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On-chip quantum NOON state sensing for temperature and humidity

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Chinese Physics B 2024年第10期33卷 15-20页

作者： Weihong Luo Chao Wu Yuxing Du Chang Zhao Miaomiao Yu Pingyu Zhu kaikai Zhang Ping Xu Institute for Quantum Information&State Key Laboratory of High Performance Computing College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China

A maximal photon number entangled state,namely NOON state,can be adopted for sensing with a quantum *** this work,we designed silicon quantum photonic chips containing two types of Mach-Zehnder interferometerswherein the two-photon NOON state,sensing element for temperature or humidity,is *** with classicallight or single photon case,two-photon NOON state sensing shows a solid enhancement in the sensing resolution *** the first demonstration of on-chip quantum photonic sensing,it reveals the advantages of photonic chips forhigh integration density,small-size,stability for multiple-parameter sensing serviceability.A higher sensing precision isexpected to beat the standard quantum limit with a higher photon number NOON state.

关键词： quantum sensing NOON state photonic chip

Stabilizing semi-transparent perovskite solar cells with a polymer composite hole transport layer

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Nano Research 2024年第3期17卷 1500-1507页

作者： Yongbin Jin Huiping Feng Zheng Fang Liu Yang kaikai Liu Bingru Deng Jingfu Chen Xueling Chen Yawen Zhong Jinxin Yang Chengbo Tian Liqiang Xie Zhanhua Wei Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021China

Semi-transparent perovskite solar cells(ST-PSCs)have broad applications in building integrated ***,the stability of ST-PSCs needs to be improved,especially in n-i-p ST-PSCs since the doped 2,2',7,7'-tetrakis(N,N-di-p-methoxyphenyl-amine)-9,9'-spirobifluorene(Spiro-OMeTAD)is unstable at elevated temperatures and high *** this work,aπ-conjugated polymer poly[(2,6-(4,8-bis(5-(2-ethylhexyl)thiophene-2-yl)-benzo[1,2-b:4,5-b']dithiophene))-alt-(5,5-(1',3'-di-2-thienyl-5',7'-bis(2-ethylhexyl)benzo[1',2'-c:4',5'-c']dithiophene-4,8-dione)](PBDB-T)is selected to form a polymer composite hole transport layer(HTL)with *** sulfur atom of the thiophene unit and the carbonyl group of the polymer interact with the undercoordinated Pb2+at the perovskite surface,which stabilizes the perovskite/HTL interface and passivates the interfacial *** incorporation of the polymer also increases the glass transition temperature and the moisture resistance of *** a result,we obtain ST-PSCs with a champion efficiency of 13.71%and an average visible light transmittance of 36.04%.Therefore,a high light utilization efficiency of 4.94%can be ***,the encapsulated device can maintain 84%of the initial efficiency after 751 h under continuous one-sun illumination(at 30%relative humidity)at the open circuit and the unencapsulated device can maintain 80%of the initial efficiency after maximum power tracking for more than 1250 h under continuous one-sun illumination.

关键词： semi-transparent solar cells π-conjugated polymer composite hole transport layer building integrated photovoltaics

Self-assembled nanoparticles targeted against miR-155 and CXCR4 for combination therapy of liver fibrosis

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Self-assembled nanoparticles targeted against miR-155 and CX...

隧道洞室地基稳定性双阶段多策略粒子群BP网络模型研究

2018年第十二届中国药物制剂大会

作者：武鹏凯 Ling Ding Xingping Luo Fei Yu Jing Li kaikai wang Minjie Sun David Oupicky State Key Laboratory of Natural Medicines Department of Pharmaceutics China Pharmaceutical University Center for Drug Delivery and Nanomedicine Department of Pharmaceutical Sciences University of Nebraska Medical Center

Emerging evidence has suggested that the expression of chemokine receptor-4（CXCR4） and the level of mi R-155 are increased in hepatic stellate cells（HSCs） and Kupffer cells（KCs） of fibrotic liver, respectively [1,2]. Thus, a novel strategy for the treatment of liver fibrosis was to develope dual function copolymers for CXCR4 inhibition and delivery most of mi R-155 inhibitor（anti-miR-155） into Kupffer cells（KCs） to achieve combined therapy. In this study, we have developed dual-function delivery vectors based on cholesterol-modified poly（ethylenimine）（PEI） conjugated with CXCR4-inhibiting cyclam moieties（Chol-PEI-C） and used them to deliver mi R-155 inhibitor（anti-miR-155） to the liver（Fig.1）. The results showed that the polyplexes formed by Chol-PEI-C and anti-miR-155 could not only suppress the activation of HSCs by reducing α-SMA expression, but also decrease the levels of pro-inflammation cytokines like TGF-β1 and ECM component like collagen, finally achieved an improved therapy in fibrotic liver induced by carbon tetrachloride（CCl4） and bile duct ligation（BDL）. In summary, dual-function copolymers for CXCR4 inhibition and therapeutic mi RNA delivery provide a novel, promising strategy to the design of combination nanoparticles for liver fibrosis treatment.

关键词： MicroRNA polyplexes hepatic stellate cells Kupffer cells liver fibrosis

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现代隧道技术 2017年第3期54卷 50-57页

作者：胡军董建华王凯凯 f辽宁科技大学土木工程学院鞍山114051

影响隧道洞室地基稳定性的因素众多,这些因素与隧道洞室地基稳定性之间存在着复杂的非线性关系,并且常规的方法很难描述这种复杂的关系。文章提出了一种双阶段多策略粒子群算法(DMPSO)优化的BP神经网络隧道洞室地基稳定性评价模型。粒... 详细信息

影响隧道洞室地基稳定性的因素众多,这些因素与隧道洞室地基稳定性之间存在着复杂的非线性关系,并且常规的方法很难描述这种复杂的关系。文章提出了一种双阶段多策略粒子群算法(DMPSO)优化的BP神经网络隧道洞室地基稳定性评价模型。粒子群算法具有全局优化能力强、搜索效率高等特点,算法改进后使这些特点更加突出。BP算法有很强的非线性映射能力、泛化能力,但也有收敛速度慢,容易陷入局部最优等缺陷。采用双阶段多策略粒子群算法(DMPSO)搜索BP模型的权值和阈值,弥补了BP模型的缺陷,提高了其预测的准确度。文章以重庆小什字车站洞室地基为例,证明了双阶段多策略粒子群算法优化的BP神经网络模型(DMPSO-BP)的可行性,并且该模型比模糊神经网络和粒子群优化的BP神经网络(PSO-BP)模型有更好的预测精度。

关键词：粒子群算法相互交流 BP神经网络隧道洞室地基稳定性

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模拟移动床色谱分离纯化绿豆ACE抑制肽

中国食品学报 2017年第9期17卷 142-150页

作者：刁静静王凯凯张丽萍曹龙奎黑龙江八一农垦大学国家杂粮工程技术研究中心黑龙江大庆163319 黑龙江八一农垦大学食品学院黑龙江大庆163319

模拟移动床(Simulated Moving Bed,SMB)色谱多被用于二元糖混合物、二甲苯异构体等化学成分的大批量分离。本文采用SMB技术产业化分离具有较高血管紧张素转化酶(ACE)抑制活性的绿豆肽。以ACE抑制活性和收率为指标,分析SMB系统中不同操... 详细信息

模拟移动床(Simulated Moving Bed,SMB)色谱多被用于二元糖混合物、二甲苯异构体等化学成分的大批量分离。本文采用SMB技术产业化分离具有较高血管紧张素转化酶(ACE)抑制活性的绿豆肽。以ACE抑制活性和收率为指标,分析SMB系统中不同操作参数对产业化分离绿豆肽效率的影响,并采用二维纳升液质谱联用技术(2D-nano LC-MS/MS)分析高活性绿豆ACE抑制肽的氨基酸序列。结果表明:采用SMB技术可实现高活性绿豆ACE抑制肽的产业化分离。通过调整各区流速提高产品的活性和收率。在进样流速9 m L/min,水洗脱1流速19 m L/min,醇洗脱流速11 m L/min,水洗脱2流速19 m L/min条件下,分离得到的绿豆肽ACE抑制率为95.32%,其收率86%。将分离的高活性绿豆ACE抑制肽进行质谱分析,得出其氨基酸序列分别为Phe-LeuVal-Asn-Arg-Ile(885.1 u)、Phe-Leu-Val-Asn-Pro-Asp-Asp(961.06 u)、Lys-Asp-Asn-Val-Ile-Ser-GluLeu(1 043.13 u)。

关键词：模拟移动床分离纯化绿豆ACE抑制肽

表面增强拉曼光谱技术检测伽马辐射损伤DNA-AuNPs组装体

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辐射研究与辐射工艺学报 2019年第4期37卷 52-58页

作者：陈雨王凯凯张海黔南京航空航天大学材料科学与技术学院

本文旨在发展一种基于辐射敏感基因和表面增强拉曼散射(Surface enhanced Raman scattering,SERS)光谱技术的辐射探测方法.通过对辐射敏感基因片段进行巯基修饰,将其以Au-S共价键偶联到金纳米粒子(Gold nanoparticles,AuNPs)表面,形成... 详细信息

本文旨在发展一种基于辐射敏感基因和表面增强拉曼散射(Surface enhanced Raman scattering,SERS)光谱技术的辐射探测方法.通过对辐射敏感基因片段进行巯基修饰,将其以Au-S共价键偶联到金纳米粒子(Gold nanoparticles,AuNPs)表面,形成单链和双链两种DNA-AuNPs组装体.利用SERS技术研究DNA-AuNPs组装体对γ射线的辐射响应性质,以及金纳米粒子的局域增强效应对组装体γ射线响应的影响.结果表明:吸收剂量为0~200 Gy时,双链DNA-AuNPs组装体在663 cm^-1处的拉曼峰有明显变化,表现出对吸收剂量的响应性;吸收剂量为0~100 Gy时,单链DNA-AuNPs组装体同样呈现辐射响应性质,且辐射响应灵敏度随着组装体纳米金浓度的增加而增加,这可归因于AuNPs的局域等离激元的增强效应.结果提示,DNA-AuNPs组装体和SERS光谱技术相结合,有望成为一种用于电离辐射剂量测量的新型探测方法.

关键词：辐射敏感基因伽马辐射表面增强拉曼散射金纳米粒子

Exfoliation of bulk 2H-MoS_(2)into bilayer 1T-phase nanosheets via ether-induced superlattices

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Nano Research 2024年第6期17卷 5705-5711页

作者： Xiuling Shi Dongmei Lin Zhuorui Xiao Yibo Weng Hanxiang Zhou Xiaoying Long Zhiyu Ding Fuyuan Liang Yan Huang Guohua Chen kaikai Li Tong-Yi Zhang School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518055China Department of Mechanical Engineering Research Institute for Smart EnergyThe Hong Kong Polytechnic UniversityHong KongChina School of Energy and Environment City University of Hong KongTat Chee AvenueKowloonHong KongChina The Hong Kong University of Science and Technology(Guangzhou) Guangzhou Municipal Key Laboratory of Materials InformaticsAdvanced Materials Thrust and Sustainable Energy and Environment ThrustNanshaGuangzhou 511400China

The exfoliation of bulk 2H-molybdenum disulfide(2H-MoS_(2))into few-layer nanosheets with 1T-phase and controlled layers represents a daunting challenge towards the device applications of MoS_(2).Conventional ion intercalation assisted exfoliation needs the use of hazardous n-butyllithium and/or elaborate control of the intercalation potential to avoid the decomposition of the MoS_(2).This work reports a facile strategy by intercalating Li ions electrochemically with ether-based electrolyte into the van der Waals(vdW)channels of MoS_(2),which successfully avoids the decomposition of MoS_(2)at low *** co-intercalation of Li+and the ether solvent into MoS_(2)makes a first-order phase transformation,forming a superlattice phase,which preserves the layered structure and hence enables the exfoliation of bulk 2H-MoS_(2)into bilayer nanosheets with *** with the pristine 2H-MoS_(2),the bilayer 1T-MoS_(2)nanosheets exhibit better electrocatalytic performance for the hydrogen evolution reaction(HER).This facile method should be easily extended to the exfoliation of various transition metal dichalcogenides(TMDs).

关键词： exfoliation of MoS_(2) phase transformations superlattices ether electrolyte hydrogen evolution reaction(HER)

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水溶液中一步合成二吡咯甲烷类化合物

有机化学 2012年第3期32卷 616-620页

作者：吴振豪胡江磊王凯凯高超王洪宇张龙长春工业大学吉林省石化资源与生物质综合利用工程实验室长春130012

在水相中,以磷钨酸为催化剂,吡咯与羰基化合物为底物,室温下一步合成了二吡咯甲烷类化合物,反应产物纯度高,无需进一步纯化.该方法具有明显的环境友好、产率高和操作过程简便的优点.

关键词：二吡咯甲烷吡咯羰基化合物水绿色化学

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RNA结合蛋白在胶质瘤中的研究进展

中华神经医学杂志 2018年第9期17卷 892-896页

作者：张俊王开开赵世光哈尔滨医科大学附属第一医院神经外科哈尔滨150001

神经胶质瘤是中枢神经系统最常见的原发性恶性肿瘤。尽管近年来胶质瘤的治疗有了巨大的进步，但是它的预后仍然很差，因此亟需新的胶质瘤检测和治疗方法。RNA结合蛋白（RBPs）是一类能直接与RNA结合的蛋白，它可通过与RNA结合形成核糖... 详细信息

神经胶质瘤是中枢神经系统最常见的原发性恶性肿瘤。尽管近年来胶质瘤的治疗有了巨大的进步，但是它的预后仍然很差，因此亟需新的胶质瘤检测和治疗方法。RNA结合蛋白（RBPs）是一类能直接与RNA结合的蛋白，它可通过与RNA结合形成核糖核蛋白复合物（RNP），参与到RNA的剪切、聚腺苷酸化、定位、稳定性维持及翻译等过程。研究证明RBPs在肿瘤的发生与发展中发挥极其重要的作用．目前有研究证明它与胶质瘤也密切相关。本文将围绕RBPs在胶质瘤中的最新研究进展进行综述，并着重描述RBPs调控RNA生物活性的具体分子机制。

关键词：神经胶质瘤 RNA结合蛋白肿瘤