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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li kai-yu tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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Hydrogen storage in Li-doped fullerene-intercalated hexagonal boron nitrogen layers

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Frontiers of physics 2016年第5期11卷 119-126页

作者： Yi-Han Cheng Chuan-yu Zhang Juan Ren kai-yu tong Physics Department Chengdu University of Technology Chengdu 610059 China School of Science Xi'an Technological University Xi 'an 710032 China

New materials for hydrogen storage of Li-doped fullerene （C20, C28, C36, C50, C60, C70）-intercalated hexagonal boron nitrogen （h-BN） frameworks were designed by using density functional theory （DFT） calculations. First-principles molecular dynamics （MD） simulations showed that the struc- tures of the Cn-BN （n = 20, 28, 36, 50, 60, and 70） frameworks were stable at room temperature. The interlayer distance of the h-BN layers was expanded to 9.96-13.59 A° by the intercalated fullerenes. The hydrogen storage capacities of these three-dimensional （3D） frameworks were studied using grand canonical Monte Carlo （GCMC） simulations. The GCMC results revealed that at 77 K and 100 bar （10 MPa）, the C50-BN framework exhibited the highest gravimetric hydrogen uptake of 6.86 wt% and volumetric hydrogen uptake of 58.01 g/L. Thus, the hydrogen uptake of the Li-doped Cn-intercalated h-BN frameworks was nearly double that of the non-doped framework at room temperature. Furthermore, the isosteric heats of adsorption were in the range of 10-21 kJ/mol, values that are suitable for adsorbing/desorbing the hydrogen molecules at room temperature. At 193 K （-80 ℃） and 100 bar for the Li-doped C50-BN framework, the gravimetric and volumetric uptakes of H2 reached 3.72 wt% and 30.08 g/L, respectively.

关键词： hydrogen storage boron nitrogen doping first-principles grand canonical Monte Carlo

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Prospects of elafibranor in treating alcohol-associated liver diseases

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World Journal of Gastroenterology 2025年第2期31卷 132-137页

作者： Wei-tong Cui Hua-Ru Xue Dian-Fang Wei Xiao-yu Feng kai Wang School of Basic Medicine Qilu Medical UniversityZibo 255300Shandong ProvinceChina School of Medical Imaging Qilu Medical UniversityZibo 255300Shandong ProvinceChina

Alcohol-related liver disease(ALD),which is induced by excessive alcohol con-sumption,is a leading cause of liver-related morbidity and *** pa-tients exhibit a spectrum of liver injuries,including hepatic steatosis,inflam-mation,and fibrosis,similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis,metabolic dysfunction-associated steatotic liver disease,and nonalcoholic *** has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and in vitro cell models of metabolic dysfunc-tion-associated steatotic liver disease and nonalcoholic ***,the efficacy of elafibranor in treating ALD remains *** this article,we comment on the recent publication by Koizumi et al that evaluated the effects of elafibranor on liver fibrosis and gut barrier function in an ALD mouse *** findings indicate the potential of elafibranor for ALD treatment,but further experimental investigations and clinical trials are warranted.

关键词： Elafibranor Alcohol-associated liver diseases Peroxisome proliferator-activated receptor Lipid Apoptosis Steatosis Inflammation Fibrosis

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神经电信号中眼轮匝肌功能状态的识别

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中国医学物理学杂志 2007年第5期24卷 342-345页

作者：曹军邵时云李辉李乐 kai-yu tong 第四军医大学口腔医学院正畸科西安710032 西安交通大学生物医学工程研究所西安710032 香港理工大学医疗科技与资讯学系

目的:提取能反映眼轮匝肌功能活动的狗面神经颧支的神经电信号(ENG),通过对ENG信号的分析,识别出眼轮匝肌的功能状态。方法:利用植入到狗面神经颧支周围的Cuff电极提取有闭眼动作发生期间的神经电信号,采用幅度阈值法,通过对ENG信号的分... 详细信息

目的:提取能反映眼轮匝肌功能活动的狗面神经颧支的神经电信号(ENG),通过对ENG信号的分析,识别出眼轮匝肌的功能状态。方法:利用植入到狗面神经颧支周围的Cuff电极提取有闭眼动作发生期间的神经电信号,采用幅度阈值法,通过对ENG信号的分析,识别出闭眼动作发生时眼轮匝肌的收缩动作。结果:研究中我们提取到了能反映闭眼动作发生的ENG信号,并且通过对信号的分析,识别出了眼轮匝肌收缩动作的发生。结论:可以通过对眼轮匝肌支配神经上ENG信号的分析,监控眼轮匝肌的功能状态。

关键词：神经电信号眼轮匝肌信号识别

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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： tong Li Quhan Cheng Jingai Zhang Boxin Liu yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

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Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

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World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： yu Li Chen-kai Huang Yi Hu Xiao-Dong Zhou Cong He Jia-Wei Zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina HuanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-yu Bian yu-Fang Feng Wen-Ting He tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

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Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

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Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long Zhou Wei-Jin Jiang Ji yu Mao-Jun Yao yun-tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

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Hydraulic modeling and optimization of jet mill bit considering the characteristics of depressurization and cuttings cleaning

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Petroleum Science 2023年第5期20卷 3085-3099页

作者： tong Cao Xu-yue Chen kai-An yu Lin Tang School of Mechatronic Engineering Xi'an Technological UniversityXi'anShaanxi710021China MOE Key Laboratory of Petroleum Engineering China University of PetroleumBeijing102249China College of Mechanical and Transportation Engineering China University of PetroleumBeijing102249China

A jet mill bit(JMB)is proposed to increase the drilling efficiency and safety of horizontal wells,which has the hydraulic characteristics of depressurization and cuttings *** paper fills the gap in the hydraulic study of the JMB by focusing on the hydraulic modeling and optimization of the JMB and considering these two hydraulic ***,the hydraulic depressurization model and the hydraulic cuttings cleaning model of the JMB are developed *** the models,the pressure ratio and efficiency are chosen as the evaluation parameters of the depressurization capacity of the JMB,and the jet hydraulic power and jet impact force are chosen as the evaluation parameters of cuttings cleaning capacity of the ***,based on the hydraulic models,the effects of model parameters[friction loss coefficient,target inclination angle,rate of penetration(ROP),flow ratio,and well depth]on the hydraulic performance of the JMB are *** results show that an increase in the friction loss coefficient and target inclination angle cause a significant reduction in the hydraulic depressurization capacity,and the effect of ROP is *** flow ratio is positively related to the hydraulic cuttings cleaning capacity,and the well depth determines the maximum hydraulic cuttings cleaning ***,by combining the hydraulic depressurization model and hydraulic cuttings cleaning model,an optimization method of JMB hydraulics is proposed to simultaneously maximize the jet depressurization capacity and the cuttings cleaning *** to the drilling parameters given,the optimal values of the drilling fluid flow rate,backward nozzle diameter,forward nozzle diameter,and throat diameter can be ***,a case study is conducted to verify the effectiveness of the optimization method.

关键词： Jet mill bit Hydraulic depressurization model Hydraulic cuttings cleaning model Parametric study Hydraulic optimization

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Readily accessible rhodamine B-based photoresponsive material

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Science China Chemistry 2014年第2期57卷 248-251页

作者： LI kai XIANG yu tong AiJun TANG Ben Zhong Beijing Key Laboratory Microanalytical Methods and Instrumentation Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education Department of Chemistry Tsinghua University Department of Chemistry Institute of Molecular Functional MaterialsState Key Laboratory of Molecular NeuroscienceThe Hong Kong University of Science & Technology

A photochromic rhodamine B-based material containing Cd（Ⅱ） as bridge was facilely prepared. The 4-methoxylsalicylalde hyde rhodamine B bydrazone Cd（Ⅱ） complex displayed unusual ring-open response upon 365 nm UV irradiation, exhibiting long photochromic lifetime and good fatigue resistance. The UV-induced ring-open of the complex led to a distinct color and fluorescence change in acetonitrile. A new mechanism was put forward： salicylaldehyde part in the complex underwent UV-promoted isomerization from enol-form to keto-form, enhancing the chelation of Cd（Ⅱ） and yielding the ring-opening rhodamine B part. Compared to other reported photochromic systems, this new photochromic material offered attractive new insights into the development of low cost photochromic materials with good performance.

关键词： photochromism coordination compound rhodamine B salicylaldehyde hydrazone cadmium UV-light

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