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强化降压治疗对心房颤动风险的影响

中华高血压杂志 2020年第5期28卷 449-449页

作者：赵狄(译) 刘莉(校) soliman EZ Rahman A Zhang Z Rodriguez CJ Chang TI Bates JT Ghazi L Blackshear JL Chonchol M Fine LJ Ambrosius WT Lewis CE 不详

强化降压治疗是否降低高血压患者心房颤动风险仍不明确。研究人员获取来自收缩压干预试验(systolic blood pressure intervention trial,SPRINT)中心血管病风险增加的高血压患者资料进行分析,评估与标准降压治疗(收缩压靶目标<140 mm Hg... 详细信息

强化降压治疗是否降低高血压患者心房颤动风险仍不明确。研究人员获取来自收缩压干预试验(systolic blood pressure intervention trial,SPRINT)中心血管病风险增加的高血压患者资料进行分析,评估与标准降压治疗(收缩压靶目标<140 mm Hg,1mm Hg=0.133kPa)比较,强化降压治疗(收缩压靶目标<120mm Hg)是否降低心房颤动风险。本研究纳入入组时无心房颤动,且有可用基线及随访心电图资料的患者8022例.

关键词：强化降压治疗心房颤动靶目标心血管病风险收缩压高血压患者

糖尿病患者强化降压对心房颤动事件和P波指数的作用

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中华高血压杂志 2017年第4期25卷 398-398页

作者： Chen LY Bigger JT Hickey KT Chen H Lopez-Jimenez C Banerji MA Evans G Fleg JL Papademetriou V Thomas A Woo V Seaquist ER soliman EZ 陈云叶鹏

目前为止还没有成熟的治疗手段用于预防2型糖尿病（type 2diabetes,T2DM）患者的心房颤动。该文比较标准降压与强化降压降低T2DM患者心房颤动发生率或P波指数的差异（P波指数是提示左心房异常的心电图指标,是心房颤动的中间表型）。

关键词： 2型糖尿病心房颤动 P波患者降压数心电图指标 T2DM

INSTRUCTIONS TO AUTHORS

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World Journal of Neurology 2012年第1期2卷 1-10页

作者： Sherifa Ahmad Hamed Nabil Abdel-Hakim Metwaly Mahmoud Mohamad Hassan Khalid Ahmad Mohamed Mohamad Abdel-Rahman Ahmad Ahmad Abdel-Magid soliman Abdel-Rahman Mohamed Elsaied Department of Neurology and Psychiatry Assiut University HospitalAssiut 12111Egypt Department of Neurology and Psychiatry Al-Azhar University HospitalAssiut 12111Egypt Department of Clinical Pathology South Valley University Hospital83523 QenaEgypt

AIM:To characterize the relationship between depression and epilepsy-related seizures,treatment,hormonal and biological ***:Included were 200 Egyptian adults(male=100,female=100)with epilepsy(mean age:30.87±7.88 years;duration of illness:13.89±7.64 years)and 100 healthy matched subjects for *** interview,Beck Depression Inventory(BDIII)and Hamilton Anxiety Rating Scale(HAM-A)were used to assess depression and *** levels of free testosterone,sex hormone binding globulin,prolactin,free thyroxin and thyroid stimulating hormone,serotonin,noradrenaline and adrenaline neurotransmitters were measured to assess endocrine and biological ***:Patients had higher rates of depressive disorder(25.5%or 51/200),mostly intermixed with anxiety(47.06%),psychotic features(19.61%),aggression(40%)and suicide(55%).Compared to controls,higher scores on the BDI-II were observed with right-sided epileptic foci(P=0.011),polytherapy(P=0.001)and lack of control on antiepileptic drugs(AEDs)(P=0.0001).Patients had lower levels of serotonin(P=0.001)[marked with depression(P=0.012)]and adrenaline(P=0.0001),while noradrenaline was lower with temporal lobe epilepsy(P=0.039),left-sided foci(P=0.047)and lack of control on AEDs(P=0.017).Negative correlations were observed between levels of serotonin and BDI-II(P=0.048)and HAM-A(P=0.009)scores,but not with AEDs dose or drug ***:Comorbid depressive disorder with epilepsy appears to be closely related to seizure type,focus,side,intractability to medications and neurotransmitter ***,optimizing seizure control and early recognition and management of depression is necessary to improve patients’quality of life.

关键词： Adrenaline Antiepileptic drugs Depression Epilepsy Noradrenaline Serotonin

Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 156-171页

作者： Pegah Hosseini-Carroll Monica Mutyala Abhishek Seth Shaheen Nageeb Demiana soliman Moheb Boktor Ankur Sheth Jonathon Chapman James Morris Paul Jordan Kenneth Manas Felix Becker Jonathan Steven Alexander Department of Medicine Section of Gastroenterology and Hepatology Louisiana State University Health Sciences Center Department of Molecular and Cellular Physiology Louisiana State University Health Sciences Center Digestive Health Center of Louisiana Department of General and Visceral Surgery

Inflammatory bowel diseases(IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them(both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care(particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy duringIBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become,(or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception(in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using "top-down" care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed.

关键词： Inflammatory bowel diseases Pregnancy Biologics Br

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小儿Meckel憩室的腹腔镜治疗

世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 46-46页

作者： Shalaby R.Y. soliman S.M. FawyM. Samaha A. 宁亮 Dar Al-Shifa Hospital PO Box 3390 Safat 13034 Kuwait

Background: Rectal bleeding, recurrent abdominal pain, nausea, and vomiting i n children could present a diagnostic as well as therapeutic challenge. Meckel s diverticulum (MD) is one of the causes. The objective of the current study wa s to evaluate the feasibility and outcome of laparoscopic management of MD. Meth ods: The clinical data of 33 children admitted with rectal bleeding and/or recur rent abdominal pain with no identifiable cause were reviewed over a period of 8 years. There were 23 boys and 10 girls with a mean age of 5.12 ± 2 years (rang e, 3- 12 years). In 21 cases, MD was an incidental finding on laparoscopic appe ndectomy and symptomatic in 12 cases. Patients with rectal bleeding were subject ed to upper gastrointestinal endoscopy; colonoscopy, and technetium Tc 99m- lab eled pertechnetate scan (MS). All patients were subjected to routine laboratory investigations and diagnostic laparoscopy. Results: Of the 1200 appendectomies, incidental MD was found in 21 (1.9% ) patients and symptomatic in 12 cases. Upp er gastrointestinal endoscopy and colonoscopy did not show a bleeding source in 7 patients presented with bleeding per rectum. Four cases showed a positive MS u ptake. Of these, 3 were found on laparoscopy to have an MD. Three cases showed a negative scan. Of these, 2 had an MD. In 5 cases with recurrent abdominal pain , nausea, vomiting, and abdominal distention, diagnostic laparoscopy revealed Meckel’s diverticulitis in 3 cases and intussusception secondary to MD in 1 ca se. Laparoscopic Meckel’s diverticulectomy and laparoscopic- assisted Meckel ’s diverticulectomy was done for 18 and 12 cases, respectively. Ectopic gastri c mucosa was present in 13 cases (44% ). Conclusions: Laparoscopy is safe, cost - effective, and efficient for the diagnosis and definitive treatment of MD. Co mpared with conventional laparotomy, it has the advantage of precise operative d iagnosis, less traumatic access, fewer intraoperative and postoperative complica tion

关键词：腔镜治疗 Meckel憩室复发性腹痛直肠出血异位胃黏膜阑尾切除术结肠镜检查术后并发症内窥镜检查常规化验检查

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强化降压对高血压患者左心室肥厚的影响

中华高血压杂志 2017年第6期25卷 571-571页

作者：刘莉叶鹏 soliman EZ Ambrosius WT Cushman WC Zhang ZM Bates JT Neyra JA Carson TY Tamariz L Ghazi L Cho ME Shapiro BP He J Fine LJ Lewis CE SPRINT Research Study Group

目前尚不清楚超出推荐值的强化降压是否更能降低高血压患者的左心室肥厚（left ventricular hypertrophy,LVH）发生风险,以及LVH风险降低能否解释强化降压的益处。soliman等纳入收缩压干预试验（systolic blood pressure intervention,S... 详细信息

目前尚不清楚超出推荐值的强化降压是否更能降低高血压患者的左心室肥厚（left ventricular hypertrophy,LVH）发生风险,以及LVH风险降低能否解释强化降压的益处。soliman等纳入收缩压干预试验（systolic blood pressure intervention,SPRINT）中患有高血压但无糖尿病的8164例受试者（平均年龄67.9岁,女性35.3%,31.2%为非洲裔）,

关键词：高血压患者左心室肥厚降压发生风险干预试验平均年龄推荐值 LVH

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年轻绝经前妇女患子宫内膜癌的危险因素

世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 57-57页

作者： soliman P.T. Oh J.C. Schmeler K.M. 张丽娟

OBJECTIVE:Endometrial cancer is the most common gynecologic malignancy in the United States. The mean age at diagnosis is 61 years; however, 5- 30% of women are aged younger than 50 years at the time of diagnosis. The objective of this study was to conduct a clinical and pathologic review of endometrial cancers diagnosed in premenopausal women aged younger than 50 years, to better identify the risk factors for this subgroup of women. METHODS: We conducted a retrospective cohort study of patients with histologically confirmed endometrial cancer treated at the University of Texas, M. D. Anderson Cancer Center from 1989 to 2003. Clinical characteristics including age, body mass index (BMI), parity, diabetes, and personal or family history of cancer were obtained from the medical record. Pathologic information was obtained from pathology reports. RESULTS: Twelve percent (188/1531) of all patients with endometrial adenocarcinoma were aged younger than 50 years. The mean age at diagnosis was 41 years (range 21- 49 years). Mean BMI was 34 kg/m2 (range 18- 68); 58% of patients had a BMI of 30 or greater. Fifty- five percent were nulliparous and 39% reported irregular menstrual cycles. The incidence of both diabetes and hypertension was 23% . Thirty- six patients (19% ) had synchronous ovarian cancers. CONCLUSION: We found that the majority of patients diagnosed with endometrial cancer at a young age were obese and nulliparous. In addition, we found a high incidence of synchronous primary ovarian cancers in this cohort of young, premenopausal women.

关键词：发病年龄妇科恶性肿瘤组织学诊断德克萨斯大学安德森癌症中心回顾性队列研究未产妇美国妇女月经周期并发率

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遗传性肥胖与心房颤动的关系

中华高血压杂志 2017年第2期25卷 110-110页

作者：刘莉叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM

观察性研究已经确定了体质量指数（body mass index,BMI）与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关... 详细信息

观察性研究已经确定了体质量指数（body mass index,BMI）与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法：纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人,

关键词：心房颤动遗传性肥胖因果关系体质量指数混杂因素预测因子队列研究