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Coronary artery disease and heart failure:Late-breaking trials presented at American Heart Association scientific session 2023

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World Journal of Cardiology 2024年第7期16卷 389-396页

作者： Avilash mondal Sashwath Srikanth Sanjana Aggarwal Naga R Alle Olufemi Odugbemi Ikechukwu Ogbu Rupak Desai Department of Internal Medicine Nazareth HospitalPhiladelphiaPA 19152United States Department of Internal Medicine East Carolina University GreenvilleGreenvilleNC 27834United States Department of Internal Medicine Hamdard Institute of Medical Sciences and ResearchNew Delhi 110062India Department of Medicine Narayana Medical CollegeNelloreAndhra Pradesh 524003India Department of Internal Medicine Lincoln Medical CenterBronxNY 10451United States Department of Internal Medicine Mountainview Hospital Sunrise GMELas VegasNV 89108United States Independent Researcher AtlantaGA 30079United States

The late-breaking science presented at the 2023 scientific session of the American Heart Association paves the way for future pragmatic trials and provides meaningful information to guide management strategies in coronary artery disease and heart failure(HF).The dapagliflozin in patient with acute myocardial infarction(DAPA-MI)trial showed that dapagliflozin use among patients with acute MI without a history of diabetes mellitus or chronic HF has better cardiometabolic outcomes compared with placebo,with no difference in cardiovascular *** MINT trial showed that in patients with acute MI and anemia(Hgbk antagonist,placebo was noninferior to daily aspirin with respect to the composite endpoint of bleeding and thrombotic events at 1 *** TEAMMATE trial showed that everolimus with low-dose tacrolimus is safe in children and young adults when given≥6 months after cardiac *** patients being treated for HF with reduced ejection fraction(HFrEF)with specific out-of-pocket(OOP)costs for multiple medication options at the time of the clinical encounter may reduce‘contingency planning’and increase the extent to which patients are taking the medications decided *** primary outcome,which was cost-informed decisionmaking,defined as the clinician or patient mentioning costs of HFrEF medication,occurred in 49%of encounters with the checklist only

关键词： Heart failure Coronary artery disease Clinical trials Myocardial infarction Cardiovascular outcome Percutaneous coronary intervention Blood transfusion Cardiac transplant

Solid and liquid state characterization of tetrahydrocurcumin using XRPD, FT-IR, DSC, TGA, LC-MS, GC-MS, and NMR and its biological activities

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Journal of Pharmaceutical Analysis 2020年第4期10卷 334-345页

作者： Mahendra kumar Trivedi Parthasarathi Panda kalyan kumar Sethi Mayank Gangwar Sambhu Charan mondal Snehasis Jana Trivedi Global Inc. Henderson89052NevadaUSA Trivedi Science Research Laboratory Pvt.Ltd. Thane(W)-400604MaharashtraIndia

Tetrahydrocurcumin(THC)is one of the major metabolites of curcumin(CUR),an ancient bioactive natural polyphenolic *** research article describes both the solid and liquid state characterization of THC using advanced spectroscopic and thermo-analytical ***-inflammatory,anti-oxidant,and neuroprotective activities of THC were investigated using in vitro cell *** chromatography-mass spectrometry analysis revealed that our sample comprised 95.15%THC,0.51%tetrahydrodemethoxycurcumin(THDC),3.40%hexahydrocurcumin,and 0.94%*** chromatography-mass spectrometry analysis indicated the presence of 96.68%THC and 3.32%*** in solution existed as keto-enol tautomers in three different forms at different retention time,but the enol form was found to be dominant,which was also supported by nuclear magnetic resonance *** was thermally stable up to 335.55*** exhibited more suppression of cytokines(TNF-a,IL-1b,and MIP-1a)than CUR in a concentration-dependent manner in mouse splenocytes,while Nk-cell and phagocytosis activity was increased in *** showed a significant reduction of free radicals(LPO)along with improved antioxidant enzymes(SOD and catalase)and increased free radical scavenging activity against ABTSt radicals in HepG2 *** displayed higher protection capability than CUR from oxidative stress and neuronal damage by improving cell viability against H2O2 induced HepG2 cells and MPPt induced SH-SY5Y cells,respectively,in a concentration-dependent ***,a variation of the biological activities of THC might rely on its keto-enol form and the presence of other THC analogs as *** present study could be advantageous for further research on THC for better understanding its physicochemical properties and biological variation.

关键词： Tetrahydrocurcumin Liquid chromatography-mass spectrometry Spectroscopic and thermal analysis keto-enol tautomer Anti-inflammatory Antioxidant

Pollen Morphology of Indian Species of Saraca L.(Leguminosae)-A Threatened and Legendary Medicinal Tree

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Phyton-International Journal of Experimental Botany 2019年第3期88卷 295-315页

作者： Sujit Sil Tanmoy Mallick Tuhin Pal Animesh mondal kalyan kumar De Asok Ghosh Postgraduate Department of Botany Hooghly Muhammad Mohsin College(Estd.1836)Chinsurah712101HooghlyWest BengalIndia UGC-CAS Department of Botany Taxonomy of Angiosperms and Biosystematics LaboratoryUniversity of BurdwanGolapbagBurdwan713104West BengalIndia

The genus Saraca L.(Leguminosae)is a universal panacea in herbal *** present study investigates the comparative pollen morphology of four species of Saraca ***(Roxb.)de Wilde,***(Jack)Miq.,*** L.,and *** Cantley ex Prain growing in India to reveal differences of their pollen structures to aid taxonomic and evolutionary *** detailed morphology and surface structure of pollen grains were studied and described using light microscopy and scanning electron *** pollen grains of Saraca showed isopolar,para-syncolporate,tricolporate,with radially symmetric,prolate and prolate-spheroidal *** surface of pollen of *** is rugulate with large lirae but in ***,the surface is micro-rugulate to vermiculate with relatively thin lirae and that of *** is indistinct as the psilate surface with a frequent protuberance and fewer perforations were observed along with the gemmae like *** ornamentation helped to separate *** and *** thickness varies from 3-4μ*** of protuberance and exine thickness varies among individuals of the species spread over different *** work also provides a unique palynological identity and interrelationship of these four species based on cluster analysis taking 23 pollen characters with the help of statistical method like the plotting of ternary *** plots also helped to calculate the level of plasticity of each character in the intra-and inter-specific level.

关键词： Cluster analysis palynology SEM study surface ornamentation ternary graph

Neoarchaean-Palaeoproterozoic Mafic Dyke Swarms from the Singhbhum Granite Complex,Singhbhum Craton,Eastern India:Implications for Identification of Large Igneous Provinces and Their Possible Continuation on Other Formerly Adjacent Crustal Blocks

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 17-18页

作者： Rajesh k.Srivastava Ulf Soderlund Richard E.Ernst Sisir k.mondal Amiya k.Samal Centre of Advanced Study in Geology Institute of ScienceBanaras Hindu University Department of Geology Lund University Department of Earth Sciences Carleton University Faculty of Geology and Geography Tomsk State University Department of Geological Sciences Jadavpur University

The Singhbhum craton of the eastern India consists of the Singhbhum Granite Complex(SGC)and the Chotanagpur Gneissic Complex(CGC)separated by the Singhbhum Mobile Belt(SMB).The CGC is intruded by Mesoproterozoic as we... 详细信息

关键词： In Implications for Identification of Large Igneous Provinces and Their Possible Continuation on Other Formerly Adjacent Crustal Blocks Neoarchaean-Palaeoproterozoic Mafic Dyke Swarms from the Singhbhum Granite Complex Eastern India

Feasibility of Al−TiC coating on AZ91 magnesium alloy by TIG alloying method for tribological application

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Transactions of Nonferrous Metals Society of China 2020年第6期30卷 1550-1559页

作者： Chinmaya kumar PADHEE Manoj MASANTA A.k.mondal Department of Mechanical Engineering National Institute of Technology RourkelaRourkela 769008India Department of Metallurgical Engineering Indian Institute of Technology(BHU)VaranasiVaranasi 221005India

An attempt was made to improve the surface properties of the AZ91 Mg alloy through surface alloying of a mixture of Al and TiC with the help of TIG arc as heat *** microstructural evolution of the alloyed layer on the AZ91 alloy was analysed through SEM and XRD *** micro-hardness and the dry sliding wear behaviour were assessed by Vickers micro-hardness tester and pin-on-disc wear test setup,*** is revealed that almost uniform alloyed layer forms on the AZ91 alloy substrate for a specific current and scan speed employed in the present *** alloyed layer exhibits hardness value up to 305 HV0.25,and almost negligible wear as compared to the as-received AZ91 alloy substrate.

关键词： AZ91 magnesium alloy Al-TiC coating TIG alloying micro-hardness dry sliding wear

Oligomerization of Vibrio cholerae Hemolysin Induces CXCR3 Upregulation and Activation of B-1a Cell

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Cellular & Molecular Immunology 2008年第3期5卷 231-234页

作者： Gayatri Mukherjee kalyan k Banerjee Tapas Biswas Divisions of Immunology National Institute of Cholera and Enteric Diseases P-33 C.I.T. Road Scheme XM Kolkata-700 010 West Bengal India Biochemistry National Institute of Cholera and Enteric Diseases P-33 C.I.T. Road Scheme XM Kolkata-700 010 West Bengal India

The hemolysin oligomer promotes the proliferation of B-1a cells and the expression of CD25, which is indicative of cell activation, on B-1a cells. The upregulation of CD86 induced by the oligomer showed its selective bias for the B7-2 member of B7 family while the monomer failed to induce these effects. The oligomer induced the expression of CXCR3, associated with B cell activation, while the monomer induced the expression of CXCL4, a powerful angiostatic chemokine. In conclusion, we found that B-1a cells responded to the apoptogenic monomer by expressing CXCL4, whereas oligomerization of the immunogen induced CXCR3 to shift the response towards activation.

关键词： B-1a cell CD86 CXCL4 CXCR3 Vibrio cholerae hemolysin

Transference of Love-type waves in a bedded structure containing a functionally graded material and a porous piezoelectric medium

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Applied Mathematics and Mechanics(English Edition) 2019年第8期40卷 1083-1096页

作者： S.mondal S.A.SAHU k.k.PANkAJ Department of Applied Mathematics Indian Institute of Technology (ISM)

The frequency of the Love-type surface waves in a bedded structure con- sisting of a porous piezoelectric (PP) medium and a functionally graded material (FGM) substrate is approximated. The FGM layer is assumed to have a constant initial stress. The Wentzel-kramers-Brillouin (WkB) approximation technique is used for the wave solution in the FGM layer, and the method of separation of variables is applied for the solution in the porous piezoelectric medium. The dependence of the wave frequency on the wave number is obtained for both electrically open and short cases. The effects of the gradient coefficient of the FGM layer, the initial stresses (tensile stress and compressive stress), and the width of the FGM layer are marked distinctly and shown graphically. The findings may contribute towards the design and optimization of acoustic wave devices.

关键词： porous piezoelectric (PP) material functionally graded material (FGM) Love-type wave Wentzel-kramers-Brillouin (WkB) approximation

SYNTHESIS AND CHARACTERIZATION OF HYBRID PROTON CONDUCTING MEMBRANES OF POLY(VINYL ALCOHOL) AND PHOSPHOMOLYBDIC ACID

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Chinese Journal of Polymer Science 2006年第5期24卷 449-456页

作者： Arfat Anis A.k. Banthia S. mondal A.k. Thakur Materials Science Centre Indian Institute of TechnologyKharagpur 721302India Department of Physics & Meteorology Indian Institute of TechnologyKharagpur 721302India

Hybrid proton conducting membranes of poly（vinyl alcohol）（PVA） and phosphomolybdic acid （PMA） were prepared by solution casting method. The effect of PMA doping and PVA crosslinking density on the membrane properties and proton conductivity were investigated. The crosslinking reaction between the hydroxyl group of PVA and the aldehyde group of glutaraldehyde （GA） was characterized by IR spectroscopy. Proton conductivity of the membranes increases with an increase in concentration of the doped PMA and also with an increase in crosslinking density of the membranes. Proton conductivity results indicate that a significant amount of PMA was maintained in the membranes even after several hours of immersion in water. A maximum conductivity of 0.0101 S cm^-1 was obtained for the membrane with 33.3 wt% PMA and crosslinking density of 5.825 mol%. X-ray diffraction studies were carried out to investigate the influence of PMA doping and crosslinking density on the nature of the membranes. These properties make them very good candidates for polymer electrolyte membranes for direct methanol fuel cell application.

关键词： Polymer electrolyte membranes Proton conductor Phosphomolybdic acid Crosslinked PVA membranes.

Clone-World:A visual analytic system for large scale software clones

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Visual Informatics 2019年第1期3卷 18-26页

作者： Debajyoti mondal Manishankar mondal Chanchal k.Roy kevin A.Schneider Yukun Li Shisong Wang Department of Computer Science University of SaskatchewanSaskatoonSKCanada

With the era of big data approaching,the number of software systems,their dependencies,as well as the complexity of the individual system is becoming larger and more *** these evolving software systems is thus a primary challenge for cost-effective software management and *** this paper we perform a case study with evolving code *** programmers often need to manually analyze the co-evolution of clone fragments to decide about refactoring,tracking,and bug ***,manual analysis is time consuming,and nearly infeasible for a large number of clones,e.g.,with millions of similarity pairs,where clones are evolving over hundreds of software *** propose an interactive visual analytics system,Clone-World,which leverages big data visualization approach to manage code clones in large software ***-World,gives an intuitive yet powerful solution to the clone analytic ***-World combines multiple informationlinked zoomable views,where users can explore and analyze clones through interactive exploration in real *** studies and experts’reviews suggest that Clone-World may assist developers in many real-life software development and maintenance *** believe that Clone-World will ease the management and maintenance of clones,and inspire future innovation to adapt visual analytics to manage big software systems.

关键词： Visual analytics Software clones Multivariate networks