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MH-STRALP:A scoring system for prognostication in patients with upper gastrointestinal bleeding

World Journal of Gastrointestinal Surgery 2024年第3期16卷 790-806页

作者： Jun-Nan Hu Fei Xu Ya-Rong Hao Chun-Yan Sun kai-Ming Wu yong Lin Lan Zhong Xin Zeng Department of Gastroenterology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Gastroenterology Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China

BACKGROUND Upper gastrointestinal bleeding(UGIB)is a common medical emergency and early assessment of its outcomes is vital for treatment *** To develop a new scoring system to predict its *** In this retrospective study,692 patients with UGIB were enrolled from two cen-ters and divided into a training(n=591)and a validation cohort(n=101).The clinical data were collected to develop new prognostic prediction *** en-dpoint was compound outcome defined as(1)demand for emergency surgery or vascular intervention,(2)being transferred to the intensive care unit,or(3)death during *** models’predictive ability was compared with previously esta-blished scores by receiver operating characteristic(ROC)*** Totally 22.2%(131/591)patients in the training cohort and 22.8%(23/101)in the validation cohort presented poor *** on the stepwise-forward Lo-gistic regression analysis,eight predictors were integrated to determine a new post-endoscopic prognostic scoring system(MH-STRALP);a nomogram was de-termined to present the *** with the previous scores(GBS,Rock-all,ABC,AIMS65,and PNED score),MH-STRALP showed the best prognostic prediction ability with area under the ROC curves(AUROCs)of 0.899 and 0.826 in the training and validation cohorts,*** to the calibration cur-ve,decision curve analysis,and internal cross-validation,the nomogram showed good calibration ability and net clinical benefit in both *** removing the endoscopic indicators,the pre-endoscopic model(pre-MH-STRALP score)was ***,the pre-MHSTRALP score showed better predictive value(AUROCs of 0.868 and 0.767 in the training and validation cohorts,respectively)than the other pre-endoscopic *** The MH-STRALP score and pre-MH-STRALP score are simple,convenient,and accurate tools for prognosis prediction of UGIB,and may be applied for early decision on its management strategies.

关键词： Upper gastrointestinal bleeding Prognosis prediction Retrospective study Nomogram Post-endoscopic model Pre-endoscopic model

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Emerging WS_(2)/WSe_(2)@graphene nanocomposites: synthesis and electrochemical energy storage applications

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Rare Metals 2024年第1期43卷 1-19页

作者： Yu-Meng Gao yong Liu kai-Jia Feng Jun-Qing Ma Ying-Jie Miao Bin-Rui Xu Kun-Ming Pan Osaka Akiyoshi Guang-Xin Wang Ke-Ke Zhang Qiao-Bao Zhang National Joint Engineering Research Center for Abrasion Control and Molding of Metal Materials Henan Key Laboratory of Non-Ferrous Materials Science and Processing TechnologySchool of Materials Science and EngineeringHenan University of Science and TechnologyLuoyang 471023China Provincial and Ministerial Co-Construction of Collaborative School of Electrical Engineering Henan University of Science and TechnologyLuoyang 471023China Biomaterials Laboratory Faculty of EngineeringOkayama UniversityTsushima-NakeOkayama-Shi 700-8530Japan Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005China Fujian Key Laboratory of Surface and Interface Engineering for High Performance Materials Xiamen UniversityXiamen 361005China

In recent years, tungsten disulfide(WS_(2)) and tungsten selenide(WSe_(2)) have emerged as favorable electrode materials because of their high theoretical capacity, large interlayer spacing, and high chemical activity;nevertheless, they have relatively low electronic conductivity and undergo large volume expansion during cycling, which greatly hinder them in practical applications. These drawbacks are addressed by combining a superior type of carbon material, graphene, with WS_(2) and WSe_(2) to form a WS_(2)/WSe_(2)@graphene *** materials have received considerable attention in electro-chemical energy storage applications such as lithium-ion batteries(LIBs), sodium-ion batteries(SIBs),and supercapacitors. Considering the rapidly growing research enthusiasm on this topic over the past several years, here the recent progress of WS_(2)/WSe_(2)@graphene nanocomposites in electrochemical energy storage applications is summarized. Furthermore, various methods for the synthesis of WS_(2)/WSe_(2)@graphene nanocomposites are reported and the relationships among these methods, nano/microstructures, and electrochemical performance are systematically summarized and discussed. In addition, the challenges and prospects for the future study and application of WS_(2)/WSe_(2)@graphene nanocomposites in electrochemical energy storage applications are proposed.

关键词： WS_(2)/WSe_(2)@graphene nanocomposites Liion batteries(LIBs) Na-ion batteries(SIBs) Supercapacitors Electrochemical performance

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High-performance eight-channel system with fractal superconducting nanowire single-photon detectors

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Chip 2024年第2期3卷 45-52页

作者： Zifan Hao kai Zou Yun Meng Jun-yong Yan Fangyuan Li yongheng Huo Chao-Yuan Jin Feng Liu Thomas Descamps Adrian Iovan Val Zwiller Xiaolong Hu School of Precision Instrument and Optoelectronic Engineering Tianjin UniversityTianjin 300072China Key Laboratory of Optoelectronic Information Science and Technology Ministry of EducationTianjin 300072China State Key Laboratory of Modern Optical Instrumentation College of Information Science and Electronic EngineeringZhejiang UniversityHangzhou 300072China Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Department of Applied Physics Royal Institute of Technology(KTH)SE-10691 StockholmSweden

Superconducting nanowire single-photon detectors(SNSPDs)have become a mainstream photon-counting technology that has been widely applied in various *** far,most multi-channel SNSPD systems,either reported in literature or commercially available,are polarization sensitive,that is,the system detection efficiency(SDE)of each channel is dependent on the state of polarization of the to-be-detected ***,we reported an eight-channel system with fractal SNSPDs working in the wavelength range of 930 to 940 nm,which are all featured with low polarization *** a close-cycled Gifford-McMahon cryocooler system with the base temperature of 2.2 K,we installed and compared the performance of two types of devices:(1)SNSPD,composed of a single,continuous nanowire and(2)superconducting nanowire avalanche photodetector(SNAP),composed of 16 cascaded units of two nanowires electrically connected in *** highest SDE among the eight channels reaches 96+^(4)_(-5%),with the polarization sensitivity of 1.02 and a dark-count rate of 13 counts per *** average SDE for eight channels for all states of polarization is estimated to be 90±5%.It is concluded that both the SNSPDs and the SNAPs can reach saturated,high SDE at the wavelength of interest,and the SNSPDs show lower dark-count(false-count)rates,whereas the SNAPs show better properties in the time *** the adoption of this system,we showcased the measurements of the second-order photon-correlation functions of light emission from a singlephoton source based on a semiconductor quantum dot and from a pulsed *** is believed that this work will provide new choices of systems with single-photon detectors combining the merits of high SDE,low polarization sensitivity,and low noise that can be tailored for different applications.

关键词： Superconducting nanowire single-photon detector Superconducting strip photon detector Fractal Quantum optics Photon correlation

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Hepatocyte growth factor enhances the ability of dental pulp stem cells to ameliorate atherosclerosis in apolipoprotein E-knockout mice

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World Journal of Stem Cells 2024年第5期16卷 575-590页

作者： Han Duan Ning Tao Lin Lv kai-Xin Yan yong-Gang You Zhuang Mao Chang-Yao Wang Xue Li Jia-Yan Jin Chu-Tse Wu Hua Wang School of Life Sciences Hebei UniversityBaoding 071002Hebei ProvinceChina Beijing Institute of Radiation Medicine Beijing 100850China Department of Cardiology The Sixth Medical CentreChinese People’s Liberation Army General HospitalBeijing 100037China Department of Orthopaedics The Fourth Medical CentreChinese People’s Liberation Army General HospitalBeijing 100853China Third Cadet Regiment School of Basic Medical ScienceAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND Atherosclerosis(AS),a chronic inflammatory disease of blood vessels,is a major contributor to cardiovascular *** pulp stem cells(DPSCs)are capable of exerting immunomodulatory and anti-inflammatory effects by secreting cytokines and exosomes and are widely used to treat autoimmune and inflam-mation-related *** growth factor(HGF)is a pleiotropic cytokine that plays a key role in many inflammatory and autoimmune *** To modify DPSCs with HGF(DPSC-HGF)and evaluate the therapeutic effect of DPSC-HGF on AS using an apolipoprotein E-knockout(ApoE-/-)mouse model and an in vitro cellular *** ApoE-/-mice were fed with a high-fat diet(HFD)for 12 wk and injected with DPSC-HGF or Ad-Null modified DPSCs(DPSC-Null)through tail vein at weeks 4,7,and 11,respectively,and the therapeutic efficacy and mechanisms were analyzed by histopathology,flow cytometry,lipid and glucose measurements,real-time reverse transcription polymerase chain reaction(RT-PCR),and enzyme-linked immunosorbent assay at the different time points of the *** in vitro inflammatory cell model was established by using RAW264.7 cells and human aortic endothelial cells(HAOECs),and indirect co-cultured with supernatant of DPSC-Null(DPSC-Null-CM)or DPSC-HGF-CM,and the effect and mechanisms were analyzed by flow cytometry,RT-PCR and western *** factor-κB(NF-κB)activators and inhibitors were also used to validate the related signaling *** DPSC-Null and DPSC-HGF treatments decreased the area of atherosclerotic plaques and reduced the expression of inflammatory factors,and the percentage of macrophages in the aorta,and DPSC-HGF treatment had more pronounced *** treatment had no effect on serum lipoprotein *** FACS results showed that DPSCs treatment reduced the percentages of monocytes,neutrophils,and M1 macrophages in the peripheral blood and ***-Null-CM and DPSC-HGF-CM reduced adhesion molecule expression in tu

关键词： Atherosclerosis Apolipoprotein E-knockout mice Cell therapy Dental pulp stem cells Hepatocyte growth factor

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Spatial-and spin-resolution ARPES and magnetism beamline at SSRF

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Nuclear Science and Techniques 2024年第8期35卷 23-37页

作者： Fang‑Yuan Zhu Jie‑Feng Cao Xiang‑Yu Meng Jun‑Qin Li Rui Yu Ya‑Mei Wang Shan Qiao Bo Zhao Ming‑Zhu Zhang Zhong‑kai Liu Mei‑Xiao Wang yong Wang Ren‑Zhong Tai Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China ShanghaiTech Laboratory for Topological Physics School of Physical Science and TechnologyShanghai Tech UniversityShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China

The BL07U beamline is a new extreme ultraviolet and soft X-ray beamline housed in the Shanghai Synchrotron Radiation Facility. Beamlines are used in nano-resolved angle-resolved photoemission spectroscopy(nano-ARPES), spin-resolved angle-resolved photoemission spectroscopy(spin-ARPES), X-ray magnetic circular dichroism spectroscopy, and X-ray magnetic linear dichroism spectroscopy for certain scientific research. The BL07U beamline, which is based on a pair of elliptical polarized undulators and a variable-included-angle plane-grating monochromator, delivers circularly or linear polarized X-rays within the energy range of 50–2000 eV. The beamline features two branches: One dedicated to nano-ARPES,which has a minimum spot size of only ~ 200 nm, and another branch comprising spin-ARPES, a vector magnetic field, and superconductive magnetic end-station.

关键词： Soft X-ray beamline Nano-ARPES Spin-ARPES XMCD/XMLD

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脱硫胶粉/SBS复合改性沥青黏温特性及烟气排放研究

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公路 2024年第5期69卷 372-376页

作者：谌凯杨法勇中铁十局集团有限公司西安市710016 西安公路研究院有限公司西安市710065

在“碳达峰、碳中和”发展战略背景下,制备脱硫胶粉/SBS复合改性沥青,研究其使用性能、黏温特性和烟气排放。研究结果表明:复合改性沥青的针入度、软化点、延度及黏度均满足规范要求,具备优异的高温性能及抗拉伸能力,在高温下黏度大、... 详细信息

在“碳达峰、碳中和”发展战略背景下,制备脱硫胶粉/SBS复合改性沥青,研究其使用性能、黏温特性和烟气排放。研究结果表明:复合改性沥青的针入度、软化点、延度及黏度均满足规范要求,具备优异的高温性能及抗拉伸能力,在高温下黏度大、低温下黏度小,保证了施工和易性;在现场生产过程中烟气排放相比常规SBS改性沥青得到有效降低,SO_(2)排放降低25%左右,NO_(2)、NO_(x)排放降低超50%。

关键词：道路工程复合改性沥青脱硫胶粉黏温特性烟气排放

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Unveiling the secrets of gastrointestinal mucous adenocarcinoma survival after surgery with artificial intelligence:A population-based study

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2404-2418页

作者： Jie Song Xiang-Xiu Yan Fang-Liang Zhang yong-Yi Lei Zi-Yin Ke Fang Li kai Zhang Yu-Qi He Wei Li Chao Li Yuan-Ming Pan Department of Gastroenterology Dongying People’s HospitalDongying Hospital of Shandong Provincial Hospital GroupDongying 257000Shandong ProvinceChina Gastrointestinal Surgery Department Suining Central HospitalSuining 629000Sichuan ProvinceChina Obstetrical Department Suining Central HospitalSuining 629000Sichuan ProvinceChina School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina Department of Pathology Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049China General Department Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Department of Gastroenterology Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Department of Thoracic Surgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Department of Gastroenterology Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049China Cancer Research Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

BACKGROUND Research on gastrointestinal mucosal adenocarcinoma(GMA)is limited and controversial,and there is no reference tool for predicting postoperative *** To investigate the prognosis of GMA and develop predictive *** From the Surveillance,Epidemiology,and End Results database,we collected clinical information on patients with *** random sampling,the patients were divided into the discovery(70%of the total,for model training),validation(20%,for model evaluation),and completely blind test cohorts(10%,for further model evaluation).The main assessment metric was the area under the receiver operating characteristic curve(AUC).All collected clinical features were used for Cox proportional hazard regression analysis to determine factors influencing GMA’s *** This model had an AUC of 0.7433[95% confidence intervals(95%CI):0.7424-0.7442]in the discovery cohort,0.7244(GMA:0.7234-0.7254)in the validation cohort,and 0.7388(95%CI:0.7378-0.7398)in the test *** packaged it into Windows software for doctors’use and uploaded *** gastric adenocarcinoma had the worst prognosis,and these were protective factors of GMA:Regional nodes examined[hazard ratio(HR):0.98,95%CI:0.97-0.98,P<0.001]and chemotherapy(HR:0.62,95%CI:0.58-0.66,P<0.001).CONCLUSION The deep learning-based tool developed can accurately predict the overall survival of patients with GMA *** surgery,chemotherapy,and adequate lymph node dissection during surgery can improve patient outcomes.

关键词： Deep learning Gastrointestinal mucous adenocarcinoma Overall survival Surgery Clinical tool

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2×3 kW bidirectional output fiber oscillator employing spindle-shaped ytterbium-doped fiber

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Chinese Optics Letters 2024年第7期22卷 42-46页

作者： Lingfa Zeng Baolai yang Penglin Zhong Huan yang Peng Wang Zhiping Yan Xiaoming Xi Liangjin Huang Hanwei Zhang Xiaolin Wang Zhiyong Pan kai Han Zefeng Wang College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China

A 2×3 kW-level bidirectional output fiber oscillator is realized by combining the specially designed spindle-shaped ytterbium-doped fiber,non-wavelength-stabilized 976-nm LDs,and grating bandwidth optimization to balance transverse mode instability and stimulated Raman *** maximum output powers at both ends are 3265 and 2840 W,respectively,with a total efficiency of 73.2%.The M^(2) factors of the lasers at both ends are about 1.98 and 2.38,*** beam profile at both ends shows that a bidirectional output annular beam fiber oscillator has been realized,which has great potential in practical applications.

关键词： fiber laser bidirectional output fiber oscillator spindle-shaped ytterbium-doped fiber

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基于相位同步动力学重构网络单纯复形的相互作用

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物理学报 2024年第12期73卷 78-88页

作者：罗恺明管曙光邹勇华东师范大学物理与电子科学学院上海200241

复杂网络的高阶相互作用,如单纯复形和超边等,已经成为了研究的热点.本文提出一种基于节点同步动力学的特性来重构网络的单纯复形结构的新方法.通过分析Kuramoto-Sakaguchi模型中节点相位的时间序列同步性,建立了网络拓扑结构的解析描述... 详细信息

复杂网络的高阶相互作用,如单纯复形和超边等,已经成为了研究的热点.本文提出一种基于节点同步动力学的特性来重构网络的单纯复形结构的新方法.通过分析Kuramoto-Sakaguchi模型中节点相位的时间序列同步性,建立了网络拓扑结构的解析描述,实现了对网络结构的精确辨识.该方法的核心在于,运用理论手段推导得到了拉普拉斯矩阵与线性化Kuramoto-Sakaguchi系统相位之间的解析联系.这一联系不仅具有强大的普适性,而且能够有效地应用于识别包含任意阶单纯复形相互作用的网络结构.本文的研究进一步表明,这种解析关系能够用于鉴别网络中的对称节点,并且通过数值模拟证实了间接相互作用节点之间发生遥同步的现象与网络结构的对称性有着密切的联系.这些发现为深入理解网络的结构特性和动力学行为提供了新的理论工具和视角.

关键词：复杂网络单纯复形相位同步高阶相互作用

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30mm电热化学炮膛内压力波数值模拟研究

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兵工学报 2016年第9期37卷 1578-1584页

作者：倪琰杰程年恺金涌杨春霞李海元栗保明南京理工大学瞬态物理国家重点实验室江苏南京210094 中国兵器科学研究院北京100089

使用包含瞬态燃速公式的一维内弹道模型模拟30 mm电热化学发射过程,通过与发射实验结果相比较,验证了该模型的精确性。对比常规发射和电热化学发射膛内压力波曲线可知,电热化学发射技术可以有效降低膛内压力波。进一步分析输入电能、放... 详细信息

使用包含瞬态燃速公式的一维内弹道模型模拟30 mm电热化学发射过程,通过与发射实验结果相比较,验证了该模型的精确性。对比常规发射和电热化学发射膛内压力波曲线可知,电热化学发射技术可以有效降低膛内压力波。进一步分析输入电能、放电时序、发射药弧厚、装填密度等参数变化对膛内压力波的影响。研究表明:同步放电的条件下,电能比不大于0.042时,压力波峰值变化很小;电能比大于0.042时,压力波峰值随着电能比的增加迅速增大;首个负波幅值随着电能比线性递增,但受电能比影响小于压力波峰值;采用时序放电时,在控制压力波的前提下,电能比与放电电流的脉宽呈正比;在较高电能比下,压力波峰值与放电电流的脉宽呈反比;随着发射药装填密度的增加,膛内压力波增大;但在控制压力波的前提下,可输入的电能比无明显变化,首个负波幅值随着电能比的变化趋势不变;弧厚的变化对压力波的影响可忽略不计。

关键词：兵器科学与技术电热化学发射压力波一维数值模拟等离子体固体发射药

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