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Grasshopper KUWAHARA and Gradient Boosting Tree for Optimal Features Classifications

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Computers, Materials & Continua 2022年第8期72卷 3985-3997页

作者： Rabab Hamed M.Aly Aziza I.Hussein kamel H.rahouma The Higher Institute for Management and Information Technology Minya61768Egypt Department of Electrical and Computer Engineering Effat UniversityJeddahKSA Electrical Engineering Department Faculty of EngineeringMinia UniversityMinia6111Egypt

This paper aims to design an optimizer followed by a Kawahara filter for optimal classification and prediction of employees’*** algorithm starts by processing data by a modified K-means technique as a hierarchical clustering method to quickly obtain the best features of employees to reach their best *** work of this paper consists of two *** first part is based on collecting data of employees to calculate and illustrate the performance of each *** second part is based on the classification and prediction techniques of the employee *** model is designed to help companies in their decisions about the employees’*** classification and prediction algorithms use the Gradient Boosting Tree classifier to classify and predict the *** of the paper give the percentage of employees which are expected to leave the company after predicting their performance for the coming *** also show that the Grasshopper Optimization,followed by“KF”with the Gradient Boosting Tree as classifier and predictor,is characterized by a high *** proposed algorithm is compared with other known techniques where our results are fund to be superior.

关键词： Metaheuristic algorithm KUWAHARA filter Grasshopper optimization algorithm and Gradient boosting tree

Prognostic Clinico-Pathological Features of 99 Cases Advanced Non-Small Cell Lung Cancer—Egyptian National Cancer Institute

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Advances in Lung Cancer 2015年第3期4卷 29-36页

作者： Hala Aziz Shokralla Mohamed rahouma Medical Oncology Department National Cancer Institute Cairo Egypt Surgical Oncology Department National Cancer Institute Cairo Egypt

Background: Worldwide, lung cancer is the most commonly diagnosed cancer and causes more deaths than any other cancer. In Egypt;it accounts for 7% of male cancer & 3% in females. It is considered to be 3rd most common cancer in Egyptian males & 6th most common of both sexes. Materials and Methods: A total of 99 advanced non-small cell lung cancer patients who underwent first line platinum containing chemotherapy in our institute were included in this study. All clinical and pathological data were collected from patient’s files retrospectively between 2012-2014. Results: All 99 cases were diagnosed at late stage IIIB-IV (59 cases were IIIB).The median age was 54 years (range: 30 - 70) with 53% of cases are ≥ 54 years. 71% were males with male: female ratio of 2.4:1. All male patients were chronic smokers. The most frequent symptom was coughing (68%). Most of the patients had primary lung cancer in the right lung (77%). The most common histological subtype was squamous cell carcinoma (35.4%) with 54 cases present with PS-I, the remain was PS-II. All cases received platinum containing chemotherapy. The majority of cases experienced a progressive disease 60.6%. The median progression free survival (PFS) was 6 months & median overall survival (OS) was 18 months. We found that PS, disease stage, pathological subtypes and response to treatment statistically affect both median OS & PFS. Age affects only OS. Conclusions: Our analysis suggests that some of clinico-pathological factors & response to first line platinum containing regimens affect both OS & PFS of advanced NSCLC. This may be beneficial as prognostic markers and further studies were needed to aid in identification and treatment of these patients.

关键词： Non-Small Cell Lung Cancer Clinico-Pathological Prognosis NCI Egypt

Malignant Pleural Mesothelioma in Young People

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Journal of Cancer Therapy 2017年第5期8卷 443-451页

作者： Ahmed El Bastawisy Maha Yahia Mohammed rahouma Omnia Aboelazm Jaylan Ahmed National Cancer Institute Cairo University Cairo Egypt Weill Cornell Medicine New York USA Baheya Cancer Center Giza Egypt

Background: malignant pleural mesothelioma (MPM) is characterized by long latency period between exposure to asbestos and development of the disease so we hypothesize that MPM in the young has different characteristics. Patients and Methods: This is a retrospective study including all eligible patients with malignant pleural mesothelioma presenting to National Cancer Institute, Cairo University during the period from 2008 to 2013. Patients were divided into two groups: Group 1: patients aged ≤45 years. Group 2: Patients aged >45 years. Both groups were assessed regarding different clinicpathological features. Primary Objectives: comparison of different epidemiological features of both groups. Secondary Objectives: assessment of clinical response (CR), progression free survival (PFS) and overall survival (OS) in both groups. Results: 102 Patients were included with median follow up of 14.4 months. Group (1) included 35 patients with mean age 40 ± 3.65 years (31 to 45 years). Group (2) included 67 patients with mean age of 58.6 ± 8.5 years (46 to 87 years). 68% of group (1) came from endemic areas which is significantly higher than group (2): (35.8%), p = 0.02. History of Asbestos exposure was highly significantly different between the 2 groups, 77.1% in group (1) versus 38.8% in group (2), p < 0.001. Other factors showed no significant differences between the two groups. Overall clinical response (CR + PR) was 20% in group (1) versus 17.9% in group (2). P = 0.7. There was a trend towards longer median PFS in young patients, (19.8 ± 8.4 versus 6.9 ± 1.4 months). p = 0.09. The median OS of young patients is significantly longer (20.6 ± 6.3 months) than older patients (11.4 ± 3.6). p = 0.05. Conclusions: Mesothelioma in the young is more sensitive to asbestos exposure, has better OS and likely a different disease entity which needs further studies to understand its underlying biological features.

关键词： Malignant Pleural Mesothelioma-Young

The Antiviral Efficacy of Withania somnifera(Ashwagandha) against Hepatitis C Virus Activity: In Vitroand in SilicoStudy

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Advances in Microbiology 2020年第9期10卷 463-477页

作者： Dina Mofed Wafaa Ahmed Abdel-Rahman Zekri Ola Said Mohamed rahouma Ahmed Hassan Ibrahim Faraag Biochemistry and Molecular Biology Unit Department of Cancer Biology National Cancer Institute Cairo University Cairo Egypt Immunity and Virology Unit Department of Cancer Biology National Cancer Institute Cairo University Cairo Egypt Department of Surgical Oncology National Cancer Institute Cairo University Cairo Egypt Department of Botany and Microbiology Faculty of Science Helwan University Cairo Egypt

Objective: Evaluation antiviral effects of Withania somnifera (Ashwagandha) leaf extract against HCV. Methods: cell proliferation was assessed using MTT assay after isolation of lymphocyte cells and treated with Ashwagandha water extract (ASH-WX) (6.25 mg/ml - 100 mg/ml). Assessment of quantitative Real-time PCR, Colony forming assay, TNF-α and molecular docking studies after infection of normal lymphocyte cells with 1 ml (1.5 × 106 HCV) serum then incubated with ASH-WX at concentration 25 mg/ml & 50 mg/ml. Results: MTT assay revealed a significant increase (p α significantly decreased following ASH-WX treatment compared with control untreated infected cells (p 3 IU/mL. Colony formation assay test revealed colony formation reduction compared to positive untreated control. Molecular docking analysis revealed good prediction of binding between Ashwagandha and NS5B and PKN2 compared to Sovaldi. Conclusion: ASH-WX may be a powerful antiviral against HCV infection.

关键词： Antiviral Ashwagandha Hepatitis C Virus Docking Lymphocyte