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Socioeconomic inequalities in cancer incidence and mortality:An analysis of GLOBOCAN 2022

Chinese Medical Journal 2024年第12期137卷 1407-1413页

作者： Wei cao kang Qin Feng Li Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Hangzhou Center for Disease Control and Prevention HangzhouZhejiang 310021China The Third People’s Hospital of Xiaoshan HangzhouZhejiang 311251China

Background:Given the recent updates in cancer burden estimates by GLOBOCAN 2022,this study was undertaken to provide pertinent perspectives within the context of the Human Development Index(HDI)and major world ***:Datasets sourced from GLOBOCAN encompassed cancer cases and deaths across all cancer types in 2022,alongside projections up to *** incidences and deaths of the top 10 cancers within China and four distinct HDI-classified regions were compared using descriptive ***-standardized incidence rates(ASIRs)and mortality rates(ASMRs)worldwide for the most prevalent cancers in 2022 across ten largest economies and four-tier HDIs were *** top five cancer types concerning both incidence and mortality in China were delineated by sex and age ***:In males,prostate cancer predominated in countries with low,high(except China),and very high *** and liver cancers were prominent causes of death in countries with low *** females,breast and cervical cancers predominated in countries with low-to-medium *** and colorectal cancer incidence and deaths increased with high HDI for both *** and ASMRs for breast,prostate,lung,and colorectal cancers in the top 10 economies were higher than the global ***,liver,stomach,and cervical cancers in most Western countries exhibited lower *** China,hematologic malignancies(43%)were prevalent among children aged 0-14 years,whereas thyroid cancer led among adolescents and young adults aged 15-39 *** incidence and mortality,lung cancer predominated for individuals over 40 years,except for females aged 40-59 years,in whom breast cancer *** trends indicated substantial increases in new cancer cases(76.6%)and deaths(89.7%)over the next three ***:Infection-and poverty-related cancer burdens are offset by increased prostate,breast,colorectal,and lung cancer incidence associated with rapid societal and economic transi

关键词： Incidence Mortality Tumor burden China Human Development Index Hematologic neoplasms Lung neoplasms Breast neoplasms Colorectal neoplasms Thyroid neoplasms Liver neoplasms Prostatic neoplasms Early detection of cancer

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Risk factors of abnormal urinary albumin/ creatinine ratio in people with obesity

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 89-90页

作者：曹哲 Dept Endocrinol&Metab Dis 1st Affil HospZhengzhou UnivZhengzhou 450052

Objective To explore the clinical characteristics and risk factors of abnormal urinary albumin/creatinine ratio(UACR)in obese *** Baseline data from 2011 to 2012 in Henan Sub-center of"Risk Evaluation of Cancers in Chinese Diabetic Individuals:A longitudinal(REACTION)study"were utilized and those of body mass index≥28 kg/m^(2) were *** patients were divided into UACR normal group and UACR abnormal group(101 pairs)upon being matched on a 1:1 basis by age and *** logistic regression analysis,receiver operating characteristic(ROC)curve,and restricted cubic spline(RCS)analysis were performed to explore the risk factors for abnormal *** Compared with the normal UACR group,the UACR abnormal group had a higher number of alcohol consumers,a higher prevalence of hypertension,elevated systolic blood pressure,and triglyceride(all P<0.05).Multivariate logistic regression analysis showed that alcohol consumption(P=0.008).

关键词： urinary creatinine elevated

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Magnetic resonance imaging-based lymph node radiomics for predicting the metastasis of evaluable lymph nodes in rectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1849-1860页

作者： Yong-Xia Ye Liu Yang zheng kang Mei-Qin Wang Xiao-Dong Xie Ke-Xin Lou Jun Bao Mei Du zhe-Xuan Li Department of Radiology The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina1 Department of Pathology The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina Colorectal Center The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina

BACKGROUND Lymph node(LN)staging in rectal cancer(RC)affects treatment decisions and patient *** radiologists,the traditional preoperative assessment of LN metastasis(LNM)using magnetic resonance imaging(MRI)poses a *** To explore the value of a nomogram model that combines Conventional MRI and radiomics features from the LNs of RC in assessing the preoperative metastasis of evaluable *** In this retrospective study,270 LNs(158 nonmetastatic,112 metastatic)were randomly split into training(n=189)and validation sets(n=81).LNs were classified based on pathology-MRI *** MRI features[size,shape,margin,T2-weighted imaging(T2WI)appearance,and CE-T1-weighted imaging(T1WI)enhancement]were *** radiomics models used 3D features from T1WI and T2WI ***,a nomogram model combining conventional MRI and radiomics features was *** model used univariate analysis and multivariable logistic *** employed the receiver operating characteristic curve,with DeLong test for comparing diagnostic *** performance was assessed using calibration and decision curve *** The nomogram model outperformed conventional MRI and single radiomics models in evaluating *** the training set,the nomogram model achieved an area under the curve(AUC)of 0.92,which was significantly higher than the AUCs of 0.82(P<0.001)and 0.89(P<0.001)of the conventional MRI and radiomics models,*** the validation set,the nomogram model achieved an AUC of 0.91,significantly surpassing 0.80(P<0.001)and 0.86(P<0.001),*** The nomogram model showed the best performance in predicting metastasis of evaluable LNs.

关键词： Radiomics Lymph node metastasis Rectal cancer Magnetic resonance imaging

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Camrelizumab,apatinib and hepatic artery infusion chemotherapy combined with microwave ablation for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3481-3495页

作者： Meng-Xuan Zuo Chao An Yu-zhe cao Jia-Yu Pan Lu-Ping Xie Xin-Jing Yang Wang Li Pei-Hong Wu Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Interventional Ultrasound Chinese General PLA HospitalBeijing 100853China Department of Medical Imaging and Interventional Radiology Sun Yatsen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatic arterial infusion chemotherapy and camrelizumab plus apatinib(TRIPLET protocol)is promising for advanced hepatocellular carcinoma(Ad-HCC).However,the usefulness of microwave ablation(MWA)after TRIPLET is still *** To compare the efficacy and safety of TRIPLET alone(T-A)vs TRIPLET-MWA(TM)for *** From January 2018 to March 2022,217 Ad-HCC patients were retrospectively *** them,122 were included in the T-A group,and 95 were included in the T-M group.A propensity score matching(PSM)was applied to balance *** survival(OS)was compared using the Kaplan-Meier curve with the log-rank *** overall objective response rate(ORR)and major complications were also *** After PSM,82 patients were included both the T-A group and the T-M *** ORR(85.4%)in the T-M group was significantly higher than that(65.9%)in the T-A group(P<0.001).The cumulative 1-,2-,and 3-year OS rates were 98.7%,93.4%,and 82.0%in the T-M group and 85.1%,63.1%,and 55.0%in the T-A group(hazard ratio=0.22;95%confidence interval:0.10-0.49;P<0.001).The incidence of major complications was 4.9%(6/122)in the T-A group and 5.3%(5/95)in the T-M group,which were not significantly different(P=1.000).CONCLUSION T-M can provide better survival outcomes and comparable safety for Ad-HCC than T-A.

关键词： Hepatic arterial infusion chemotherapy Hepatocellular carcinoma Molecular targeting agent Programmed cell death protein 1 inhibitors Microwave ablation

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Impacts of Comorbidity and Mental Shock on Organic Micropollutants in Surface Water During and After the First Wave of COVID-19 Pandemic in Wuhan (2019–2021), China

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Engineering 2024年第6期37卷 40-48页

作者： Jian Zhao Jin kang Xiaofeng cao Rui Bian Gang Liu Shengchao Hu Xinghua Wu Chong Li Dianchang Wang Weixiao Qi Cunrui Huang Huijuan Liu Jiuhui Qu Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China Hubei Provincial Research Institute of Environmental Science Wuhan 430072China Key Laboratory of Drinking Water Science and Technology Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Sanitary Engineering Department of Water ManagementFaculty of Civil Engineering and GeosciencesDelft University of TechnologyDelft 2600 GAThe Netherlands China Three Gorges Corporation Wuhan 430010China Vanke School of Public Health Tsinghua UniversityBeijing 100084China

The first pandemic wave of coronavirus disease 2019(COVID-19)induced a considerable increase in several antivirals and antibiotics in surface *** common symptoms of COVID-19 are viral and bacterial infections,while comorbidities(e.g.,hypertension and diabetes)and mental shock(e.g.,insomnia and anxiety)are ***,little is known about the long-term impacts of comorbidities and mental shock on organic micropollutants(OMPs)in surface ***,we monitored 114 OMPs in surface water and wastewater treatment plants(WWTPs)in Wuhan,China,between 2019 and *** pandemic-induced OMP pollution in surface water was confirmed by significant increases in 26 OMP *** increases in four antihypertensives and one diabetic drug suggest that the treatment of comorbidities may induce OMP ***,cotinine(a metabolite of nicotine)increased 155 times to 187 ngL1,which might be associated with increased ***,the increases in zolpidem and sulpiride might be the result of worsened insomnia and ***,it is reasonable to note that mental-health protecting drugs/behavior also contributed to OMP *** the observed OMPs,telmisartan,lopinavir,and ritonavir were associated with significantly higher ecological risks because of their limited WWTP-removal rate and high *** study provides new insights into the effects of comorbidities and mental shock on OMPs in surface water during a pandemic and highlights the need to monitor the fate of related pharmaceuticals in the aquatic environment and to improve their removal efficiencies in WWTPs。

关键词： Coronavirus disease 2019 Comorbidities Mental shock Micropollutant Surface water

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The origin of two divergent ovine β-globin haplotypes and their potential association with environmental adaptation

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Journal of Genetics and Genomics 2024年第8期51卷 877-879页

作者： Yuxin kang Yilin Liang Fengting Fan Hojjat Asadollahpour Nanaei Chunna cao Yu Jiang Xianyong Lan Chuanying Pan Ran Li College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China Department of Animal Science Fars Agricultural and Natural Resources Research and Education CenterAgricultural ResearchEducation&Extension Organization(AREEO)FarsIran Author links open overlay panel

Hemoglobin is responsible for transporting oxygen from the lungs to body ***,this protein is a tetramer composed of two a-globin chains and twoβ-globin *** sheep,the β-globin locus is of particular interest because it contains two different haplotypes,namely haplotype A(hap A)and hap B,which differ in length by more than 30 kb and do not undergo recombination with each other due to low sequence similarity(Bauer and Jung,1975;Jiang et al.,2015).The two haplotypes also differ in gene content with hap A possessing two clusters of hemoglobin gene families and hap B possessing only one(Aguiletam et al.,2004),which implies differentiation in their functional *** A was speculated to be associated with high-altitude adaptation in sheep(Hu et al.,2019).

关键词： chains altitude similarity

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Magnetic phase transition and continuous spin switching in a high-entropy orthoferrite single crystal

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Frontiers of physics 2024年第2期19卷 157-167页

作者： Wanting Yang Shuang Zhu Xiong Luo Xiaoxuan Ma Chenfei Shi Huan Song Zhiqiang Sun Yefei Guo Yuriy Dedkov Baojuan kang Jin-Ke Bao Shixun cao Department of Physics Shanghai UniversityShanghai 200444China Materials Genome Institute and International Center for Quantum and Molecular Structures Shanghai UniversityShanghai 200444China School of Physics Southeast UniversityNanjing 211189China Shanghai Key Laboratory of High Temperature Superconductors Shanghai UniversityShanghai 200444China

Rare-earth orthoferrite REFeO_(3)(where RE is a rare-earth ion)is gaining *** created a high-entropy orthoferrite(Tm_(0.2)Nd_(0.2)Dy_(0.2)Y_(0.2)Yb_(0.2))FeO_(3)(HEOR)by doping five RE ions in equimolar ratios and grew the single crystal by optical floating zone *** strongly tends to form a single-phase structure stabilized by high configurational *** the low-temperature region(11.6‒14.4 K),the spin reorientation transition(SRT)ofΓ_(2)(F_(x),C_(y),G_(z))‒Γ_(24)‒Γ_(4)(G_(x),A_(y),F_(z))*** weak ferromagnetic(FM)moment,which comes from the Fe sublattices distortion,rotates from the a-to *** two-step dynamic processes(Γ_(2)‒Γ_(24)‒Γ_(4))are identified by AC susceptibility *** in HEOR can be tuned in the range of 50‒60000 Oe,which is an order of magnitude larger than that of orthoferrites in the peer system,making it a candidate for high-field spin *** spin-switching(SSW)and continuous spin-switching(CSSW)effects occur under low magnetic fields due to the strong interactions between RE‒Fe *** CSSW effect is tunable between 20‒50 Oe,and hence,HEOR potentially can be applied to spin modulation ***,because of the strong anisotropy of magnetic entropy change()and refrigeration capacity(RC)based on its high configurational entropy,HEOR is expected to provide a novel approach for refrigeration by altering the orientations of the crystallographic axes(anisotropic configurational entropy).

关键词： high-entropy oxide rare-earth orthoferrite spin reorientation transition spin switching magnetocaloric effect

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Effect of Al_(2)O_(3)/SiO_(2) mass ratio and cao content on viscosity and structure of slag for pyrometallurgical processing of spent automotive catalysts

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Journal of Iron and Steel Research International 2024年第3期31卷 608-621页

作者： zhe Wang Qi-long Wei Cheng-bin Shi Zhan-cheng Guo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The effect of Al_(2)O_(3)/SiO_(2) mass ratio and cao content on the viscosity and structure of the cao-Al_(2)O_(3)-SiO_(2)-6MgO-1.5ZrO_(2)-1.5CeO_(2) slag was *** results show that with the increase in Al_(2)O_(3)/SiO_(2) mass ratio,the viscous flow units within the slag gradually change from Si-O-Si to Al-O-Al and ***,the substitution of Al_(2)O_(3) for SiO_(2) leads to the transformation of Si-O bonds towards weaker Al-O bonds,which weaken the bond strength of the aluminosilicate networks,thus leading to a decrease in the viscosity of *** increase in cao content effectively promotes the depolymerization of the aluminosilicate networks,resulting in a significant decrease in the viscosity of the *** slag with Al_(2)O_(3)/SiO_(2) of 0.7-1.5 and cao of 30 wt.%shows promise as the reference slag system for the Fe-collection smelting of spent automotive catalysts due to its good comprehensive performance.

关键词： Aluminosilicate slag Al_(2)O_(3)/SiO_(2)mass ratio cao content Viscosity Slag structure

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The appearance of cytoplasmic cytochrome C precedes apoptosis during Drosophila salivary gland degradation

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Insect Science 2024年第1期31卷 157-172页

作者： Shihui Long Wenxin cao Yongyu Qiu Ruohan Deng Jiali Liu Lidan Zhang Renke Dong Fengxin Liu Sheng Li Haigang Zhao Na Li kang Li Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouChina Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina School of Food Science and Engineering South China University of TechnologyGuangzhouChina ChemPartner PharmaTech Co. LtdJiangmenGuangdong ProvinceChina

Apoptosis is an important process for organism development that functions to eliminate cell damage,maintain homeostasis,and remove obsolete tissues during *** mammals,apoptosis is accompanied by the release of cytochrome C(Cyt-c)from mitochondria to the ***,whether this process is conserved in the fruit fly,Drosophila melanogaster,remains *** this study,we discovered that during the degradation of Drosophila salivary gland,the transcription of mitochondria apoptosis factors(MAPFs),Cyt-c,and death-associated APAF1-related killer(Dark)encoding genes are all upregulated antecedent to initiator and effector caspases encoding *** proteins Cyt-c and the active caspase 3 appear gradually in the cytoplasm during salivary gland ***,the Cyt-c protein colocates with mito-GFP,the marker indicating cytoplasmic mitochondria,and the change in mitochondrial membrane potential coincides with the appearance of Cyt-c in the ***,impeding or promoting 20E-induced transcription factor E93 suppresses or enhances the staining of Cyt-c and the active caspase 3 in the cytoplasm of salivary gland,and accordingly decreases or increases the mitochondrial membrane potential,*** research provides evidence that cytoplasmic Cyt-c appears before apoptosis during Drosophila salivary gland degradation,shedding light on partial conserved mechanism in apoptosis between insects and mammals.

关键词： active caspase 3 apoptosis Cyt-c Drosophila salivary gland

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Perinatal prevalence of birth defects in the Mainland of China,2000–2021:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第7期20卷 669-681页

作者： Liang-Yu kang Zi-Rui Guo Wei-Jing Shang Gui-Ying cao Yi-Ping Zhang Qiao-Mei Wang Hai-Ping Shen Wan-Nian Liang Min Liu Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityNo.38Xueyuan RoadHaidian DistrictBeijing100191China Vanke School of Public Health Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Department of Maternal and Child Health National Health Commission of the People’s Republic of ChinaNo.1Xizhimenwai South RoadXicheng DistrictBeijingChina Institute of Healthy China Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of Education BeijingNo.38Xueyuan RoadHaidian DistrictBeijing100191China

Background Although birth defects are of great concern globally,the latest national prevalence has not yet been quantified in *** conducted a systematic review and meta-analysis to estimate the perinatal prevalence of birth defects in the Mainland of China between 2000 and *** We performed a systematic literature search of six databases for relevant articles published between January 1,2000,and March 1,*** included published studies that reported data on the perinatal prevalence of birth defects in the Mainland of *** DerSimonian and Laird random-effects models were used to estimate the pooled prevalence and its 95%confidence interval(CI).We also conducted subgroup analyses and univariable meta-regressions to explore differences in prevalence by time period,geographic region,and other *** We included 254 studies reporting the perinatal prevalence of birth defects and 86 studies reporting only the prevalence of specific types of birth *** on 254 studies covering 74,307,037 perinatal births and 985,115 cases with birth defects,the pooled perinatal prevalence of birth defects was 122.54(95%CI 116.20–128.89)per 10,000 perinatal births in the Mainland of China during 2000–***,the perinatal prevalence of birth defects increased from 95.60(86.51–104.69)per 10,000 in 2000–2004 to 208.94(175.67–242.22)per 10,000 in 2020–*** were also significant disparities among different geographical *** heart defects(33.35 per 10,000),clefts of the lip and/or palate(13.52 per 10,000),polydactyly(12.82 per 10,000),neural tube defects(12.82 per 10,000),and inborn errors of metabolism(11.41 per 10,000)were the five most common types of birth *** perinatal prevalence among males was significantly higher than that among females(β=2.44×10^(−3),P=0.003);a higher perinatal prevalence of birth defects was observed among perinatal births whose mothers were≥35 years(β=4.34×10^(−3),P<0.001).Conclusion Compreh

关键词： Birth defects China Perinatal Prevalence

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