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Tides and short-term variabilities in the Kuroshio west of Yonakuni-jima

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Acta Oceanologica Sinica 1999年第3期18卷 311-324页

作者：袁耀初王惠群朱晓华苏纪兰陈洪方同德 Second Institute of Oceanography State Oceanic Administration Hangzhou 310012 China Department of Environmental Sciences Faculty of Engineering Hiroshima University Higashi-Hiroshima 739-8527 Japan Chugoku Natl. Indust. Res. Institute Kure Hiroshima 739-0197 Japan

Direct current measurements at the mooring station m southwest of Yonakuni-jima are carried out from may 18 to June 1, 1996. The Observed Kuroshio Current at 290 and 594 m depths of the mooring station m is quite steady ddring the pened of Observation. The rotary spectral estimates of the current data by the maximum entropy method show that there are prominent diurnal and semidiurnal spectral peaks. The semidiurnal tide is predominant at 290 m depth while there is the current fluctuation with the inertial period except for the tidal oscillation at 594 m depth. There are also peaks at the pened of 4-7 d. There is a significant coherence between two time series of currents at 290 and 594 m depths in the pened range of 3 - 5 d. The Japan meteorological Agency (JmA) wind data during the same period as the oceanic measurement are used in comparison with the current meter data. Rotary spectral estimates for the wind data show significant peaks at the period of 3 - 5 d. It is concluded from the cross spectra between the wind and the current that the current fluctuation of 3 - 5 d period at 290 m depth response to the wind fluctuation of the same periods with time lags smaller than 1 d.

关键词： Kuroshio current measurement wind data spectral estimates 3 - 5 d period

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三菱重工地面燃气轮机热障涂层研究进展

热喷涂技术 2014年第3期6卷 56-62页

作者： Yoshifumi Okajima Daisuke Kudo Naotoshi Okaya Taiji Torigoe Hideaki kaneko.m.sahiko mega Eisaku Ito Junichiro masada Keizo Tsukagoshi 吴琼

燃气轮机联合循环热效率的提高,要求涡轮进口温度不断增加。目前,三菱重工(mHI)已经积极参与日本国家项目,通过发展1700℃级燃气轮机,以使联合循环热效率实现达到62%指标。在此国家项目中开发的部分组件技术适用于1600℃级燃气轮机m501J... 详细信息

燃气轮机联合循环热效率的提高,要求涡轮进口温度不断增加。目前,三菱重工(mHI)已经积极参与日本国家项目,通过发展1700℃级燃气轮机,以使联合循环热效率实现达到62%指标。在此国家项目中开发的部分组件技术适用于1600℃级燃气轮机m501J,它具有世界上最高的涡轮进口温度。而热障涂层(TBC)是实现此目标的最关键技术之一。在发展先进的热障涂层中,在mHI工厂中建立名为T点的试验电厂是有必要的。在真实热部件中制备的先进TBC可以在工厂中进行验证,并且运行后的效果可以得到反馈。本文讨论了TBC的开发以及在三菱重工实际电厂中的验证。

关键词：燃气轮机热障涂层电厂

Phase Ⅰ trial of combination chemotherapy with gemcitabine, cisplatin, and S-1 in patients with advanced biliary tract cancer

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World Journal of Gastroenterology 2015年第19期21卷 5979-5984页

作者： Akinori Watanabe mitsuhiro Kida Shiro miyazawa Tomohisa Iwai Kosuke Okuwaki Toru kaneko Hiroshi Yamauchi miyoko Takezawa Hiroshi Imaizumi Wasaburo Koizumi Department of Gastroenterology Kitasato University School of Medicine

AIm: To evaluate the dose-limiting toxicities(DLTs)and determine the maximum-tolerated dose(mTD) and recommended dose(RD) of combination chemotherapy with gemcitabine, cisplatin and S-1 which is an oral fluoropyrimidine pro-drug in patients with advanced biliary tract ***: Patients with histologically or cytologically confirmed unresectable or recurrent biliary tract cancer were enrolled. The planned dose levels of gemcitabine(mg/m2), cisplatin(mg/m2), and S-1(mg/m2 per day) were as follows: level-1, 800/20/60;level 0, 800/25/60; level 1, 1000/25/60; and level 2,1000/25/80. In each cycle, gemcitabine and cisplatin were administered intravenously on days 1 and 15,and S-1 was administered orally twice daily on days 1to 7 and days 15 to 21, every 4 ***: Twelve patients were enrolled, and level0 was chosen as the starting dose. None of the first three patients had DLTs at level 0, and the dose was escalated to level 1. One of six patients had DLTs(grade 4 febrile neutropenia, leucopenia, and neutropenia; grade 3 thrombocytopenia) at level *** then proceeded to level 2. None of three patients had DLTs during the first cycle. Although the mTD was not determined, level 2 was designated at the RD for a subsequent phase Ⅱ ***: The RD was defined as gemcitabine1000 mg/m2(days 1, 15), cisplatin 25 mg/m2(days1, 15), and S-1 80 mg/m2 per day(days 1-7, 15-21),every 4 weeks. A phase Ⅱ study is planned to evaluate the effectiveness of combination chemotherapy withgemcitabine, cisplatin, and S-1 in advanced biliary tract cancer.

关键词： Gemcitabine Cisplatin, S-1 Advancedbiliary tract cancer

ADCP观测得到的2008年4月吕宋海峡流速剖面结构

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海洋学报 2013年第3期35卷 1-10页

作者：杨成浩廖光洪袁耀初陈洪金子新江田憲章谷口直和南馆正憲国家海洋局第二海洋研究所卫星海洋环境动力学国家重点实验室浙江杭州310012 广岛大学工学部环境科学系

基于2008年4月22—26日吕宋海峡调查航次的下放式声学多普勒流速剖面仪(LADCP)和船载ADCP(SADCP)等观测资料,并采用潮波模式模拟结果去除潮流对观测资料的影响,观测结果表明:调查期间黑潮入侵南海的位置与1992年春季比较接近,其分支位... 详细信息

基于2008年4月22—26日吕宋海峡调查航次的下放式声学多普勒流速剖面仪(LADCP)和船载ADCP(SADCP)等观测资料,并采用潮波模式模拟结果去除潮流对观测资料的影响,观测结果表明:调查期间黑潮入侵南海的位置与1992年春季比较接近,其分支位于调查海区中部C2、C7、C8和C9站,表层黑潮在C8站分离为两支,分别流向C9和C2站,C9站北向流明显比C8站减弱。在C2站,黑潮分支位于400m层以浅,其最大西向流速为77cm/s,而在C7、C8和C9站黑潮分支位于500m层以浅,黑潮在入侵南海的过程中其核心深度逐渐变浅。上层黑潮明显作反气旋弯曲。本调查航次的观测结果在定性上支持吕宋海峡水交换有"三明治"垂直结构的特性。

关键词：吕宋海峡流速剖面结构 2008年4月航次 LADCP

钙化能否预测甲状腺乳头状癌病人接受131I治疗后淋巴结转移灶131I的浓聚?CT、131I全身扫描和18F-FDG PET/CT比较

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国际医学放射学杂志 2010年第2期 203-203页

作者： K.kaneko K.Abe S.Baba Y.Tanabe H.Yabuuchi m.Hatakenaka 袁瑛 Department of Clinical Radiology Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

研究目的是阐明淋巴结钙化对甲状腺乳头状癌(PTC)病人131I治疗的预测价值。分析了19例PTC病人131I治疗期时CT上淋巴结钙化情况,并与131I全身核素扫描和

关键词：甲状腺乳头状癌淋巴结淋巴组织 FDG PET 病人

食管鳞状上皮细胞癌放化疗后完全应答病例迟发的毒性反应

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世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 39-39页

作者： Kumekawa Y. kaneko K. Ito H. 陈云茹 Second Department of Internal medicine Showa University School of Medicine 1-5-8 Hatanodai Shinagawa-ku Tokyo 142-8666 Japan

Background: We retrospectively investigated long-term toxicity after concurrent chemoradiotherapy (CRT) for patients with esophageal squamous cell carcinoma (ESCC). methods. Concurrent chemoradiotherapy was performed in 110 patients with T1 to T4 disease containing m1 lymph node (LYm) disease. Chemotherapy consisted of protracted infusion of 5-fluorouracil 400 mg/m2 per 24h on days 1 to 5 and 8 to 12, combined with 2-h infusion of cisplatin 40 mg/m2 on days 1 and 8. Radiation treatment of the mediastinum at a dose of 30Gy in 15 fractions was administered concomitantly with chemotherapy. A course schedule with a 3-week treatment and a 2-week break was applied twice, with a total radiation dose of 60Gy. For the assessment of toxicity, the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer late radiation morbidity scoring schema was adopted. Results. A total of 81 patients were recruited in patients with stage I to IVA. Of 34 patients with complete response, 1 patient died as a result of acute myocardial infarction. Grade 2, 3, and 4 late toxicities occurred with the following incidences: pericarditis in 3 patients, 1 patient, and 2 patients, respectively; heart failure in 0, 0, and 3 patients; pleural effusion in 2, 3, and 0 patients; and radiation pneumonitis in 0, 0, and 1 patient, respectively. Conclusions. Definitive chemoradiotherapy for ESCC is effective with substantial toxicities. Further investigation is warranted to minimize the normal tissue toxicities.

关键词：毒性反应放射治疗同步放化疗尿嘧啶欧洲癌症研究肿瘤放疗放射剂量急性心肌梗死放射性肺炎

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培养人角朊细胞中白介素15的基因表达

中华皮肤科杂志 1998年第4期31卷 236-238页

作者：韩钢文岩月氏马圣清金子史男北京医科大学第一医院皮肤科 100034 日本福岛医科大学皮肤科

目的　为了探讨白介素 1 5 (IL 1 5 )在表皮角朊细胞中的表达及调节。方法　应用RT PCR及Northern杂交方法分析了IL 1 5在培养的人角朊细胞及鳞状细胞癌细胞系 (HSC 5 )中的表达 ,并观察了地塞米松对角朊细胞表达IL 1 5的影响。结... 详细信息

目的　为了探讨白介素 1 5 (IL 1 5 )在表皮角朊细胞中的表达及调节。方法　应用RT PCR及Northern杂交方法分析了IL 1 5在培养的人角朊细胞及鳞状细胞癌细胞系 (HSC 5 )中的表达 ,并观察了地塞米松对角朊细胞表达IL 1 5的影响。结果　正常角朊细胞及鳞状细胞癌细胞系细胞均有IL 1 5mRNA的表达 ,1 0 -6mol/L地塞米松处理培养的角朊细胞后 ,IL 1 5mRNA表达水平明显降低。结论　表皮细胞来源的IL 1

关键词：角蛋白细胞白细胞介素15 印迹法 RNA

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1999年6月黄海南部与东海北部的环流

海洋学报(中文版) 2002年第S1期 20-30页

作者：袁耀初刘勇刚周明煜金子新袁宙江田宪彰国家海洋局第二海洋研究所国家海洋局第二海洋研究所国家海洋环境预报中心日本广岛大学工学部环境科学系日本广岛大学工学部环境科学系日本广岛大学工学部环境科学系浙江杭州310012 国家海洋局海洋动力过程和卫星海洋学重点实验室浙江杭州310012浙江杭州310012

基于 1 999年 6月 4～ 1 9日航次的CTD与海流观测 (锚碇测流与ADCP测流 ) ,采用改进逆方法 ,得出以下主要结果 :( 1 )黑潮在PN断面有一个主核心 ,主核心在陆坡上 .在PN断面最东部分 ,也存在一支北向流 .在两支北向流之间存在一个较弱的... 详细信息

基于 1 999年 6月 4～ 1 9日航次的CTD与海流观测 (锚碇测流与ADCP测流 ) ,采用改进逆方法 ,得出以下主要结果 :( 1 )黑潮在PN断面有一个主核心 ,主核心在陆坡上 .在PN断面最东部分 ,也存在一支北向流 .在两支北向流之间存在一个较弱的反气旋暖涡 ,在PN断面西侧存在一个弱的气旋式涡 ,这是在东海PN断面出现的流结构的一种形式 ;( 2 )黑潮与台湾暖流外侧分支通过PN断面的总的净北向流量约为 2 6 2× 1 0 6m3 /s.台湾暖流内侧分支通过本计算海域的流量约为 0 4× 1 0 6m3 /s .台湾暖流与黄海沿岸流对本海域的陆架部分海流起着重要作用 ;( 3)黄海沿岸流向东南方向流入本海域 ,受台湾暖流北上的作用 ,也受地形影响 ,作气旋式弯曲 ,然后向东北方向流动 ;( 4 )黄海沿岸流作气旋式弯曲的北侧存在一个气旋式涡 ,该涡具有高密、冷水的特性 ;( 5)在本海域的最北断面C3,在测站C30 6与C31 1之间 30m以深存在一个均匀冷水层 ,正是黄海冷水团的西南边缘

关键词：黄海南部与东海北部黑潮的流结构台湾暖流与黄海沿岸流高密冷水团

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

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Signal Transduction and Targeted Therapy 2016年第1期1卷 158-171页

作者： Sasha Bogdanovich Younghee Kim Takeshi mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti menotti Ruvo Annamaria Sandomenico miho Nozaki Ryo Ijima Hiroki kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoyaJapan Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.a.r.l.NaplesItaly Istituto di Biostrutture e Bioimmagini CNRNaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands School of Pathology and Laboratory medicine University of Western AustraliaCrawleyWAAustralia Division of Immunology Department of PathologyUniversity of CambridgeCambridgeUK Department of Immunology Unit of Antibodies in Therapy and PathologyInstitut PasteurParisFrance Institut National de la Santéet de la Recherche médicale(INSERm)U1222 ParisFrance Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS multimedica MilanoItaly Department of Physiology University of KentuckyLexingtonKYUSA.

Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s *** most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human *** bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in *** we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage *** approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized *** anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated ***,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA ***,mice deficient in FcγRI exhibited increased developmental and pathological *** findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies.

关键词： CD64 angiogenesis antibodies