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Protective and Adverse Roles of DDX3X in Different Cell Types in Nonalcoholic Steatohepatitis Progression

Research 2024年第3期6卷 561-574页

作者： Suzhen Yang Lin Zhou Tianming Zhao Hanlong Zhu Tingting Luo kang jiang Xiaoxiao Shi Chunyan Chen Han Zhang Si Zhao Xiaoping Zou Yuzheng Zhuge Fangyu Wang Lei Wang Mingzuo jiang Bing Xu Department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China. Department of Gastroenterology and Hepatology the Affiliated Jinling Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China School of Medicine Northwest UniversityShaanxiXi’an710069China. Department of Gastroenterology Nanjing Drum Tower HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeJiangsuNanjing210008China.

Persistent hepatic cellular metabolic stress and liver inflammatory stimuli are key signatures of nonalcoholic steatohepatitis(NASH).DDX3X is a vital molecule involved in cell fate decisions in both pro-survival stress granule(SG)and pro-death NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome assembly in response to stress ***,the role of DDX3X in NASH remains *** characterized the cell type-specific roles of DDX3X in *** liver tissues from NASH patients and normal control subjects were collected to assess DDX3X expression and *** steatohepatitis models were constructed by feeding macrophage-specific DDX3X knockout(DDX3^(XΔMφ)),hepatocyte-specific DDX3X knockout(DDX3X^(Δhep)),and wild-type control(DDX3X^(fl/fl))mice a high-fat and high-cholesterol(HFHC)diet,a methionine-and choline-deficient(MCD)diet,and a high-fat/high-iron/high-fructose/high-cholesterol,low-methionine,and choline-deficient(HFHIHFHC-MCD)*** study demonstrated that DDX3X was predominantly expressed in macrophages and hepatocytes in control liver tissues,and its expression was down-regulated in patients or mice with *** to DDX3X^(fl/fl) littermates,DDX3^(XΔMφ)mice showed improved liver histology in nutritional steatohepatitis *** of macrophage DDX3X inhibited NLRP3 inflammasome-mediated pyroptosis,causing anti-inflammatory M2 polarization and alleviating hepatocyte steatohepatitic ***3X^(Δhep) mice developed marked steatohepatitis in multiple nutritional steatohepatitis models compared to DDX3X^(fl/fl) ***3X-deleted hepatocytes showed impaired SG assembly,leading to increased sensitivity and intolerance to metabolic stimulation and resultant *** conclusion,DDX3X plays opposite roles in different cell types during the progression of NASH.A better understanding of the cell-specific differences in the crosstalk between SG formation and NLRP3 activation is crucial for developing pr

关键词： NLRP3 impaired inhibited

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微课在初中物理教学中的应用探微

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成才之路 2024年第10期 101-104页

作者：姜康甘肃省武威第四中学甘肃武威733000

微课是一种新型的教学资源,以其短小精悍、针对性强、便于传播和共享等特点,受到了广大教育工作者的青睐。在初中物理教学中,微课可以通过动画、模拟实验等多种形式,将抽象的物理知识直观化、形象化地呈现出来,以此帮助学生更好地理解... 详细信息

微课是一种新型的教学资源,以其短小精悍、针对性强、便于传播和共享等特点,受到了广大教育工作者的青睐。在初中物理教学中,微课可以通过动画、模拟实验等多种形式,将抽象的物理知识直观化、形象化地呈现出来,以此帮助学生更好地理解物理概念和规律。文章阐述微课教学的特点,分析微课在初中物理教学中的应用优势,并对微课在初中物理教学中的应用策略进行讨论,旨在使微课教学与初中物理教学融为一体,为物理教学效果提供有力保障。

关键词：微课初中物理物理教学应用优势教学效果

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360例严重药品不良反应和药物相互作用的分析

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中国现代应用药学 2024年第5期41卷 696-701页

作者：林艳花吕小群任伟芳刘玉娟姜康姜华侨复旦大学附属金山医院护理部上海201508 复旦大学附属金山医院药剂科上海201508

目的通过对真实世界中严重药品不良反应(serious adverse drug reaction,SADR)和药物-药物相互作用(drug-drug interactions,DDIs)的分析与评价,获得DDIs相关SADR的临床证据,为临床合理用药提供参考。方法收集2011年1月—2020年12月上... 详细信息

目的通过对真实世界中严重药品不良反应(serious adverse drug reaction,SADR)和药物-药物相互作用(drug-drug interactions,DDIs)的分析与评价,获得DDIs相关SADR的临床证据,为临床合理用药提供参考。方法收集2011年1月—2020年12月上报至国家药品不良反应监测中心的SADR报告,采用UpToDate中的Lexi-Interaction®软件对SADR中≥2种药物进行分析,评判是否存在潜在DDIs,并对可能由其导致的药品不良反应进行统计分析。结果360例SADR中男性稍多于女性(50.83%vs 49.17%),平均年龄(65.27±14.71)岁,≥65岁患者占56.39%。构成比最高的药物为心血管系统用药,累及器官以胃肠系统损害为主,而阿司匹林是导致SADR例次最多的药物。在含≥2种可疑药物的150例SADR中,存在潜在DDIs的有64例,占42.67%;而发生实际DDIs有42例,占28%,其中2例属于X级,16例属于D级,且多数(71.43%)报告是由相加的药效学相互作用所致。阿司匹林是潜在DDIs和实际DDIs中最常见的药物,而实际DDIs中最常涉及的药物组合为阿司匹林/氯吡格雷,其中胃肠道出血是最常见的SADR。结论应关注药物相互作用对SADR的影响,优化处方用药,特别是老年人群,依据潜在DDIs的结果,合理选用治疗药物,同时加强心血管系统药物和重点人群的监测,保障用药安全。

关键词：真实世界严重药品不良反应药物相互作用老年患者合理用药

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基于U形谐振器的无源裂缝传感器

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哈尔滨工程大学学报 2024年第8期45卷 1421-1426页

作者：姜康薛松涛谢丽宇万国春同济大学土木工程学院上海200092 日本东北工业大学工学部建筑学科宫城仙台982-8577 同济大学电子与信息工程学院上海201804

针对传统裂缝传感器需要电源供应才能正常工作的缺陷,本文提出了一种基于无应力组合式贴片天线的无源裂缝传感器设计。利用U形谐振器实现裂缝传感,改变传感器内部谐振单元的谐振频率。通过观测回波信号的幅度和相位提取传感器的谐振频率... 详细信息

针对传统裂缝传感器需要电源供应才能正常工作的缺陷,本文提出了一种基于无应力组合式贴片天线的无源裂缝传感器设计。利用U形谐振器实现裂缝传感,改变传感器内部谐振单元的谐振频率。通过观测回波信号的幅度和相位提取传感器的谐振频率,进而实现对裂缝的监测。基于天线理论建立了传感器的等效电路模型并推导谐振频率,研究裂缝宽度对传感器谐振频率的影响规律。进一步在三维电磁仿真软件CST中对传感器进行了数值模拟,并且通过试验研究了裂缝拓展对谐振频率的影响。研究表明:随着裂缝的扩展,传感器的谐振频率增加,且裂缝宽度与谐振频率之间具有较好的线性关系。

关键词：结构健康监测裂缝传感器谐振频率多维电磁特征参数组合式贴片天线无源 U形谐振器电长度

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Improvement of Cracking-resistance and Flexural Behavior of Cement-based Materials by Addition of Rubber Particles

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Journal of Wuhan University of Technology(Materials Science) 2008年第4期23卷 579-583页

作者： kang Jingfu jiang Yongqi School of Civil Engineering Tianjin University Tianjin 300072 China

By ring test and bend test, the improvement of waste tire rubber particles on the crack- resistance and flexural behaviors of cement-based materials were investigated. Test results show that the cracking time of the ring specimens can be retarded by the incorporation of rubber particles in the cement paste and mortar. The improvement in the crack-resistance depended on the rubber fraction. When the rubber fraction was 20% in volume, the cracking time was retarded about 15 h for the paste and 24 d for the mortar respectively. Flexural properties were evaluated based on the bend test results for both mortar and concrete containing different amount of rubber particles. Test results show that rubberized mortar and concrete specimens exhibit ductile failure and significant deformation before fracture. The ultimate deformations of both mortar and concrete specimen increase more than 2-4 times than control specimens.

关键词： composite material rubberized concrete cracking-resistance flexural behavior

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Support interaction of Pt/CeO2 and Pt/SiC catalysts prepared by nano platinum colloid deposition for CO oxidation

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Journal of Rare Earths 2020年第4期38卷 376-383页

作者： kang Xi Yong Wang kang jiang Jing Xie Ying Zhou Hanfeng Lu Innovation Team of Air Pollution Control Institute of Catalytic Reaction EngineeringCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China

The interaction between Pt and its various supports can regulate the intrinsic electronic structure of Pt particles and their catalytic ***,Pt/CeO2 and Pt/SiC catalysts were successfully prepared via a facile Pt colloidal particle deposition method,and their catalytic performance in CO oxidation was ***,TEM,XPS and H2-TPR were used to identify the states of Pt particles on the support surface,as well as their effect on the performance of the *** of the Pt-O-Ce interaction is one of the factors controlling catalyst *** the oxidative treatment at low temperature,the Pt-O-Ce interaction plays an important role in improving the catalytic *** calcining at high temperature,enhanced Pt-O-Ce interaction results in the absence of metallic Pt0 on the support surface,as evidenced by the appearance of Pt2+*** is consistent with the XPS data of Pt/CeO2,and is the main reason behind the deactivation of the *** contrast,either no interaction is formed between Pt and SiC or Pt nanoparticles remain in the metallic Pt0 state on the SiC surface even after aging at 800℃in an oxidizing ***,the Pt/SiC shows better thermal stability than Pt/*** interaction between Pt and the active support may be concluded to be essential for CO oxidation at low temperature,but strong interactions may induce serious deactivation of catalytic activity.

关键词： Nano platinum colloid CO oxidation Pt-O-Ce interaction CeO2 SiC Rare earths

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Ferroelectric order in hybrid organic-inorganic perovskite NH_(4)PbI_(3) with non-polar molecules and small tolerance factor

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npj Computational Materials 2023年第1期9卷 1726-1731页

作者： Jia-Bin Li Zhi-kang jiang Rui Wang Jin-Zhu Zhao Ruiqiang Wang Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of Physics and Telecommunication EngineeringSouth China Normal UniversityGuangzhou 510006PR China Guangdong-Hong Kong Joint Laboratory of Quantum Matter South China Normal UniversityGuangzhou 510006PR China Foshan(Southern China)Institute for New Materials Foshan 528300PR China Institute for Structure and Function and Department of Physics Chongqing UniversityChongqing 400044PR China Center of Quantum Materials and Devices Chongqing UniversityChongqing 400044PR China Center for Computational Science and Engineering Southern University of Science and TechnologyShenzhen 518055PR China

The appropriate theoretical picture of describing the ferroelectric order in hybrid organic-inorganic perovskite remains attractive and under intense *** rationalize the interaction between organic molecule sublattice and inorganic frame from *** systematic investigations on the NH_(4)PbI_(3),we show that the non-polar octahedral rotation dominates the process of stabilizing of the lattice with small value of tolerance *** direct coupling between molecules is *** the help of hydrogen bonding to the inorganic cage,molecule sublattice will eventually build long-range ferroelectric or anti-ferroelectric order under the constrain of the inorganic cage and further polarize the inorganic frame as the *** results also clarify that to build ferroelectricity the polar molecule is helpful but not *** the general rule for hybrid organic-inorganic perovskite,we identified the fundamental mechanism that can be considered as a critical pre-step forward to further controlling the related physics in functional materials.

关键词： inorganic ferroelectric polar

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A cloud detection method based on a time series of MODIS surface reflectance images

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International Journal of Digital Earth 2013年第S01期6卷 157-171页

作者： Hairong Tang Kai Yu Olivier Hagolle kang jiang Xiurui Geng Yongchao Zhao Key Laboratory of Technology in Geo-spatial information Processing and Application System Institute of ElectronicsChinese Academy of ScienceBeijingChina CESBIO Universite´de ToulouseUnite´mixte CNES CNRS IRD UPSToulouse Cedex 4France

The Moderate Resolution Imaging Spectroradiometer(MODIS)-Terra surface reflectance product(MOD09A1),with bands 1 to 7,is a gridded,eight-day composite product derived from the MODIS-Terra top of atmosphere reflectance *** performs cloud detection and corrects for the effects of atmospheric gases and *** cloud mask(CM)algorithms for MODIS are based on empirical thresholds on spectral reflectance and brightness *** the spatial resolution of the thermal band is 1000 m,while that of MOD09A1 is 500 m,many undetected and false clouds are observed in *** errors always result in temporal and spatial inconsistencies in higher-level *** this paper,a cloud detection algorithm(TSCD)based on a MOD09A1 time series is *** series cloud detection(TSCD)algorithm is based on the relative stability of ground reflectance and the sudden variations in reflectance that result from cloud *** algorithm first searches the clear-sky reference data,and then discriminates clouded and unclouded pixels by detecting a sudden change of reflectance in the blue wavelength and spectral correlation coefficient at the pixel *** with cloud cover assessments obtained from MODIS’original CM,TSCD provides similar or better discrimination in most situations when the land surface changes slowly.

关键词： MODIS surface reflectance time series cloud detection BRDF

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Integration of all-printed zinc ion microbattery and glucose sensor toward onsite quick detections

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SusMat 2022年第3期2卷 368-378页

作者： kang jiang Xi Wen Yuxian Deng Zeyan Zhou Qunhong Weng College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan UniversityChangshaPR China

Rational design of microsystems and efficient integration of various functional modules that can directly realize the aimed functions are very attractive for portable and onsite practical applications,which is also significant in developing miniaturized and intelligent electronics and *** the conventional electrochemical glucose sensors that always need auxiliary complex systems for power supply,signal processing,and feedbacks,we design an all-printed glucose sensor integrated with a zinc ion microbattery(ZIMB)as a micropower source for portable and onsite quick glucose *** integrated glucose sensor(GS)and ZIMB(iGS-ZIMB)systempossesses a high areal energy density of 247.3μWh/cm^(2) and power density of 1193μW/cm^(2) and exhibits high sensitivity up to 464.2μA/mM/cm^(2),wide linear range of 0.5-6.0 mM,and good reproducibility in glucose *** a simple amplification circuit design,the glucose concentration signals could be displayed within a short response time of 1.6 s without the need of external auxiliary *** iGS-ZIMB microsystem has prominent advantages in efficiency and cost and is promising for onsite medical and healthcare applications.

关键词： glucose sensors integration microbatteries printing zinc ion batteries

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放牧干扰下天山北坡中段植物功能群特征及其与土壤环境因子的关系

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植物生态学报 2024年第6期48卷 701-718页

作者：江康威张青青王亚菲李宏丁雨杨永强吐尔逊娜依·热依木新疆农业大学草业学院乌鲁木齐830052 新疆农业大学生命科学学院乌鲁木齐830052 新疆农业大学资源与环境学院乌鲁木齐830052

放牧是导致草地生态系统发生变化的重要驱动因素,然而在不同放牧强度下草地植物群落与功能群对土壤因子的响应是否一致目前仍不明确。该研究以天山北坡中段草地为研究对象,基于野外植物群落调查和室内土壤分析,分析放牧对植物群落与功... 详细信息

放牧是导致草地生态系统发生变化的重要驱动因素,然而在不同放牧强度下草地植物群落与功能群对土壤因子的响应是否一致目前仍不明确。该研究以天山北坡中段草地为研究对象,基于野外植物群落调查和室内土壤分析,分析放牧对植物群落与功能群的影响,以此为基础进一步揭示在放牧干扰下植物群落和功能群对土壤因子响应的差异。结果表明,轻度放牧和未放牧草地的主要优势功能群为多年生禾草和莎草,重度放牧样地中的主要优势功能群为毒害草,优势种为醉马草(Achnatherum inebrians)。相较于重度放牧,轻度放牧显著提高多年生禾草、豆科植物、莎草和杂类草功能群的地上生物量,显著降低了毒害草地上生物量。轻度放牧的物种多样性指数显著高于重度放牧;而在功能群多样性中,轻度放牧的Shannon-Wiener指数、Margalef指数和Pielou指数显著高于重度放牧,Simpson指数在不同放牧强度间无显著差异。冗余分析、Mantel检验以及结构方程模型的结果显示,植物群落特征、功能群和群落多样性与土壤有机碳含量、速效氮含量、速效钾含量、全磷含量、全钾含量、土壤密度和土壤含水量均存在显著相关关系;放牧直接对草地植物高度、盖度、密度、地上生物量、植物群落和功能群多样性产生显著的负向影响,也可通过提高土壤密度和降低土壤养分含量从而对群落高度、盖度、密度、地上生物量、植物群落和功能群多样性产生间接的负向影响。综上,在放牧干扰下,土壤因子对维持天山北坡中段草地植物群落的稳定生长起到至关重要的作用,该结果为新疆草地植物资源的合理利用提供科学依据。

关键词：放牧植物功能群土壤因子 Mantel检验结构方程模型天山北坡

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