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Transactions of Nonferrous Metals Society of China 2022年第10期32卷 3197-3211页

作者： Ke-wei XIE Jin-feng NIE kai-qi hu Xia MA Xiang-fa LIU Key Laboratory for Liquid-Solid Structural Evolution&Processing of Materials Ministry of EducationShandong UniversityJinan 250061China Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China School of Mechanical Engineering Shandong University of TechnologyZibo 255000China

Nano-AlN and submicron-Al_(2)O_(3) particles were simultaneously utilized in a 6061 Al matrix composite to improve the high-temperature *** to the SEM and TEM characterization,nano-AlN and submicron-Al_(2)O_(3) particles are uniformly distributed in the Al *** hardness results indicate that different from the traditional 6061 Al matrix alloy,the aging kinetics of the composite is obviously accelerated by the reinforcement *** T6-treated composite exhibits excellent tensile properties at both room temperature and elevated *** at 350℃,the T6-treated composite not only has a high yield strength of 121 MPa and ultimate tensile strength of 128 MPa,but also exhibits a large elongation of 11.6%.Different strengthening mechanisms of nano-AlN and submicron-Al_(2)O_(3) particles were also discussed in detail.

关键词： 6061 Al matrix composite nano-AlN particles submicron-Al_(2)O_(3)particles high-temperature strength

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo qi Han Tang Jianian hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

CO2-mediated bicarbonate conversion to concentrated formate in a CEM-based electrolyzer

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Journal of Energy Chemistry 2025年第1期100卷 605-611页

作者： Haocheng Xiong Donghuan Wu Haonan Li Andrew Li qikun hu Siyao Song Bingjun Xu qi Lu State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University College of Chemistry and Molecular Engineering Peking University Ordos Laboratory

Renewable energy-driven bicarbonate conversion to valuable chemicals presents an attractive strategy for mitigating CO2emissions,as bicarbonate can be efficiently generated from the capture of atmospheric CO2using alkaline solutions with reactive *** this work,we present a CO2-mediated bicarbonate conversion to pure formate using a cation exchange membrane-based electrolyzer with a 25 cm2electrode *** electrolysis achieved selectivities exceeding 75%for formate at a total current of 2.5 A,achieving formate concentrations up to 1.2 M and yields as high as 95%over extended *** techno-economic assessment confirmed the economic viability of the process,highlighting the potential for bicarbonate electrolysis as a sustainable method for producing valuable chemicals.

关键词： Electrocatalysis Techno-economic assessments Electrochemistry Flow electrolyzer

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu qi Li Ruihua Li qingwen Li kai-Yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang kai Zhang Liping Ding Liyun Wu Songfeng E qian He Nanyang Wang hui Zuo Zhengyang Zhou Feng Ding Yue hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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基于文本挖掘的论坛热点问题时变分析

软件 2017年第4期38卷 47-51页

作者：吴柳程恺胡琪江苏海事职业技术学院南京210070 解放军理工大学指挥信息系统学院南京210007

随着互联网的普及,网络论坛因其开放性和自由性成为了舆论的发源地,真实地反映了当前的新闻热点和当前民众最关心的话题。本文基于网易论坛上的网上谈兵栏目,对相关帖子进行文本挖掘,通过改进传统的网络爬虫技术对指定论坛网页进行爬取... 详细信息

随着互联网的普及,网络论坛因其开放性和自由性成为了舆论的发源地,真实地反映了当前的新闻热点和当前民众最关心的话题。本文基于网易论坛上的网上谈兵栏目,对相关帖子进行文本挖掘,通过改进传统的网络爬虫技术对指定论坛网页进行爬取,设计了关键词权重计算公式提取关键词,依据关键词归纳总结热点话题,提出话题匹配规则对话题帖子进行定位匹配。通过分析热点话题随时间变化的趋势,把握网络舆论的动向,并对话题进一步的发展趋势做出一定预测,为相关部门及时、准确把握网络舆论动态走向提供了可靠依据。

关键词：网絡爬虫中文分词关键词提取热点话题时变分析

A denoising algorithm based on the improved EWT in distributed fiber optic temperature measurement system

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Optoelectronics Letters 2025年

作者： Xu Xiaoyi hu kai Wei Xiaoying Zhang kailiang Tianjin University of Technology， School of Integrated Circuit Science and Engineering Aerospace Optoelectronic Technology Development Co.， Ltd.

In order to enhance the temperature measurement accuracy of Raman distributed fiber optic temperature measurement system， in this paper， we propose a distributed fiber optic temperature measurement signal denoising algorithm based on the empirical wavelet transform with improved thresholding. This algorithm is used to decompose the noisy signal into multiple intrinsic modal threshold functions， which are further reconstructed by correlation filtering and threshold processing each of the IMFs using an improved function. The correlation filtering mechanism in this algorithm effectively reduces the regular noise and the amount of computation to improve the response speed. The improved threshold function can significantly reduce the spiky noise and smoothen the signal. The field temperature data is collected in the experiment， and the algorithm is implemented in the FPGA platform. In measured results， the system's temperature measurement accuracy is ±0.18℃ over 2.5 km of sensing fiber， with average response time is 0.6 seconds.

关键词：

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替莫唑胺联合放射治疗脑转移瘤临床观察

中国实用神经疾病杂志 2018年第11期21卷 1222-1227页

作者：魏凯张起胡金龙付蕾河南省人民医院河南郑州450003

目的探讨替莫唑胺联合放射治疗脑转移瘤的临床效果。方法选取脑转移瘤患者92例,按照就诊先后顺序分为研究组(替莫唑胺+放射)与对照组(单纯放射)。随访24个月,对比2组临床疗效、复发时间、生存时间、生存质量、不良反应等。结果 2组临床... 详细信息

目的探讨替莫唑胺联合放射治疗脑转移瘤的临床效果。方法选取脑转移瘤患者92例,按照就诊先后顺序分为研究组(替莫唑胺+放射)与对照组(单纯放射)。随访24个月,对比2组临床疗效、复发时间、生存时间、生存质量、不良反应等。结果 2组临床缓解率比较差异有统计学意义(P0.05);治疗后,2组生存质量评分较治疗前有所改善,且研究组优于对照组,差异有统计学意义(P<0.05);2组不良反应发生率差异有统计学意义(P<0.05)。结论脑转移瘤采用替莫唑胺联合放射治疗的效果更为理想,能延长患者生存时间,提升生存质量,且能减少不良反应,安全可靠。

关键词：脑转移瘤替莫唑胺放射生存质量生存时间复发颅内高压颅内肿瘤

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便携式γ能谱仪闪烁探头改进设计及性能研究

原子能科学技术 2017年第8期51卷 1471-1477页

作者：李元东葛良全王彦瑜张开琪胡传皓卢威骅孙坤黄锐成都理工大学地学核技术四川省重点实验室四川成都610051 中国科学院近代物理研究所甘肃兰州730000 中国辐射防护研究院山西太原030006

为满足当前便携式γ能谱仪对高性能闪烁探头的需要,本文提出了采用CsI(Tl)晶体耦合雪崩光电二极管的方式代替NaI(Tl)晶体耦合光电倍增管以构成新的闪烁探测器,并设计了低噪声电荷灵敏放大器作为探测器读出电路。根据唯一变量原则分别测... 详细信息

为满足当前便携式γ能谱仪对高性能闪烁探头的需要,本文提出了采用CsI(Tl)晶体耦合雪崩光电二极管的方式代替NaI(Tl)晶体耦合光电倍增管以构成新的闪烁探测器,并设计了低噪声电荷灵敏放大器作为探测器读出电路。根据唯一变量原则分别测试了能量分辨率随温度与偏压的变化规律,并对多种放射源的γ射线进行能谱响应实验。实验结果表明:当温度为23℃且偏压为370V时,该闪烁探头对^(137) Cs、^(226) Ra、^(60) Co和^(152) Eu源的γ射线具备优异的能谱响应特性,其中,对^(137) Cs源的γ射线能量分辨率可达4.98%,输出信号信噪比可达21∶1,上升时间为80ns。可见,改进后的闪烁探头的性能有大幅提升,具备能量分辨率更佳、体积更小、抗机械性能与适用性更强等优点。

关键词： γ能谱仪闪烁探头电荷灵敏放大器雪崩光电二极管能谱响应能量分辨率