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Open Journal of Applied Sciences 2013年第1期3卷 116-122页

作者： Kohji Ishihara Aiko Fujita Akane Sakiyama Yuko Kobayashi Kaoru Hori kanako maruike Noriyoshi Masuoka Nobuyoshi Nakajima Hiroki Hamada Department of Life Science Okayama University of Science Okayama Japan Graduate School of Health and Welfare Okayama Prefectural University Soja Japan

To research the potential ability of marine-derived actinomycetes to act as biocatalysts, 8 Micromonospora strains and 5 Streptomyces strains were screened. Two recommended media (227 and 1076 media) and 2 modified media (1076-25% and P-1076-25% media) for liquid culture of these marine-derived actinomycetes were tested. As a result, 2 Micromonospora strains (Micromonospora sp. NBRC107096 and 107097) cultured with the 1076-25% medium and 2 Streptomyces strains (Streptomyces tateyamensis NBRC105048 and Streptomyces sp. NBRC105896) cultured with P-1076-25% medium showed a good growth. The stereoselective reduction of α-keto esters using these 4 actinomycetes was tested. As a result, it was found that these strains had a reducing activity toward various α-keto esters. The introduction of L-glutamate or sucrose as an additive remarkably increased the conversion ratios in the reduction of substrates by the Micromonospora strain. Furthermore, in the presence of L-alanine, Streptomyces tateyamensis NBRC105048 reduced ethyl pyruvate, ethyl 2-oxobutanoate, ethyl 2-oxopentanoate, ethyl 2-oxohexanoate, and ethyl 3-methyl-2-oxobutyrate to the corresponding α-hydroxy ester with a high conversion ratio and with excellent enantiomeric excess. Thus, we found that these marine-derived actinomycetes have great potential to be used as biocatalysts for stereoselective reduction of carbonyl compounds.

关键词： Marine Bacteria Micromonospora Streptomyces Biocatalyst Chiral Alcohol

A Case Report of Concurrent Acne-Related Occurrence Complications: Telangiectasia, Post-Inflammatory Erythema, Post-Inflammatory Hyperpigmentation, and Atrophic and Hypertrophic Scars

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第2期13卷 85-90页

作者： kanako Kita Ichiro Kurokawa Meiwa Hospital 4-31 Agenaruo-cho Nishinomiya Hyogo Japan

Prior to his initial diagnosis, a 21-year-old male had been experiencing facial acne for two years and had been treated by a doctor in private practice. The patient visited our department because the clinical manifestations of mandibular acne did not improve. At the time of initial examination, telangiectasia (TE), post-inflammatory erythema (PIE), post-inflammatory hyperpigmentation (PIH), atrophic scars (ASs), and a hypertrophic scar (HS) with induration were observed on the right neck. We diagnosed this as an acne vulgaris complication. HS lesions were topically treated by injecting triamcinolone acetonide, and the patient was prescribed 8.1 g/day of oral Saireito (Japanese herb). Adapalene benzoyl peroxide gel and topical tacrolimus hydrate ointment were used to treat PIE and TE. Both HSs and PIE improved;however, TE and AS did not improve. Currently, the patient is under observation. We consider this to be a very rare concurrent occurrence of diverse complications of acne vulgaris, and present the following case study.

关键词： Acne Vulgaris Acne-Related Concurrent Occurrence Complications Telangiectasia Atrophic Scar Hypertrophic Scar

Br-radical-mediated [3+2] annulation: synthesis of 2-bromomethylsubstituted alkenylcyclopentanes by the reaction of alkenylcyclopropanes with allyl bromides under photo irradiation

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Science China Chemistry 2019年第11期62卷 1525-1528页

作者： Takahide Fukuyama Takashi Kippo kanako Hamaoka Ilhyong Ryu Department of Chemistry Graduate School of Science Osaka Prefecture University

A radical chain addition of allyl bromides 2 to alkenylcyclopropanes 1 resulted in[3+2]annulation to give 2-bromomethylalkenylcyclopentanes 3 in good yields(16 examples).In this reaction,two kinetically fast radical reactions,cyclopropylcarbinyl radical-ring-opening and 5-exo-radical cyclization,preceded theβ-fragmentation of a bromine radical to make the formal cycloaddition possible.

关键词： [3+2]annulation bromine radical alkenylcyclopropanes alkenylcyclopentanes photo irradiation

Implicit Discontinuous Galerkin Method for RANS Simulation Utilizing Pointwise Relaxation Algorithm

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Communications in Computational Physics 2010年第3期7卷 510-533页

作者： kanako Yasue Michiko Furudate Naofumi Ohnishi Keisuke Sawada Department of Aerospace Engineering Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan

An efficient implicit procedure for the Discontinuous Galerkin (DG) methodis developed utilizing a pointwise relaxation algorithm. In the pointwise relaxation,those contributions from the degrees of freedom in own computational cell are accounted for in the implicit matrix inversion. The resulting scheme is shown to be stablewith very large CFL numbers for both the Euler and the Navier-Stokes equations fortypical test problems. In order to achieve a faster convergence, efforts are also madeto reduce computing time of the present method by utilizing a p-multigrid schemeand also by solving a simplified matrix instead of a fully loaded dense matrix in theimplicit matrix inversion. A superior performance of the present implicit DG methodon the parallel computer using up to 128 PEs is shown in terms of readily achievablescalability and high parallel efficiency. The RANS simulation of turbulent flowfieldover AGARD-B model is carried out to show the convergence property and numericalstability of the present implicit DG method for engineering applications.

关键词： Discontinuous Galerkin method pointwise relaxation implicit scheme viscous compressible flow

Characteristics and Social Support Needs Predicting Anticipatory Grief in the Spouses of Patients with Cancer at the End of Life

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International Journal of Clinical Medicine 2022年第3期13卷 98-120页

作者： kanako Amano kanako Ichikura Kazuho Hisamura Hiroki Sakurai Ryota Yanaizumi Saori Takahashi Yuko Shimizu Kazuhiro Kawada Osamu Takahashi Eisuke Matsushima Takashi Takeuchi Hidehiko Takahashi Liaison Psychiatry and Psycho-oncology Unit Department of Psychiatry and Behavioral Sciences Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan Palliative Care Ward Heiwa Hospital Yokohama Japan Department of Health Science Kitasato University School of Allied Health Sciences Sagamihara Japan Department of Medical Oncology Kanazawa Medical University Ishikawa Japan Department of Palliative Medicine Toranomon Hospital Tokyo Japan Department of Palliative Care Cancer Institute Hospital of Japanese Foundation for Cancer Research (JFCR) Tokyo Japan Department of Anesthesiology Yokohama City University Medical Center Yokohama Japan Department of Anesthesiology Seirei Yokohama Hospital Yokohama Japan Yuu Home Care Clinic Yokohama Japan Department of Psychiatry and Behavioral Sciences Graduate School of Medical and Dental Sciences Tokyo Medical and Dental Uni-versity Tokyo Japan

Background: Medical staff provide care to spouses of terminal cancer patients through trial and error by meeting their various support needs and spousal factors regarding their anticipatory grief. Studies on the association between spousal characteristics and anticipatory grief have been inconclusive;additionally, there has been insufficient research on support needs for anticipatory grief of spouses. This study aimed to explore the spousal characteristics and social support needs predicting anticipatory grief in spouses of patients with cancer at the end of life. Methods: This was a cross-sectional study. Eligible spouses (n = 102) completed a self-report questionnaire in two hospitals with palliative care units in Japan. The questionnaire included demographic information, a tool assessing social support needs of spouses, and the Anticipatory Grief Scale for Family Caregivers. Results: Simple regression analyses indicated that patient age, chemotherapy, no treatment, ECOG PS3, children aged under 20 years, total score of “social support needs regarding the disease and treatment of the patients” and subscale scores (“medical condition and cure,” “daily life and social support,” and “intimacy and employment”), and total score of “social support needs of the spouses” and subscale scores (“family psychological issues and social support” and “intimacy, employment, and society”) were significant variables (all p p Conclusions: Patients having no experience of “chemotherapy” and higher “social support needs of the spouses” in Model 1, and greater spousal needs of “family psychological issues and social support” in Model 2 were significant predictors of severe anticipatory grief. Medical staff should pay attention to these risk factors that predict anticipatory grief among spouses.

关键词： Cancer Spouse Spousal Characteristics Social Support Needs Anticipatory Grief

Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5723-5731页

作者： Akihiro Yoshihara Kota Nishihama Chisa Inoue Yuko Okano Kazuhito Eguchi Soichiro Tanaka kanako Maki Valeria Fridman D'Alessandro Atsuro Takeshita Taro Yasuma Mei Uemura Toshinari Suzuki Esteban C Gabazza Yutaka Yano Department of Diabetes and Endocrinology Japan Community Health care Organization Yokkaichi Hazu Medical CenterYokkaichi 510-0016MieJapan Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie UniversityTsu 514-8507MieJapan Department of Immunology Faculty and Graduate School of MedicineMie UniversityTsu 514-8507MieJapan Department of Immunology and Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507MieJapan

BACKGROUND Ectopic adrenocorticotropic hormone(ACTH)-secreting neuroendocrine tumors are rare *** with ACTH-secreting pancreatic neuroendocrine carcinomas have a poor *** and coagulopathies have been reported as the cause of ***,detailed clinical descriptions of the morbid complications of ACTH-secreting neuroendocrine carcinomas have not been *** SUMMARY A 78-year-old Japanese woman consulted a medical center due to systemic edema and epigastric *** analysis revealed hypercortisolemia with increased ACTH secretion without diurnal variation in serum cortisol *** enhanced computed tomography(CT)scan revealed a 3-cm tumor in the pancreatic *** cytological material from endoscopic ultrasound-guided fine-needle aspiration was compatible with ACTHsecreting pancreatic neuroendocrine *** Ki-67 index was 40%.She was transferred to Mie University Hospital for surgical *** patient was diagnosed with urinary tract infection,cytomegalovirus hepatitis,esophageal candidiasis,pulmonary infiltrates suspicious for Pneumocystis carinii pneumonia,peripheral deep vein thrombosis,pulmonary embolism,and disseminated intravascular *** multiple organ infections and thromboses responded well to antimicrobial and anticoagulant *** studies disclosed a pancreatic tumor and a metastatic lesion in the liver,whereas somatostatin receptor scintigraphy showed negative findings,suggesting the primary and metastatic tumors were poorly differentiated.A CT scan before admission showed no metastatic liver lesion,suggesting that the pancreatic tumor was rapidly *** of surgery,antitumor chemotherapy was *** patient was transferred to another hospital to initiate ***,she died four months later due to the rapidly progressive *** ACTH-secreting pancreatic neuroendocrine neoplasm is a rare disease with a very poor ***

关键词： Neuroendocrine tumors Cushing's syndrome Ectopic adrenocorticotropic hormone syndrome Pneumocystis pneumonia Pulmonary embolism Infections Case report

Performance of the procedure for ultra-rapid extraction and loop-mediated isothermal amplifcation (PURE-LAMP) method to detect malaria in Haiti

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Infectious Diseases of Poverty 2023年第3期12卷 96-96页

作者： Jeanne Perpétue Vincent Alexandre Valcena Existe kanako Komaki-Yasuda Jacques Boncy Shigeyuki Kano Department of Tropical Medicine and Malaria Research InstituteNational Center for Global Health and MedicineTokyo 162-8655Japan Gradu-ate School of Comprehensive Human Sciences University of TsukubaTsukuba 305-8575Japan Laboratoire National de SantéPublique 6120 Port-au-PrinceHaiti Present Address:Unitéd’Épidémiologie des Mala-diesÉmergentes Institut PasteurParisFrance

Background Malaria continues to cause burden in various parts of the ***,a Caribbean country,is among those aiming to eliminate malaria within a few *** surveys were conducted in Haiti during which we aimed to evaluate the performance of the simple and rapid procedure for ultra-rapid extraction-loop-mediated isothermal amplifcation(PURE-LAMP)method with dried blood spots as an alternative diagnostic method for malaria in the context of low to very low rates of *** Febrile and afebrile people were recruited from three administrative divisions within Haiti:Nippes,Sud and Grand’Anse,during the summers of 2017(early August to early September)and 2018(late July to late August).Their blood samples were tested by microscopy,rapid diagnostic tests(RDT),PURE-LAMP and nested PCR to detect Plasmodium ***,specifcity,positive and negative predictive values and kappa statistics were estimated with the nested PCR results as the gold *** Among 1074 samples analyzed,a positive rate of 8.3%was calculated based on the nested PCR *** febrile participants,the rates in 2017 and 2018 were 14.6%and 1.4%,*** positives were detected among 172 afebrile participants in 2018 by PURE-LAMP and nested PCR,and all three were from the same *** was no afebrile participants recruited in *** PURE-LAMP,RDT and microscopy had respective sensitivities of 100%,85.4%and 49.4%.All of the testing methods had specifcities over 99%.Conclusions This study confrmed the high performance of the PURE-LAMP method to detect Plasmodium infection with dried blood spots and recommends its use in targeted mass screening and treatment activities in low endemic areas of malaria.

关键词： Diagnosis Dried blood spots Haiti Loop-mediated isothermal amplifcation(LAMP) Low transmission Malaria Microscopy Nested PCR Procedure for ultra-rapid extraction(PURE) Rapid diagnostic tests

Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain

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Journal of Geriatric Cardiology 2016年第7期13卷 608-614页

作者： Shu Nishiguchi Yuma Nozaki Masayuki Yamaji kanako Oya Yuki Hikita Tomoki Aoyama Hiroshi Mabuchi Department of Physical Therapy School of Health Sciences Tokyo University of Technology Tokyo Japan Department of Physical Therapy Human Health Sciences Graduate School of Medicine Kyoto University Kyoto Japan Department of Cardiovascular Medicine Koto Memorial Hospital Shiga Japan Department of Rehabilitation Unit Koto Memorial Hospital Shiga Japan

ObjectiveTo 决定在血浆大脑 natriuretic 之间的协会在有心失败( HF )和物理脆弱以及与心血管的药的 106 个门诊病人变老的物理 *** 的每个领域的病人的肽( BNP )水平60岁以上为 HF 被就医了或被给了一为 HF 的药方药被包括。物理脆弱... 详细信息

ObjectiveTo 决定在血浆大脑 natriuretic 之间的协会在有心失败( HF )和物理脆弱以及与心血管的药的 106 个门诊病人变老的物理 *** 的每个领域的病人的肽( BNP )水平60岁以上为 HF 被就医了或被给了一为 HF 的药方药被包括。物理脆弱用下列五个领域被估计：缓慢，软弱，疲劳，低活动，并且缩小，根据心血管的健康学习。病人们根据脆弱分数被划分成 nonfrailty 和脆弱组。血浆 BNP 水平被测量。6-min 散步测试被执行测量 *** BNP 在二个组之间是显著地不同的(脆弱组：158.0 ±；214.7 pg/mL， nonfrailty 组：65.2 ±；88.0 pg/mL， P <；0.01 ) 。Multivariate 逻辑回归分析表明转变木头的血浆 BNP (木头 BNP ) 显著地与物理脆弱被联系(或：1.68， 95% CI：1.11-2.56 ) ，并且木头 BNP 显著地与缓慢领域被联系(走的速度 <；1.0 m/s ) 物理脆弱(或：1.75， 95% CI：1.15-2.67 ) 。另外，木头 BNP 否定地被相关到 6 分钟的散步距离(6MWD )(ρ；=−； 0.37， P <；0.01 ) ，当 6MWD 断然被相关到走速度时(ρ；= 0.66， P <；0.01 ).ConclusionsPlasma BNP 水平与物理脆弱有关，特别在缓慢领域。耐力可以在在血浆 BNP 水平和走的速度之间的协会干涉。

关键词：心力衰竭脑钠肽老年人血浆身体患者慢度 Logistic回归分析

Acceleration of Cell Growth by Xyloglucan Oligosaccharides in Suspension-Cultured Tobacco Cells

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Molecular Plant 2010年第3期3卷 549-554页

作者： Rumi Kaid Satoko Sugawara kanako Negoro Hisae Maki Takahisa Hayashi Takako S. Kaneko Department of Chemical and Biological Sciences Japan Women's University Tokyo 112-8681 Japan Research Institute for Sustainable Humanosphere Kyoto University Kyoto 611-0011 Japan Institute of Sustainability Science Kyoto University Kyoto 611-0011 Japan

The incorporation of xyloglucan oligosaccharide （XXXG） into the walls of suspension-cultured tobacco cells accelerated cell expansion followed by cell division, changed cell shape from cylindrical to spherical, decreased cell size, and caused cell aggregation. Fluorescent XXXG added to the culture medium was found to be incorporated into the surface of the entire wall, where strong incorporation occurred not only on the surface, but also in the interface walls between cells during cell division. Cell expansion was always greater in the transverse direction than in the longitudinal direction and then, immediately, expansion led to cell division in the presence of XXXG; this process might result in the high level of cell aggregation seen in cultured tobacco cells. We concluded that the integration of this oligosaccharide into the walls could accelerate not only cell expansion, but also cell division in cultured cells.

关键词： Xyloglucan oligosaccharide ceil expansion cell division wall loosening suspension-cultured cells.

Perceptions of Collaboration and Satisfaction with Collaboration Regarding Care Decision-Making in Intensive Care Units in Japan: A National Survey

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Open Journal of Nursing 2020年第8期10卷 731-744页

作者： kanako Yamamoto Graduate School of Nursing St. Luke’s International University Department of Critical Care Tokyo Japan

Multi-professional collaboration is being promoted worldwide as a response to the need for sophisticated medical care and for catering to patients’ diverse needs. Patients in Intensive Care Units (ICUs) are seriously ill, and their families may be at risk depending on the patient’s situation. Considering these characteristics of patients and families, there is a strong need for multi-professional collaboration within ICUs. The purpose of this descriptive study was to examine recognition and other factors related to collaboration and satisfaction involving care decisions in Japanese ICUs. A mail survey about collaboration of activities and systems was sent to physicians, clinical engineers, and nurses working in ICUs in Japan, 387 consented to participate in this study. Results showed that satisfaction scores were generally high among the three aforementioned professions, but collaboration scores on deciding care for patients showed significant differences (p < 0.05). The total collaboration score was the highest among physicians (36.7 ± 6.7 points), followed by nurses (32.8 ± 7.4 points), and CEs (32.8 ± 7.4 points). The factors that commonly affected collaboration scores were the satisfaction score and the ability to collaborate with other professionals and set team medical care as a goal. Moreover, it is worth noting that the degree of difficulty in collaboration negatively affected this factor. On the other hand, other factors differed among the three professions, suggesting that the purpose and need for collaboration differ depending on the profession.

关键词： Intensive Care Unit Interprofessional Collaboration Decision-Making Quantitative Method