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Lived Experience of Sickle Cell Patients during and after Crisis

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Open Journal of Nursing 2021年第4期11卷 219-229页

作者： Mudhar Mohammed Al Adawi Hanan Said Al Hamami Fathiya Suliman Al Harrasi Badriya Salim Al Hinai kamila Al Alawi Department of Nursing Royal Hospital MOH Muscat Oman Department of Nursing Rustaq Hospital MOH Rustaq Oman Oman College of Health Science South Batinah Oman WHO-Oman Muscat Oman

Aims and Objectives: To understand the lived experience and needs of patients with sickle cell disease during and two weeks after their crisis and identify the obstacles faced by patients while they are in the hospital. Background: Although there is no specific data of a number of affected individuals with sickle cell disease in Oman based on their age, the majority of the Omani population are youth. This category of the population is either in their high school or working in the governmental or private sector in the country. When the most productive category of the population are getting frequently absent due to sickle cell crisis and complication of sickle cell crisis from their work, this leads to huge financial and human resource burden. Design: Phenomenology. Method: This qualitative descriptive research was conducted using face-to-face interviews based on an interview protocol. The interview protocol was developed by the authors based on a framework called domains of well-being. Twenty adult patients have been recruited for the interview after meeting inclusion criteria and were asked about their well-being and lived experience during sickle cell crisis. Authors used SRQR checklist in reporting the study. Results: Thirteen themes were identified related to patients’ lived experience and their well-being during sickle cell crisis. Patients reported physical, emotional, social, and spiritual alteration. Major themes that emerged are communication, medical team interpretation of genuine pain, Emotional disturbance during the crisis, What does this study contribute to the wider global clinical community? Nurses and doctors should use therapeutic communication when dealing with sickle cell patients. Nurses should establish rapport and trust with patients. In each health care setting, there should be a social worker to deal with patients with chronic illness social relationships bet

关键词： Sickle Cell Patients Lived Experience Phenomenology Face to Face Interview Well-Being of Patients

Analysis of EGFR gene mutations in lung adenocarcinoma in Karamay,Xinjiang,China

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Oncology and Translational Medicine 2023年第5期9卷 234-237页

作者： Yu-Hua Ma Yuan-Xin Li Min Jiang Jing Gao Yi-Ning Lai kamila Kulaixijiang Min Zhu Fei Liang Xinjiang Key Laboratory of Clinical Genetic Testing and Biomedical Information KaramayChina Xinjiang Clinical Research Center for Precision Medicine of Digestive System Tumor KaramayChina Department of Pathology Karamay Central HospitalKaramayChina

Background:To investigate the mutation types and mutation rate of the epidermal growth factor receptor(EGFR)gene in patients with lung adenocarcinoma and the clinical features of lung adenocarcinoma with EGFR gene mutations in Karamay,Xinjiang,***:Paraffin-embedded tissue samples of adenocarcinoma patients were collected in the Karamay Central Hospital from March 2016 to June 2019,and mutations in exon 18–21 of the EGFR gene were detected by the allele-specific amplification polymerase chain reaction(Amplification RefractoryMutation System–PCR)*** relationships between themutation types,mutation incidence,and clinical features were ***:Of the 170 patients with lung adenocarcinoma,83 had EGFR *** total mutation rate of EGFR in patients with lung adenocarcinoma was 48.8%,which included mutations in exons 18(1.2%[2/170]),19(19.4%[33/170]),20(2.4%[4/170]),and 21(20.6%[35/170]).Intriguingly,there was a case with 9 mutations in exons 20 and *** mutations in exon 19 of EGFR resulted in the deletion of codons 746 to *** main mutation in exon 21 was L858R(91.4%[32/35]).There was no significant difference in exons 19 and 21 mutation rates(P>0.05).The mutation rate of EGFR in female patients was significantly higher than that in male patients(P0.05).The EGFR mutation rate may be related to the degree of tumor ***:Among patients with lung adenocarcinoma in Kelamayi(city in Xinjiang),EGFR mutations were more frequently detected in female patients,and the main sites of mutations were exons 19 and 21.

关键词： EGFR gene Gene mutation Lung adenocarcinoma

The intrinsic or the extrinsic pathways of apoptosis in the epidermis after cladribine application?

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Journal of Biomedical Science and Engineering 2013年第3期6卷 265-272页

作者： Patrycja Chylinska-Wrzos Ewelina Wawryk-Gawda Marta Lis-Sochocka Marian Jedrych Miroslaw Lancut kamila Bulak Joanna Leszcz-Stankiewicz Barbara Jodlowska-Jedrych Dental and Implant Center Lublin Poland Department of Histology and Embryology with Experimental Cytology Unit Medical University of Lublin Lublin Poland Department of Mathematics and Biostatistics Medical University of Lublin Lublin Poland

Purpose: This study was aimed to assess the expression of caspase 8 and caspase 9 in the epidermis, during apoptosis after cladribine administration. Materials and Methods: The experiment was carried on 10 Wistar rats. The animals were placed into 2 groups: control group and experimental group. Animals in the control group, in addition to standard feed and water, were injected with a physiological salt in a quantity corresponding to the drug dosage, over the course of the experiment. The experimental group animals were treated with cladribine in the dose of 0.07 mg/kg/24h, for 6 consecutive days in the morning, in 3 cycles with a 5-week gap in administering the drug. After the completion of the experiment, the animals were decapitated, and full thickness slices of skin were taken from all the rats for immunohisto- chemical study. The results of the statistical surveys were analysed in Statistica 10.0. The difference in intensity of expression of caspase 9 and caspase 8 in the groups were investigated using the Chiquadrat test. Statistical significance was considered at p < 0.05. Results: The statistical analysis found significant correlation in expression of caspase 9 between examined groups (p < 0.0001). There were no statistical relationships in the presence of the expression of caspase 8 between examined groups (p = 0.0526). Conclusion: Our findings suggest that mechanism of apoptosis in the rats’ epidermis, induced by cladribine given in the scheme used in the treatment of MS in humans, involves caspase 9 activity. This means that 2-CdA initiates the intrinsic apoptosis pathway.

关键词： Cladribine Apoptosis Caspase 8 Caspase 9 Epidermis

Kinetics and thermodynamic studies of Methyl Orange removal by polyvinylidene fluoride-PEDOT mats

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Journal of Environmental Sciences 2021年第2期33卷 62-73页

作者： Romario J.da Silva Lizeth Carolina Mojica-Sanchez Filipe D.S.Gorza Graciela C.Pedro Bruna G.Maciel Gabriela P.Ratkovski Herica D.daRocha kamila T.O.do Nascimento Juan CMedina-Llamas Alicia E.Chavez-Guajardo Jose J.Alcaraz-Espinoza Celso P.de Melo Program a de Pos-Graduagao em Ciencia de Materials U niversidade Federal de Pernambuco50670-901 RecifePEBrazil Departamento de Ffsica Uniuersidade Federal de Pemambiico50670-901 Reci/ePEBrazil Centro de Estudios Cientificosy Tecnologicos No.18 Instituto Politecnico Nacional98160 ZacatecasZacMexico Unidad Academica de Ciencias de la Tierra Uniuersidad Aut6noma de Zacatecas98058 ZacatecasZacMexico Departamento de Quimica Universidad Autonoma Metropolitana09340Ciudad de MexicoMexico

We report the preparation of poly(3,4-ethylene dioxythiophene)(PEDOT)-modified polyvinylidene fluoride electrospun fibers and their use as a novel adsorbent material for the removal of the anionic dye Methyl Orange(MO)from aqueous *** novel adsorbent material can be used to selectively remove MO on a wide p H range(3.0-10.0),with a maximum capacity of 143.8 mg/g at p H *** used in a recirculating filtration system,the maximum absorption capacity was reached in a shorter time(20 min)than that observed for batch mode experiments(360 min).Based on the analyses of the kinetics and adsorption isotherm data,one can conclude that the predominant mechanism of interaction between the membrane and the dissolved dye molecules is ***,considering the estimated values for the Gibbs energy,and entropy and enthalpy changes,it was established that the adsorption process is spontaneous and occurs in an endothermic *** good mechanical and environmental stability of these membranes allowed their use in at least 20 consecutive adsorption/desorption cycles,without significant loss of their *** suggest that the physical-chemical characteristics of PEDOT make these hybrid mats a promising adsorbent material for use in water remediation protocols and effluent treatment systems.

关键词： Electrospinning Composite mats Pedot Pvdf mats Dye removal Water remediation

“I Love Learning Chinese!”

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Fostering Moral Competence With the Konstanz Method of Dilemma Discussion

China Today 2019年第2期

作者： kamila Carter

HOW do foreigners feel about learning Chinese?Some students who were awarded the Confucius Institute Scholarship were interviewed by China Today. The following are their views and *** Carter, the *** 12-year-old girl is a student of Confucius Institute at San Diegio State University in the U.S. Both her parents are hearing-impaired. With the help of her grandmother, she learned how to communicate with family（共2页)

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Psychology Research 2016年第4期6卷 242-249页

作者： kamila Stastna Roudnice nad Labem Czech Republic

The Hesitance of Nurses to Apply for Midwifery Specialization: Explorative Qualitative Study

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Open Journal of Nursing 2023年第8期13卷 512-527页

作者： Fahima Al Harthy Mudhar Al Adawi Khalid Al Busaidi Aisha Al Mamari Asma Al Zaabi Zubaida Suliman Al Balushi Shakila Al Habsi kamila Al-Alawi Royal Hospital Ministry of Health (MOH) Muscat Oman Midwifery Programme Higher Institute of Health Specialties Muscat Oman MoH Muscat Oman

Background: Many countries across the world are facing an ongoing shortage of midwife practitioners due to several reasons such as increased workload, working overtime, poor-quality midwifery care, low staff morale, stress and burnout, lack of opportunity for training, lack of management support, financial issues and lack of recognition and compromised autonomy. Purpose: To explore the reasons behind nurses’ hesitance to apply for midwifery specialization. The objectives of this study were to understand the challenges that lie in front of Omani nurses and the motivational factors to apply for a midwifery programme. Method: Exploratory qualitative study was conducted at the largest tertiary hospital in Oman. Purposive sampling was applied for participant recruitment. Face-to-face interviews and focus group discussions were used as data collection methods. The study included general nurses, nurses in charge working in the maternity unit as well as nurses whose applications were accepted for midwifery education. Qualified midwives were excluded. The data collection process yielded twenty-five nurses. The interview protocol highlighted the impact and perception of the midwifery specialization on nurses’ careers. Thematic analysis was employed for data analysis. Results: Three over-arching major themes were identified. These are 1) nurses’ perceptions about the nature of work in maternity wards, the nurses have positive perception toward working in maternity wards and labor room because of working exclusively with female patients and their babies 2) factors influencing the decision to study midwifery specialization, work overload, stress, lack of support from administration were the most common reason behind the nurses not to apply for midwifery specialization and 3) support and recommendations required for midwives, the nurses mentioned that their identity, promotions and support from the administration will encourage them to apply for midwifery specialization. Conclusi

关键词： Midwifery Specialization Hesitancy Challenges

Determination of Enantiomeric Composition of Substituted Tetrahydroisoquinolines Based on Derivatization with Menthyl Chloroformate

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American Journal of Analytical Chemistry 2013年第3期4卷 125-133页

作者： Jan Prech Václav Matousek JiriVáclavik Jan Pechacek kamila Syslova Petr Sot Jakub Januscak Beáta Vilhanová Marek Kuzma Jaromir Toman Petr Kacer Department of Organic Technology Institute of Chemical TechnologyPragueCzech Republic Laboratory of Molecular Structure Characterization Institute of MicrobiologyAcademy of Sciences of the Czech RepublicPragueCzech Republic

A method for the analysis of the optical purity of a series of chiral substituted tetrahydroisoquinolines (THIQs) was developed. The method is based on pre-column derivatization of the analytes with the derivatization reagent (–)-(1R)-menthyl chloroformate. The derivatization reaction selectively gives diastereomeric carbamates that are resolvable on an achiral non-polar GC column. The developed technique covers variously substituted THIQs, which differ significantly in volatility, steric and electronic properties. In all cases, the resolution factors (R) exceeded the value of 1.5. The method represents a robust way of analysis of mixtures of THIQs, which are often present in various matrixes such as body fluids, tissues and reaction mixtures.

关键词： Tetrahydroisoquinolines Enantiomeric Composition Derivatization Menthyl Chloroformate Gas Chromatography