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PROTEIN SECONDARy STRUCTURE PREDICATION USING THE 3D PROFILE METHOD

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PROTEIN SECONDARY STRUCTURE PREDICATION USING THE 3D PROFILE...

Thermo-kinetic characteristics on stabilizing hetero-phase interface of metal matrix composites by crystal plasticity finite element method

Sixteenth Congress of the International Union of Crystallography

作者： kam y.j.zhang David Eisenberg Molecular Biology Institute ＆ Department of Chemistry and Biochemistry University of CaliforniaLos AngelesCA90024-1570USA.

＜正＞A new method for the prediction of protein secondary structures has been *** method uses die 3D profile（Bowie,Liithy ＆ Eisenberg,Science,1991,253,164-170） to represent the three dimensional（3D） structure by the environments of each residue. Environmental properties include the buried area,fraction polarity and secondary *** have modified the 3D profile method to use a Fourier series to represent the residue preferences as a function

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journal of Materials Science & Technology 2024年第2期169卷 53-67页

作者： y.B.zhang S.j.Song F.Liu State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Analytical&Testing Center Northwestern Polytechnical UniversityXi’an 710072China

Using dislocation-based constitutive modeling in three-dimension crystal plasticity finite element(3D CPFE)simulations,co-deformation and instability of hetero-phase interface in different material systems were herein studied for polycrystalline metal matrix composites(MMCs).Local stress and strain fields in two types of 3layer MMCs such as fcc/fcc Cu-Ag and fcc/bcc Cu-Nb have been predicted under simple compressive ***,more severe strain-induced interface instability can be observed in the fcc/bcc systems than in the fcc/fcc systems upon refining to metallic nanolayered composites(MNCs).By detailed analysis of stress and strain localization,it has been demonstrated that the interface instability is always accompanied by high-stress concentration,i.e.,thermodynamic characteristics,or high strain prevention i.e.,kinetic characteristics,at the hetero-phase *** then follows that the thermodynamic driving forceG and the kinetic energy barrier Q during dislocation and shear banding can be adopted to classify the deformation modes,following the so-called thermo-kinetic *** by inserting a high density of high-energy interfaces into the Cu-Nb composites,such thermo-kinetic integration at the hetero-phase interface allows a successful establishment of MMCs with the high△G-high Q deformation mode,which ensures high hardening and uniform strain distri-bution,thus efficiently suppressing the shear band,stabilizing the hetero-phase interface,and obtaining an exceptional combination in strength and *** hetero-phase interface chosen by a couple of thermodynamics and kinetics can be defined as breaking the thermo-kinetic correlation and has been proposed for artificially designing MNCs.

关键词： Thermodynamics and kinetics Physics-based constitutive modeling Hetero-phase interface Crystal plasticity finite element

Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS heterojunction with photothermal effect for efficient photocatalytic hydrogen production

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journal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.y.Huang Z.yang S.y.yang Z.H.Dai y.j.Liu j.H.Liao G.y.Zhong Z.j.Xie y.P.Fang S.S.zhang Key Laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic *** photocatalysts with full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction catalyst is obtained by in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous *** unique 2D/2D structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the ***,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite catalyst with photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS *** study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.

关键词： Two-dimensional structure Heterostructure Photothermal effect Photocatalyst Hydrogen evolution

Asymptotics for the joint tail probability of bidimensional randomly weighted sums with applications to insurance

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Science China Mathematics 2024年第1期67卷 163-186页

作者： yang yang Shaoying Chen kam Chuen yuen School of Statistics and Data Science Nanjing Audit UniversityNanjing 211815China Department of Statistics and Actuarial Science The University of Hong KongHong Kong 999077China

This paper studies the joint tail behavior of two randomly weighted sums∑_(i=1)^(m)Θ_(i)X_(i)and∑_(j=1)^(n)θ_(j)y_(j)for some m,n∈N∪{∞},in which the primary random variables{X_(i);i∈N}and{y_(i);i∈N},respectively,are real-valued,dependent and heavy-tailed,while the random weights{Θi,θi;i∈N}are nonnegative and arbitrarily dependent,but the three sequences{X_(i);i∈N},{y_(i);i∈N}and{Θ_(i),θ_(i);i∈N}are mutually *** two types of weak dependence assumptions on the heavy-tailed primary random variables and some mild moment conditions on the random weights,we establish some(uniformly)asymptotic formulas for the joint tail probability of the two randomly weighted sums,expressing the insensitivity with respect to the underlying weak dependence *** applications,we consider both discrete-time and continuous-time insurance risk models,and obtain some asymptotic results for ruin probabilities.

关键词： asymptotic joint tail behavior randomly weighted sum heavy-tailed distribution dependence insurance risk model

Broad-spectrum ginsentides are principal bioactives in unraveling the cure-all effects of ginseng

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Acta Pharmaceutica Sinica B 2024年第2期14卷 653-666页

作者： Shining Loo Antony kam Bamaprasad Dutta Xiaohong zhang Nan Feng Siu Kwan Sze Chuan-Fa Liu Xiaoliang Wang james P.Tam School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Academy of Pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Department of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Institute of Materia Medica Chinese Academy of Medical SciencesBeijing 100050China Department of Health Sciences Brock UniversityNiagara RegionON L2S 3A1Canada

Stress and illness connection is complex and involves multiple physiological *** ginsengs,reputed for their broad-spectrum“cure-all”effect,are widely prescribed to treat stress and related ***,the identity of ginseng’s“cure-all”medicinal compounds that relieve stress remains ***,we identify ginsentides as the principal bioactives that coordinate multiple systems to restore homeostasis in response to *** are disulfide-rich,cell-penetrating and proteolytic-stable *** affinity-enrichment mass spectrometry target identification together with in vitro,ex vivo and in vivo validations,we show that highly purified or synthetic ginsentides promote vasorelaxation by producing nitric oxide through endothelial cells via intracellular PI3K/Akt signaling pathway,alleviate a1-adrenergic receptor overactivity by reversing phenylephrine-induced constriction of aorta,decrease monocyte adhesion to endothelial cells via CD166/ESAM/CD40 and inhibit P2y12 receptors to reduce platelet *** administered ginsentides were effective in animal models to reduce ADP-induced platelet aggregation,to prevent collagen and adrenalineinduced pulmonary thrombosis as well as anti-stress behavior of tail suspension and forced swimming tests in ***,these results strongly suggest that ginsentides are the principal panacea compounds of ginsengs because of their ability to target multiple extra-and intra-cellular proteins to reverse stress-induced damages.

关键词： Ginseng Cysteine-rich peptides Microproteins Cure-all Stress Homeostasis

EC330, a small-molecule compound, is a potential novel inhibitor of LIF signaling

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journal of Molecular Cell Biology 2020年第6期12卷 477-480页

作者： Xuetian yue Fangnan Wu jianming Wang Kaitlin Kim Bindu Santhamma Kalarickal VDileep kam yjzhang Suryavathi Viswanadhapalli Ratna KVadlamudi Gulzar Ahmed Zhaohui Feng Klaus Nickisch Wenwei Hu Rutgers Cancer Institute of New jersey Rutgers UniversityNew BrunswickNJ 08903USA Evestra Inc.San AntonioTX 78245USA Laboratory for Structural Bioinformatics Center for Biosystems Dynamics ResearchRIKENYokohama 230-0045Japan Department of Obstertrics and Gynecology University of Texas Health San AntonioSan AntonioTX 78229USA

Dear Editor,LIF,a multi-functional cytokine,is frequently overexpressed in many human cancers,including breast,colorectal,and pancreatic cancers(Liu et al.,2013;Li et al.,2014;yu et al.,2014;Pascual-Garcia et al.,2019;Shi et al.,2019;Wang et al.,2019).LIF overexpression is frequently associated with poor prognosis in human cancers(Liu et al.,2013;Li et al.,2014;yu et al.,2014).LIF functions through binding to LIF receptor complex composed of LIF receptor(LIF-R)and glycoprotein gp130(Taga and Kishimoto,1997;Heinrich et al.,2003;Watanabe et al.,2006).LIF overexpression induces activation of several oncogenic signaling pathways in a cell/tissue type-specific manner,including STAT3,PI3K/AKT,and mTOR,which in turn promotes proliferation,metastasis,and therapeutic resistance of cancer cells(Liu et al.,2013;Li et al.,2014;yu et al.,2014;Shi et al.,2019).Recent studies have suggested that LIF is a potential important target for cancer therapy,especially for cancers with LIF *** neutralization antibodies(LIF neu Abs)have been reported to block LIF signaling and largely abolish the promoting effect of LIF on cancer progression(Li et al.,2014;yue et al.,2016;Shi et al.,2019).

关键词： PI3K/AKT STAT3 metastasis

STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai j.j.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen j.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng j.Cheng S.Cheng T.G.Cheng j.P.Dai L.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko j.M.Dias D.Z.Ding L.y.Dong W.H.Dong V.Druzhinin D.S.Du y.j.Du Z.G.Du L.M.Duan D.Epifanov y.L.Fan S.S.Fang Z.j.Fang G.Fedotovich C.Q.Feng X.Feng y.T.Feng j.L.Fu j.Gao y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl j.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo j.C.Guo j.Guo y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao j.B.He S.Q.He X.G.He y.L.He Z.B.He Z.X.Heng B.L.Hou T.j.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.j.Hu W.H.Hu X.H.Hu y.C.Hu j.Hua G.S.Huang j.S.Huang M.Huang Q.y.Huang W.Q.Huang X.T.Huang X.j.Huang y.B.Huang y.S.Huang N.Hüsken V.Ivanov Q.P.ji j.j.jia S.jia Z.K.jia H.B.jiang j.jiang S.Z.jiang j.B.jiao Z.jiao H.j.jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.Lei E.Levichev C.H.Li C.Li D.y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.j.Li H.L.Li j.M.Li j.Li L.Li L.Li L.y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.j.Li X.Li X.H.Li X.Q.Li X.H.Li y.Li y.y.Li Z.j.Li H.Liang j.H.Liang y.T.Liang G.R.Liao L.Z.Liao y.Liao C.X.Lin D.X.Lin X.S.Lin B.j.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu j.Liu j.j.Liu j.B.Liu K.Liu K.y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu y.W.Liu y.Liu y.L.Liu Z.Q.Liu Z.y.Liu Z.W.Liu I.Logashenko y.Long C.G.Lu j.X.Lu N.Lu Q.F.Lü y.Lu y.Lu Z.Lu P.Lukin F.j.Luo T.Luo X.F.Luo y.H.Luo H.j.Lyu X.R.Lyu j.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng L.Peng X.y.Peng X.j.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi y.Q.Qi W.B.Qian y.Qian C.F.Qiao j.j.Qin j.j.Qin L.Q.Qin X.S.Qin T.L.Qiu j.Rademacker C.F.Redmer H.y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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蜂花粉中多酚类化合物的研究进展

中国蜂业 2024年第4期75卷 36-42页

作者：蔡雯雯(编译) 董捷乔(编译) 江涛(编译) Qiao j zhang y Haubruge E 哈尔滨商业大学食品工程学院哈尔滨150076 资源昆虫高效养殖与利用全国重点实验室中国农业科学院蜜蜂研究所北京100093 不详

蜂花粉是由蜜蜂采集加工而成的花粉团状物,其富含大量的生物活性物质,包括多糖、蛋白质、脂质、多酚等,具有较高的药用功效和食用价值。多项研究表明多酚类化合物具有特定的抗氧化、抗菌、抗糖尿病、抗高血脂以及抗炎等作用。蜂花粉的... 详细信息

蜂花粉是由蜜蜂采集加工而成的花粉团状物,其富含大量的生物活性物质,包括多糖、蛋白质、脂质、多酚等,具有较高的药用功效和食用价值。多项研究表明多酚类化合物具有特定的抗氧化、抗菌、抗糖尿病、抗高血脂以及抗炎等作用。蜂花粉的多酚类化合物,特别是酚胺和黄酮苷已成为近期研究重点,也是蜂花粉发挥重要活性功能的主要成分。本文综述了近年来世界各地不同种类的蜂花粉中多酚类化合物的成分及含量,为蜂花粉后续研究提供参考。

关键词：蜂花粉多酚含量

Short-range ordering plays a determining role in the low-cycle fatigue life improvement of fcc metals: A conclusive study on low solid-solution hardening Ni-Cr alloys

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journal of Materials Science & Technology 2023年第25期156卷 157-171页

作者： y.j.zhang D.Han X.W.Li Department of Materials Physics and Chemistry School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationNortheastern UniversityShenyang 110819China

The effect of short-range ordering (SRO) on the low-cycle fatigue (LCF) behavior of low solid-solution hardening Ni-Cr alloys with high stacking fault energies (SFEs) was systematically studied under cycling at constant total strain amplitude (Δε t /2) in the range of 0.1%–0.7%. The results show that an inducement of SRO structures can notably improve the fatigue life of the alloy regardless of Δε t /2, and several unique fatigue characteristics have been detected, including the transition of fatigue cracking mode from intergranular cracking to slip band cracking, the non-negligible evolution from non-Masing behavior in pure Ni to Masing behavior in the Ni-40Cr alloy, and the secondary cyclic hardening behavior in the Ni-10Cr and Ni-20Cr alloys. All these experimental phenomena are tightly associated with the transformation in cyclic deformation mechanisms that is induced by SRO based on the “glide plane softening” effect. Furthermore, a comprehensive fatigue life prediction model based on total hysteresis energy has been reasonably proposed, focusing on the analyses of the macroscopic model parameters (namely the fatigue cracking resistance exponent β and the crack propagation resistance parameter W 0 ) and microscopic damage mechanisms. In brief, on the premise that the effects of SFE and friction stress can be nearly ignored, as in the case of the present low solid-solution hardening Ni-Cr alloys with high SFEs, an enhancement of SRO in face-centered cubic metals has been convincingly confirmed to be an effective strategy to improve their LCF performance.

关键词： Ni-Cr alloy Short range ordering Low solid-solution hardening Low-cycle fatigue Slip mode Fatigue life prediction model