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Asian Journal of Pharmaceutical Sciences 2016年第2期11卷 297-300页

作者： Ashraf A.Khalil Marwa M.S.diab kamal d.moudgil department of Protein Technology City of Scientific Research and Technological ApplicationsBorg ElarabAlexandriaEgypt Molecular drug Evaluation department National Organization for Drug Control and Research(NODCAR)Giza 12553Egypt University of Maryland School of Medicine BaltimoreMD 21201USA

The 4 th Euro-Mediterranean Conference of Natural Products and drug discovery: Back to Mother Nature (Bio Nat-IV) was recently (from March 3 rd through 7 th, 2015) convened in Cairo and Sharm El-Sheikh along the Red Sea coast of Egypt. Overall, the meeting provided a platform for scientists from different nations to discuss emerging ideas that focused on cell signaling in cancer;the pathogenesis of autoimmune diseases;the identification and use of natural products as well as novel drug delivery approaches for the treatment of cancer,arthritis, diabetes, tuberculosis, fungal infection, etc.;and untapped or unconventional sources for natural products. This fourth in a row conference tried to bridge the gap not only between basic research and clinical applications, but also between developed nations and developing countries. With the continuing success of these past meetings, the fifth EuroMediterranean Conference of Natural Products and drug discovery(BioNat-V) is slated to be in February 2017.

关键词： BioNat Natural products drug discovery Mother Nature Cooperation

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Control of autoimmune arthritis by herbal extracts and their bioactive components

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Asian Journal of Pharmaceutical Sciences 2016年第2期11卷 301-307页

作者： Shivaprasad H.Venkatesha Brian Astry Siddaraju M.Nanjundaiah Hong R.Kim Rajesh Rajaiah Yinghua Yang Li Tong Hua Yu Brian M.Berman kamal d.moudgil department of Microbiology and Immunology University of Maryland School of MedicineBaltimoreMD 21201United States Southern Medical University GuangzhouChina Center for Integrative Medicine University of Maryland School of MedicineBaltimoreMD 21201United States division of Rheumatology Department of MedicineUniversity of Maryland School of MedicineBaltimoreMD 21201United States

Autoimmune diseases such as rheumatoid arthritis (RA) cause significant morbidity and loss of productivity. Many potent conventionally used drugs are available for these diseases, but their prolonged use is accompanied by severe adverse effects besides a high ***, there is an unmet need for effective but less expensive medications for RA and other autoimmune diseases. Natural plant products belonging to the traditional systems of medicine, such as the traditional Chinese medicine and Indian Ayurvedic medicine, offer a vast and promising resource in this regard. However, herbal medicinal products are often poorly characterized for their composition as well as mechanisms of action. We review here the results of our systematically performed studies aimed at defining the anti-arthritic activity of three herbal extracts, namely, modified Huo-luo-xiao-ling dan (HLXL), Celastrus aculeatus Merr., and polyphenolic fraction of green tea (Camellia sinensis), as well as a purifiedcompound Celastrol, a bioactive component of Celastrus. Specifically, we examined the effects of these herbal products on the immunological, biochemical and molecular biological effector pathways in autoimmune arthritis. We have also reviewed here related studies on these herbal products by other investigators. Taken together, we suggest further testing of these herbal products in RA patients.

关键词： drug discovery Herbal medicine Immune response Traditional Chinese medicine Natural products Rheumatoid arthritis

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南蛇藤提取物对Lewis大鼠关节炎症的抑制作用及机制研究

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南蛇藤提取物对Lewis大鼠关节炎症的抑制作用及机制研究

南蛇藤提取物对Lewis大鼠佐剂性关节炎(AA)预防及治疗作用

第三届全国中医药免疫学术研讨会

作者：佟丽 kamal d.moudgil 广州南方医科大学中医药学院美国马里兰大学医学院

目的:研究南蛇藤(Celastrus aculeatus Merr)提取物对Mtb诱导Lewis大鼠类风湿关节炎的抑制作用及相关作用机制。方法:采用heat-killed *** H37Ra(Mtb)免疫Lewis大鼠,诱导类风湿关节炎模型,观察南蛇藤提取物对Lewis大鼠关节炎的抑制作用...

目的:研究南蛇藤(Celastrus aculeatus Merr)提取物对Mtb诱导Lewis大鼠类风湿关节炎的抑制作用及相关作用机制。方法:采用heat-killed *** H37Ra(Mtb)免疫Lewis大鼠,诱导类风湿关节炎模型,观察南蛇藤提取物对Lewis大鼠关节炎的抑制作用;同时采用同位素标记等方法,观察南蛇藤提取物对抗原特异性淋巴细胞(Lymph node cells,LNC)增殖的影响;以ELISA方法检测LNC 培养液中IFN-γ,IL-10的水平。结果:南蛇藤提取物灌胃给药1．5-3g／kg,对Lewis大鼠关节炎的发生具有较好的抑制作用, 这种抑制作用从给药后第8天开始,持续到第26天。LNC实验表明,南蛇藤提取物对 Bhsp65(Mycobacterral heat shock protein 65)持异性T淋巴细胞增殖具有抑制作用,这种作用在大鼠关节炎的不同时期具有不同的影响。细胞因子实验结果表明,南蛇藤提取物能上调LNC 培养液中IL-10水平．结论:南蛇藤提取物对Mtb诱导的Lewis大鼠类风湿关节炎具有抑制作用,这种抑制作用与抑制特异性淋巴细胞增殖,上调IL-10水平。

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来源： cnki会议评论

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中国免疫学杂志 2008年第5期24卷 421-423页

作者：佟丽 kamal d.moudgil 陈育尧肖长虹南方医科大学中医药学院广州510515 Maryland university school of medicine. Baltimore Md USA

目的：观察南蛇藤提取物对Mtb诱发的Lewis大鼠佐剂型关节炎的影响。方法：以Mtb（Heat-killed mycobaeterium tubreuolsis H37Ra）免疫Lewis大鼠（1mg／只），诱发佐剂性关节炎模型，免疫后8天，出现临床类风湿关节炎症状。大鼠分成预... 详细信息

目的：观察南蛇藤提取物对Mtb诱发的Lewis大鼠佐剂型关节炎的影响。方法：以Mtb（Heat-killed mycobaeterium tubreuolsis H37Ra）免疫Lewis大鼠（1mg／只），诱发佐剂性关节炎模型，免疫后8天，出现临床类风湿关节炎症状。大鼠分成预防组及治疗组，分别灌胃南蛇藤（1．5～3g／kg）、生理盐水及甲氨碟呤（0．5mg／kg）。用积分法定期评定四肢炎症程度。实验结束后，大鼠关节做病理检测。结果：实验结果表明，预防组与模型对照组比较，南蛇藤提取物显著降低关节炎模型大鼠的临床积分，抑制关节炎症的发生（P〈0．05，P〈0．01）。治疗组中南蛇藤提取物组与甲氨碟呤组比较无显著性差异（P〉0．05）。病理结果显示南蛇藤提取物可减轻Lewis大鼠关节的损伤破坏程度。结论：南蛇藤提取物对AA模型大鼠关节炎症及病情进展有显著的抑制作用。

关键词：南蛇藤提取物动物模型佐剂型关节炎

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基因和肿瘤

国际儿科学杂志 1988年第3期 139-142页

作者： moudgil K d ,吴荫云

在自然界,一个正常细胞的肿瘤转化可能是一个多步骤的过程,涉及几种环境和遗传因素的相互作用。致癌作用的机理就是指许多致病因素单个或多个协同作用的过程。肿瘤研究中主要的进展之一就是发现基因与体内肿瘤的成因有关,而在组织培养... 详细信息

在自然界,一个正常细胞的肿瘤转化可能是一个多步骤的过程,涉及几种环境和遗传因素的相互作用。致癌作用的机理就是指许多致病因素单个或多个协同作用的过程。肿瘤研究中主要的进展之一就是发现基因与体内肿瘤的成因有关,而在组织培养中获得了正常细胞的肿瘤转化。这些基因被命名为致癌基因。重组dNA技术(或遗传工程)和dNA介导基因转移(转移感染)技术的进展已有助于更精确地鉴定致癌基因,并评价它们在肿瘤转化中的作用。

关键词：致癌基因编码蛋白染色体 dNA 基因组生长因子染色体组致癌性病毒肿瘤病毒逆转录病毒