engineering J K K Munirajah College of TechnologyErode638506India

With the worldwide analysis,heart disease is considered a significant threat and extensively increases the mortality ***,the investigators mitigate to predict the occurrence of heart disease in an earlier stage using the design of a better Clinical Decision Support System(CDSS).Generally,CDSS is used to predict the individuals’heart disease and periodically update the condition of the *** research proposes a novel heart disease prediction system with CDSS composed of a clustering model for noise removal to predict and eliminate ***,the Synthetic Over-sampling prediction model is integrated with the cluster concept to balance the training data and the Adaboost classifier model is used to predict heart ***,the optimization is achieved using the Adam Optimizer(AO)model with the publicly available dataset known as the Stalog *** flowis used to construct the model,and the evaluation is done with various prevailing approaches like Decision tree,Random Forest,Logistic Regression,Naive Bayes and so *** statistical analysis is done with theWilcoxon rank-summethod for extracting the p-value of the *** observed results show that the proposed model outperforms the various existing approaches and attains efficient prediction *** model helps physicians make better decisions during complex conditions and diagnose the disease at an earlier ***,the earlier treatment process helps to eliminate the death ***,simulation is done withMATLAB 2016b,and metrics like accuracy,precision-recall,F-measure,p-value,ROC are analyzed to show the significance of the model.

关键词： Heart disease clinical decision support system over-sampling AdaBoost classifier adam optimizer Wilcoxon ranking model

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Improved Secure Identification-Based Multilevel Structure of Data Sharing in Cloud Environments

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Computer Systems Science & Engineering 2022年第11期43卷 785-801页

作者： Saraswathi Shunmuganathan sridharan kannan T.V.Madhusudhana Rao K.Ambika T.Jayasankar Department of Computer Science and Engineering SSN College of EngineeringChennaiTamil Nadu603110India Department of Computer Science and Engineering J.K.K.Munirajah College of TechnologyErodeTamil Nadu638506India Department of Computer Science and Engineering Vignan’s Institute of Information TechnologyVisakhapatnam530049India Department of Computer Science and Engineering University College of EngineeringBIT CampusAnna UniversityTiruchirappalliTamil Nadu620024India Department of Electronics and Communication Engineering University College of EngineeringBIT CampusAnna UniversityTiruchirappalli620024India

The Cloud Computing Environment(CCE)developed for using the dynamic cloud is the ability of software and services likely to grow with any *** has transformed the methodology for storing the enterprise data,accessing the data,and Data Sharing(DS).Big data frame a constant way of uploading and sharing the cloud data in a hierarchical architecture with different kinds of separate privileges to access the *** the requirement of vast volumes of storage area in the CCEs,capturing a secured data access framework is an important *** paper proposes an Improved Secure Identification-based Multilevel Structure of Data Sharing(ISIMSDS)to hold the DS of big data in *** complex file partitioning technique is proposed to verify the access privilege context for sharing data in complex *** access control Encryption Method(EM)is used to improve the *** Complexity is measured to increase the authentication *** active attack is protected using this ISIMSDS *** proposed ISIMSDS method assists in diminishing the Complexity whenever the user’s population is increasing *** security analysis proves that the proposed ISIMSDS methodology is more secure against the chosen-PlainText(PT)attack and provides more efficient computation and storage space than the related *** performance of the proposed ISIMSDS methodology provides more efficiency in communication costs such as encryption,decryption,and retrieval of the data.

关键词： Data sharing cloud environments big data chosen-plaintext attack security

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A Novel Approach Based on Hybrid Algorithm for Energy Efficient Cluster Head Identification in Wireless Sensor Networks

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Computer Systems Science & Engineering 2022年第10期43卷 259-273页

作者： C.Ram Kumar K.Murali Krishna Mohammad Shabbir Alam K.Vigneshwaran sridharan kannan C.Bharatiraja Department of Electronics and Communication Engineering Dr.N.G.P.Institute of TechnologyCoimbatore641048India Department of Electronics and Communication Engineering Vignan’s Institute of Information TechnologyDuvvadaVisakhapatnam530049India Department of Computer Science College of Computer Science and Information TechnologyJazan UniversityJizan45142Kingdom of Saudi Arabia Department of Electronics and Communication Engineering K.Ramakrishnan College of EngineeringTiruchirappalli621112India Department of Computer Science and Engineering JKK Munirajah College of TechnologyErode638506India Department of Electrical and Electronics Engineering SRM Institute of Science and TechnologyChennai603203India

The Wireless Sensor Networks(WSN)is a self-organizing network with random deployment of wireless nodes that connects each other for effective monitoring and data *** clustering technique employed to group the collection of nodes for data transmission and each node is assigned with a cluster *** major concern with the identification of the cluster head is the consideration of energy consumption and hence this paper proposes an hybrid model which forms an energy efficient cluster head in the Wireless Sensor *** proposed model is a hybridization of Glowworm Swarm Optimization(GSO)and Artificial Bee Colony(ABC)algorithm for the better identification of cluster *** performance of the proposed model is compared with the existing techniques and an energy analysis is performed and is proved to be more efficient than the existing model with normalized energy of 5.35%better value and reduction of time complexity upto 1.46%.Above all,the proposed model is 16%ahead of alive node count when compared with the existing methodologies.

关键词： Wireless sensor network cluster cluster head hybrid model glowworm swarm optimization artificial bee colony algorithm energy consumption

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Is fat-free mass-based gentamicin dosing regimen preferable than whole-body weight in neonates?

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Pediatric Investigation 2023年第2期7卷 86-94页

作者： kannan sridharan Muna Al Jufairi Eman Al Ansari Lulwa Alsadah Howra Wasel Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Neonatal Intensive Care Unit Salmaniya Medical ComplexMinistry of HealthManamaKingdom of Bahrain Department of Pediatrics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain College of Medicine and Medical Sciences Arabian Gulf UniversityManamaKingdom of Bahrain

Importance:Body fluid dynamics and renal maturation status vary during the neonatal *** hypothesized that differences in peak and trough gentamicin concentrations could be ***:To predict the peak and trough gentamicin concentrations in critically ill neonates and to predict the changes in the predicted peak plasma concentrations of gentamicin following fat-free mass ***:Critically ill neonates that received gentamicin and have gentamicin concentration measured were *** mass was estimated using skinfold *** in the peak plasma concentrations(Cmax)using whole-body weight(estimated using the current dosing regimen)and predicted concentrations following the fat-free mass-based dosing were the outcome ***:Eighty-nine critically ill neonates were ***-therapeutic Cmax was estimated using the current dosing regimen in 32.6%,and 22.5%neonates following the first and second doses of *** neonates had significantly higher fat mass compared to term *** except one had Cmax above 12μg/ml after the first dose and all had after the second gentamicin dose following the predicted fat-free massbased gentamicin *** recommended doses are as follows:extreme preterm:7.95 mg/kg every 48 h;very preterm:7.30 mg/kg every 36-48 h;late preterm:5.90 mg/kg every 36-48 h;and term neonates at 5.10 mg/kg every 24 ***:Fat-free mass dosing may be considered for obtaining optimal therapeutic effects in the neonatal population.

关键词： Aminoglycosides Body weight Fat Fat-free mass Gentamicin

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Multifunctional applications of gadolinium-doped cerium oxide(Ce1-xGdxO2-?) ceramics:A review

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Journal of Rare Earths 2024年第10期42卷 1817-1834页

作者： Subhadip Das Rakesh Bhaskar kannan Badri Narayanan Department of Ceramic Engineering National Institute of Technology Rourkela School of Chemical Engineering Yeungnam University

Cerium oxide（CeO2）,or ceria,and its doped derivatives have been extensively studied for several decades and are well-known oxides valued for their unique structural properties and wide range of *** materials play a crucial role in sustainable development within *** modification through de fect e ngineering of the highly stable cubic fluorite phase enhances the versatility of this doped ceria to a new *** the numerous dopants of the CeO2matrix,ceria doped with gadolinium（Gd）,known as Ce1-xGdxO2-?（CGO）,is gaining popularity due to its *** introduction of defect-induced vacancies in the oxygen sublattice（V_o） and a change in the average valence of cerium(Ce3+/Ce4+) are primarily responsible for the improved performance compared to pristine *** materials are currently undergoing intensive research for potential use as electrolytes in intermediate-temperature solid oxide fuel cells（IT-SOFCs） and dense oxygen-permeable membranes（OPMs）.Additionally,they are being commercially utilized for power generation and oxygen *** materials are also attracting significant attention in various fields such as optics,photocatalysis,electrostriction,spintronics,gas sensing,electrocatalysis,and biomedical *** review paper aims to compile the latest contributions to CGO materials and comprehensively cover their various application *** crystal structure,defect equilibrium in Gd3+-doped CeO2,the origin of multifunctionality,and the prospects of these materials are also exclusively discussed.

关键词： Biomedicine Gadolinium-doped CeO2 Gas sensors Photo/electrocatalysts Rare earths Spintronics

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On the Geometry of the Anti-canonical Bundle of the Bott–Samelson–Demazure–Hansen Varieties

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1920-1940页

作者： Indranil BISWAS S.Senthamarai kannan Pinakinath SAHA School of Mathematics Tata Institute of Fundamental Research1 Homi Bhabha RoadMumbai 400005India Chennai Mathematical Institute Plot H1SIPCOT IT ParkSiruseriKelambakkam603103India

Let G be a semi-simple simply connected algebraic group over the field C of complex *** T be a maximal torus of G,and let W be the Weyl group of G with respect to *** Z(w,i)be the Bott–Samelson–Demazure–Hansen variety corresponding to a tuple i associated to a reduced expression of an element w∈*** prove that for the tuple i associated to any reduced expression of a minuscule Weyl group element w,the anti-canonical line bundle on Z(w,i)is globally *** consequence,we prove that Z(w,i)is weak *** that G is a simple algebraic group whose type is different from *** S={α1,...,αn}be the set of simple *** w be such that support of w is equal to *** prove that Z(w,i)is Fano for the tuple i associated to any reduced expression of w if and only if w is a Coxeter element and w^(−1)(Σ_(t=1)^(n)α_(t))∈−S.

关键词： Bott-Samelson-Demazure-Hansen variety Coxeter element anti-canonical line bundle Fano weak Fano

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Intangibles and management earnings forecasts

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China Journal of Accounting Research 2024年第2期17卷 54-73页

作者： Ashraf Khallaf Yezen kannan American University of Sharjah United Arab Emirates Zayed University United Arab Emirates

We investigate how the accounting treatment of intangible assets on managers’likelihood of issuing voluntary earnings guidance(MEF).We find that unrecognized intangibles(immediately expensed)are negatively associated with MEF issuance,while recognized intangibles(capitalized)show a positive asso*** findings hold across various factors such as analysts’coverage,industry type and for a subsample that excludes software firms permitted to capitalize software development costs under SFAS *** additional,we investigate the cross-sectional determinants of MEF issuance based on the characteristics of firm *** find a significant increase in the likelihood of MEF issuance for higher unrecognized intangibles with greater earnings *** suggests that managers may prioritize delivering valuerelevant information to market participants to alleviate uncertainty.

关键词： Voluntary disclosures Management earnings forecasts Intangibles Information asymmetry Uncertainty

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Experiment and performance analysis of serpentine-shaped cantilever beam for pipeline vibration-based piezoelectric energy harvester prototype development

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Clean Energy 2024年第4期8卷 111-134页

作者： Wan Nabila Mohd Fairuz Illani Mohd Nawi Mohamad Radzi Ahmad Ramani kannan Department of Electrical&Electronics Engineering Universiti Teknologi PETRONASBandar Seri Iskandar31750 TronohPerak Darul RidzuanMalaysia

Pipelines produce vibrations during fluid or gas *** vibrations are less likely to cause structural failure as they exist with a small magnitude and can be harvested into useful *** paper presents a study on the piezoelectric energy-harvesting method converting mechanical energy from pipeline vibration into electrical *** performance of the serpentine-shaped piezoelectric cantilever beam was observed to check whether the design can produce the highest output voltage within the allowable vibration region of the pipeline from 10 to 300 Hz through finite element analysis using COMSOL Multiphysics software(Supplementary Material).In addition,this study investigates the energy-harvesting potential of the proposed design under real pipeline vibration conditions through a lab vibration *** harvested energy output is evaluated based on various vibration frequencies and amplitudes,which gives an idea of the device and its performance under different operating *** experiment result shows that the energy harvester produced an open-circuit voltage of 10.28-15.45 V with 1 g of vibration *** results of this research will contribute to the development of efficient piezoelectric energy harvesters adapted for pipeline environments.

关键词： piezoelectric energy harvester unimorph piezoelectric cantilever beam pipeline vibration energy harvesting COMSOL finite element modelling

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Characterization and screening of cotton(Gossypium hirsutum L.)germplasm for leafhopper(Amrasca biguttula biguttula(Ishida))resistance

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Journal of Cotton Research 2024年第2期7卷 188-195页

作者： Mawblei Chossterfield Premalatha Nallathambi Manivannan Alagarsamy Senguttuvan kannan Department of Genetics and Plant Breeding Tamil Nadu Agricultural UniversityCoimbatore 641003India Department of Cotton Tamil Nadu Agricultural UniversityCoimbatore 641003India Indian Council of Agricultural Research‑Centre Institute for Cotton Research Regional StationCoimbatore 641003India

Background Cotton(Gossypium hirsutum L.)is one of the most significant fibre and cash crops and plays an important role in Indian industrial and agricultural ***,over the years quantity and quality have been hampered by the pest *** alone has been shown to cause yield losses of up to 40%.In this study,screening and evaluation were performed to identify and categorize 100 cotton genotypes along with 5 checks as resistant,moderately resistant,sensitive and highly sensitive to *** A total of hundred genotypes were evaluated along with five checks for leafhopper *** on the screening results,a total of 19 genotypes were resistant to leafhoppers,which was on par with the findings of the check KC *** contents of total soluble sugar,total soluble protein,and total free amino acids were significantly positively correlated with the mean grade,whereas total phenols content and trichome density were significantly negatively correlated with the susceptibility ***,based on screening and biochemical analysis,the genotypes KC 2,JR-23,Samaru-26-T,D 4,TCH 1728,RS 253,and B-61-1862 exhibited high resistance to *** According to the findings of this study,choosing genotypes with high total phenolics content together with high trichome density and low contents of total soluble sugar,total soluble protein,and free amino acids may aid in the development of resistant genotypes.

关键词： Gossypium Amrasca biguttula biguttula Field screening Host plant resistance Biochemical parameters

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