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3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma

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Food Science and Human Wellness 2024年第3期13卷 1453-1464页

作者： Mengjie Liu Xuqiang Liu kaiyue he Yongping Jian Yujia Li Jinrong Guo Jingyu Yang Zhixiang Xu Wenyi Kang School of Life Sciences Henan UniversityKaifeng 475004China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China Shenzhen Research Institute of henan University Shenzhen 518000China

3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)is a pentacyclic triterpene mainly distributed in food and medicinal plants,which exhibits various pharmacological ***,whether these functions are attributed to eBAG or additional components in these plants remain ***,we report that eBAG exerted an inhibitory activity against hepatocellular carcinoma and esophageal cancer *** induced non-apoptotic cell death in hepatocellular carcinoma *** eBAG-induced cell death was inhibited by knock-down of autophagy related gene(ATG)5 and ATG7,by administration of 3-methyladenine,a selective autophagy inhibitor that suppresses phosphoinositide 3-kinase(PI3K),and by chloroquine,a classic autophagy flux *** demonstrated that eBAG induced an autophagy-mediated cell *** of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP,activation of AMP-activated protein kinase(AMPK),and inhibition of ***-treatment with compound C,an AMPK inhibitor,abrogated cell death induced by *** further validated the anti-tumor effect of eBAG in the murine xenograft model of hepatocellular carcinoma and found that eBAG treatment promoted the induction of autophagy and reduction of tumor growth in *** a functional food ingredient,eBAG is a potential therapeutic agent for the treatment of hepatocellular carcinoma and esophageal cancer.

关键词： eBAG Autophagy ATP AMPK hepatocellular carcinoma

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ICD-11纳入传统医学编码对疾病负担测算的影响研究

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中国全科医学 2024年第6期27卷 746-750页

作者：周静静贺凯玥刘爱玲赵兰慧高婧周尚成广州中医药大学公共卫生与管理学院广东省广州市510006 广州中医药大学护理学院广东省广州市510006

基于国际疾病和相关健康问题分类(ICD)编码的疾病负担测算在全球已得到广泛应用,但是目前该类研究多基于西医疾病编码。随着中医药国际化程度的提高,ICD-11纳入传统医学编码,有利于促进中医疾病诊断的完善,利于计算患病率、生存率、服... 详细信息

基于国际疾病和相关健康问题分类(ICD)编码的疾病负担测算在全球已得到广泛应用,但是目前该类研究多基于西医疾病编码。随着中医药国际化程度的提高,ICD-11纳入传统医学编码,有利于促进中医疾病诊断的完善,利于计算患病率、生存率、服药情况、救治水平,可进一步评价中医病种的疾病负担情况,促进临床诊疗决策及卫生资源的合理配置,从而进一步促进中医药的国际化。但是,ICD-11中传统医学编码不完善,和西医疾病编码、我国中医国家标准之间的映射不足对中医疾病负担测算带来新的挑战。本文立足于疾病负担测算的编码体系,分析了当前中医疾病负担测算研究中的不足、ICD-11纳入传统医学编码后对中医疾病负担测算的影响,并对ICD-11传统医学编码和西医疾病编码、我国新国家标准进行了初步比较,为未来中医疾病负担的测算编码的完善提供参考。提出未来可利用大数据技术促进中医标准化术语和ICD-11传统医学编码、ICD-11传统医学编码和西医疾病编码之间的映射,从而促进中医疾病负担的研究。

关键词：全球疾病负担中医药学国际疾病分类第十一次修订本医疗编码传统医学编码

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滨海海底边界层对底栖微体化石仿真模拟的影响

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地学前缘 2024年第2期31卷 410-422页

作者：张毅恒张涛雍媛媛鱼驰洋肖巨月何凯悦王邓王星王宾杨晓光韩健西北大学信息科学与技术学院陕西西安710069 西北大学地质学系大陆动力学国家重点实验室/早期生命与环境陕西省重点实验室陕西西安710069 临沂大学生命科学学院山东临沂276000

计算流体力学CFD(computational fluid dynamics)近年来在古生物学研究中已有大量应用。该方法在研究生物化石的个体形态、器官功能,以及其与生存环境之间的关系方面具有重要意义。目前古生物领域的CFD仿真对象多为厘米级别体型的生物,... 详细信息

计算流体力学CFD(computational fluid dynamics)近年来在古生物学研究中已有大量应用。该方法在研究生物化石的个体形态、器官功能,以及其与生存环境之间的关系方面具有重要意义。目前古生物领域的CFD仿真对象多为厘米级别体型的生物,而对于毫米级别大小的微体生物的仿真则相对较少。区别于厘米级别的宏体生物,底栖型微体生物的生活环境局限于海床上方垂直高度较小的区域,受海底黏性边界层低流速区域的影响更为明显,因而在设置这类化石仿真的水流环境时应当考虑对于边界层流域水体流速以及海床表面地理环境的还原。本文基于随机表面生成的方法,构建了不平坦的滨海海床表面模型,并模拟了水流在海底边界层附近受海床表面地形影响的流动状态;基于获得的仿真流速数据,我们仿真了寒武纪微型底栖刺细胞动物化石Quadrapyrgite在起伏的海床表面环境中四个不同位置的受水流阻力情况。仿真结果显示,近海床表面处的水体流动可形成明显的低流速区域,且低流速区域的厚度随着入口速度增大而变薄。在起伏表面的凹凸区域中,凸起地带的迎水面形成的低流速区域较薄,流速变化较快;而在凸起地带背水面以及凹陷地带形成的低流速区域较厚,流速较缓且易形成涡旋。流速的差异体现在不同位置的Quadrapyrgite的受阻力大小不同上,其差值可达数倍到数十倍。这种量级的受阻力差值可以在毫米级到厘米级尺度上塑造、影响底栖型生物的分布甚至其自身的摄食行为。本文的研究为CFD方法模拟底栖微型化石的生存环境提供了更加深入的思路和方法。

关键词：底栖微体化石计算流体力学海底边界层傅里叶变换随机表面产生方法

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Enhanced photodetector performance of black phosphorus by interfacing with chiral perovskite

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Nano Research 2022年第8期15卷 7492-7497页

作者： Yang Cao Congzhou Li Jie Deng Tong Tong Yuchi Qian Guixiang Zhan Xu Zhang kaiyue heHuifang Ma Junran Zhang Jing Zhou Lin Wang Key Laboratory of Flexible Electronics and Institute of Advanced Materials School of Physical and Mathematical SciencesNanjing Tech UniversityNanjing 211816China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 20083China

heterogeneous stackings of two-dimensional(2D)semiconductors and halide perovskites have attracted much attention owing to their respective superior optoelectronic *** phosphorus(BP),as a unique 2D member with narrow bandgap,high mobility,and strong anisotropy,has never been combined with 2D layered ***,we construct a new BP-based van der Waals heterostructure combing with 2D chiral hybrid perovskite(i.e.,(MBA)_(2)PbI_(4))for promoting the performance and enriching the functionalities of BP.A series of BP characteristics,including carrier mobility,photoresponsivity,and polarization sensitivity,are synergistically enhanced when interfacing with(MBA)_(2)PbI_(4).For instance,the photodetector responsivity and photogain of BP in heterostructures are boosted by almost one order of magnitude with respect to BP alone,which is more obvious under excitation above the bandgap of *** is because the interfacing perovskite provides an inflow of numerous photogenerated carriers to BP,to reinforce the charge carrier transfer,separation,and transport ***,the ability of both linearly and circularly polarized photodetection can be integrated into the BP/(MBA)_(2)PbI_(4)*** work sheds new insight on the heterostructure assembly for promising optoelectronic applications within 2D materials and perovskite families.

关键词： chiral perovskite black phosphorus heterostructure photodetector

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High-sensitive two-dimensional PbI_(2)photodetector with ultrashort channel

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Frontiers of physics 2023年第6期18卷 173-181页

作者： kaiyue he Jijie Zhu Zishun Li Zhe Chen hehe Zhang Chao Liu Xu Zhang Shuo Wang Peiyi Zhao Yu Zhou Shizheng Zhang Yao Yin Xiaorui Zheng Wei Huang Lin Wang School of Flexible Electronics(Future Technologies)&Institute of Advanced Materials(IAM) Key Laboratory of Flexible Electronics(KLOFE)Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech UniversityNanjing 211816China Research Center for Industries of the Future(RCIF) School of EngineeringWestlake UniversityHangzhou 310030China

Photodetectors based on two-dimensional(2D)semiconductors have attracted many research interests owing to their excellent optoelectronic characteristics and application potential for highly integrated ***,the unique morphology of 2D materials also restricts the further improvement of the device performance,as the carrier transport is very susceptible to intrinsic and extrinsic environment of the ***,we report the highest responsivity(172 A/W)achieved so far for a PbI_(2)-based photodetector at room temperature,which is an order of magnitude higher than previously *** scanning probe lithography(t-SPL)was used to pattern electrodes to realize the ultrashort channel(~60 nm)in the *** shortening of the channel length greatly reduces the probability of the photo-generated carriers being scattered during the transport process,which increases the photocurrent density and thus the *** work shows that the combination of emerging processing technologies and 2D materials is an effective route to shrink device size and improve device performance.

关键词： two-dimensional photodetectors carrier scattering ultrashort channel thermal scanning probe lithography PbI_(2)nanosheets

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Carbon Monoxide Modulates Auxin Transport and Nitric Oxide Signaling in Plants under Iron Deficiency Stress

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Phyton-International Journal of Experimental Botany 2024年第1期93卷 45-61页

作者： kaiyue Hong Yasmina Radani Waqas Ahmad Ping Li Yuming Luo Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental ProtectionHuaiyin Normal UniversityHuaian223300China School of Life Sciences Nanjing Forestry UniversityNanjing210037China School of Life Sciences Shanghai UniversityShanghai200444China

Carbon monoxide(CO)and nitric oxide(NO)are signal molecules that enhance plant adaptation to environmental *** is an essential phytohormone for plant growth and *** and NO play crucial roles in modulating the plant’s response to iron *** deficiency leads to an increase in the activity of heme oxygenase(HO)and the subsequent generation of ***,it alters the polar subcellular distribution of Pin-Formed 1(PIN1)proteins,resulting in enhanced auxin *** alteration,in turn,leads to an increase in NO ***,iron deficiency enhances the activity of ferric chelate reductase(FCR),as well as the expression of the Fer-like iron deficiency-induced transcription factor 1(FIT)and the ferric reduction oxidase 2(FRO2)genes in plant *** of the long hypocotyl 1(HY1)gene,which encodes heme oxygenase,or the CO donor treatment resulted in enhanced basipetal auxin transport,higher FCR activity,and the expression of FIT and FRO2 genes under Fe ***,a potential mechanism is proposed:CO and NO interact with auxin to address iron deficiency *** alters auxin transport,enhancing its accumulation in roots and up-regulating key iron-related genes like FRO2 and *** auxin levels affect NO signaling,leading to greater sensitivity in root *** interplay promotes FCR activity,which is crucial for iron ***,these molecules enhance iron uptake and root growth,revealing a novel aspect of plant physiology in adapting to environmental stress.

关键词： Carbon monoxide nitric oxide auxin iron deficiency signal molecule plants

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Identification and Transcriptional Regulation of CAMTA Genes in Liriodendron chinense

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 413-425页

作者： kaiyue Hong Yasmina Radani Teja Manda Jinhui Chen Liming Yang State Key Laboratory of Tree Genetics and Breeding College of Life SciencesNanjing Forestry UniversityNanjing210037China

This study explores CAMTA genes in the rare and endangered Chinese plant species,Liriodendron *** the completion of whole-genome sequencing,the roles of CAMTA genes in calcium regulation and stress responses in this species remain largely *** the *** genome,we identiﬁed two CAMTA genes,Lchi09764 and Lchi222536,characterized by four functional domains:CG-1,TIG,ANK repeats,and IQ *** analyses,including phylogenetic investigations,cis-regulatory element analyses,and chromosomal location studies,aim to elucidate the deﬁning features of CAMTA genes in *** Weighted Gene Co-Expression Network Analysis(WGCNA),we explored the impact of CAMTA genes on different organs and their regulation under abiotic stress *** identiﬁcation of signiﬁcant gene modules and the prediction of promoter binding sites revealed co-expressed genes associated with CAMTA transcription *** summary,this study provides initial insights into CAMTA genes in ***,laying the groundwork for future research on their evolution and biological *** knowledge enhancement contributes to a better understanding of plant responses to environmental stress—an essential aspect of plant biology.

关键词： Liriodendron chinense CAMTA genes abiotic stress WGCNA different organs

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Dimensional reduction enhances photocatalytic carbon dioxide reduction performance of metal-organic frameworks

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Nano Research 2024年第5期17卷 3653-3659页

作者： kaiyue Ma Jixin Li Jinlu Liu Chunguang Li Zhan Shi Shouhua Feng State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China

Metal-organic frameworks(MOFs)have shown significant potential as *** has been widely assumed that all catalytic active sites within MOFs are functional in photocatalytic reactions but for a three-dimensional MOF,whether the internal catalytic active sites can effectively absorb light and actively contribute to photocatalytic reactions remains to be *** this context,we synthesized a two-dimensional nanosheet MOF(2D-MOF)and a three-dimensional bulk MOF(3D-MOF)composed of Zr^(6) clusters and tetracarboxylic porphyrin(TCPP)by the approach described in the ***(bpy)(CO)^(3)Cl(bpy=2,2’-bipyridine),which has remarkable CO_(2) photoreduction ability,was introduced to the two MOFs to create two new photocatalysts 2D-MOF-Re and 3D-MOF-Re,*** CO_(2) reduction experiments show that based on the equal number of catalytic active sites,the CO turnover number(TON)of 2D-MOF-Re reaches 27.8 in 6 h,which is 50 times that of *** result shows that certain catalytic active sites inside the bulk MOF are inactive due to the inability to absorb *** study illuminates the potential of the dimensional reduction approach in the design of photocatalysts to exploit the capabilities fully.

关键词： photocatalysis CO_(2)reduction metal-organic frameworks(MOFs) nanosheets light absorption

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AZD1775 and anti-PD-1 antibody synergistically sensitize hepatoma to radiotherapy

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Chinese Medical Journal 2024年第2期137卷 222-231页

作者： Yichun Yin Jian Wang Junxuan Yi kaiyue Zhang Zimeng Yin Shunzi Jin Baisong Zheng Public health of College Jilin UniversityJilinChangchun 130021China Institute of Virology and AIDS Research The First Hospital of Jilin UniversityJilinChangchun 130021China NHC Key Laboratory of Radiobiology(Jilin University) JilinChangchun 130021China

Background:Radiation(IR)-induced DNA damage triggers cell cycle arrest and has a suppressive effect on the tumor microenvironment(TME).Wee1,a cell cycle regulator,can eliminate G2/M arrest by phosphorylating cyclin-dependent kinase 1(CDK1).Meanwhile,programed death-1/programed death ligand-1(PD-1/PDL-1)blockade is closely related to *** study aims to investigate the effects and mechanisms of Wee1 inhibitor AZD1775 and anti-PD-1 antibody(anti-PD-1 Ab)on radiosensitization of ***:The anti-tumor activity of AZD1775 and IR was determined by 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide(MTT)assay on human and mouse hepatoma cells hepG2,hepa1-6,and *** anti-hepatoma mechanism of AZD1775 and IR revealed by flow cytometry and Western blot in vitro.A hepatoma subcutaneous xenograft mice model was constructed on Balb/c mice,which were divided into control group,IR group,AZD1775 group,IR+AZD1775 group,IR+anti-PD-1 Ab group,and the IR+AZD1775+anti-PD-1 Ab *** CD8^(+)T cells in TME were analyzed by flow ***:Combining IR with AZD1775 synergistically reduced the viability of hepatoma cells in ***1775 exhibited antitumor effects by decreasing CDK1 phosphorylation to reverse the IR-induced G2/M arrest and increasing IR-induced DNA ***1775 treatment also reduced the proportion of PD-1^(+)/CD8^(+)T cells in the spleen of hepatoma subcutaneous xenograft *** studies revealed that AZD1775 and anti-PD-1 Ab could enhance the radiosensitivity of hepatoma by enhancing the levels of interferonγ(IFNγ)^(+)or Ki67^(+)CD8 T cells and decreasing the levels of CD8^(+)Tregs cells in the tumor and spleen of the hepatoma mice model,indicating that the improvement of TME was manifested by increasing the cytotoxic factor IFNγexpression,enhancing CD8^(+)T cells proliferation,and weakening CD8^(+)T cells ***:This work suggests that AZD1775 and anti-PD-1 Ab synergistically sensitize hepatoma to radiothera

关键词： hepatoma Radiation AZD1775 Anti-PD-1 antibody DNA damage Tumor microenvironment

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Simple chemical synthesis and isotropic negative thermal expansion in MHfF_(6)(M=Ca,Mn,Fe,and Co)

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Nano Research 2024年第3期17卷 2195-2203页

作者： Yongqiang Qiao Sen Zhang Peixian Zhang Juan Guo Andrea Sanson Xi Zhen kaiyue Zhao Qilong Gao Jun Chen Key Laboratory of Materials Physics of Ministry of Education and School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Department of Physics and Astronomy University of PadovaPadova I-35131Italy Beijing Advanced Innovation Center for Materials Genome Engineering Department of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China

The rapid progress of modern technologies has accelerated the prominence of thermal expansion mismatch between materials,and tunable thermal expansion materials will be a powerful safeguard against this ***,isotropic MHfF_(6)(M=Ca,Mn,Fe,and Co)compounds with tunable thermal expansion have been produced via a low-cost synthetic method and *** utilizing temperature dependent X-ray diffraction(XRD)and Raman spectroscopy,combined with first principles calculations,it was revealed that the transverse thermal vibrations of the F atoms are dominated by low-frequency phonons with negative Grüneisen parameters and are therefore the origin of the negative thermal expansion(NTE).Very interestingly,with the increase of the M atomic number,the metal…F atomic linkages become stiffer,reducing the number of vibrational modes with negative Grüneisen parameters,so that the strong NTE can be gradually adjusted to moderate NTE and to near zero thermal *** present study achieves the tunable thermal expansion in a new compound family and shed light on the internal mechanism from the perspective of lattice vibrational dynamics.

关键词： negative thermal expansion fluorides chemical synthesis nanosheet structure first principles calculations

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